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1.发明申请Pharmaceutical Pellets Comprising Modified Starch and Therapeutic Applications Therefor 审中-公开包含改性淀粉的药物颗粒及其治疗应用公开(公告)号：US20100105784A1
公开(公告)日：2010-04-29
申请号：US12603917
申请日：2009-10-22
申请人： Jean Paul Remon , Chris Vervaet , Paul Foreman
发明人： Jean Paul Remon , Chris Vervaet , Paul Foreman
CPC分类号： A61K9/0034 , A61K9/1652
摘要： Vaginal use compositions comprising pellets prepared from a debranched starch. Pellets may be conveniently prepared via extrusion/spheronization.
摘要翻译： 阴道用组合物包含由脱支淀粉制备的颗粒。 可以通过挤出/滚圆法方便地制备颗粒。
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2.发明申请PHARMACEUTICAL PELLETS COMPRISING MODIFIED STARCH AND THERAPEUTIC APPLICATIONS THEREFOR 审中-公开包含改性淀粉和治疗应用的药物颗粒公开(公告)号：US20120207823A1
公开(公告)日：2012-08-16
申请号：US13454592
申请日：2012-04-24
申请人： Jean Paul Remon , Chris Vervaet , Paul Foreman
发明人： Jean Paul Remon , Chris Vervaet , Paul Foreman
IPC分类号： A61K9/48 , A61K31/4164 , A61K31/4174 , A61K9/14 , A61P31/10 , A61P31/00 , A61P29/00 , A61K31/57 , A61P15/02
CPC分类号： A61K9/0034 , A61K9/1652
摘要： Vaginal use compositions comprising pellets prepared from a debranched starch. Pellets may be conveniently prepared via extrusion/spheronization.
摘要翻译： 阴道用组合物包含由脱支淀粉制备的颗粒。 可以通过挤出/滚圆法方便地制备颗粒。
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3.发明授权公开(公告)号：US08318230B2
公开(公告)日：2012-11-27
申请号：US11410375
申请日：2006-04-25
IPC分类号： A23B4/03
CPC分类号： A61K47/36 , A61K9/1652 , A61K31/52
摘要： This patent pertains to the use of debranched starch in the preparation of pharmaceutical pellets by extrusion spheronization. Such excipients are useful in any dry dosage form, including tablets and capsules, for either immediate or sustained release.
摘要翻译： 本专利涉及使用脱支淀粉通过挤出滚圆法制备药丸。 这种赋形剂可用于任何干剂型，包括片剂和胶囊剂，用于立即或持续释放。
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4.发明申请公开(公告)号：US20110008454A1
公开(公告)日：2011-01-13
申请号：US12815781
申请日：2010-06-15
申请人： Jean Paul Remon , Chris Vervaet
发明人： Jean Paul Remon , Chris Vervaet
IPC分类号： A61K9/16 , A61K31/165
CPC分类号： A61K9/1652 , A61K9/1641 , A61K9/1694
摘要： A pharmaceutical or veterinary granule composition in the form of a mixture consisting essentially of: (i) at least one drug classifiable as Class II or Class IV of the Biopharmaceutical Classification System, wherein said drug (i) constitutes from 0.5% to 20% by weight of the composition, and excipients, said pharmaceutical or veterinary granule composition providing a drug release of at least 70% within 10 minutes in water, (ii) a first excipient being a maltodextrin representing from 40% by weight to 80% by weight of said composition, (iii) a wetting amount of a second excipient being a polyethylene glycol having a weight number molecular weight between 300 and 5,000, said second excipient comprising a solid fraction and a liquid fraction, and representing from 15% to 40% by weight of said composition, and optionally one or more pharmaceutically acceptable fillers selected from the group consisting of hydrocolloids, glidants, lubricants, surfactants and diluents, wherein the weight ratio of said first excipient (ii) to said second excipient (iii) is in a range from 1:1 to 5:1.
