专利检索 ap:"Hye-JIn Chung" 第 1 页

1.

发明申请
NOVEL ISOINDOLINONE DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST T-TYPE CALCIUM CHANNEL AND METHOD FOR PREPARATION THEREOF 有权
标题翻译：具有抗T型钙通道的抑制活性的新型茚二酮衍生物及其制备方法

公开(公告)号：US20100004286A1

公开(公告)日：2010-01-07

申请号：US12256701

申请日：2008-10-23

申请人： Yong Seo CHO , Ae Nim PAE , Hyunah CHOO , Jae Kyun LEE , You Na OH , Hee Sup SHIN , Dong Jin KIM , Hoh Gyu HAHN , Kyung Il CHOI , Ghilsoo NAM , Kye Jung SHIN , Soon Bang KANG , Eun Joo ROH , Dong Yun SHIN , Seon Hee SEO , Hyewhon RHIM , Gyo Chang KEUM , Key-Sun KIM , Chan Seong CHEONG , Eunice Eun-Kyeong KIM , Cheolju LEE , Youngsoo KIM , Kee Hyun CHOI , Kee Dal NAM , Woong Seo PARK , Yong Koo KANG , Hye Jin CHUNG

发明人： Yong Seo CHO , Ae Nim PAE , Hyunah CHOO , Jae Kyun LEE , You Na OH , Hee Sup SHIN , Dong Jin KIM , Hoh Gyu HAHN , Kyung Il CHOI , Ghilsoo NAM , Kye Jung SHIN , Soon Bang KANG , Eun Joo ROH , Dong Yun SHIN , Seon Hee SEO , Hyewhon RHIM , Gyo Chang KEUM , Key-Sun KIM , Chan Seong CHEONG , Eunice Eun-Kyeong KIM , Cheolju LEE , Youngsoo KIM , Kee Hyun CHOI , Kee Dal NAM , Woong Seo PARK , Yong Koo KANG , Hye Jin CHUNG

IPC分类号： A61K31/454 , C07D401/12 , A61P35/00 , A61P9/12 , A61P25/08

CPC分类号： C07D401/12 , A61K31/454

摘要： Disclosed are isoindolinone derivatives, represented by Chemical Formula 1, having inhibitory activity against T-type calcium channels, pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition comprising the same as an active ingredient. wherein R1˜R6 are as defined in the specification.

摘要翻译： 公开了由化学式1表示的具有对T型钙通道的抑制活性的异吲哚啉酮衍生物，其药学上可接受的盐，其制备方法和包含其作为活性成分的药物组合物。其中R1〜R6如说明书中所定义。

2.

发明授权
Pyrazolylmethylamine compounds as calcium channel modulators and preparation method thereof 有权
标题翻译：吡唑基甲胺化合物作为钙通道调节剂及其制备方法

公开(公告)号：US08299072B2

公开(公告)日：2012-10-30

申请号：US12568243

申请日：2009-09-28

申请人： Ghilsoo Nam , Kyung Il Choi , Hye Ran Kim , Seon Hee Seo , Yoon Jee Kim , Hee Sup Shin , Dong Jin Kim , Ae Nim Pae , Hye Jin Chung , Hyunah Choo , Hyewhon Rhim , Yong Seo Cho , Eun Joo Roh , Gyo Chang Keum , Kee Hyun Choi , Kye Jung Shin , Hoh Gyu Hahn , Chan Seong Cheong , Jae Kyun Lee , Kee Dal Nam , Yong Koo Kang , Youngsoo Kim , Woong Seo Park , Eunice Eun-Kyeong Kim , Key-Sun Kim , Hesson Chung , Dong Yun Shin , Chi man Song

