公开(公告)号：US20120264117A1

公开(公告)日：2012-10-18

申请号：US13525271

申请日：2012-06-15

申请人： Glenn Sanders ,  Evaldas Katilius ,  Larry Gold

发明人： Glenn Sanders ,  Evaldas Katilius ,  Larry Gold

IPC分类号： C12N5/076 ,  C07H21/04 ,  C07H21/00 ,  C40B20/00 ,  C12Q1/68

CPC分类号： C12N15/115 ,  C12N5/061 ,  C12N2310/16 ,  C12N2320/10 ,  C12N2330/00

摘要： The present disclosure describes the isolation, identification and purification of aptamers having sufficiently high affinity and specificity to capture and immobilize intact sperm cells in the presence of female epithelial cells and other non-sperm semen components. The present disclosure also describes affinity-based methods for the detection of sperm cells in samples, including from forensic sample surrogates consisting of swab eluates containing a mixture of HeLa cells and sperm cells. The present disclosure describes methods for eluting sperm cell samples from swabs; methods for purifying sperm cells and methods for amplification and analysis of male DNA. The affinity-based system described herein is inexpensive, simple to use and easily implemented in forensic laboratories.

摘要翻译： 本公开描述了具有足够高的亲和性和特异性的适体的分离，鉴定和纯化，以在存在雌性上皮细胞和其它非精液精液组分的情况下捕获和固定完整精子细胞。 本公开还描述了用于检测样品中精子细胞的基于亲和性的方法，包括由包含HeLa细胞和精子细胞的混合物的拭子洗脱液组成的法医样品替代物。 本公开描述了从拭子洗脱精子细胞样品的方法; 纯化精子细胞的方法和扩增和分析雄性DNA的方法。 本文描述的基于亲和性的系统是廉价的，易于使用并且容易地在法医实验室中实施。

公开(公告)号：US20110284464A1

公开(公告)日：2011-11-24

申请号：US13170375

申请日：2011-06-28

申请人： Fabio Roncadi ,  Marco Salsa ,  Matteo Malagoli ,  Glenn Sanders ,  Gary Warns

发明人： Fabio Roncadi ,  Marco Salsa ,  Matteo Malagoli ,  Glenn Sanders ,  Gary Warns

IPC分类号： B01D61/32 ,  G05B13/02

CPC分类号： A61M1/16 ,  A61M1/1613 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3368 ,  A61M2205/502 ,  A61M2205/505 ,  G06F19/00 ,  G06F19/3481 ,  G16H40/63 ,  Y10S210/929

摘要： A medical apparatus comprises a control system allowing storage of a number of shaping profiles. Each shaping profile is stored as a plurality of pairs, including a shaping profile reference value and a time interval value. The reference value is represented as fraction, for instance a percentage, of the total weight loss the apparatus should achieve at the end of a treatment time. Each time interval value is represented either as fraction of the total treatment time or as a prefixed actual time interval. The control system calculates the actual weight loss rate versus time profile based on the desired total weight loss, on the desired total treatment time as well as on selected desired shaping profile.

摘要翻译： 医疗装置包括允许存储多个成形轮廓的控制系统。 每个整形轮廓被存储为多对，包括整形轮廓参考值和时间间隔值。 参考值表示为设备在治疗时间结束时应达到的总重量损失的分数，例如百分比。 每个时间间隔值被表示为总治疗时间的分数，或者作为前置实际时间间隔。 控制系统基于期望的总重量损失，在期望的总治疗时间以及所选择的所需整形轮廓上计算实际的体重减轻率与时间曲线。

公开(公告)号：US5696832A

公开(公告)日：1997-12-09

申请号：US491688

申请日：1995-06-14

申请人： Glenn Sanders

发明人： Glenn Sanders

IPC分类号： H04R29/00 ,  H04S7/00

CPC分类号： H04S7/302

摘要： Apparatus for limiting and displaying fader levels employing a display device provided with a linear bar graph display having a plurality of bar graph segments and having an input to which a display signal of variable value can be applied. The display signal has a value range with predetermined maximum and minimum values. The device responds to any value of the display signal to illuminate a corresponding segment. A fader mechanism is manually adjustable to produce a fader signal of variable value. The fader signal has a value range with maximum and minimum values which respectively exceed and fall below the corresponding maximum and minimum values of the display signal. A computer has an input at which the fader signal is applied. The computer stores the maximum and minimum values of the display signal and compares the value of the fader signal with the stored values to produce a display signal. The display signal has a value equal to the fader signal unaltered when the value of the fader signal falls within the range of the display signals; the display signal has its maximum value when the value of the fader signal is in excess of the maximum value of the display signal and has its minimum value when the value of the fader signal falls below the minimum value of the display signal. The display signal appears at an output of the computer is supplied to the input of the display device.

