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公开(公告)号：US08725470B1
公开(公告)日：2014-05-13
申请号：US13109954
申请日：2011-05-17
CPC分类号： G06F17/5095 , G06F17/5009 , G06F17/5018 , G06F2217/16
摘要： A method and associated system for multi-disciplinary optimization of various parameters associated with a space vehicle that experiences aerocapture and atmospheric entry in a specified atmosphere. In one embodiment, simultaneous maximization of a ratio of landed payload to vehicle atmospheric entry mass, maximization of fluid flow distance before flow separation from vehicle, and minimization of heat transfer to the vehicle are performed with respect to vehicle surface geometric parameters, and aerostructure and aerothermal vehicle response for the vehicle moving along a specified trajectory. A Pareto Optimal set of superior performance parameters is identified.
摘要翻译： 一种用于与特定气氛中经历气蚀和大气进入的空间车辆相关的各种参数的多学科优化的方法和相关系统。 在一个实施例中，相对于车辆表面几何参数，航空结构和车辆空中结构以及相对于车辆大气进入质量的比例，同时最大化着陆有效载荷与车辆大气进入质量之间的最大化，流动与车辆分离之前的流体流动距离的最大化以及对车辆的热传递的最小化 车辆沿指定轨迹行驶的空气热响应。 识别出优秀性能参数的帕累托最优集。
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公开(公告)号：US08293879B2
公开(公告)日：2012-10-23
申请号：US11906189
申请日：2007-10-01
申请人： James L. Brown
发明人： James L. Brown
CPC分类号： G01N33/564 , C07K14/721 , C07K2319/61 , G01N2333/726 , G01N2800/24 , Y10S435/80
摘要： The present invention provides methods and compositions useful in the diagnosis and management of autoimmune diseases. In particular, the present invention provides improved methods and compositions for the diagnosis and management of Graves' disease. The methods of the present invention not only avoids the need for radioactivity and are much simpler, economical, and rapid than methods traditionally used for the diagnosis of Graves' disease, but also improve upon the sensitivity and detection abilities of previous luciferase-based autoantibody detection assays.
摘要翻译： 本发明提供了用于诊断和治疗自身免疫疾病的方法和组合物。 特别地，本发明提供了用于诊断和治疗格雷夫斯病的改进方法和组合物。 本发明的方法不仅避免了对放射性的需要，而且比传统上用于诊断格雷夫斯病的方法简单，经济和快速，而且改进了以前基于荧光素酶的自身抗体检测的灵敏度和检测能力 测定。
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3.发明授权公开(公告)号：US07597113B2
公开(公告)日：2009-10-06
申请号：US12346677
申请日：2008-12-30
申请人： Rodolfo Garcia , James L. Brown
发明人： Rodolfo Garcia , James L. Brown
CPC分类号： E03B9/04 , E03B9/10 , Y10T137/5327 , Y10T137/545 , Y10T137/5462 , Y10T137/7043 , Y10T137/7062
摘要： Improvements in present day fire hydrants are presented. The improvement relates to a fire hydrant where the above ground structure is essentially removed and is replaced with an adaptable connection. The connection uses the same mounting hole pattern as used in the above ground hydrant. In operation, the adaptable connection is protected by a hinged cover that is opened to provide access to the adaptable connection. The adaptable connection includes a bayonet type connection where a portable fire hydrant is secured and rotated to start the flow of water. The adapter includes an electronic communication device that transmits real-time information on connection and flow characteristics. The adaptable fire connection eliminates the appearance of the fire hydrant, the potential of a vehicle hitting a fire hydrant and the material cost associated with above ground fire hydrants.
摘要翻译： 介绍了当前消防栓的改进措施。 该改进涉及一种消防栓，其中上述地面结构基本上被移除并被适应性连接所取代。 连接使用与上述消防栓相同的安装孔图案。 在操作中，适应性连接由打开的铰接盖保护，以提供对适应性连接的访问。 可适应的连接包括卡口式连接，便携式消防栓被固定并旋转以开始水流。 适配器包括发送关于连接和流量特性的实时信息的电子通信装置。 适应性的消防连接消除了消防栓的出现，车辆撞上消火栓的可能性以及与地面消防栓相关的材料成本。
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4.发明授权公开(公告)号：US06431549B1
公开(公告)日：2002-08-13
申请号：US09489456
申请日：2000-01-21
申请人： James E. Hill , James L. Brown , Richard C. Jeffries , Steven W. Hallstrom , James S. Tregaskis
发明人： James E. Hill , James L. Brown , Richard C. Jeffries , Steven W. Hallstrom , James S. Tregaskis
IPC分类号： E04B1682
CPC分类号： F16J15/14 , B05C5/0216 , B62D25/06 , B62D33/06 , F16J15/061 , F16J15/108
摘要： A sealing method and apparatus involves positioning sealant carriers in a gap between first and second components to be sealed. Sealant is applied to a first major surface of the sealant carriers. As the first and second components are tightened together, the carriers are compressed and cause sealant to travel from the first major surface and through the carriers to a second major surface which is opposed to the first major surface. The sealant carriers may be positioned on respective carrier supports while sealant is being applied to the first major surface of the sealant carriers. The supports are used in initially positioning the sealant carriers in place and then are removed prior to tightening the first and second components together. The supports may include alignment mechanisms for use in aligning the sealant carriers with one of the first and second components. The sealant adheres the sealant carriers to such one of the first and second components following removal of the supports.