发明人： Ghilsoo Nam , Kyung Il Choi , Hye Ran Kim , Seon Hee Seo , Yoon Jee Kim , Hee Sup Shin , Dong Jin Kim , Ae Nim Pae , Hye Jin Chung , Hyunah Choo , Hyewhon Rhim , Yong Seo Cho , Eun Joo Roh , Gyo Chang Keum , Kee Hyun Choi , Kye Jung Shin , Hoh Gyu Hahn , Chan Seong Cheong , Jae Kyun Lee , Kee Dal Nam , Yong Koo Kang , Youngsoo Kim , Woong Seo Park , Eunice Eun-Kyeong Kim , Key-Sun Kim , Hesson Chung , Dong Yun Shin , Chi man Song

IPC分类号： A61K31/496 , A61K31/506 , A61K31/5377 , C07D231/12 , C07D401/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/10

CPC分类号： C07D231/12 , C07D401/04 , C07D405/04 , C07D405/10 , C07D405/12

摘要： The present invention relates to pyrazolylmethylamine-piperazine derivatives and their pharmaceutically acceptable salts effective as calcium channel modulators and a method of manufacturing the same. The present invention also relates to the medicinal use of the above compounds as therapeutic treatment of diseases due to their effect as calcium channel modulators.

摘要翻译： 本发明涉及作为钙通道调节剂有效的吡唑基甲胺 - 哌嗪衍生物及其药学上可接受的盐及其制备方法。本发明还涉及由于其作为钙通道调节剂的作用而使上述化合物作为疾病的治疗性治疗的药物用途。

3.

发明授权
Phenylacetate derivatives or pharmaceutically acceptable salts thereof, preparation method thereof and composition for prevention or treatment of diseases induced by activation of T-type calcium ion channel containing the same as an active ingredient 有权
标题翻译：苯乙酸衍生物或其药学上可接受的盐，其制备方法和预防或治疗由含有其作为活性成分的T型钙离子通道激活引起的疾病的组合物

公开(公告)号：US07939672B2

公开(公告)日：2011-05-10

申请号：US12429004

申请日：2009-04-23

申请人： Kye Jung Shin , Hyung Kook Lee , Eun Joo Roh , Dong Jin Kim , Kyung Il Choi , Hyewhon Rhim , Hye Jin Chung , Seon Hee Seo

发明人： Kye Jung Shin , Hyung Kook Lee , Eun Joo Roh , Dong Jin Kim , Kyung Il Choi , Hyewhon Rhim , Hye Jin Chung , Seon Hee Seo

IPC分类号： C07D235/08

CPC分类号： C07D211/34 , C07D211/14 , C07D211/18 , C07D211/22 , C07D211/70 , C07D235/14 , C07D235/16 , C07D295/145 , C07D295/15

摘要： Disclosed herein are a new phenylacetate derivative represented by Chemical Formula 1 or pharmaceutically acceptable salt thereof, a preparation method thereof, and a composition for prevention or treatment of diseases induced by the activation of T-type calcium ion channels containing the same. The composition containing the phenylacetate derivative according to the present invention effectively inhibits the activation of T-type calcium ion channels and may be useful in the prevention or treatment of diseases such as hypertension, cancer, epilepsy, and neurogenic pains induced by the activation of T-type calcium ion channels. wherein, X, R1, and R3 are as defined herein.

摘要翻译： 本文公开了由化学式1表示的新的苯乙酸酯衍生物或其药学上可接受的盐，其制备方法，以及用于预防或治疗由含有其的T型钙离子通道活化引起的疾病的组合物。含有本发明的苯乙酸酯衍生物的组合物有效地抑制T型钙离子通道的活化，并且可用于预防或治疗诸如高血压，癌症，癫痫和T激活诱导的神经源性疼痛等疾病型钙离子通道。其中X，R 1和R 3如本文所定义。

4.

