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公开(公告)号：US20230279324A1
公开(公告)日：2023-09-07
申请号：US17941237
申请日：2022-09-09
Applicant: Intelligent Virus Imaging Inc.
Inventor： Janosch Hauser , Gustaf Kylberg , Göran Stemme , Ida-Maria Sintorn , Niclas Roxhed
CPC classification number: C12M23/16 , B01L3/502738 , B01L2400/0688 , B01L2300/0864
Abstract: The method is for preparing a sample in a microfluidic device. A microfluidic device is provided that has a first reservoir in fluid communication with a second reservoir in fluid communication with and adjacent to a draining unit that has a first absorbing member disposed therein. The first reservoir contains a first liquid that is held in the first reservoir by a capillary stop valve connecting the first and second reservoirs. The second reservoir has a sample support disposed therein. A second liquid, containing substances, is added to the second reservoir. The second liquid contacts the first liquid and the first absorbing member. The first absorbing member absorbs the second liquid and the first liquid. The substances adhere to the sample support.
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公开(公告)号：US20220081662A1
公开(公告)日：2022-03-17
申请号：US17025390
申请日：2020-09-18
Applicant: Intelligent Virus Imaging Inc.
Inventor： Janosch Hauser , Gustaf Kylberg , Göran Stemme , Ida-Maria Sintorn , Niclas Roxhed
Abstract: The method is for preparing a sample in a microfluidic device. A microfluidic device is provided that has a first reservoir in fluid communication with a second reservoir in fluid communication with and adjacent to a draining unit that has a first absorbing member disposed therein. The first reservoir contains a first liquid that is held in the first reservoir by a capillary stop valve connecting the first and second reservoirs. The second reservoir has a sample support disposed therein. A second liquid, containing substances, is added to the second reservoir. The second liquid contacts the first liquid and the first absorbing member. The first absorbing member absorbs the second liquid and the first liquid. The substances adhere to the sample support.
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公开(公告)号：US20210341372A1
公开(公告)日：2021-11-04
申请号：US17371143
申请日：2021-07-09
Applicant: Intelligent Virus Imaging Inc.
Inventor： Mathieu Colomb-Delsuc , Lars Haag , Rickard Nordström , Martin Ryner
Abstract: The method is for quantitative measurement of particle content using hydrated state imaging such as CryoTEM. A sample of virus-like particles (VLPs) or virus particles is provided. Preferably, the sample is rapidly frozen into a cryogenic liquid at a cryogenic temperature. While at the cryogenic temperature, the particle content of each VLP in the frozen sample is observed in the CryoTEM. An amount of the particle content of the VLPs is determined to assess whether the VLPs are empty or not.
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公开(公告)号：US11485945B2
公开(公告)日：2022-11-01
申请号：US17025390
申请日：2020-09-18
Applicant: Intelligent Virus Imaging Inc.
Inventor： Janosch Hauser , Gustaf Kylberg , Göran Stemme , Ida-Maria Sintorn , Niclas Roxhed
Abstract: The method is for preparing a sample in a microfluidic device. A microfluidic device is provided that has a first reservoir in fluid communication with a second reservoir in fluid communication with and adjacent to a draining unit that has a first absorbing member disposed therein. The first reservoir contains a first liquid that is held in the first reservoir by a capillary stop valve connecting the first and second reservoirs. The second reservoir has a sample support disposed therein. A second liquid, containing substances, is added to the second reservoir. The second liquid contacts the first liquid and the first absorbing member. The first absorbing member absorbs the second liquid and the first liquid. The substances adhere to the sample support.
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公开(公告)号：US11484882B2
公开(公告)日：2022-11-01
申请号：US17023922
申请日：2020-09-17
Applicant: Intelligent Virus Imaging Inc.
Inventor： Janosch Hauser , Gustaf Kylberg , Göran Stemme , Ida-Maria Sintorn , Niclas Roxhed
IPC: B01L3/00
Abstract: The microfluidic device has a first reservoir that preferably includes a first liquid. The first liquid is being held by a capillary stop valve in the first reservoir. A second reservoir is in fluid communication with the first reservoir. The second reservoir has a second liquid and a sample support disposed therein. The second reservoir has an inlet opening defined therein. A draining unit is adjacent to the second reservoir. The draining unit is in fluid communication with the second reservoir. The draining unit has a first absorption member disposed therein.
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Patent Agency Ranking
公开(公告)号：US20220157069A1
公开(公告)日：2022-05-19
申请号：US17665684
申请日：2022-02-07
Applicant: Intelligent Virus Imaging Inc.