摘要翻译： 密封方法和装置包括将密封剂载体定位在待密封的第一和第二组分之间的间隙中。 将密封剂施加到密封剂载体的第一主表面。 当第一和第二部件被紧固在一起时，载体被压缩并使密封剂从第一主表面行进并通过载体移动到与第一主表面相对的第二主表面。 密封剂载体可以位于相应的载体支撑件上，同时将密封剂施加到密封剂载体的第一主表面。 在将密封剂载体初始定位的位置中使用支撑件，然后在将第一和第二部件紧固在一起之前被移除。 支撑件可以包括用于将密封剂载体与第一和第二部件中的一个对准的对准机构。 在移除支撑件之后，密封剂将密封剂载体粘附到第一和第二部件中的一个。
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公开(公告)号：US4111308A
公开(公告)日：1978-09-05
申请号：US745266
申请日：1977-01-14
申请人： James L. Brown
发明人： James L. Brown
IPC分类号： G11B23/023 , B65D85/672 , A47F7/00
CPC分类号： G11B23/023
摘要： A holder for cassette tape cartridges includes a pair of parallel spaced-apart fingers for receiving a pair of spaced-apart openings in the cassette cartridges, and a member connecting the rear end portions of the fingers to the base. In one embodiment of the present invention, the connecting member swivelly connects the pair of parallel spaced-apart fingers to the base and detents secure releaseably the fingers in adjusted positions.
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公开(公告)号：US4087796A
公开(公告)日：1978-05-02
申请号：US734492
申请日：1976-10-21
申请人： James L. Brown
发明人： James L. Brown
摘要： An analog-to-digital converter utilizing a pulse density concept wherein a pulse generator is used and the rate of generation of pulses is a function of the difference between the analog input and the indicated digital output. The pulses are utilized in an adding/accumulation circuit for adjusting the output value upwardly or downwardly to minimize the error input. A digital-to-analog converter is used between the output of the accumulator and an algebraic summing network in a feedback manner to compare with the analog input and produce the error signal.
摘要翻译： 利用脉冲密度概念的模数转换器，其中使用脉冲发生器，并且脉冲的产生速率是模拟输入和指示数字输出之间的差值的函数。 这些脉冲用于加法/积累电路，用于向上或向下调整输出值以使误差输入最小化。 在反馈方式中，在累加器的输出和代数求和网络之间使用数模转换器，以与模拟输入进行比较并产生误差信号。
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公开(公告)号：US3966896A
公开(公告)日：1976-06-29
申请号：US503648
申请日：1974-09-06
申请人： Joel Glovsky , James L. Brown
发明人： Joel Glovsky , James L. Brown
CPC分类号： C12Q1/37 , G01N2333/96472 , Y10S435/81 , Y10S435/968 , Y10S436/804 , Y10S436/808 , Y10S436/815 , Y10S436/826
摘要： A radioimmunoassay method for the in vitro determination of the renin activity of an unknown plasma sample. In this method an unknown generation sample is provided by mixing the unknown plasma sample with a generation buffer solution and an inhibitor for enzymes which convert angiotensin I to other substances. The unknown generation sample is incubated to generate angiotensin I therein by action of renin upon angiotensinogen, thereby producing a generated unknown sample. A generated unknown radioimmunoassay reaction mixture is provided by mixing the generated unknown plasma sample with a predetermined amount of radioactively labeled angiotensin I, a predetermined amount of an antibody for angiotensin I, and an amount of an assay buffer solution sufficient to provide in the unknown reaction mixture renin and angiotensinogen concentrations at which there is no substantial angiotensin I generation at the temperatures to which the generated unknown radioimmunoassay reaction mixture is subsequently exposed. The reaction mixture is incubated at a temperature of at least about 12.degree.C. so that a competitive binding reaction takes place between the antibody and both labeled and unlabeled angiotensin I. Bound angiotensin I is separated from unbound angiotensin I and the relative proportions of bound and unbound labeled angiotensin I in the reaction mixture are determined. The angiotensin I content of the generated unknown reaction mixture is determined by comparison of the relative proportions of bound and unbound labeled angiotensin I in the reaction mixture with the relative proportions of bound and unbound labeled angiotensin I in standard radioimmunoassay reaction mixtures containing known amounts of unlabeled angiotensin I. The renin activity of the plasma is determined from the difference between the angiotensin I content of the generated unknown reaction mixture and the angiotensin I content of an ungenerated radioimmunoassay reaction mixture containing a sample of the same unknown plasma. A kit useful in carrying out the method of the invention is also disclosed.