发明申请
NOVEL PYRAZOLYLMETHYLAMINE COMPOUNDS AS CALCIUM CHANNEL MODULATORS AND PREPARATION METHOD THEREOF 有权
标题翻译：新型吡咯烷基胺化合物作为钙通道调节剂及其制备方法

公开(公告)号：US20100094006A1

公开(公告)日：2010-04-15

申请号：US12568243

申请日：2009-09-28

申请人： Ghilsoo NAM , Kyung Il Choi , Hye Ran Kim , Seon Hee Seo , Yoon Jee Kim , Hee Sup Shin , Dong Jin Kim , Ae Nim Pae , Hye Jin Chung , Hyunah Choo , Hyewhon Rhim , Yong Seo Cho , Eun Joo Roh , Gyo Chang Keum , Kee Hyun Choi , Kye Jung Shin , Hoh Gyu Hahn , Chan Seong Cheong , Jae Kyun Lee , Kee Dal Nam , Yong Koo Kang , Youngsoo Kim , Woong Seo Park , Eunice Eun-Kyeong Kim , Key-Sun Kim , Hesson Chung , Dong Yun Shin , Chi man Song

发明人： Ghilsoo NAM , Kyung Il Choi , Hye Ran Kim , Seon Hee Seo , Yoon Jee Kim , Hee Sup Shin , Dong Jin Kim , Ae Nim Pae , Hye Jin Chung , Hyunah Choo , Hyewhon Rhim , Yong Seo Cho , Eun Joo Roh , Gyo Chang Keum , Kee Hyun Choi , Kye Jung Shin , Hoh Gyu Hahn , Chan Seong Cheong , Jae Kyun Lee , Kee Dal Nam , Yong Koo Kang , Youngsoo Kim , Woong Seo Park , Eunice Eun-Kyeong Kim , Key-Sun Kim , Hesson Chung , Dong Yun Shin , Chi man Song

IPC分类号： C07D403/12 , C07D241/04 , C07D231/12

CPC分类号： C07D231/12 , C07D401/04 , C07D405/04 , C07D405/10 , C07D405/12

摘要： The present invention relates to pyrazolylmethylamine-piperazine derivatives and their pharmaceutically acceptable salts effective as calcium channel modulators and a method of manufacturing the same. The present invention also relates to the medicinal use of the above compounds as therapeutic treatment of diseases due to their effect as calcium channel modulators.

摘要翻译： 本发明涉及作为钙通道调节剂有效的吡唑基甲胺 - 哌嗪衍生物及其药学上可接受的盐及其制备方法。本发明还涉及由于其作为钙通道调节剂的作用而使上述化合物作为疾病的治疗性治疗的药物用途。

5.

发明申请
BENZOARYLUREIDO COMPOUNDS, AND COMPOSITION FOR PREVENTION OR TREATMENT OF NEURODEGENERATIVE BRAIN DISEASE CONTAINING THE SAME 有权
标题翻译：苯并噻唑化合物及其组合物，用于预防或治疗含有其的神经损伤性脑病

公开(公告)号：US20110319456A1

公开(公告)日：2011-12-29

申请号：US13142313

申请日：2009-12-29

申请人： Hoh-Gyu Hahn , Kee-Dal Nam , Dong-Yun Shin , Chan-Ho Park , Sung-Woo Cho , Eun-A Kim , Ghil-Soo Nam , Kyung-Il Chol , Seon-Hee Seo , Hee-Sup Shin , Dong-JIn Kim , Ae-Nim Pae , Hye-JIn Chung , Hyun-Ah Choo , Hye-Whon Rhim , Yong-Seo Cho , Eun-Jon Roh , Gyo-Chang Keum , Kee-Hyun Choi , Kye-Jung Shin , Chan-Seong Cheong , Jae-Kyun Lee , Yong-Koo Kang , Young-Soo Kim , Woong-Seo Park , Key-Sun Kim , He-Sson Chung , Chi-Man Song , Sun-Joon Min , Eunlce Eun-Kyeong Kim , Cheol-Ju Lee , Soon-Bang Kang

发明人： Hoh-Gyu Hahn , Kee-Dal Nam , Dong-Yun Shin , Chan-Ho Park , Sung-Woo Cho , Eun-A Kim , Ghil-Soo Nam , Kyung-Il Chol , Seon-Hee Seo , Hee-Sup Shin , Dong-JIn Kim , Ae-Nim Pae , Hye-JIn Chung , Hyun-Ah Choo , Hye-Whon Rhim , Yong-Seo Cho , Eun-Jon Roh , Gyo-Chang Keum , Kee-Hyun Choi , Kye-Jung Shin , Chan-Seong Cheong , Jae-Kyun Lee , Yong-Koo Kang , Young-Soo Kim , Woong-Seo Park , Key-Sun Kim , He-Sson Chung , Chi-Man Song , Sun-Joon Min , Eunlce Eun-Kyeong Kim , Cheol-Ju Lee , Soon-Bang Kang

