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公开(公告)号：US10451566B2
公开(公告)日：2019-10-22
申请号：US16068232
申请日：2017-09-11
Applicant: Intelligent Virus Imaging Inc.
Inventor： Ida-Maria Sintorn , Martin Ryner , Gustaf Kylberg , Josefina Nilsson
Abstract: The method is for quantification of purity of sub-visible particle samples. A sample to be analyzed is place in an electron microscope to obtain an electron microscopy image of the sample. The sample contains objects. The objects that have sizes being different from a size range of primary particles and sizes being within the size range of primary particles are enhanced. The objects are detected as being primary particles or debris. The detected primary particles are excluded from the objects so that the objects contain debris but no primary particles. A first total area (T1) of the detected debris is measured. A second total area (T2) of the detected primary particles is measured.
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公开(公告)号：US20230279324A1
公开(公告)日：2023-09-07
申请号：US17941237
申请日：2022-09-09
Applicant: Intelligent Virus Imaging Inc.
Inventor： Janosch Hauser , Gustaf Kylberg , Göran Stemme , Ida-Maria Sintorn , Niclas Roxhed
CPC classification number: C12M23/16 , B01L3/502738 , B01L2400/0688 , B01L2300/0864
Abstract: The method is for preparing a sample in a microfluidic device. A microfluidic device is provided that has a first reservoir in fluid communication with a second reservoir in fluid communication with and adjacent to a draining unit that has a first absorbing member disposed therein. The first reservoir contains a first liquid that is held in the first reservoir by a capillary stop valve connecting the first and second reservoirs. The second reservoir has a sample support disposed therein. A second liquid, containing substances, is added to the second reservoir. The second liquid contacts the first liquid and the first absorbing member. The first absorbing member absorbs the second liquid and the first liquid. The substances adhere to the sample support.
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公开(公告)号：US20220081662A1
公开(公告)日：2022-03-17
申请号：US17025390
申请日：2020-09-18
Applicant: Intelligent Virus Imaging Inc.
Inventor： Janosch Hauser , Gustaf Kylberg , Göran Stemme , Ida-Maria Sintorn , Niclas Roxhed
Abstract: The method is for preparing a sample in a microfluidic device. A microfluidic device is provided that has a first reservoir in fluid communication with a second reservoir in fluid communication with and adjacent to a draining unit that has a first absorbing member disposed therein. The first reservoir contains a first liquid that is held in the first reservoir by a capillary stop valve connecting the first and second reservoirs. The second reservoir has a sample support disposed therein. A second liquid, containing substances, is added to the second reservoir. The second liquid contacts the first liquid and the first absorbing member. The first absorbing member absorbs the second liquid and the first liquid. The substances adhere to the sample support.
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公开(公告)号：US20220080419A1
公开(公告)日：2022-03-17
申请号：US17023922
申请日：2020-09-17
Applicant: Intelligent Virus Imaging Inc.
Inventor： Janosch Hauser , Gustaf Kylberg , Göran Stemme , Ida-Maria Sintorn , Niclas Roxhed
IPC: B01L3/00
Abstract: The microfluidic device has a first reservoir that preferably includes a first liquid. The first liquid is being held by a capillary stop valve in the first reservoir. A second reservoir is in fluid communication with the first reservoir. The second reservoir has a second liquid and a sample support disposed therein. The second reservoir has an inlet opening defined therein. A draining unit is adjacent to the second reservoir. The draining unit is in fluid communication with the second reservoir. The draining unit has a first absorption member disposed therein.
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公开(公告)号：US11002689B2
公开(公告)日：2021-05-11
申请号：US16549603
申请日：2019-08-23
Applicant: Intelligent Virus Imaging Inc.
Inventor： Ida-Maria Sintorn , Martin Ryner , Gustaf Kylberg , Josefina Nilsson
IPC: G01N23/04 , G01B21/28 , C12Q1/70 , G06K9/00 , G01N15/14 , G06K9/46 , G01B15/00 , G01N15/10 , G01N15/00
Abstract: The method is for quantification of purity of sub-visible particle samples. A sample to be analyzed is place in an electron microscope to obtain an electron microscopy image of the sample. The sample contains objects. The objects that have sizes being different from a size range of primary particles and sizes being within the size range of primary particles are enhanced. The objects are detected as being primary particles or debris. The detected primary particles are excluded from the objects so that the objects contain debris but no primary particles. A first total area (T1) of the detected debris is measured. A second total area (T2) of the detected primary particles is measured.