摘要翻译： 一种用于限制和显示推子电平的装置，该显示装置具有带有多个条形图段的线性条形图显示，并且具有可以应用可变值的显示信号的输入。 显示信号具有预定最大值和最小值的值范围。 设备响应显示信号的任何值以照亮相应的段。 推子机构可手动调节，以产生可变值的推子信号。 推子信号具有分别超过并低于显示信号的对应最大值和最小值的最大值和最小值的值范围。 计算机具有施加推子信号的输入。 计算机存储显示信号的最大值和最小值，并将推子信号的值与存储的值进行比较以产生显示信号。 当推子信号的值落在显示信号的范围内时，显示信号具有等于推子信号的值; 当推子信号的值超过显示信号的最大值时，显示信号具有其最大值，并且当推子信号的值下降到低于显示信号的最小值时，显示信号具有其最小值。 出现在计算机输出端的显示信号提供给显示设备的输入。

公开(公告)号：US5182654A

公开(公告)日：1993-01-26

申请号：US482640

申请日：1990-02-21

申请人： Glenn Sanders

发明人： Glenn Sanders

IPC分类号： H04N5/93 ,  H04N5/95

CPC分类号： H04N5/95 ,  H04N5/93

摘要： A set of offset signal values is obtained for use with a time base corrector unit which is capable of playing a video tape to produce a corresponding output video signal containing various viewing parameters such as video gain, chroma gain, set up and hue. A tape having a known set of parameter values and carrying test patterns is used together with a source of a standard reference video signal, and a source of a variable offset signal. The viewing parameter settings of the unit are adjusted to conform to the known set of parameter values. The tape is played in the unit, thus displaying the test pattern video output signal. The output signal is displayed with the reference signal, the reference signal containing the same parameters but with different values. An offset signal is applied to the input of the unit. The offset signal is varied to vary the video output signal for each parameter in turn until each parameter of the varied output signal is visually identical to that of the standard reference signal, thereby obtaining a set of offset signal values associated with the unit, each value in the set being associated with a different parameter.

摘要翻译： 获得一组偏移信号值，用于能够播放录像带以产生包含视频增益，色度增益，设置和色调等各种观看参数的相应输出视频信号的时基校正单元。 具有已知的一组参数值并携带测试图案的磁带与标准参考视频信号的源和可变偏移信号的源一起使用。 调整设备的查看参数设置以符合已知的一组参数值。 磁带在本机中播放，从而显示测试图形视频输出信号。 输出信号与参考信号一起显示，参考信号包含相同的参数但具有不同的值。 偏移信号被施加到单元的输入。 改变偏移信号以改变每个参数的视频输出信号，直到变化的输出信号的每个参数在视觉上与标准参考信号的参数相同，从而获得与该单元相关联的一组偏移信号值，每个值 该组与不同的参数相关联。

公开(公告)号：US20160256279A1

公开(公告)日：2016-09-08

申请号：US15058285

申请日：2016-03-02

申请人： Glenn Sanders ,  S. Alex Paolicelli

发明人： Glenn Sanders ,  S. Alex Paolicelli

IPC分类号： A61F2/28 ,  G05B19/4099 ,  G06F19/00

CPC分类号： A61F2/28 ,  A61F2/2846 ,  A61F2/30942 ,  A61F2002/2825 ,  A61F2002/30011 ,  A61F2002/30014 ,  A61F2002/3092 ,  A61F2002/30948 ,  G05B19/4099 ,  G05B2219/49023 ,  G16H50/50

摘要： The present disclosure relates to patient-specific bone implants and methods for designing and making such implants. A method includes obtaining an image of a bone having an injured, diseased, or degenerative portion; determining in the image the margins at each end of the injured portion of the bone; transforming the image into a three-dimensional model; conducting a virtual surgery to remove the injured portion of the bone and create a virtual bone gap in the image; designing a patient-specific implant to fit the virtual bone gap, wherein the designed implant includes a framework having a porosity sufficient to allow blood entry through the framework and having mechanical properties similar to that of bone; and fabricating an implant based on the designed implant. Optionally, bone regeneration material is placed within the framework.

