公开(公告)号：US06274304B1

公开(公告)日：2001-08-14

申请号：US08195018

申请日：1994-02-14

申请人： Herbert Buschek ,  Michael Kuehnl ,  Roland Ihrig ,  Klaus Erler ,  Maria Cully

发明人： Herbert Buschek ,  Michael Kuehnl ,  Roland Ihrig ,  Klaus Erler ,  Maria Cully

IPC分类号： C12Q100

CPC分类号： B01L3/508 ,  B01L3/50825

摘要： There is provided a system for the preparation of liquids from at least one solid and at least one liquid phase. The system is composed of a vessel in which the solid or solids are located and a drying chamber which is connected to the vessel or can be connected to the vessel. The drying chamber is separated from the vessel interior by a separating means which is permeable to water vapour but is impermeable to liquids. The system is suitable for the production of liquids from moisture-sensitive solids. These solids can be stored in the vessel since the air humidity in the interior is lowered by the desiccant. The preparation of the liquid by addition of a liquid phase can be carried out in one and the same vessel since the desiccant is separated from the vessel interior.

摘要翻译： 提供了用于从至少一个固体和至少一个液相制备液体的系统。 该系统由固体或固体所在的容器和连接到容器上或可连接到容器的干燥室组成。 干燥室通过分离装置与容器内部分离，该分离装置可渗透水蒸汽，但不透液体。 该系统适用于从湿度敏感的固体生产液体。 这些固体可以储存在容器中，因为内部的空气湿度被干燥剂降低。 由于干燥剂与容器内部分离，所以通过添加液相来制备液体可以在同一个容器中进行。

公开(公告)号：US08940230B2

公开(公告)日：2015-01-27

申请号：US11895271

申请日：2007-08-23

申请人： Michael Kühnl ,  Herbert Buschek ,  Reinhold Krämer ,  Petra Ickler

发明人： Michael Kühnl ,  Herbert Buschek ,  Reinhold Krämer ,  Petra Ickler

IPC分类号： G01N21/76 ,  G01N21/00 ,  G01N21/66 ,  G01N21/05

CPC分类号： G01N21/76 ,  G01N21/05 ,  G01N21/66

摘要： A cell for conducting electrochemiluminescence measurements is disclosed. The cell in one embodiment provides a measurement cell housing having a cavity, a fluid inlet channel for inducing fluid into the cavity and a fluid outlet channel for discharging fluid from the cavity at axial ends. The cell also provides at least one working electrode and a counter electrode on or in the cavity, and an optical viewing element for observing electrochemiluminescence effects in the cavity, wherein the fluid inlet channel has an at least approximately continuous curved course in a transition area to the cavity so that the fluid inlet channel at its end which is joined to the cavity is shaped in such a manner as to constitute a continuous course of the transition between the fluid inlet channel and the cavity to generate a largely steady flow profile when inducing fluid into the measurement cell cavity.

摘要翻译： 公开了用于进行电化学发光测量的电池。 在一个实施例中，电池提供具有空腔的测量单元壳体，用于将流体引入空腔的流体入口通道和用于在轴向端部处从空腔排出流体的流体出口通道。 电池还在空腔中或空腔中提供至少一个工作电极和对电极，以及用于观察空腔中的电化学发光效应的光学观察元件，其中流体入口通道在过渡区域中具有至少大致连续的弯曲过程 使得其端部处的流体入口通道连接到腔体的形状成形为在流体入口通道和空腔之间的过渡的连续过程，以在诱导流体时产生大致稳定的流动分布 进入测量单元腔。

公开(公告)号：US5424212A

公开(公告)日：1995-06-13

申请号：US197457

申请日：1994-02-16

申请人： Judith Pinsl-Ober ,  Herbert Buschek ,  Klaus Erler

发明人： Judith Pinsl-Ober ,  Herbert Buschek ,  Klaus Erler

IPC分类号： G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  G01N21/13 ,  G01N33/48