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公开(公告)号：US08975016B2
公开(公告)日：2015-03-10
申请号：US13166228
申请日：2011-06-22
IPC分类号： C12Q1/70 , G01N33/50 , G01N33/543 , G01N33/569
CPC分类号： G01N33/56983 , G01N33/5091 , G01N33/54326 , G01N2333/075 , G01N2333/11 , G01N2333/115 , G01N2333/135
摘要： The present invention describes a liquid direct fluorescence antibody assay that is rapid and sensitive to detect respiratory virus in infected cells. The assay includes centrifugation of the specimen, incubation of sample and reagents in solution, and detection of the absence or presence of respiratory virus. Sapogenin is used as a detergent to permeabilize the cells for entry of the monoclonal antibodies to react with intracellular antigens. The cells are stained with fluorescently labeled monoclonal antibodies against the viral antigens along with a background stain and a fluorescent nuclear stain. This counter staining decreases background and allows co-localization of antigen and nuclear structures for enhanced detection.
摘要翻译： 本发明描述了一种液体直接荧光抗体测定，其在感染的细胞中检测呼吸道病毒是快速且敏感的。 该测定包括样品的离心，样品和试剂在溶液中的孵育，以及检测到不存在或存在呼吸道病毒。 皂甙元被用作洗涤剂以使细胞透化以进入单克隆抗体以与胞内抗原反应。 细胞用针对病毒抗原的荧光标记的单克隆抗体以及背景染料和荧光核染色染色。 该反染色降低背景，并允许抗原和核结构的共定位以增强检测。
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公开(公告)号：US20100261153A1
公开(公告)日：2010-10-14
申请号：US12425256
申请日：2009-04-16
IPC分类号： C12Q1/70
CPC分类号： G01N33/56983 , G01N33/5091 , G01N33/54326 , G01N2333/075 , G01N2333/11 , G01N2333/115 , G01N2333/135
摘要： The present invention describes a liquid direct fluorescence antibody assay that is rapid and sensitive to detect respiratory virus in infected cells. The assay includes centrifugation of the specimen, incubation of sample and reagents in solution, and detection of the absence or presence of respiratory virus. Sapogenin is used as a detergent to permeabilize the cells for entry of the monoclonal antibodies to react with intracellular antigens. The cells are stained with fluorescently labeled monoclonal antibodies against the viral antigens along with a background stain and a fluorescent nuclear stain. This counter staining decreases background and allows co-localization of antigen and nuclear structures for enhanced detection.
摘要翻译： 本发明描述了一种液体直接荧光抗体测定，其在感染的细胞中检测呼吸道病毒是快速且敏感的。 该测定包括样品的离心，样品和试剂在溶液中的孵育，以及检测到不存在或存在呼吸道病毒。 皂甙元被用作洗涤剂以使细胞透化以进入单克隆抗体以与胞内抗原反应。 细胞用针对病毒抗原的荧光标记的单克隆抗体以及背景染料和荧光核染色染色。 该反染色降低背景，并允许抗原和核结构的共定位以增强检测。
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公开(公告)号：US5025545A
公开(公告)日：1991-06-25
申请号：US569771
申请日：1990-08-21
申请人： James L. Brown
发明人： James L. Brown
IPC分类号： A47B88/04
CPC分类号： A47B88/04 , A47B2210/0054 , A47B2210/0059 , Y10T29/4984 , Y10T29/49876
摘要： A two-piece bracket assembly for use in cabinetry as a drawer slide rear mounting include one piece to receive the rear end of a drawer slide. The other piece is fastened to the inside of the cabinet back. The first piece is pushed into the second piece and retained by spring-clip detent action. Horizontal sliding movement of the clipped portion of the second piece in the first piece is possible when needed for adjustment of the slides to establish parallelism of the drawer front with the cabinet front, without adjustment of the piece fastened to the cabinet back.
摘要翻译： 用于橱柜的两件式支架组件作为抽屉滑动后部安装，包括一个接收抽屉滑块后端的部件。 另一件被固定在机柜内部。 第一件被推入第二件，并通过弹簧夹锁定动作保持。 当需要调整滑块以便使抽屉前部与机柜前部平行时，第一件的夹紧部分的水平滑动运动是可能的，而不会调整固定在机柜背部的零件。
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