摘要翻译： 以混合物形式的药物或兽用颗粒组合物，其基本上由以下组成：（i）至少一种可分类为生物药物分类系统的II类或IV类的药物，其中所述药物（i）构成0.5％至20％ 所述组合物的重量和赋形剂，所述药物或兽用颗粒组合物在水中在10分钟内提供至少70％的药物释放，（ii）作为麦芽糖糊精的第一赋形剂，代表40重量％至80重量％ 所述组合物，（iii）第二赋形剂的润湿量，其为重量数分子量为300至5,000的聚乙二醇，所述第二赋形剂包含固体部分和液体部分，并且代表15重量％至40重量％ 的所述组合物，以及任选的一种或多种药学上可接受的填料，其选自水胶体，助流剂，润滑剂，表面活性剂和稀释剂，其中重量 所述第一赋形剂（ii）与所述第二赋形剂（iii）的比例在1:1至5:1的范围内。
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公开(公告)号：US20090041852A1
公开(公告)日：2009-02-12
申请号：US12293019
申请日：2007-03-15
申请人： Jean Paul Remon , Chris Vervaet , Evy Corbanie
发明人： Jean Paul Remon , Chris Vervaet , Evy Corbanie
IPC分类号： A61K9/14 , A61K39/12 , A61K39/02 , A61K39/002 , A61K39/155 , A61K39/17 , A61K39/145 , A61K39/215 , A61K39/125 , A61K39/29 , A61K39/15 , A61K39/21 , A61K39/23 , A61K39/245 , A61K39/275 , A61K39/205 , A61P37/00 , A61P31/12
CPC分类号： A61K39/00 , A61K9/0078 , A61K9/1623 , A61K9/1635 , A61K2039/544 , A61K2039/552 , C12N2760/18134
摘要： This invention provides a dry powder composition for poultry vaccination via inhalation comprising an effective amount of a poultry vaccine agent, and a supporting amount of carriers for said poultry vaccine agent, said carriers comprising a combination of a reducing or non-reducing sugar and a biocompatible polymer, said dry powder composition being in the form of particles having an average particle size from 2 to 30 μm and a particle size polydispersity from 1.1 to 4.0. This invention also relates to a method for producing said dry powder compositions and a system for vaccination of poultry by inhalation.
摘要翻译： 本发明提供了一种用于通过吸入进行家禽接种的干粉组合物，其包含有效量的家禽疫苗剂和所述家禽疫苗剂的载体量，所述载体包含还原糖或非还原糖和生物相容性的组合 聚合物，所述干粉组合物为平均粒度为2〜30μm，粒径多分散性为1.1〜4.0的颗粒状。 本发明还涉及一种生产所述干粉组合物的方法和一种通过吸入对家禽进行疫苗接种的系统。
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公开(公告)号：US09168303B2
公开(公告)日：2015-10-27
申请号：US14131495
申请日：2012-07-12
CPC分类号： A61K47/32 , A61K9/0036 , A61K31/19 , A61K47/38
摘要： The present invention in general relates to an intravaginal delivery system as well as uses thereof and methods for manufacturing and use of the same. In particular the present invention relates to an intravaginal delivery system for the controlled release of one or more organic acids, such as lactic acid; said intravaginal delivery system being characterized in that it comprises a combination of ethylene vinyl acetate (EVA) copolymers and carboxylic polymers, such as for example methacrylic acid-methacrylic ester copolymers.
摘要翻译： 本发明一般涉及阴道内递送系统及其用途及其制造和使用方法。 特别地，本发明涉及用于控制释放一种或多种有机酸如乳酸的阴道内递送系统; 所述阴道内递送系统的特征在于其包含乙烯乙酸乙烯酯（EVA）共聚物和羧酸聚合物的组合，例如甲基丙烯酸 - 甲基丙烯酸酯共聚物。
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公开(公告)号：US20110150940A1
公开(公告)日：2011-06-23
申请号：US12970225
申请日：2010-12-16
申请人： Jean Paul Remon , Chris Vervaet , Evy Corbanie , Johannes Hubertus Henricus van Eck , Wilhelmus Johannes Mathernus Landman
发明人： Jean Paul Remon , Chris Vervaet , Evy Corbanie , Johannes Hubertus Henricus van Eck , Wilhelmus Johannes Mathernus Landman
IPC分类号： A61K9/14 , A61K39/12 , A61K39/02 , A61K39/00 , A61K39/245 , A61K39/29 , A61K39/145 , A61K39/155 , A61K39/17 , A61K39/275 , A61K39/235 , A61K39/21 , A61K39/215 , A61K39/125 , A61K39/15 , A61P31/14 , A61P31/20 , A61P31/04 , A61P31/10
CPC分类号： A61K39/00 , A61K9/0078 , A61K9/1623 , A61K9/1635 , A61K2039/544 , A61K2039/552 , C12N2760/18134
摘要： This invention provides a dry powder composition for poultry vaccination via inhalation comprising an effective amount of a poultry vaccine agent, and a supporting amount of carriers for said poultry vaccine agent, said carriers comprising a combination of a reducing or non-reducing sugar and a biocompatible polymer, said dry powder composition being in the form of particles having an average particle size from 2 to 30 μm and a particle size polydispersity from 1.1 to 4.0. This invention also relates to a method for producing said dry powder compositions and a system for vaccination of poultry by inhalation.
