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公开(公告)号：US10451566B2
公开(公告)日：2019-10-22
申请号：US16068232
申请日：2017-09-11
Applicant: Intelligent Virus Imaging Inc.
Inventor： Ida-Maria Sintorn , Martin Ryner , Gustaf Kylberg , Josefina Nilsson
Abstract: The method is for quantification of purity of sub-visible particle samples. A sample to be analyzed is place in an electron microscope to obtain an electron microscopy image of the sample. The sample contains objects. The objects that have sizes being different from a size range of primary particles and sizes being within the size range of primary particles are enhanced. The objects are detected as being primary particles or debris. The detected primary particles are excluded from the objects so that the objects contain debris but no primary particles. A first total area (T1) of the detected debris is measured. A second total area (T2) of the detected primary particles is measured.
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公开(公告)号：US20230279324A1
公开(公告)日：2023-09-07
申请号：US17941237
申请日：2022-09-09
Applicant: Intelligent Virus Imaging Inc.
Inventor： Janosch Hauser , Gustaf Kylberg , Göran Stemme , Ida-Maria Sintorn , Niclas Roxhed
CPC classification number: C12M23/16 , B01L3/502738 , B01L2400/0688 , B01L2300/0864
Abstract: The method is for preparing a sample in a microfluidic device. A microfluidic device is provided that has a first reservoir in fluid communication with a second reservoir in fluid communication with and adjacent to a draining unit that has a first absorbing member disposed therein. The first reservoir contains a first liquid that is held in the first reservoir by a capillary stop valve connecting the first and second reservoirs. The second reservoir has a sample support disposed therein. A second liquid, containing substances, is added to the second reservoir. The second liquid contacts the first liquid and the first absorbing member. The first absorbing member absorbs the second liquid and the first liquid. The substances adhere to the sample support.
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公开(公告)号：US20220081662A1
公开(公告)日：2022-03-17
申请号：US17025390
申请日：2020-09-18
Applicant: Intelligent Virus Imaging Inc.
Inventor： Janosch Hauser , Gustaf Kylberg , Göran Stemme , Ida-Maria Sintorn , Niclas Roxhed
Abstract: The method is for preparing a sample in a microfluidic device. A microfluidic device is provided that has a first reservoir in fluid communication with a second reservoir in fluid communication with and adjacent to a draining unit that has a first absorbing member disposed therein. The first reservoir contains a first liquid that is held in the first reservoir by a capillary stop valve connecting the first and second reservoirs. The second reservoir has a sample support disposed therein. A second liquid, containing substances, is added to the second reservoir. The second liquid contacts the first liquid and the first absorbing member. The first absorbing member absorbs the second liquid and the first liquid. The substances adhere to the sample support.
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公开(公告)号：US20220080419A1
公开(公告)日：2022-03-17
申请号：US17023922
申请日：2020-09-17
Applicant: Intelligent Virus Imaging Inc.
Inventor： Janosch Hauser , Gustaf Kylberg , Göran Stemme , Ida-Maria Sintorn , Niclas Roxhed
IPC: B01L3/00
Abstract: The microfluidic device has a first reservoir that preferably includes a first liquid. The first liquid is being held by a capillary stop valve in the first reservoir. A second reservoir is in fluid communication with the first reservoir. The second reservoir has a second liquid and a sample support disposed therein. The second reservoir has an inlet opening defined therein. A draining unit is adjacent to the second reservoir. The draining unit is in fluid communication with the second reservoir. The draining unit has a first absorption member disposed therein.
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公开(公告)号：US11002689B2
公开(公告)日：2021-05-11
申请号：US16549603
申请日：2019-08-23
Applicant: Intelligent Virus Imaging Inc.
Inventor： Ida-Maria Sintorn , Martin Ryner , Gustaf Kylberg , Josefina Nilsson
IPC: G01N23/04 , G01B21/28 , C12Q1/70 , G06K9/00 , G01N15/14 , G06K9/46 , G01B15/00 , G01N15/10 , G01N15/00
Abstract: The method is for quantification of purity of sub-visible particle samples. A sample to be analyzed is place in an electron microscope to obtain an electron microscopy image of the sample. The sample contains objects. The objects that have sizes being different from a size range of primary particles and sizes being within the size range of primary particles are enhanced. The objects are detected as being primary particles or debris. The detected primary particles are excluded from the objects so that the objects contain debris but no primary particles. A first total area (T1) of the detected debris is measured. A second total area (T2) of the detected primary particles is measured.