CPC分类号： G01N35/00663 ,  G01N35/00712 ,  G01N35/025 ,  G01N2035/00435 ,  G01N2035/00534 ,  G01N2035/00564 ,  G01N2035/00673 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/1076 ,  G01N2035/1086 ,  Y10T436/11 ,  Y10T436/115831

摘要： Analysis system for the automatic analysis of body fluids for a plurality of different analytes (parameters). An analytical apparatus incorporates reaction vessels (8) which are transported on the apparatus to various handling stations (10 to 16). The system also includes liquid reagents, which are held in readiness on the apparatus in reagent vessels (9), their volume sufficing for a large number of analyses. In order to achieve a high degree of analytical accuracy with reduced probability of operating errors and without significant increasing of the overall system costs, a calibrator is stored ready for use in liquid form in a calibrator station (17) of the analytical apparatus, the calibration is initiated and carried out fully automatically (i.e. without human intervention) for the various parameters independently of one another. For the initiation of the calibration for a parameter, in at least one system-immanent calibration-influencing variable is determined and combined logically with a control value defined specifically for the respective parameter and the decision on the initiation of the calibration is taken automatically in accordance with the logic combination.

摘要翻译： 用于多种不同分析物（参数）的体液自动分析的分析系统。 分析装置包括在装置上运送到各种处理站（10至16）的反应容器（8）。 该系统还包括液体试剂，其在试剂容器（9）中的装置上保持准备，其容量足以进行大量分析。 为了实现高度的分析精度，降低了操作错误的可能性，并且没有显着提高整个系统成本，校准器被储存成准备在液体形式中用于分析仪器的校准器站（17），校准 对于各个参数彼此独立地启动和完全自动执行（即无需人为干预）。 为了启动参数的校准，在至少一个系统内在的校准影响变量中被确定并且与逻辑上与专门针对相应参数定义的控制值进行组合，并且根据校准自动地进行关于校准开始的决定 与逻辑组合。

公开(公告)号：US4557600A

公开(公告)日：1985-12-10

申请号：US413011

申请日：1982-08-30

申请人： Sigmar Klose ,  Manfred Pasch ,  Wolfgang Kleemann ,  Friedhelm Vieth ,  Herbert Buschek

发明人： Sigmar Klose ,  Manfred Pasch ,  Wolfgang Kleemann ,  Friedhelm Vieth ,  Herbert Buschek

IPC分类号： G01N35/00 ,  B04B5/04 ,  G01N21/07 ,  G01N37/00 ,  G01N1/10

CPC分类号： B04B5/0407 ,  G01N21/07 ,  G01N2035/00495 ,  Y10T436/111666

摘要： A process and a device for the centrifugal control and mixing of a limited volumes of fluid, especially in the rotor of a centrifugal analyzer, has at least one baffle chamber, in a flow canal for the fluid the volume of which is greater than the volume of fluid. It is so shaped that, when the device is rotated at a sufficiently high first speed of rotation, the fluid remains in it. An outlet canal is connected to the baffle chamber the fluid. At least a part thereof lies closer to the axis of rotation than the fluid surface during the rotation with the first speed of rotation. The walls of the outlet canal consist of a material which is wettable by the fluid and, in combination therewith, have cross-section which forces the fluid out of the baffle chamber; by boundary surface force when the device is rotated at a second, slower speed.