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Patent Agency Ranking
公开(公告)号：US10571375B2
公开(公告)日：2020-02-25
申请号：US16416186
申请日：2019-05-18
Applicant: Intelligent Virus Imaging Inc.
Inventor： Rickard Nordstrom Nordstrom , Ida-Maria Sintorn , Lars Haag
Abstract: The method is for quantification of sub-visible particles. A filter membrane is provided that has a plurality of pores defined therethrough. The pores are sealed with a sealant such as glycine or poly-vinyl alcohol (PVA). A sample droplet, containing liquid and sub-visible particles, is applied onto the filter membrane. The liquid dissolves the sealant in pores disposed directly below the sample droplet. The liquid flows through the pores in which the sealant has been dissolved and the sub-visible particles remain on top of the filter membrane. The particles are enumerated in an electron microscope.
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公开(公告)号：US20190271620A1
公开(公告)日：2019-09-05
申请号：US16416186
申请日：2019-05-18
Applicant: Intelligent Virus Imaging Inc.
Inventor： Rickard Nordstrom Nordstrom , Ida-Maria Sintorn , Lars Haag
Abstract: The method is for quantification of sub-visible particles. A filter membrane is provided that has a plurality of pores defined therethrough. The pores are sealed with a sealant such as glycine or poly-vinyl alcohol (PVA). A sample droplet, containing liquid and sub-visible particles, is applied onto the filter membrane. The liquid dissolves the sealant in pores disposed directly below the sample droplet. The liquid flows through the pores in which the sealant has been dissolved and the sub-visible particles remain on top of the filter membrane. The particles are enumerated in an electron microscope.
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公开(公告)号：US11485945B2
公开(公告)日：2022-11-01
申请号：US17025390
申请日：2020-09-18
Applicant: Intelligent Virus Imaging Inc.
Inventor： Janosch Hauser , Gustaf Kylberg , Göran Stemme , Ida-Maria Sintorn , Niclas Roxhed
Abstract: The method is for preparing a sample in a microfluidic device. A microfluidic device is provided that has a first reservoir in fluid communication with a second reservoir in fluid communication with and adjacent to a draining unit that has a first absorbing member disposed therein. The first reservoir contains a first liquid that is held in the first reservoir by a capillary stop valve connecting the first and second reservoirs. The second reservoir has a sample support disposed therein. A second liquid, containing substances, is added to the second reservoir. The second liquid contacts the first liquid and the first absorbing member. The first absorbing member absorbs the second liquid and the first liquid. The substances adhere to the sample support.
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公开(公告)号：US11484882B2
公开(公告)日：2022-11-01
申请号：US17023922
申请日：2020-09-17
Applicant: Intelligent Virus Imaging Inc.
Inventor： Janosch Hauser , Gustaf Kylberg , Göran Stemme , Ida-Maria Sintorn , Niclas Roxhed
IPC: B01L3/00
Abstract: The microfluidic device has a first reservoir that preferably includes a first liquid. The first liquid is being held by a capillary stop valve in the first reservoir. A second reservoir is in fluid communication with the first reservoir. The second reservoir has a second liquid and a sample support disposed therein. The second reservoir has an inlet opening defined therein. A draining unit is adjacent to the second reservoir. The draining unit is in fluid communication with the second reservoir. The draining unit has a first absorption member disposed therein.
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公开(公告)号：US20190178762A1
公开(公告)日：2019-06-13
申请号：US16277393
申请日：2019-02-15
Applicant: Intelligent Virus Imaging Inc.
Inventor： Rickard Nordstrom , Ida-Maria Sintorn , Lars Haag
CPC classification number: G01N1/4077 , G01N15/14 , G01N15/1468 , G01N2001/4088 , G01N2015/0038 , G01N2015/1486
Abstract: The method is for quantification of sub-visible particles. A filter membrane is provided that has a plurality of pores defined therethrough. The filter membrane is in operational engagement with a vacuum chamber. The pores are sealed with a sealant. A sample droplet, containing a liquid and sub-visible particles, is applied onto the filter membrane. The liquid dissolves the sealant in pores disposed directly below the sample droplet. The liquid flows through the pores in which the sealant has been dissolved and the sub-visible particles remain on top of the filter membrane. The particles are enumerated in an electron microscope.
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