摘要翻译： 本发明提供了一种用于通过吸入进行家禽接种的干粉组合物，其包含有效量的家禽疫苗剂和所述家禽疫苗剂的载体量，所述载体包含还原糖或非还原糖和生物相容性的组合 聚合物，所述干粉组合物为平均粒度为2〜30μm，粒径多分散性为1.1〜4.0的颗粒状。 本发明还涉及一种生产所述干粉组合物的方法和一种通过吸入对家禽进行疫苗接种的系统。
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8.发明申请公开(公告)号：US20110027377A1
公开(公告)日：2011-02-03
申请号：US12815715
申请日：2010-06-15
申请人： Jean Paul Remon , Chris Vervaet
发明人： Jean Paul Remon , Chris Vervaet
IPC分类号： A61K9/16 , A61K31/165
CPC分类号： A61K9/1652 , A61K9/1641 , A61K9/1694
摘要： A pharmaceutical or veterinary granule composition in the form of a mixture consisting essentially of: (i) at least one drug classifiable as Class II or Class IV of the Biopharmaceutical Classification System, wherein said drug (i) constitutes from above about 20% to 50% by weight of the composition, said pharmaceutical or veterinary granule composition providing a drug release of at least 70% within 10 minutes in water, (ii) a first excipient being a maltodextrin representing from 40% by weight to 85% by weight of said composition, (iii) a wetting amount of a second excipient being a polyethylene glycol having a weight number molecular weight between 300 and 5,000, said second excipient comprising a solid fraction and a liquid fraction, and representing from 15% to 40% by weight of said composition, and optionally one or more pharma-ceutically acceptable fillers selected from the group consisting of hydrocolloids, glidants, lubricants, surfactants and diluents, wherein the weight ratio of said first excipient (ii) to said second excipient (iii) is in a range from 1:1 to 5:1.
摘要翻译： 基本上由以下组成的混合物的药物或兽用颗粒组合物：（i）至少一种可分类为生物制药分类系统的II类或IV类的药物，其中所述药物（i）构成高于约20％至50 所述药物或兽用颗粒组合物在水中在10分钟内提供至少70％的药物释放，（ii）作为麦芽糖糊精的第一赋形剂代表所述组合物的40重量％至85重量％ 组合物，（iii）第二赋形剂的润湿量，其为重量数分子量为300至5,000的聚乙二醇，所述第二赋形剂包含固体部分和液体部分，并且占所述第二赋形剂的15重量％至40重量％ 所述组合物和任选的一种或多种选自水胶体，助流剂，润滑剂，表面活性剂和稀释剂的药物可接受的填料，其中重量比 所述第一赋形剂（ii）与所述第二赋形剂（iii）的比例为1：1至5：1。
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公开(公告)号：US20140154293A1
公开(公告)日：2014-06-05
申请号：US14131495
申请日：2012-07-07
CPC分类号： A61K47/32 , A61K9/0036 , A61K31/19 , A61K47/38
摘要： The present invention in general relates to an intravaginal delivery system as well as uses thereof and methods for manufacturing and use of the same. In particular the present invention relates to an intravaginal delivery system for the controlled release of one or more organic acids, such as lactic acid; said intravaginal delivery system being characterized in that it comprises a combination of ethylene vinyl acetate (EVA) copolymers and carboxylic polymers, such as for example methacrylic acid-methacrylic ester copolymers.
摘要翻译： 本发明一般涉及阴道内递送系统及其用途及其制造和使用方法。 特别地，本发明涉及用于控制释放一种或多种有机酸如乳酸的阴道内递送系统; 所述阴道内递送系统的特征在于其包含乙烯乙酸乙烯酯（EVA）共聚物和羧酸聚合物的组合，例如甲基丙烯酸 - 甲基丙烯酸酯共聚物。
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公开(公告)号：US20130149357A1
公开(公告)日：2013-06-13
申请号：US13818263
申请日：2011-08-24
CPC分类号： A61K9/14 , A61J3/00 , A61K9/0019 , A61K9/0024 , A61K9/1617 , A61K9/1623 , A61K9/1641 , A61K39/385 , A61K47/10 , A61K47/36 , A61K47/42 , A61K2039/55555
摘要： The present invention discloses a composition comprising a polyelectrolyte complex and a polyol, characterised in that said polyol is in amorphous form. Optionally, the composition further comprises one or more drugs, wherein each drug has a molecular weight of at least 1000 Dalton. Said compositions are obtainable by spray-drying. The compositions may be prepared in particle form and as a suspension of particles. Pharmaceutical compositions are also provided for use in extracellular drug delivery. Pharmaceutical compositions are also provided that exhibit a controlled dual drug release.
摘要翻译： 本发明公开了一种包含聚电解质络合物和多元醇的组合物，其特征在于所述多元醇为无定形形式。 任选地，组合物还包含一种或多种药物，其中每种药物具有至少1000道尔顿的分子量。 所述组合物可通过喷雾干燥获得。 组合物可以以颗粒形式和作为颗粒的悬浮液制备。 还提供药物组合物用于细胞外药物递送。 还提供显示受控双重药物释放的药物组合物。
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