摘要翻译： 用于离心控制和混合有限体积的流体的方法和装置，特别是在离心分析器的转子中具有至少一个挡板室，用于用于流体的流道中，该流体的体积大于体积 的流体。 它是如此的形状，使得当装置以足够高的第一旋转速度旋转时，流体保留在其中。 出口管连接到挡板室的流体。 至少其一部分在与第一旋转速度旋转期间比流体表面更靠近旋转轴线。 出口管的壁由可被流体润湿的材料组成，并且与其组合具有迫使流体离开挡板的横截面; 当装置以第二，较慢的速度旋转时，通过边界表面力。

公开(公告)号：US20080047332A1

公开(公告)日：2008-02-28

申请号：US11895271

申请日：2007-08-23

申请人： Michael Kuhnl ,  Herbert Buschek ,  Reinhold Kramer ,  Petra Ickler

发明人： Michael Kuhnl ,  Herbert Buschek ,  Reinhold Kramer ,  Petra Ickler

IPC分类号： G01N1/00

CPC分类号： G01N21/76 ,  G01N21/05 ,  G01N21/66

摘要： A cell for conducting electrochemiluminescence measurements is disclosed. The cell in one embodiment provides a measurement cell housing having a cavity, a fluid inlet channel for inducing fluid into the cavity and a fluid outlet channel for discharging fluid from the cavity at axial ends. The cell also provides at least one working electrode and a counter electrode on or in the cavity, and an optical viewing element for observing electrochemiluminescence effects in the cavity, wherein the fluid inlet channel has an at least approximately continuous curved course in a transition area to the cavity so that the fluid inlet channel at its end which is joined to the cavity is shaped in such a manner as to constitute a continuous course of the transition between the fluid inlet channel and the cavity to generate a largely steady flow profile when inducing fluid into the measurement cell cavity.

摘要翻译： 公开了用于进行电化学发光测量的电池。 在一个实施例中，电池提供具有空腔的测量单元壳体，用于将流体引入空腔的流体入口通道和用于在轴向端部处从空腔排出流体的流体出口通道。 电池还在空腔中或空腔中提供至少一个工作电极和对电极，以及用于观察空腔中的电化学发光效应的光学观察元件，其中流体入口通道在过渡区域中具有至少大致连续的弯曲过程 使得其端部处的流体入口通道连接到腔体的形状成形为在流体入口通道和空腔之间的过渡的连续过程，以在诱导流体时产生大致稳定的流动分布 进入测量单元腔。

公开(公告)号：US4668622A

公开(公告)日：1987-05-26

申请号：US681009

申请日：1984-12-13

申请人： Manfred Kuhr ,  Rudolf Machat ,  Wolfgang Weckerle ,  Hans-Georg Batz ,  Rupert Herrmann ,  Wolfgang Kleeman ,  Herbert Buschek

发明人： Manfred Kuhr ,  Rudolf Machat ,  Wolfgang Weckerle ,  Hans-Georg Batz ,  Rupert Herrmann ,  Wolfgang Kleeman ,  Herbert Buschek

IPC分类号： G01N33/535 ,  C07H15/203 ,  C09B11/00 ,  C12Q1/34 ,  C12Q1/54 ,  G01N33/48 ,  C07H15/00

CPC分类号： C07H15/203 ,  C12Q1/34 ,  C12Q2334/40 ,  G01N2333/924

摘要： The present invention provides phenolsulphonphthaleinyl-.beta.-D-galactosides of the general formula: ##STR1## wherein R.sup.1 to R.sup.4, which can be the same or different, are hydrogen or halogen atoms or nitro or amino groups, R.sup.5 to R.sup.12, which can be the same or different, are hydrogen or halogen atoms or lower alkyl, hydroxyl, lower alkoxy, carboxyl or nitro groups and M.sup.+ is a proton, an alkali metal, alkaline earth metal or ammonium ion.The present invention also provides a process for preparing these galactosides and diagnostic agents containing them.

