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1.Azetidine derivative and antidepressant composition including the same 有权
标题翻译: 氮杂环丁烷衍生物和包含其的抗抑郁药组合物公开(公告)号:US09120771B2
公开(公告)日:2015-09-01
申请号:US14239890
申请日:2012-09-04
申请人: Hoh-Gyu Hahn , Kee-Dal Nam , Min-soo Han , Young-Hue Han , Chi-Man Song , Dong-Yun Shin
发明人: Hoh-Gyu Hahn , Kee-Dal Nam , Min-soo Han , Young-Hue Han , Chi-Man Song , Dong-Yun Shin
IPC分类号: C07D403/06 , C07D205/04
CPC分类号: C07D403/06 , C07D205/04
摘要: The present invention relates to an azetidine derivative or a pharmaceutically acceptable salt thereof, and an antidepressant agent or a composition for the prevention or treatment of psychiatric disorders including the same. The azetidine derivative is useful as a triple reuptake inhibitor capable of inhibiting reuptake of the neurotransmitters, dopamine, serotonin, and norepinephrine at the same time.
摘要翻译: 本发明涉及氮杂环丁烷衍生物或其药学上可接受的盐,以及用于预防或治疗包括它们的精神障碍的抗抑郁药或组合物。 氮杂环丁烷衍生物可用作能够同时抑制神经递质,多巴胺,5-羟色胺和去甲肾上腺素再摄取的三重再摄取抑制剂。
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2.Benzoarylureido compounds, and composition for prevention or treatment of neurodegenerative brain disease containing the same 有权
标题翻译: 苯并芳基脲基化合物,以及用于预防或治疗含有其的神经退行性脑病的组合物公开(公告)号:US09012481B2
公开(公告)日:2015-04-21
申请号:US13142313
申请日:2009-12-29
申请人: Hoh-Gyu Hahn , Kee-Dal Nam , Dong-Yun Shin , Chan-Ho Park , Sung-Woo Cho , Eun-A Kim , Ghil-Soo Nam , Kyung-Il Chol , Seon-Hee Seo , Hee-Sup Shin , Dong-Jin Kim , Ae-Nim Pae , Hye-Jin Chung , Hyun-Ah Choo , Hye-Whon Rhim , Yong-Seo Cho , Eun-Joo Roh , Gyo-Chang Keum , Kee-Hyun Choi , Kye-Jung Shin , Chan-Seong Cheong , Jae-Kyun Lee , Yong-Koo Kang , Young-Soo Kim , Woong-Seo Park , Key-Sun Kim , He-Sson Chung , Chi-Man Song , Sun-Joon Min , Eunice Eun-Kyeong Kim , Cheol-Ju Lee , Soon-Bang Kang
发明人: Hoh-Gyu Hahn , Kee-Dal Nam , Dong-Yun Shin , Chan-Ho Park , Sung-Woo Cho , Eun-A Kim , Ghil-Soo Nam , Kyung-Il Chol , Seon-Hee Seo , Hee-Sup Shin , Dong-Jin Kim , Ae-Nim Pae , Hye-Jin Chung , Hyun-Ah Choo , Hye-Whon Rhim , Yong-Seo Cho , Eun-Joo Roh , Gyo-Chang Keum , Kee-Hyun Choi , Kye-Jung Shin , Chan-Seong Cheong , Jae-Kyun Lee , Yong-Koo Kang , Young-Soo Kim , Woong-Seo Park , Key-Sun Kim , He-Sson Chung , Chi-Man Song , Sun-Joon Min , Eunice Eun-Kyeong Kim , Cheol-Ju Lee , Soon-Bang Kang
IPC分类号: C07D235/22 , C07D263/58 , C07D333/06 , C07D327/04 , C07D277/82
CPC分类号: C07D277/82 , C07D235/22 , C07D263/58 , C07D327/04 , C07D333/06
摘要: Novel benzoarylureido compounds and a use thereof for prevention and/or treatment of the neurodegenerative brain disease are provided. The neurodegenerative brain diseases may include Alzheimer's disease, dementia, Parkinson's disease, stroke, amyloidosis, Pick's disease, Lou Gehrig's disease, Huntington's disease, Creutzfeld-Jakob disease, and the like.
