公开(公告)号：US08288714B2

公开(公告)日：2012-10-16

申请号：US12944357

申请日：2010-11-11

Applicant: Alexander A. Makarov ,  Eduard V. Denisov ,  Gerhard Jung ,  Robert Malek ,  Oliver Lange

Inventor： Alexander A. Makarov ,  Eduard V. Denisov ,  Gerhard Jung ,  Robert Malek ,  Oliver Lange

IPC: H01J49/00

CPC classification number: H01J49/423 ,  H01J49/004 ,  H01J49/425 ,  H01J49/4295

Abstract: This invention relates to a method of trapping ions and to an ion trapping assembly. In particular, the present invention has application in gas-assisted trapping of ions in an ion trap prior to a mass analysis of the ions in a mass spectrometer. The invention provides a method of trapping ions in a target ion trap of an ion trapping assembly that comprises a series of volumes arranged such that ions can traverse from one volume to the next, the volumes including the target ion trap, whereby ions are allowed to pass repeatedly through the volumes such that they also pass into and out from the target ion trap without being trapped. Potentials may be used to reflect the ions from respective ends of the ion trapping assembly. Optionally, a potential well and/or gas-assisted cooling may be used to cause the ions to settle in the target ion trap.

Abstract translation: 本发明涉及一种捕获离子和离子捕获组件的方法。 特别地，本发明在质谱仪中对离子的质量分析之前，已经将其应用于离子阱中的气体辅助捕获。 本发明提供了一种捕获离子捕获组件的靶离子阱中的离子的方法，该方法包括一系列体积排列使得离子可以从一个体积向下一个体积横越，该体积包括目标离子阱，从而使离子被允许 反复通过体积，使得它们也被进入和离开目标离子阱而不被捕获。 电位可用于从离子捕获组件的相应末端反射离子。 任选地，潜在的井和/或气体辅助冷却可用于使离子沉淀在目标离子阱中。

公开(公告)号：US20120248308A1

公开(公告)日：2012-10-04

申请号：US13474020

申请日：2012-05-17

Applicant: Alexander Makarov ,  Eduard V. Denisov ,  Gerhard Jung ,  Wilko Balschun ,  Steven Roy Horning

Inventor： Alexander Makarov ,  Eduard V. Denisov ,  Gerhard Jung ,  Wilko Balschun ,  Steven Roy Horning

IPC: H01J49/28

CPC classification number: H01J49/4245 ,  H01J49/0027 ,  H01J49/02 ,  H01J49/282 ,  H01J49/406 ,  H01J49/425

Abstract: An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U′(r, φ, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U′(r, φ, z) is the result of a perturbation W to an ideal field U(r, φ, z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, φ, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2 π radians over an ion detection period Tm.

Abstract translation: 公开了诸如轨道捕获器的静电捕获器，具有电极结构。 产生形式为U'（r，＆phgr; z）的静电捕获场，以捕获陷阱内的离子，使得它们经历同步振荡。 捕获场U'（r，＆phgr; z）是对于理想场U（r，＆phgr; z）的扰动W的结果，其在例如轨道捕获的情况下例如是超对数的。 扰动W可以以各种方式引入，例如通过使陷波器的几何形状变形，使得其不再遵循理想场U（r，＆phgr; z）的等电位，或者通过添加失真场（电 或磁性）。 扰动的幅度使得至少一些捕获的离子具有大于零但小于2的绝对相位扩展; 弧度超过离子检测周期Tm。

公开(公告)号：US08198581B2

公开(公告)日：2012-06-12

申请号：US12749334

申请日：2010-03-29

Applicant: Alexander Makarov ,  Eduard V. Denisov ,  Gerhard Jung ,  Wilko Balschun ,  Stevan Roy Horning

Inventor： Alexander Makarov ,  Eduard V. Denisov ,  Gerhard Jung ,  Wilko Balschun ,  Stevan Roy Horning

IPC: H01J49/28

CPC classification number: H01J49/4245 ,  H01J49/0027 ,  H01J49/02 ,  H01J49/282 ,  H01J49/406 ,  H01J49/425

Abstract: An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U′(r, φ, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U′(r, φ, z) is the result of a perturbation W to an ideal field U(r, φ, z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, φ, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2 Π radians over an ion detection period Tm.