Inventor： Martin Ryner
Abstract: The method is for dividing dark objects, substructures and background of an image from an electron microscope into segments by analyzing pixel values. The segments are transformed and aligned so that the transformed objects, sub-structures and background are meaningfully comparable. The transformed segments are clustered into classes which are used for ontological investigation of samples that are visualized by using electron microscopy. A triangle inequality comparison can be used to further cluster groups of objects to transfer understanding from different interactions between objects and to associate interactions with each other.
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公开(公告)号：US11125672B2
公开(公告)日：2021-09-21
申请号：US16326358
申请日：2018-01-25
Applicant: Intelligent Virus Imaging Inc.
Inventor： Mathieu Colomb-Delsuc , Lars Haag , Rickard Nordström , Martin Ryner
Abstract: The method is for quantitative measurement of particle content using hydrated state imaging such as CryoTEM. A sample of virus-like particles (VLPs) or virus particles is provided. Preferably, the sample is rapidly frozen into a cryogenic liquid at a cryogenic temperature. While at the cryogenic temperature, the particle content of each VLP in the frozen sample is observed in the CryoTEM. An amount of the particle content of the VLPs is determined to assess whether the VLPs are empty or not.
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公开(公告)号：US20190178762A1
公开(公告)日：2019-06-13
申请号：US16277393
申请日：2019-02-15
Applicant: Intelligent Virus Imaging Inc.
Inventor： Rickard Nordstrom , Ida-Maria Sintorn , Lars Haag
CPC classification number: G01N1/4077 , G01N15/14 , G01N15/1468 , G01N2001/4088 , G01N2015/0038 , G01N2015/1486
Abstract: The method is for quantification of sub-visible particles. A filter membrane is provided that has a plurality of pores defined therethrough. The filter membrane is in operational engagement with a vacuum chamber. The pores are sealed with a sealant. A sample droplet, containing a liquid and sub-visible particles, is applied onto the filter membrane. The liquid dissolves the sealant in pores disposed directly below the sample droplet. The liquid flows through the pores in which the sealant has been dissolved and the sub-visible particles remain on top of the filter membrane. The particles are enumerated in an electron microscope.
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公开(公告)号：US09928989B2
公开(公告)日：2018-03-27
申请号：US15620942
申请日：2017-06-13
Applicant: Intelligent Virus Imaging Inc
Inventor： Ida-Maria Sintorn , Rickard Nordstrom , Gustaf Kylberg
IPC: H01J37/153 , H01J37/26
CPC classification number: H01J37/153 , H01J37/26 , H01J2237/1532 , H01J2237/223
Abstract: The method is for automatic astigmatism correction of a lens system. A first image of a first frequency spectrum in a microscope is provided. The first image of a view is not in focus. The first image is then imaged. A first roundness measure of a distribution and directions of intensities in the first image is determined. The lens is changed to a second stigmator setting to provide a second image of a second frequency spectrum. The second image of the view is not in focus. The second image is the same view as the first image of the view at the first stigmator setting. A second roundness measure of a distribution and directions of intensities in the second image is determined. The first roundness measure is compared with the second roundness measure. The image with the roundness measure indicating the roundest distribution is selected.
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公开(公告)号：US20170018396A1
公开(公告)日：2017-01-19
申请号：US15124099
申请日：2015-06-17
Applicant: INTELLIGENT VIRUS IMAGING INC.
Inventor： Ida-Maria Sintorn , Rickard Nordstrom Nordstrom , Gustaf Kylberg
IPC: H01J37/153
CPC classification number: H01J37/153 , H01J2237/1532 , H01J2237/223
Abstract: The method is for automatic astigmatism correction of a lens system. A first image is provided that is not in focus at a first stigmator setting of a set of lenses. A calculating device calculates a corresponding first Fourier spectrum image. A distribution and direction of pixels of the Fourier spectrum image are determined by calculating a first vector and a second vector. The first vector is compared with the second vector. The lens system is changed from a first stigmator setting to a second stigmator setting to provide a second image. A corresponding Fourier spectrum image is calculated. The distribution and direction of pixels of the second Fourier spectrum image is determined by calculating a third vector and a fourth vector. The third vector is compared to the fourth vector. The image that has the lowest vector ratio is selected.
Abstract translation: 该方法用于透镜系统的自动散光校正。 提供在一组透镜的第一施放器设置处不聚焦的第一图像。 计算装置计算对应的第一傅立叶光谱图像。 通过计算第一矢量和第二矢量来确定傅里叶谱图像的像素的分布和方向。 将第一个向量与第二个向量进行比较。 透镜系统从第一施放器设置改变为第二施放器设置以提供第二图像。 计算相应的傅立叶光谱图像。 通过计算第三矢量和第四矢量来确定第二傅立叶光谱图像的像素的分布和方向。 将第三个向量与第四个向量进行比较。 选择具有最低矢量比的图像。
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