摘要翻译: 提供了新的苯甲酰脲基化合物及其用于预防和/或治疗神经退行性脑病的用途。 神经变性脑疾病可包括阿尔茨海默病,痴呆,帕金森病,中风,淀粉样变性,皮克病,卢格里希氏病,亨廷顿舞蹈病,克雅氏病,雅各布病等。
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3.AZETIDINE DERIVATIVE AND ANTIDEPRESSANT COMPOSITION INCLUDING THE SAME 有权
标题翻译: AZETIDINE衍生物和抗菌组合物,包括它们公开(公告)号:US20140171402A1
公开(公告)日:2014-06-19
申请号:US14239890
申请日:2012-09-04
申请人: Hoh-Gyu Hahn , Kee-Dal Nam , Min-soo Han , Young-Hue Han , Chi-Man Song , Dong-Yun Shin
发明人: Hoh-Gyu Hahn , Kee-Dal Nam , Min-soo Han , Young-Hue Han , Chi-Man Song , Dong-Yun Shin
IPC分类号: C07D403/06 , C07D205/04
CPC分类号: C07D403/06 , C07D205/04
摘要: The present invention relates to an azetidine derivative or a pharmaceutically acceptable salt thereof, and an antidepressant agent or a composition for the prevention or treatment of psychiatric disorders including the same. The azetidine derivative is useful as a triple reuptake inhibitor capable of inhibiting reuptake of the neurotransmitters, dopamine, serotonin, and norepinephrine at the same time.
摘要翻译: 本发明涉及氮杂环丁烷衍生物或其药学上可接受的盐,以及用于预防或治疗包括它们的精神障碍的抗抑郁药或组合物。 氮杂环丁烷衍生物可用作能够同时抑制神经递质,多巴胺,5-羟色胺和去甲肾上腺素再摄取的三重再摄取抑制剂。
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4.BENZOARYLUREIDO COMPOUNDS, AND COMPOSITION FOR PREVENTION OR TREATMENT OF NEURODEGENERATIVE BRAIN DISEASE CONTAINING THE SAME 有权
标题翻译: 苯并噻唑化合物及其组合物,用于预防或治疗含有其的神经损伤性脑病公开(公告)号:US20110319456A1
公开(公告)日:2011-12-29
申请号:US13142313
申请日:2009-12-29
申请人: Hoh-Gyu Hahn , Kee-Dal Nam , Dong-Yun Shin , Chan-Ho Park , Sung-Woo Cho , Eun-A Kim , Ghil-Soo Nam , Kyung-Il Chol , Seon-Hee Seo , Hee-Sup Shin , Dong-JIn Kim , Ae-Nim Pae , Hye-JIn Chung , Hyun-Ah Choo , Hye-Whon Rhim , Yong-Seo Cho , Eun-Jon Roh , Gyo-Chang Keum , Kee-Hyun Choi , Kye-Jung Shin , Chan-Seong Cheong , Jae-Kyun Lee , Yong-Koo Kang , Young-Soo Kim , Woong-Seo Park , Key-Sun Kim , He-Sson Chung , Chi-Man Song , Sun-Joon Min , Eunlce Eun-Kyeong Kim , Cheol-Ju Lee , Soon-Bang Kang
发明人: Hoh-Gyu Hahn , Kee-Dal Nam , Dong-Yun Shin , Chan-Ho Park , Sung-Woo Cho , Eun-A Kim , Ghil-Soo Nam , Kyung-Il Chol , Seon-Hee Seo , Hee-Sup Shin , Dong-JIn Kim , Ae-Nim Pae , Hye-JIn Chung , Hyun-Ah Choo , Hye-Whon Rhim , Yong-Seo Cho , Eun-Jon Roh , Gyo-Chang Keum , Kee-Hyun Choi , Kye-Jung Shin , Chan-Seong Cheong , Jae-Kyun Lee , Yong-Koo Kang , Young-Soo Kim , Woong-Seo Park , Key-Sun Kim , He-Sson Chung , Chi-Man Song , Sun-Joon Min , Eunlce Eun-Kyeong Kim , Cheol-Ju Lee , Soon-Bang Kang
IPC分类号: A61K31/428 , C07D235/30 , C07D417/12 , A61P25/16 , A61K31/4184 , A61K31/423 , A61P25/28 , A61P25/00 , C07D277/82 , C07D263/58
CPC分类号: C07D277/82 , C07D235/22 , C07D263/58 , C07D327/04 , C07D333/06
摘要: Novel benzoarylureido compounds and a use thereof for prevention and/or treatment of the neurodegenerative brain disease are provided. The neurodegenerative brain diseases may include Alzheimer's disease, dementia, Parkinson's disease, stroke, amyloidosis, Pick's disease, Lou Gehrig's disease, Huntington's disease, Creutzfeld-Jakob disease, and the like.