IPC分类号： A61K31/428 , C07D235/30 , C07D417/12 , A61P25/16 , A61K31/4184 , A61K31/423 , A61P25/28 , A61P25/00 , C07D277/82 , C07D263/58

CPC分类号： C07D277/82 , C07D235/22 , C07D263/58 , C07D327/04 , C07D333/06

摘要： Novel benzoarylureido compounds and a use thereof for prevention and/or treatment of the neurodegenerative brain disease are provided. The neurodegenerative brain diseases may include Alzheimer's disease, dementia, Parkinson's disease, stroke, amyloidosis, Pick's disease, Lou Gehrig's disease, Huntington's disease, Creutzfeld-Jakob disease, and the like.

摘要翻译： 提供了新的苯甲酰脲基化合物及其用于预防和/或治疗神经退行性脑病的用途。神经变性脑疾病可包括阿尔茨海默病，痴呆，帕金森病，中风，淀粉样变性，皮克病，卢格里希氏病，亨廷顿舞蹈病，克雅氏病，雅各布病等。

6.

发明申请
NOVEL PHENYLACETATE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD THEREOF AND COMPOSITION FOR PREVENTION OR TREATMENT OF DISEASES INDUCED BY ACTIVATION OF T-TYPE CALCIUM ION CHANNEL CONTAINING THE SAME AS AN ACTIVE INGREDIENT 有权
标题翻译：新型苯乙酸衍生物或其药学上可接受的盐，其制备方法和组合物，用于预防或治疗通过激活含有其作为活性成分的T型钙通道引起的疾病

公开(公告)号：US20100056545A1

公开(公告)日：2010-03-04

申请号：US12429004

申请日：2009-04-23

申请人： Kye Jung SHIN , Hyung Kook LEE , Eun Joo ROH , Dong Jin KIM , Kyung Il CHOI , Hyewhon RHIM , Hye Jin CHUNG , Seon Hee SEO

发明人： Kye Jung SHIN , Hyung Kook LEE , Eun Joo ROH , Dong Jin KIM , Kyung Il CHOI , Hyewhon RHIM , Hye Jin CHUNG , Seon Hee SEO

IPC分类号： A61K31/4965 , C07D235/16 , C07D295/15 , C07D211/34 , A61K31/4184 , A61K31/445 , A61P35/00 , A61P9/12 , A61P25/00

CPC分类号： C07D211/34 , C07D211/14 , C07D211/18 , C07D211/22 , C07D211/70 , C07D235/14 , C07D235/16 , C07D295/145 , C07D295/15

摘要： Disclosed herein are a new phenylacetate derivative represented by Chemical Formula 1 or pharmaceutically acceptable salt thereof, a preparation method thereof, and a composition for prevention or treatment of diseases induced by the activation of T-type calcium ion channels containing the same. The composition containing the phenylacetate derivative according to the present invention effectively inhibits the activation of T-type calcium ion channels and may be useful in the prevention or treatment of diseases such as hypertension, cancer, epilepsy, and neurogenic pains induced by the activation of T-type calcium ion channels. wherein, X, R1, and R3 are as defined herein.

摘要翻译： 本文公开了由化学式1表示的新的苯乙酸酯衍生物或其药学上可接受的盐，其制备方法，以及用于预防或治疗由含有其的T型钙离子通道活化引起的疾病的组合物。含有本发明的苯乙酸酯衍生物的组合物有效地抑制T型钙离子通道的活化，并且可用于预防或治疗诸如高血压，癌症，癫痫和T激活诱导的神经源性疼痛等疾病型钙离子通道。其中X，R 1和R 3如本文所定义。