摘要翻译： 本发明提供以下通式的苯酚磺酞基-β-D-半乳糖苷：其中R 1至R 4可相同或不同，为氢或卤素原子或硝基或氨基，R 5至R 12， 氢原子或卤素原子或低级烷基，羟基，低级烷氧基，羧基或硝基，M +是质子，碱金属，碱土金属或铵离子可相同或不同。 本发明还提供了制备这些半乳糖苷和含有它们的诊断剂的方法。

公开(公告)号：US4476223A

公开(公告)日：1984-10-09

申请号：US452690

申请日：1982-12-23

申请人： Herbert Buschek ,  Helmut Schlumberger ,  Joachim Siedel

发明人： Herbert Buschek ,  Helmut Schlumberger ,  Joachim Siedel

IPC分类号： C12N20060101 ,  C12N9/16 ,  C12N9/18 ,  C12N9/96 ,  C12Q20060101 ,  C12Q1/44 ,  C12Q1/46 ,  C12Q1/60 ,  C12Q1/61 ,  C12R1/38 ,  C12R1/39

CPC分类号： C12N9/96 ,  C12Q1/60

摘要： The present invention provides a process for the stabilization of an aqueous solution of cholesterol esterase from Pseudomonas, especially in the presence of a surface-active agent, wherein the enzyme is dissolved in a phosphate-free buffer which contains 10 to 200 mMol/liter of magnesium ions.

摘要翻译： 本发明提供了一种稳定来自假单胞菌属的胆固醇酯酶水溶液的方法，特别是在表面活性剂存在下，其中酶溶解在无磷酸盐缓冲液中，该缓冲液含有10〜200mMol / 镁离子。

公开(公告)号：US4282001A

公开(公告)日：1981-08-04

申请号：US26851

申请日：1979-04-04

申请人： Sigmar Klose ,  Herbert Buschek ,  Helmut Schlumberger

发明人： Sigmar Klose ,  Herbert Buschek ,  Helmut Schlumberger

IPC分类号： B01J20/22 ,  C12Q1/54 ,  C12Q1/60 ,  C12Q1/62 ,  G01N1/34 ,  G01N31/00 ,  G01N33/04 ,  G01N33/48 ,  G01N33/96 ,  G01N33/52 ,  G01N33/66 ,  G01N33/92

CPC分类号： G01N33/96 ,  C12Q1/54 ,  C12Q1/60 ,  C12Q1/62 ,  G01N1/34 ,  G01N33/04 ,  Y10T436/25

摘要： For the removal of turbidities in reaction mixtures clouded by sample material, especially for photometric measurement, there are added to the reaction mixture:(a) at least one low molecular weight organic compound, such as an aromatic alcohol or amine, which contains an electronegative substituent, for example a phenol or naphthol, which is substituted with one or more halogen atoms and/or hydroxyl groups and(b) at least one detergent which dissolves to give without compound (a), a clear solution and which forms a sparingly soluble complex with component (a), such as a non-ionic polyethylene oxide adduct or a cationic detergent, especially an alkyl, aralkyl or alkylthio ether or an alkyl or aralkyl ester of a polyethylene oxide glycol containing 8 to 22 carbon atoms in the alkyl radical and 5 to 25 ethylene oxide units or an alkyl dimethyl benzyl ammonium chloride compound containing 8 to 22 carbon atoms in the alkyl radical,in an amount sufficient for the appearance of a precipitate of the complex, whereafter further detergent is added thereto until the precipitated complex dissolves again.

摘要翻译： 对于通过样品材料（特别是用于光度测量）混浊的反应混合物中的浊度的去除，加入到反应混合物中：（a）至少一种低分子量有机化合物，例如芳族醇或胺，其含有电负性 取代基，例如苯酚或萘酚，其被一个或多个卤素原子和/或羟基取代，和（b）至少一种在没有化合物（a）的情况下溶解而得到的洗涤剂，澄清溶液并形成微溶于 与组分（a）的复合物，例如非离子聚环氧乙烷加合物或阳离子洗涤剂，特别是在烷基中含有8-22个碳原子的聚环氧乙烷的烷基，芳烷基或烷硫基醚或烷基或芳烷基酯 和5至25个环氧乙烷单元或烷基中含有8至22个碳原子的烷基二甲基苄基氯化铵化合物，其量足以出现沉淀物 然后向其中加入另外的洗涤剂，直到沉淀的复合物再次溶解。