公开(公告)号：US20210341372A1

公开(公告)日：2021-11-04

申请号：US17371143

申请日：2021-07-09

Applicant: Intelligent Virus Imaging Inc.

Inventor： Mathieu Colomb-Delsuc ,  Lars Haag ,  Rickard Nordström ,  Martin Ryner

IPC: G01N15/10 ,  C12N7/00 ,  C12Q1/70 ,  G01N1/38

Abstract: The method is for quantitative measurement of particle content using hydrated state imaging such as CryoTEM. A sample of virus-like particles (VLPs) or virus particles is provided. Preferably, the sample is rapidly frozen into a cryogenic liquid at a cryogenic temperature. While at the cryogenic temperature, the particle content of each VLP in the frozen sample is observed in the CryoTEM. An amount of the particle content of the VLPs is determined to assess whether the VLPs are empty or not.

公开(公告)号：US11125672B2

公开(公告)日：2021-09-21

申请号：US16326358

申请日：2018-01-25

Applicant: Intelligent Virus Imaging Inc.

Inventor： Mathieu Colomb-Delsuc ,  Lars Haag ,  Rickard Nordström ,  Martin Ryner

IPC: C12N7/00 ,  G01N1/38 ,  G01N15/10 ,  C12Q1/70

Abstract: The method is for quantitative measurement of particle content using hydrated state imaging such as CryoTEM. A sample of virus-like particles (VLPs) or virus particles is provided. Preferably, the sample is rapidly frozen into a cryogenic liquid at a cryogenic temperature. While at the cryogenic temperature, the particle content of each VLP in the frozen sample is observed in the CryoTEM. An amount of the particle content of the VLPs is determined to assess whether the VLPs are empty or not.

公开(公告)号：US20190331584A1

公开(公告)日：2019-10-31

申请号：US16326358

申请日：2018-01-25

Applicant: Intelligent Virus Imaging Inc.

Inventor： Mathieu Colomb-Delsuc ,  Lars Haag ,  Rickard Nordström ,  Martin Ryner

IPC: G01N15/10 ,  C12Q1/70 ,  G01N1/38 ,  C12N7/00

Abstract: The method is for quantitative measurement of particle content using hydrated state imaging such as CryoTEM. A sample of virus-like particles (VLPs) or virus particles is provided. Preferably, the sample is rapidly frozen into a cryogenic liquid at a cryogenic temperature. While at the cryogenic temperature, the particle content of each VLP in the frozen sample is observed in the CryoTEM. An amount of the particle content of the VLPs is determined to assess whether the VLPs are empty or not.