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    Ion trapping
    1.
    发明授权
    Ion trapping 有权
    离子捕获

    公开(公告)号：US07847243B2

    公开(公告)日：2010-12-07

    申请号：US11909850

    申请日：2006-03-29

    Applicant: Alexander Alekseevich Makarov ,  Eduard V. Denisov ,  Gerhard Jung ,  Robert Malek ,  Oliver Lange

    Inventor： Alexander Alekseevich Makarov ,  Eduard V. Denisov ,  Gerhard Jung ,  Robert Malek ,  Oliver Lange

    IPC: H01J49/00

    CPC classification number: H01J49/423 ,  H01J49/004 ,  H01J49/425 ,  H01J49/4295

    Abstract: This invention relates to a method of trapping ions and to an ion trapping assembly. In particular, the present invention has application in gas-assisted trapping of ions in an ion trap prior to a mass analysis of the ions in a mass spectrometer. The invention provides a method of trapping ions in a target ion trap of an ion trapping assembly that comprises a series of volumes arranged such that ions can traverse from one volume to the next, the volumes including the target ion trap, whereby ions are allowed to pass repeatedly through the volumes such that they also pass into and out from the target ion trap without being trapped. Potentials may be used to reflect the ions from respective ends of the ion trapping assembly. Optionally, a potential well and/or gas-assisted cooling may be used to cause the ions to settle in the target ion trap.

    Abstract translation: 本发明涉及一种捕获离子和离子捕获组件的方法。 特别地，本发明在质谱仪中对离子的质量分析之前，已经将其应用于离子阱中的气体辅助捕获。 本发明提供了一种捕集离子捕获组件的靶离子阱中的离子的方法，该离子捕获组件包括一系列体积，这些体积被布置成使得离子可以从一个体积向下一个体积穿过，包括靶离子阱，其中离子被允许 反复通过体积，使得它们也被进入和离开目标离子阱而不被捕获。 电位可用于从离子捕获组件的相应末端反射离子。 任选地，潜在的井和/或气体辅助冷却可用于使离子沉淀在目标离子阱中。

    Mass Spectrometry
    2.
    发明申请
    Mass Spectrometry 有权
    质谱

    公开(公告)号：US20100193680A1

    公开(公告)日：2010-08-05

    申请号：US12762140

    申请日：2010-04-16

    Applicant: Alexander Alekseevich MAKAROV ,  Eduard V. Denisov ,  Gerhard Jung ,  Alexander Kholomeev ,  Oliver Lange

    Inventor： Alexander Alekseevich MAKAROV ,  Eduard V. Denisov ,  Gerhard Jung ,  Alexander Kholomeev ,  Oliver Lange

    IPC: H01J49/26

    CPC classification number: H01J49/04

    Abstract: This invention relates to a mass spectrometer including a reaction cell and to a method of using such a mass spectrometer. In particular, although not exclusively, this invention relates to a tandem mass spectrometer and to tandem mass spectrometry. The invention provides a method of mass spectrometry using a mass spectrometer having a longitudinal axis, comprising guiding ions to travel along the longitudinal axis of the mass spectrometer in a forwards direction to pass through an intermediate ion store and then to enter a reaction cell, to process the ions within the reaction cell, to eject the processed ions to travel back along the longitudinal axis to enter the intermediate ion store once more, and to eject one or more pulses of the processed ions in an off-axis direction to a mass analyser.

    Abstract translation: 本发明涉及包括反应池的质谱仪和使用这种质谱仪的方法。 具体地说，尽管不是排他地，本发明涉及串联质谱仪和串联质谱法。 本发明提供了使用具有纵向轴线的质谱仪的质谱法，其包括引导离子沿着向前方向沿着质谱仪的纵向轴线行进以通过中间离子储存器然后进入反应池，至 处理反应池内的离子，以便使经处理的离子沿着纵轴排出回来，再次进入中间离子储存区，并将处理离子的一个或多个脉冲沿离轴方向排出到质量分析器 。

    Electrostatic Trap
    3.
    发明申请
    Electrostatic Trap 有权
    静电捕集阱

    公开(公告)号：US20080315080A1

    公开(公告)日：2008-12-25

    申请号：US10587478

    申请日：2006-06-05

    Applicant: Alexander Makarov ,  Eduard V. Denisov ,  Gerhard Jung ,  Wilko Balschun ,  Stevan Roy Horning

    Inventor： Alexander Makarov ,  Eduard V. Denisov ,  Gerhard Jung ,  Wilko Balschun ,  Stevan Roy Horning

    IPC: B01D59/46

    CPC classification number: H01J49/4245 ,  H01J49/0027 ,  H01J49/02 ,  H01J49/282 ,  H01J49/406 ,  H01J49/425

    Abstract: An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U′(r,φ,z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U′(r, φ,z) is the result of a perturbation W to an ideal field U(r, φ,z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, φ,z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than about 2π radians over an ion detection period Tm.

