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公开(公告)号：US20210341372A1
公开(公告)日：2021-11-04
申请号：US17371143
申请日：2021-07-09
Applicant: Intelligent Virus Imaging Inc.
Inventor： Mathieu Colomb-Delsuc , Lars Haag , Rickard Nordström , Martin Ryner
Abstract: The method is for quantitative measurement of particle content using hydrated state imaging such as CryoTEM. A sample of virus-like particles (VLPs) or virus particles is provided. Preferably, the sample is rapidly frozen into a cryogenic liquid at a cryogenic temperature. While at the cryogenic temperature, the particle content of each VLP in the frozen sample is observed in the CryoTEM. An amount of the particle content of the VLPs is determined to assess whether the VLPs are empty or not.
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公开(公告)号：US11125672B2
公开(公告)日：2021-09-21
申请号：US16326358
申请日：2018-01-25
Applicant: Intelligent Virus Imaging Inc.
Inventor： Mathieu Colomb-Delsuc , Lars Haag , Rickard Nordström , Martin Ryner
Abstract: The method is for quantitative measurement of particle content using hydrated state imaging such as CryoTEM. A sample of virus-like particles (VLPs) or virus particles is provided. Preferably, the sample is rapidly frozen into a cryogenic liquid at a cryogenic temperature. While at the cryogenic temperature, the particle content of each VLP in the frozen sample is observed in the CryoTEM. An amount of the particle content of the VLPs is determined to assess whether the VLPs are empty or not.
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公开(公告)号：US20190178762A1
公开(公告)日：2019-06-13
申请号：US16277393
申请日：2019-02-15
Applicant: Intelligent Virus Imaging Inc.
Inventor： Rickard Nordstrom , Ida-Maria Sintorn , Lars Haag
CPC classification number: G01N1/4077 , G01N15/14 , G01N15/1468 , G01N2001/4088 , G01N2015/0038 , G01N2015/1486
Abstract: The method is for quantification of sub-visible particles. A filter membrane is provided that has a plurality of pores defined therethrough. The filter membrane is in operational engagement with a vacuum chamber. The pores are sealed with a sealant. A sample droplet, containing a liquid and sub-visible particles, is applied onto the filter membrane. The liquid dissolves the sealant in pores disposed directly below the sample droplet. The liquid flows through the pores in which the sealant has been dissolved and the sub-visible particles remain on top of the filter membrane. The particles are enumerated in an electron microscope.
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公开(公告)号：US10571375B2
公开(公告)日：2020-02-25
申请号：US16416186
申请日：2019-05-18
Applicant: Intelligent Virus Imaging Inc.
Inventor： Rickard Nordstrom Nordstrom , Ida-Maria Sintorn , Lars Haag
Abstract: The method is for quantification of sub-visible particles. A filter membrane is provided that has a plurality of pores defined therethrough. The pores are sealed with a sealant such as glycine or poly-vinyl alcohol (PVA). A sample droplet, containing liquid and sub-visible particles, is applied onto the filter membrane. The liquid dissolves the sealant in pores disposed directly below the sample droplet. The liquid flows through the pores in which the sealant has been dissolved and the sub-visible particles remain on top of the filter membrane. The particles are enumerated in an electron microscope.
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Patent Agency Ranking
公开(公告)号：US20190271620A1
公开(公告)日：2019-09-05
申请号：US16416186
申请日：2019-05-18
Applicant: Intelligent Virus Imaging Inc.
Inventor： Rickard Nordstrom Nordstrom , Ida-Maria Sintorn , Lars Haag
Abstract: The method is for quantification of sub-visible particles. A filter membrane is provided that has a plurality of pores defined therethrough. The pores are sealed with a sealant such as glycine or poly-vinyl alcohol (PVA). A sample droplet, containing liquid and sub-visible particles, is applied onto the filter membrane. The liquid dissolves the sealant in pores disposed directly below the sample droplet. The liquid flows through the pores in which the sealant has been dissolved and the sub-visible particles remain on top of the filter membrane. The particles are enumerated in an electron microscope.
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公开(公告)号：US20190331584A1
公开(公告)日：2019-10-31
申请号：US16326358
申请日：2018-01-25
Applicant: Intelligent Virus Imaging Inc.
Inventor： Mathieu Colomb-Delsuc , Lars Haag , Rickard Nordström , Martin Ryner
Abstract: The method is for quantitative measurement of particle content using hydrated state imaging such as CryoTEM. A sample of virus-like particles (VLPs) or virus particles is provided. Preferably, the sample is rapidly frozen into a cryogenic liquid at a cryogenic temperature. While at the cryogenic temperature, the particle content of each VLP in the frozen sample is observed in the CryoTEM. An amount of the particle content of the VLPs is determined to assess whether the VLPs are empty or not.
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公开(公告)号：US10345207B2
公开(公告)日：2019-07-09
申请号：US16277393
申请日：2019-02-15
Applicant: Intelligent Virus Imaging Inc.
Inventor： Rickard Nordstrom , Ida-Maria Sintorn , Lars Haag
Abstract: The method is for quantification of sub-visible particles. A filter membrane is provided that has a plurality of pores defined therethrough. The filter membrane is in operational engagement with a vacuum chamber. The pores are sealed with a sealant. A sample droplet, containing a liquid and sub-visible particles, is applied onto the filter membrane. The liquid dissolves the sealant in pores disposed directly below the sample droplet. The liquid flows through the pores in which the sealant has been dissolved and the sub-visible particles remain on top of the filter membrane. The particles are enumerated in an electron microscope.
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公开(公告)号：US10247648B2
公开(公告)日：2019-04-02
申请号：US15736621
申请日：2016-10-21
Applicant: Intelligent Virus Imaging Inc.
Inventor： Rickard Nordstrom , Ida-Maria Sintorn , Lars Haag
Abstract: The method is for quantification of sub-visible particles. A filter membrane is provided that has a plurality of pores defined therethrough. The filter membrane is in operational engagement with a vacuum chamber. The pores are sealed with a sealant. A sample droplet, containing a liquid and sub-visible particles, is applied onto the filter membrane. The liquid dissolves the sealant in pores disposed directly below the sample droplet. The liquid flows through the pores in which the sealant has been dissolved and the sub-visible particles remain on top of the filter membrane. The particles are enumerated in an electron microscopy.
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公开(公告)号：US20180172566A1
公开(公告)日：2018-06-21
申请号：US15736621
申请日：2016-10-21
Applicant: Intelligent Virus Imaging Inc.
Inventor： Rickard Nordstrom , Ida-Maria Sintorn , Lars Haag
CPC classification number: G01N1/4077 , G01N15/14 , G01N15/1468 , G01N2001/4088 , G01N2015/0038 , G01N2015/1486
Abstract: The method is for quantification of sub-visible particles. A filter membrane is provided that has a plurality of pores defined therethrough. The filter membrane is in operational engagement with a vacuum chamber. The pores are sealed with a sealant. A sample droplet, containing a liquid and sub-visible particles, is applied onto the filter membrane. The liquid dissolves the sealant in pores disposed directly below the sample droplet. The liquid flows through the pores in which the sealant has been dissolved and the sub-visible particles remain on top of the filter membrane. The particles are enumerated in an electron microscopy.
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