摘要翻译： 本公开涉及患者特异性骨植入物和用于设计和制造这种植入物的方法。 一种方法包括获得具有受损，患病或退化部分的骨骼的图像; 在图像中确定骨骼的受损部分的每个端部的边缘; 将图像转换为三维模型; 进行虚拟手术以去除骨骼的受伤部分并在图像中产生虚拟骨隙; 设计特定于患者的植入物以适应虚拟骨间隙，其中设计的植入物包括具有足以允许血液进入框架并且具有类似于骨的机械性质的孔隙的骨架; 以及基于所设计的植入物制造植入物。 任选地，将骨再生材料置于框架内。

公开(公告)号：US08431376B2

公开(公告)日：2013-04-30

申请号：US11568286

申请日：2005-04-26

申请人： Thale Cross Jarvis ,  Charles S. McHenry ,  Nebojsa Janjic ,  Garry Dallmann ,  James M. Bullard ,  Stacie Bell ,  Glenn Sanders ,  Frank Dean

发明人： Thale Cross Jarvis ,  Charles S. McHenry ,  Nebojsa Janjic ,  Garry Dallmann ,  James M. Bullard ,  Stacie Bell ,  Glenn Sanders ,  Frank Dean

IPC分类号： C12N9/00

CPC分类号： C07K14/21 ,  C07K14/195 ,  C07K14/31 ,  C12N15/63 ,  C12N15/69 ,  C12N15/70

摘要： Reconstituted bacterial replication assemblies and methods for their use are provided.

摘要翻译： 提供重组的细菌复制组件及其使用方法。

公开(公告)号：US07988850B2

公开(公告)日：2011-08-02

申请号：US11640919

申请日：2006-12-19

申请人： Fabio Roncadi ,  Marco Salsa ,  Matteo Malagoli ,  Glenn Sanders ,  Gary Warns

发明人： Fabio Roncadi ,  Marco Salsa ,  Matteo Malagoli ,  Glenn Sanders ,  Gary Warns

IPC分类号： A61M1/14

CPC分类号： A61M1/16 ,  A61M1/1613 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3368 ,  A61M2205/502 ,  A61M2205/505 ,  G06F19/00 ,  G06F19/3481 ,  G16H40/63 ,  Y10S210/929

摘要： A medical apparatus comprises a control system allowing storage of a number of shaping profiles. Each shaping profile is stored as a plurality of pairs, including a shaping profile reference value and a time interval value. The reference value is represented as fraction, for instance a percentage, of the total weight loss the apparatus should achieve at the end of a treatment time. Each time interval value is represented either as fraction of the total treatment time or as a prefixed actual time interval. The control system calculates the actual weight loss rate versus time profile based on the desired total weight loss, on the desired total treatment time as well as on selected desired shaping profile.

摘要翻译： 医疗装置包括允许存储多个成形轮廓的控制系统。 每个整形轮廓被存储为多对，包括整形轮廓参考值和时间间隔值。 参考值表示为设备在治疗时间结束时应达到的总重量损失的分数，例如百分比。 每个时间间隔值被表示为总治疗时间的分数，或者作为前置实际时间间隔。 控制系统基于期望的总重量损失，在期望的总治疗时间以及所选择的所需整形轮廓上计算实际的体重减轻率与时间曲线。

公开(公告)号：US20070138069A1

公开(公告)日：2007-06-21

申请号：US11640919

申请日：2006-12-19

申请人： Fabio Roncadi ,  Marco Salsa ,  Matteo Malagoli ,  Glenn Sanders ,  Gary Warns

发明人： Fabio Roncadi ,  Marco Salsa ,  Matteo Malagoli ,  Glenn Sanders ,  Gary Warns

IPC分类号： B01D61/00

CPC分类号： A61M1/16 ,  A61M1/1613 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3368 ,  A61M2205/502 ,  A61M2205/505 ,  G06F19/00 ,  G06F19/3481 ,  G16H40/63 ,  Y10S210/929

摘要： A medical apparatus comprises a control system allowing storage of a number of shaping profiles. Each shaping profile is stored as a plurality of pairs, including a shaping profile reference value and a time interval value. The reference value is represented as fraction, for instance a percentage, of the total weight loss the apparatus should achieve at the end of a treatment time. Each time interval value is represented either as fraction of the total treatment time or as a prefixed actual time interval. The control system calculates the actual weight loss rate versus time profile based on the desired total weight loss, on the desired total treatment time as well as on selected desired shaping profile.

