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公开(公告)号：US20210341372A1
公开(公告)日：2021-11-04
申请号：US17371143
申请日：2021-07-09
Applicant: Intelligent Virus Imaging Inc.
Inventor： Mathieu Colomb-Delsuc , Lars Haag , Rickard Nordström , Martin Ryner
Abstract: The method is for quantitative measurement of particle content using hydrated state imaging such as CryoTEM. A sample of virus-like particles (VLPs) or virus particles is provided. Preferably, the sample is rapidly frozen into a cryogenic liquid at a cryogenic temperature. While at the cryogenic temperature, the particle content of each VLP in the frozen sample is observed in the CryoTEM. An amount of the particle content of the VLPs is determined to assess whether the VLPs are empty or not.
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公开(公告)号：US11288491B2
公开(公告)日：2022-03-29
申请号：US16326359
申请日：2018-07-02
Applicant: Intelligent Virus Imaging Inc.
Inventor： Martin Ryner
Abstract: The method is for dividing dark objects, sub-structures and background of an image from an electron microscope into segments by analyzing pixel values. The segments are transformed and aligned so that the transformed objects, sub-structures and background are meaningfully comparable. The transformed segments are clustered into classes which are used for ontological investigation of samples that are visualized by using electron microscopy. A triangle inequality comparison can be used to further cluster groups of objects to transfer understanding from different interactions between objects and to associate interactions with each other.
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公开(公告)号：US11002689B2
公开(公告)日：2021-05-11
申请号：US16549603
申请日：2019-08-23
Applicant: Intelligent Virus Imaging Inc.
Inventor： Ida-Maria Sintorn , Martin Ryner , Gustaf Kylberg , Josefina Nilsson
IPC: G01N23/04 , G01B21/28 , C12Q1/70 , G06K9/00 , G01N15/14 , G06K9/46 , G01B15/00 , G01N15/10 , G01N15/00
Abstract: The method is for quantification of purity of sub-visible particle samples. A sample to be analyzed is place in an electron microscope to obtain an electron microscopy image of the sample. The sample contains objects. The objects that have sizes being different from a size range of primary particles and sizes being within the size range of primary particles are enhanced. The objects are detected as being primary particles or debris. The detected primary particles are excluded from the objects so that the objects contain debris but no primary particles. A first total area (T1) of the detected debris is measured. A second total area (T2) of the detected primary particles is measured.
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公开(公告)号：US20220157069A1
公开(公告)日：2022-05-19
申请号：US17665684
申请日：2022-02-07
Applicant: Intelligent Virus Imaging Inc.
Inventor： Martin Ryner
Abstract: The method is for dividing dark objects, substructures and background of an image from an electron microscope into segments by analyzing pixel values. The segments are transformed and aligned so that the transformed objects, sub-structures and background are meaningfully comparable. The transformed segments are clustered into classes which are used for ontological investigation of samples that are visualized by using electron microscopy. A triangle inequality comparison can be used to further cluster groups of objects to transfer understanding from different interactions between objects and to associate interactions with each other.
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公开(公告)号：US11125672B2
公开(公告)日：2021-09-21
申请号：US16326358
申请日：2018-01-25
Applicant: Intelligent Virus Imaging Inc.
Inventor： Mathieu Colomb-Delsuc , Lars Haag , Rickard Nordström , Martin Ryner
Abstract: The method is for quantitative measurement of particle content using hydrated state imaging such as CryoTEM. A sample of virus-like particles (VLPs) or virus particles is provided. Preferably, the sample is rapidly frozen into a cryogenic liquid at a cryogenic temperature. While at the cryogenic temperature, the particle content of each VLP in the frozen sample is observed in the CryoTEM. An amount of the particle content of the VLPs is determined to assess whether the VLPs are empty or not.
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Patent Agency Ranking
公开(公告)号：US20190331584A1
公开(公告)日：2019-10-31
申请号：US16326358
申请日：2018-01-25
Applicant: Intelligent Virus Imaging Inc.
Inventor： Mathieu Colomb-Delsuc , Lars Haag , Rickard Nordström , Martin Ryner
Abstract: The method is for quantitative measurement of particle content using hydrated state imaging such as CryoTEM. A sample of virus-like particles (VLPs) or virus particles is provided. Preferably, the sample is rapidly frozen into a cryogenic liquid at a cryogenic temperature. While at the cryogenic temperature, the particle content of each VLP in the frozen sample is observed in the CryoTEM. An amount of the particle content of the VLPs is determined to assess whether the VLPs are empty or not.
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公开(公告)号：US20190011378A1
公开(公告)日：2019-01-10
申请号：US16068232
申请日：2017-09-11
Applicant: Intelligent Virus Imaging Inc.
Inventor： Ida-Maria Sintorn , Martin Ryner , Gustaf Kylberg , Josefina Nilsson
Abstract: The method is for quantification of purity of sub-visible particle samples. A sample to be analyzed is place in an electron microscope to obtain an electron microscopy image of the sample. The sample contains objects. The objects that have sizes being different from a size range of primary particles and sizes being within the size range of primary particles are enhanced. The objects are detected as being primary particles or debris. The detected primary particles are excluded from the objects so that the objects contain debris but no primary particles. A first total area (T1) of the detected debris is measured. A second total area (T2) of the detected primary particles is measured.
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公开(公告)号：US11574486B2
公开(公告)日：2023-02-07
申请号：US17665684
申请日：2022-02-07
Applicant: Intelligent Virus Imaging Inc.
Inventor： Martin Ryner
Abstract: The method is for dividing dark objects, substructures and background of an image from an electron microscope into segments by analyzing pixel values. The segments are transformed and aligned so that the transformed objects, sub-structures and background are meaningfully comparable. The transformed segments are clustered into classes which are used for ontological investigation of samples that are visualized by using electron microscopy. A triangle inequality comparison can be used to further cluster groups of objects to transfer understanding from different interactions between objects and to associate interactions with each other.
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公开(公告)号：US20210286969A1
公开(公告)日：2021-09-16
申请号：US16326359
申请日：2018-07-02
Applicant: Intelligent Virus Imaging Inc.
Inventor： Martin Ryner
Abstract: The method is for dividing dark objects, substructures and background of an image from an electron microscope into segments by analysing pixel values. The segments are transformed and aligned so that the transformed objects, sub-structures and background are meaningfully comparable. The transformed segments are clustered into classes which are used for ontological investigation of samples that are visualized by using electron microscopy. A triangle inequality comparison can be used to further cluster groups of objects to transfer understanding from different interactions between objects and to associate interactions with each other.
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公开(公告)号：US10451566B2
公开(公告)日：2019-10-22
申请号：US16068232
申请日：2017-09-11
Applicant: Intelligent Virus Imaging Inc.
Inventor： Ida-Maria Sintorn , Martin Ryner , Gustaf Kylberg , Josefina Nilsson
Abstract: The method is for quantification of purity of sub-visible particle samples. A sample to be analyzed is place in an electron microscope to obtain an electron microscopy image of the sample. The sample contains objects. The objects that have sizes being different from a size range of primary particles and sizes being within the size range of primary particles are enhanced. The objects are detected as being primary particles or debris. The detected primary particles are excluded from the objects so that the objects contain debris but no primary particles. A first total area (T1) of the detected debris is measured. A second total area (T2) of the detected primary particles is measured.
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