    Abstract translation: 公开了诸如轨道捕获器的静电捕获器，具有电极结构。 产生U'（r，phi，z）形式的静电捕获场，以捕获陷阱内的离子，使它们经历同步振荡。 捕获场U'（r，phi，z）是对于理想场U（r，phi，z）的扰动W的结果，其在例如轨道捕获的情况下例如是超对数的。 扰动W可以以各种方式引入，例如通过使陷波器的几何形状变形，使得其不再遵循理想场U（r，phi，z）的等电位，或者通过添加失真场（电或 磁性）。 扰动的幅度使得至少一些捕获的离子在离子检测周期Tm之后具有大于零但小于约2pi弧度的绝对相位扩展。

    Mass spectrometer having an ICP source
    6.
    发明授权
    Mass spectrometer having an ICP source 失效
    质谱仪具有ICP源

    公开(公告)号：US5552599A

    公开(公告)日：1996-09-03

    申请号：US315569

    申请日：1994-09-30

    Applicant: Ulrich Giessmann ,  Gerhard Jung ,  Curt Brunnee

    Inventor： Ulrich Giessmann ,  Gerhard Jung ,  Curt Brunnee

    IPC: H01J49/02 ,  H01J49/10 ,  H01J49/32

    CPC classification number: H01J49/32 ,  H01J49/105

    Abstract: A mass spectrometer includes an inductive coupled plasma source whose flame is near ground potential, an interface, a flight tube, and an analyzer that includes magnetic and electric sectors, and an ion detector, which detector is operated at high voltage for ion acceleration. The magnetic sector includes a magnet and pole pieces that are insulated electrically relative to the flight tube. The pressure within the interface preferably does not exceed 10.sup.-3 mbar. By varying the magnetic field and the acceleration potential, identification of a specified mass over defined time intervals is carried out. The disclosed mass spectrometer provides improved coupling between the plasma ion source and a double-focussing analyzer, while advantageously providing a low voltage regime for the plasma source.

    Abstract translation: 质谱仪包括其火焰接近地电位的感应耦合等离子体源，界面，飞行管和包括磁性和电气部分的分析仪，以及离子检测器，该检测器以高电压操作用于离子加速。 磁性部件包括相对于飞行管电绝缘的磁体和极片。 界面内的压力优选不超过10-3毫巴。 通过改变磁场和加速电位，执行在规定的时间间隔内确定指定的质量。 所公开的质谱仪提供等离子体离子源和双重聚焦分析仪之间的改进的耦合，同时有利地为等离子体源提供低电压状态。

    Lens arrangement for the focusing of electrically charged particles, and mass spectrometer with such a lens arrangement
    7.
    发明授权
    Lens arrangement for the focusing of electrically charged particles, and mass spectrometer with such a lens arrangement 失效
    用于聚焦带电粒子的透镜布置和具有这种透镜布置的质谱仪

    公开(公告)号：US4766314A

    公开(公告)日：1988-08-23

    申请号：US857168

    申请日：1986-04-29

    Applicant: Gerhard Jung

    Inventor： Gerhard Jung

    IPC: H01J49/06 ,  H01J49/32

    CPC classification number: H01J49/06 ,  H01J49/32

    Abstract: A lens arrangement (30) for the focusing of a beam of electrically charged particles (24) in the beam path of imaging systems, more particularly in mass spectrometers (10), is indicated, the lens arrangement (30) being connected to an electrical voltage supply. The lens arrangement (30) is situated at the location or in the vicinity of the intermediate image (29) produced by the imaging system, and consists of a plurality of plates (32 to 35) disposed in succession, with aligned transmission apertures (38 to 41), the plates being connected to adjustable electrical voltages.

    Abstract translation: 指示用于在成像系统的光束路径中更特别地在质谱仪（10）中聚焦带电粒子（24）的透镜装置（30），透镜装置（30）连接到电气 电压供应 透镜装置（30）位于由成像系统产生的中间图像（29）的位置或附近，并且由多个连续布置的板（32至35）组成，具有对准的传输孔（38 到41），板被连接到可调节的电压。

    Electrostatic Trap
    8.
    发明申请
    Electrostatic Trap 有权
    静电捕集阱

    公开(公告)号：US20130126724A1

    公开(公告)日：2013-05-23

    申请号：US13737771

    申请日：2013-01-09

    Applicant: Alexander A. MAKAROV ,  Eduard V. DENISOV ,  Gerhard JUNG ,  Wilko BALSCHUN ,  Stevan R. HORNING

    Inventor： Alexander A. MAKAROV ,  Eduard V. DENISOV ,  Gerhard JUNG ,  Wilko BALSCHUN ,  Stevan R. HORNING

    IPC: H01J49/28 ,  H01J49/00

    CPC classification number: H01J49/4245 ,  H01J49/0027 ,  H01J49/02 ,  H01J49/282 ,  H01J49/406 ,  H01J49/425

    Abstract: An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U′ (r, Φ, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U′(r, Φ, z) is the result of a perturbation W to an ideal field U(r, Φ, z) which, for example, is hypologarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, Φ, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2 n radians over an ion detection period Tm.