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Patent Agency Ranking
公开(公告)号：US20190011378A1
公开(公告)日：2019-01-10
申请号：US16068232
申请日：2017-09-11
Applicant: Intelligent Virus Imaging Inc.
Inventor： Ida-Maria Sintorn , Martin Ryner , Gustaf Kylberg , Josefina Nilsson
Abstract: The method is for quantification of purity of sub-visible particle samples. A sample to be analyzed is place in an electron microscope to obtain an electron microscopy image of the sample. The sample contains objects. The objects that have sizes being different from a size range of primary particles and sizes being within the size range of primary particles are enhanced. The objects are detected as being primary particles or debris. The detected primary particles are excluded from the objects so that the objects contain debris but no primary particles. A first total area (T1) of the detected debris is measured. A second total area (T2) of the detected primary particles is measured.
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公开(公告)号：US20170287676A1
公开(公告)日：2017-10-05
申请号：US15620942
申请日：2017-06-13
Applicant: Intelligent Virus Imaging Inc.
Inventor： Ida-Maria Sintorn , Rickard Nordstrom Nordstrom , Gustaf Kylberg
IPC: H01J37/153 , H01J37/26
CPC classification number: H01J37/153 , H01J37/26 , H01J2237/1532 , H01J2237/223
Abstract: The method is for automatic astigmatism correction of a lens system. A first image of a first frequency spectrum in a microscope is provided. The first image of a view is not in focus. The first image is then imaged. A first roundness measure of a distribution and directions of intensities in the first image is determined. The lens is changed to a second stigmator setting to provide a second image of a second frequency spectrum. The second image of the view is not in focus. The second image is the same view as the first image of the view at the first stigmator setting. A second roundness measure of a distribution and directions of intensities in the second image is determined. The first roundness measure is compared with the second roundness measure. The image with the roundness measure indicating the roundest distribution is selected.
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公开(公告)号：US09711323B2
公开(公告)日：2017-07-18
申请号：US15124099
申请日：2015-06-17
Applicant: Intelligent Virus Imaging Inc.
Inventor： Ida-Maria Sintorn , Rickard Nordstrom Nordstrom , Gustaf Kylberg
IPC: H01J37/26 , H01J3/12 , H01J29/56 , H01J37/153
CPC classification number: H01J37/153 , H01J2237/1532 , H01J2237/223
Abstract: The method is for automatic astigmatism correction of a lens system. A first image is provided that is not in focus at a first stigmator setting of a set of lenses. A calculating device calculates a corresponding first Fourier spectrum image. A distribution and direction of pixels of the Fourier spectrum image are determined by calculating a first vector and a second vector. The first vector is compared with the second vector. The lens system is changed from a first stigmator setting to a second stigmator setting to provide a second image. A corresponding Fourier spectrum image is calculated. The distribution and direction of pixels of the second Fourier spectrum image is determined by calculating a third vector and a fourth vector. The third vector is compared to the fourth vector. The image that has the lowest vector ratio is selected.
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公开(公告)号：US11485945B2
公开(公告)日：2022-11-01
申请号：US17025390
申请日：2020-09-18
Applicant: Intelligent Virus Imaging Inc.
Inventor： Janosch Hauser , Gustaf Kylberg , Göran Stemme , Ida-Maria Sintorn , Niclas Roxhed
Abstract: The method is for preparing a sample in a microfluidic device. A microfluidic device is provided that has a first reservoir in fluid communication with a second reservoir in fluid communication with and adjacent to a draining unit that has a first absorbing member disposed therein. The first reservoir contains a first liquid that is held in the first reservoir by a capillary stop valve connecting the first and second reservoirs. The second reservoir has a sample support disposed therein. A second liquid, containing substances, is added to the second reservoir. The second liquid contacts the first liquid and the first absorbing member. The first absorbing member absorbs the second liquid and the first liquid. The substances adhere to the sample support.
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公开(公告)号：US11484882B2
公开(公告)日：2022-11-01
申请号：US17023922
申请日：2020-09-17
Applicant: Intelligent Virus Imaging Inc.
Inventor： Janosch Hauser , Gustaf Kylberg , Göran Stemme , Ida-Maria Sintorn , Niclas Roxhed
IPC: B01L3/00
Abstract: The microfluidic device has a first reservoir that preferably includes a first liquid. The first liquid is being held by a capillary stop valve in the first reservoir. A second reservoir is in fluid communication with the first reservoir. The second reservoir has a second liquid and a sample support disposed therein. The second reservoir has an inlet opening defined therein. A draining unit is adjacent to the second reservoir. The draining unit is in fluid communication with the second reservoir. The draining unit has a first absorption member disposed therein.
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