摘要翻译： 医疗装置包括允许存储多个成形轮廓的控制系统。 每个整形轮廓被存储为多对，包括整形轮廓参考值和时间间隔值。 参考值表示为设备在治疗时间结束时应达到的总重量损失的分数，例如百分比。 每个时间间隔值被表示为总治疗时间的分数，或者作为前置实际时间间隔。 控制系统基于期望的总重量损失，在期望的总治疗时间以及所选择的所需整形轮廓上计算实际的体重减轻率与时间曲线。

公开(公告)号：US20060202933A1

公开(公告)日：2006-09-14

申请号：US11361314

申请日：2006-02-24

申请人： Nicholas Pasch ,  Michael Sauvante ,  Glenn Sanders ,  Kazuo Senda ,  Hajime Seki

发明人： Nicholas Pasch ,  Michael Sauvante ,  Glenn Sanders ,  Kazuo Senda ,  Hajime Seki

IPC分类号： G09G3/36

CPC分类号： H01H59/0009 ,  H01H1/645

摘要： A robust microelectromechanical switch. In an illustrative embodiment, the switch is adapted for use in a display and includes a first flexible surface and a second surface. The second surface is angled relative to the first surface, forming a wedge the first surface and the second surface. A first terminal and a second terminal are positioned relative to the first flexible surface and the second surface so that selective flexing of the flexible surface electrically couples or uncouples the first terminal to the second terminal. In a more specific embodiment, the switch further includes a first mechanism for selectively applying an electrostatic force between the first flexible surface and the second surface. The first surface is positioned on a first elastic flexible layer, and the second surface is positioned on a second layer. The first mechanism includes a first actuator electrode that is coupled to the first surface, and a second actuator electrode that is coupled to the second surface. A sufficient charge differential applied between the first actuator electrode and the second actuator electrode will attract the first electrode to the second electrode, thereby flexing the flexible layer toward the second layer. The sidewalls define a perimeter of a cell that houses the switch. A protrusion extends from a third layer between the sidewalls, thereby indenting the first layer, and thereby forming the wedge.

摘要翻译： 坚固的微机电开关。 在说明性实施例中，开关适用于显示器并且包括第一柔性表面和第二表面。 第二表面相对于第一表面成角度，在第一表面和第二表面上形成楔形物。 第一端子和第二端子相对于第一柔性表面和第二表面定位，使得柔性表面的选择性挠曲将第一端子电耦合或断开到第二端子。 在更具体的实施例中，开关还包括用于在第一柔性表面和第二表面之间选择性地施加静电力的第一机构。 第一表面位于第一弹性柔性层上，第二表面位于第二层上。 第一机构包括耦合到第一表面的第一致动器电极和耦合到第二表面的第二致动器电极。 施加在第一致动器电极和第二致动器电极之间的足够的电荷差将吸引第一电极到第二电极，从而使柔性层向第二层弯曲。 侧壁限定容纳开关的电池的周边。 突起从侧壁之间的第三层延伸，从而压入第一层，从而形成楔形物。

公开(公告)号：US20050236260A1

公开(公告)日：2005-10-27

申请号：US11046325

申请日：2005-01-27

申请人： Nicholas Pasch ,  Glenn Sanders ,  Hajime Seki

发明人： Nicholas Pasch ,  Glenn Sanders ,  Hajime Seki

IPC分类号： H01H57/00 ,  H01H59/00

CPC分类号： H01H59/0009 ,  H01H2001/0084 ,  H01H2059/0036

摘要： Micro-electromechanical devices having an improved flexible layer enable the use of material having a wider range of elastic modulus. The MEM devices include a substantially non-pliable layer and a substantially flexible layer both of which include electrodes that when energized will create electrostatic forces that attracts the flexible layer to the non-pliable layer. The flexible layer has perforations or apertures cut into the flexible layer of a MEMs device to alter operational properties such as electrostatic sensitivity, resonance frequency, rate of change of sensitivity above the resonance frequency, oscillating mass, panel stiffness and others parameters.

摘要翻译： 具有改进的柔性层的微机电装置能够使用具有更宽范围的弹性模量的材料。 MEM器件包括基本上不柔软的层和基本上柔性的层，两者都包括电极，当被激发时将产生吸引柔性层到非柔性层的静电力。 柔性层具有切割到MEMs装置的柔性层中的穿孔或孔，以改变诸如静电敏感性，共振频率，谐振频率以上的灵敏度变化率，振动质量，面板刚度等参数的操作性能。