    Abstract translation: 公开了诸如轨道捕获器的静电捕获器，具有电极结构。 产生形式为U'（r，Phi，z）的静电捕获场以捕获陷阱内的离子，使得它们经历同步振荡。 捕获场U'（r，Phi，z）是对于理想场U（r，Phi，z）的扰动W的结果，在理想场U（r，Phi，z）中，例如在轨道阱的情况下是对数的。 扰动W可以以各种方式引入，例如通过使陷波器的几何形状变形，使得其不再遵循理想场U（r，Phi，z）的等电位，或者通过添加失真场（电或 磁性）。 扰动的幅度使得至少一些捕获的离子在离子检测周期Tm之后具有大于零但小于2n弧度的绝对相位扩展。

    Ion trapping
    9.
    发明授权
    Ion trapping 有权
    离子捕获

    公开(公告)号：US08288714B2

    公开(公告)日：2012-10-16

    申请号：US12944357

    申请日：2010-11-11

    Applicant: Alexander A. Makarov ,  Eduard V. Denisov ,  Gerhard Jung ,  Robert Malek ,  Oliver Lange

    Inventor： Alexander A. Makarov ,  Eduard V. Denisov ,  Gerhard Jung ,  Robert Malek ,  Oliver Lange

    IPC: H01J49/00

    CPC classification number: H01J49/423 ,  H01J49/004 ,  H01J49/425 ,  H01J49/4295

    Abstract: This invention relates to a method of trapping ions and to an ion trapping assembly. In particular, the present invention has application in gas-assisted trapping of ions in an ion trap prior to a mass analysis of the ions in a mass spectrometer. The invention provides a method of trapping ions in a target ion trap of an ion trapping assembly that comprises a series of volumes arranged such that ions can traverse from one volume to the next, the volumes including the target ion trap, whereby ions are allowed to pass repeatedly through the volumes such that they also pass into and out from the target ion trap without being trapped. Potentials may be used to reflect the ions from respective ends of the ion trapping assembly. Optionally, a potential well and/or gas-assisted cooling may be used to cause the ions to settle in the target ion trap.

    Abstract translation: 本发明涉及一种捕获离子和离子捕获组件的方法。 特别地，本发明在质谱仪中对离子的质量分析之前，已经将其应用于离子阱中的气体辅助捕获。 本发明提供了一种捕获离子捕获组件的靶离子阱中的离子的方法，该方法包括一系列体积排列使得离子可以从一个体积向下一个体积横越，该体积包括目标离子阱，从而使离子被允许 反复通过体积，使得它们也被进入和离开目标离子阱而不被捕获。 电位可用于从离子捕获组件的相应末端反射离子。 任选地，潜在的井和/或气体辅助冷却可用于使离子沉淀在目标离子阱中。

    ELECTROSTATIC TRAP
    10.
    发明申请
    ELECTROSTATIC TRAP 审中-公开
    静电捕捉

    公开(公告)号：US20120248308A1

    公开(公告)日：2012-10-04

    申请号：US13474020

    申请日：2012-05-17

    Applicant: Alexander Makarov ,  Eduard V. Denisov ,  Gerhard Jung ,  Wilko Balschun ,  Steven Roy Horning

    Inventor： Alexander Makarov ,  Eduard V. Denisov ,  Gerhard Jung ,  Wilko Balschun ,  Steven Roy Horning

    IPC: H01J49/28

    CPC classification number: H01J49/4245 ,  H01J49/0027 ,  H01J49/02 ,  H01J49/282 ,  H01J49/406 ,  H01J49/425

    Abstract: An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U′(r, φ, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U′(r, φ, z) is the result of a perturbation W to an ideal field U(r, φ, z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, φ, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2 π radians over an ion detection period Tm.

    Abstract translation: 公开了诸如轨道捕获器的静电捕获器，具有电极结构。 产生形式为U'（r，＆phgr; z）的静电捕获场，以捕获陷阱内的离子，使得它们经历同步振荡。 捕获场U'（r，＆phgr; z）是对于理想场U（r，＆phgr; z）的扰动W的结果，其在例如轨道捕获的情况下例如是超对数的。 扰动W可以以各种方式引入，例如通过使陷波器的几何形状变形，使得其不再遵循理想场U（r，＆phgr; z）的等电位，或者通过添加失真场（电 或磁性）。 扰动的幅度使得至少一些捕获的离子具有大于零但小于2的绝对相位扩展; 弧度超过离子检测周期Tm。

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