摘要翻译: 提供了新的苯甲酰脲基化合物及其用于预防和/或治疗神经退行性脑病的用途。 神经变性脑疾病可包括阿尔茨海默病,痴呆,帕金森病,中风,淀粉样变性,皮克病,卢格里希氏病,亨廷顿舞蹈病,克雅氏病,雅各布病等。
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5.NOVEL PYRAZOLYLMETHYLAMINE COMPOUNDS AS CALCIUM CHANNEL MODULATORS AND PREPARATION METHOD THEREOF 有权
标题翻译: 新型吡咯烷基胺化合物作为钙通道调节剂及其制备方法公开(公告)号:US20100094006A1
公开(公告)日:2010-04-15
申请号:US12568243
申请日:2009-09-28
申请人: Ghilsoo NAM , Kyung Il Choi , Hye Ran Kim , Seon Hee Seo , Yoon Jee Kim , Hee Sup Shin , Dong Jin Kim , Ae Nim Pae , Hye Jin Chung , Hyunah Choo , Hyewhon Rhim , Yong Seo Cho , Eun Joo Roh , Gyo Chang Keum , Kee Hyun Choi , Kye Jung Shin , Hoh Gyu Hahn , Chan Seong Cheong , Jae Kyun Lee , Kee Dal Nam , Yong Koo Kang , Youngsoo Kim , Woong Seo Park , Eunice Eun-Kyeong Kim , Key-Sun Kim , Hesson Chung , Dong Yun Shin , Chi man Song
发明人: Ghilsoo NAM , Kyung Il Choi , Hye Ran Kim , Seon Hee Seo , Yoon Jee Kim , Hee Sup Shin , Dong Jin Kim , Ae Nim Pae , Hye Jin Chung , Hyunah Choo , Hyewhon Rhim , Yong Seo Cho , Eun Joo Roh , Gyo Chang Keum , Kee Hyun Choi , Kye Jung Shin , Hoh Gyu Hahn , Chan Seong Cheong , Jae Kyun Lee , Kee Dal Nam , Yong Koo Kang , Youngsoo Kim , Woong Seo Park , Eunice Eun-Kyeong Kim , Key-Sun Kim , Hesson Chung , Dong Yun Shin , Chi man Song
IPC分类号: C07D403/12 , C07D241/04 , C07D231/12
CPC分类号: C07D231/12 , C07D401/04 , C07D405/04 , C07D405/10 , C07D405/12
摘要: The present invention relates to pyrazolylmethylamine-piperazine derivatives and their pharmaceutically acceptable salts effective as calcium channel modulators and a method of manufacturing the same. The present invention also relates to the medicinal use of the above compounds as therapeutic treatment of diseases due to their effect as calcium channel modulators.
摘要翻译: 本发明涉及作为钙通道调节剂有效的吡唑基甲胺 - 哌嗪衍生物及其药学上可接受的盐及其制备方法。 本发明还涉及由于其作为钙通道调节剂的作用而使上述化合物作为疾病的治疗性治疗的药物用途。
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6.Pyrazolylmethylamine compounds as calcium channel modulators and preparation method thereof 有权
标题翻译: 吡唑基甲胺化合物作为钙通道调节剂及其制备方法公开(公告)号:US08299072B2
公开(公告)日:2012-10-30
申请号:US12568243
申请日:2009-09-28
申请人: Ghilsoo Nam , Kyung Il Choi , Hye Ran Kim , Seon Hee Seo , Yoon Jee Kim , Hee Sup Shin , Dong Jin Kim , Ae Nim Pae , Hye Jin Chung , Hyunah Choo , Hyewhon Rhim , Yong Seo Cho , Eun Joo Roh , Gyo Chang Keum , Kee Hyun Choi , Kye Jung Shin , Hoh Gyu Hahn , Chan Seong Cheong , Jae Kyun Lee , Kee Dal Nam , Yong Koo Kang , Youngsoo Kim , Woong Seo Park , Eunice Eun-Kyeong Kim , Key-Sun Kim , Hesson Chung , Dong Yun Shin , Chi man Song
发明人: Ghilsoo Nam , Kyung Il Choi , Hye Ran Kim , Seon Hee Seo , Yoon Jee Kim , Hee Sup Shin , Dong Jin Kim , Ae Nim Pae , Hye Jin Chung , Hyunah Choo , Hyewhon Rhim , Yong Seo Cho , Eun Joo Roh , Gyo Chang Keum , Kee Hyun Choi , Kye Jung Shin , Hoh Gyu Hahn , Chan Seong Cheong , Jae Kyun Lee , Kee Dal Nam , Yong Koo Kang , Youngsoo Kim , Woong Seo Park , Eunice Eun-Kyeong Kim , Key-Sun Kim , Hesson Chung , Dong Yun Shin , Chi man Song
IPC分类号: A61K31/496 , A61K31/506 , A61K31/5377 , C07D231/12 , C07D401/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/10
CPC分类号: C07D231/12 , C07D401/04 , C07D405/04 , C07D405/10 , C07D405/12
摘要: The present invention relates to pyrazolylmethylamine-piperazine derivatives and their pharmaceutically acceptable salts effective as calcium channel modulators and a method of manufacturing the same. The present invention also relates to the medicinal use of the above compounds as therapeutic treatment of diseases due to their effect as calcium channel modulators.
摘要翻译: 本发明涉及作为钙通道调节剂有效的吡唑基甲胺 - 哌嗪衍生物及其药学上可接受的盐及其制备方法。 本发明还涉及由于其作为钙通道调节剂的作用而使上述化合物作为疾病的治疗性治疗的药物用途。
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