公开(公告)号：US20090041852A1

公开(公告)日：2009-02-12

申请号：US12293019

申请日：2007-03-15

申请人： Jean Paul Remon ,  Chris Vervaet ,  Evy Corbanie

发明人： Jean Paul Remon ,  Chris Vervaet ,  Evy Corbanie

IPC分类号： A61K9/14 ,  A61K39/12 ,  A61K39/02 ,  A61K39/002 ,  A61K39/155 ,  A61K39/17 ,  A61K39/145 ,  A61K39/215 ,  A61K39/125 ,  A61K39/29 ,  A61K39/15 ,  A61K39/21 ,  A61K39/23 ,  A61K39/245 ,  A61K39/275 ,  A61K39/205 ,  A61P37/00 ,  A61P31/12

CPC分类号： A61K39/00 ,  A61K9/0078 ,  A61K9/1623 ,  A61K9/1635 ,  A61K2039/544 ,  A61K2039/552 ,  C12N2760/18134

摘要： This invention provides a dry powder composition for poultry vaccination via inhalation comprising an effective amount of a poultry vaccine agent, and a supporting amount of carriers for said poultry vaccine agent, said carriers comprising a combination of a reducing or non-reducing sugar and a biocompatible polymer, said dry powder composition being in the form of particles having an average particle size from 2 to 30 μm and a particle size polydispersity from 1.1 to 4.0. This invention also relates to a method for producing said dry powder compositions and a system for vaccination of poultry by inhalation.

摘要翻译： 本发明提供了一种用于通过吸入进行家禽接种的干粉组合物，其包含有效量的家禽疫苗剂和所述家禽疫苗剂的载体量，所述载体包含还原糖或非还原糖和生物相容性的组合 聚合物，所述干粉组合物为平均粒度为2〜30μm，粒径多分散性为1.1〜4.0的颗粒状。 本发明还涉及一种生产所述干粉组合物的方法和一种通过吸入对家禽进行疫苗接种的系统。

公开(公告)号：US20110150940A1

公开(公告)日：2011-06-23

申请号：US12970225

申请日：2010-12-16

申请人： Jean Paul Remon ,  Chris Vervaet ,  Evy Corbanie ,  Johannes Hubertus Henricus van Eck ,  Wilhelmus Johannes Mathernus Landman

发明人： Jean Paul Remon ,  Chris Vervaet ,  Evy Corbanie ,  Johannes Hubertus Henricus van Eck ,  Wilhelmus Johannes Mathernus Landman

IPC分类号： A61K9/14 ,  A61K39/12 ,  A61K39/02 ,  A61K39/00 ,  A61K39/245 ,  A61K39/29 ,  A61K39/145 ,  A61K39/155 ,  A61K39/17 ,  A61K39/275 ,  A61K39/235 ,  A61K39/21 ,  A61K39/215 ,  A61K39/125 ,  A61K39/15 ,  A61P31/14 ,  A61P31/20 ,  A61P31/04 ,  A61P31/10

CPC分类号： A61K39/00 ,  A61K9/0078 ,  A61K9/1623 ,  A61K9/1635 ,  A61K2039/544 ,  A61K2039/552 ,  C12N2760/18134

摘要： This invention provides a dry powder composition for poultry vaccination via inhalation comprising an effective amount of a poultry vaccine agent, and a supporting amount of carriers for said poultry vaccine agent, said carriers comprising a combination of a reducing or non-reducing sugar and a biocompatible polymer, said dry powder composition being in the form of particles having an average particle size from 2 to 30 μm and a particle size polydispersity from 1.1 to 4.0. This invention also relates to a method for producing said dry powder compositions and a system for vaccination of poultry by inhalation.

摘要翻译： 本发明提供了一种用于通过吸入进行家禽接种的干粉组合物，其包含有效量的家禽疫苗剂和所述家禽疫苗剂的载体量，所述载体包含还原糖或非还原糖和生物相容性的组合 聚合物，所述干粉组合物为平均粒度为2〜30μm，粒径多分散性为1.1〜4.0的颗粒状。 本发明还涉及一种生产所述干粉组合物的方法和一种通过吸入对家禽进行疫苗接种的系统。

公开(公告)号：US20090232744A1

公开(公告)日：2009-09-17

申请号：US12380378

申请日：2009-02-26

申请人： Manfred Keller ,  Evy Corbanie

发明人： Manfred Keller ,  Evy Corbanie

IPC分类号： A61K9/12 ,  A61K31/7048 ,  A61K31/7028

CPC分类号： A61K9/0078 ,  A61K31/7028 ,  A61K31/7048 ,  A61K47/12

摘要： The invention provides an aqueous pharmaceutical composition for administration as an aerosol to the respiratory tract, nose or oropharyngeal region comprising (i) a macrolide having a poor taste and poor chemical stability in aqueous solution; (ii) at least one salt selected from the group consisting of sodium gluconate, sodium aspartate, sodium acetate, sodium lactate, sodium succinate, sodium maleate, magnesium gluconate, magnesium aspartate, magnesium citrate, magnesium acetate, magnesium lactate, magnesium succinate, and magnesium maleate; or mixtures thereof and (iii) a taste-masking agent different from said salt; wherein (a) the concentration of said macrolide in the composition is in the range of about 0.25 wt.-% to about 15 wt.-%; (b) the molar ratio of said macrolide:said salt is in the range from about 1:0.5 to about 1:100; (c) the pH of the composition is in the range of about 3 to 9; and (d) the osmolality of the composition is in the range of about 150 mOsmol/kg to about 1500 mOsmol/kg. The invention further provides a method of generating an aerosol, preferably by means of a nebuliser, which uses such an aqueous pharmaceutical composition. The macrolide may be used alone or in combination with other drugs. The composition is suitable to treat inflammatory disorders and/or infections of the respiratory tract. It has an improved taste and stability.

摘要翻译： 本发明提供一种用于作为气溶胶施用于呼吸道，鼻或口咽区域的水性药物组合物，其包含（i）具有差的味道和在水溶液中的化学稳定性差的大环内酯类; （ii）至少一种选自葡萄糖酸钠，天冬氨酸钠，乙酸钠，乳酸钠，琥珀酸钠，马来酸钠，葡糖酸镁，天冬氨酸镁，柠檬酸镁，乙酸镁，乳酸镁，琥珀酸镁和 马来酸镁 或其混合物和（iii）不同于所述盐的掩味剂; 其中（a）所述大环内酯在组合物中的浓度在约0.25重量％至约15重量％的范围内; （b）所述大环内酯：所述盐的摩尔比在约1:0.5至约1:100的范围内; （c）组合物的pH在约3至9的范围内; 和（d）组合物的重量摩尔渗透压浓度在约150mOsmol / kg至约1500mOsmol / kg的范围内。 本发明还提供了一种产生气雾剂的方法，优选通过使用这种水性药物组合物的雾化器。 大环内酯可以单独使用或与其他药物组合使用。 该组合物适用于治疗炎症性疾病和/或呼吸道感染。 它具有改善的味道和稳定性。