Abstract translation: 公开了诸如轨道捕获器的静电捕获器，具有电极结构。 产生形式为U'（r，＆phgr; z）的静电捕获场，以捕获陷阱内的离子，使得它们经历同步振荡。 捕获场U'（r，＆phgr; z）是对于理想场U（r，＆phgr; z）的扰动W的结果，其在例如轨道捕获的情况下例如是超对数的。 扰动W可以以各种方式引入，例如通过使陷波器的几何形状变形，使得其不再遵循理想场U（r，＆phgr; z）的等电位，或者通过添加失真场（电 或磁性）。 扰动的幅度使得至少一些捕获的离子的绝对相位差大于零但小于2＆Pgr; 弧度超过离子检测周期Tm。

公开(公告)号：US20110139093A1

公开(公告)日：2011-06-16

申请号：US12921054

申请日：2009-02-24

Applicant: Rainer Rausch ,  Gerhard Jung

Inventor： Rainer Rausch ,  Gerhard Jung

IPC: F24H1/30

CPC classification number: F24H1/32

Abstract: A cast iron or aluminum sectional boiler, in particular a condensing boiler, having generally annular sections, one front section, one cover-like rear section and at least one center section being provided which form a furnace chamber having generally surrounding heating gas passages, and their annular water compartments are connected to one another via hubs. The sections have one lower return connection and one upper feed connection as well as at least two anchor rods for holding the section block together. The cast iron or aluminum sectional boiler is optimized with respect to compactness and robustness. Annular gaps are in each case provided as heating gas passages between two adjacent sections, each of which, starting from the furnace chamber, runs approximately radially outwards and leads into an exhaust gas collection chamber on the outside of the sections.

Abstract translation: 一种铸铁或铝分段锅炉，特别是冷凝锅炉，其具有大体环形部分，一个前部分，一个盖状后部部分和至少一个中心部分，其形成具有大致周围的加热气体通道的炉室，以及 它们的环形水隔间通过轮毂相互连接。 这些部分具有一个下部返回连接和一个上部进料连接以及用于将截面块保持在一起的至少两个锚杆。 铸铁或铝分段锅炉在紧凑性和坚固性方面进行了优化。 在每个情况下，环形间隙都设置在两个相邻部分之间的加热气体通道，每个区域从炉室开始大致径向向外延伸，并且进入排气收集室。

公开(公告)号：US07220970B2

公开(公告)日：2007-05-22

申请号：US11015405

申请日：2004-12-17

Applicant: Lothar Rottmann ,  Gerhard Jung ,  Franz-Josef Mersch

Inventor： Lothar Rottmann ,  Gerhard Jung ,  Franz-Josef Mersch

IPC: H01J49/00

CPC classification number: H01J37/244 ,  H01J49/025 ,  H01J2237/24405 ,  H01J2237/2444

Abstract: The invention relates to a method and a device for the measurement of ions by coupling different measurement methods/techniques, a first detector being a collector (17) and a second detector being an SEM (18), and the ions to be measured or resulting secondary particles being selectively delivered to the collector or the SEM. The SEM (18) is operated selectively in analog mode or count mode. The collector (17) is provided with an integrator.

Abstract translation: 本发明涉及一种用于通过耦合不同测量方法/技术测量离子的方法和装置，第一检测器是收集器（17），第二检测器是SEM（18），以及待测量或产生的离子 二次颗粒被选择性地递送到收集器或SEM。 SEM（18）在模拟模式或计数模式下选择性地工作。 集电器（17）设有积分器。

公开(公告)号：US07847243B2

公开(公告)日：2010-12-07

申请号：US11909850

申请日：2006-03-29

Applicant: Alexander Alekseevich Makarov ,  Eduard V. Denisov ,  Gerhard Jung ,  Robert Malek ,  Oliver Lange

Inventor： Alexander Alekseevich Makarov ,  Eduard V. Denisov ,  Gerhard Jung ,  Robert Malek ,  Oliver Lange

IPC: H01J49/00

CPC classification number: H01J49/423 ,  H01J49/004 ,  H01J49/425 ,  H01J49/4295

Abstract: This invention relates to a method of trapping ions and to an ion trapping assembly. In particular, the present invention has application in gas-assisted trapping of ions in an ion trap prior to a mass analysis of the ions in a mass spectrometer. The invention provides a method of trapping ions in a target ion trap of an ion trapping assembly that comprises a series of volumes arranged such that ions can traverse from one volume to the next, the volumes including the target ion trap, whereby ions are allowed to pass repeatedly through the volumes such that they also pass into and out from the target ion trap without being trapped. Potentials may be used to reflect the ions from respective ends of the ion trapping assembly. Optionally, a potential well and/or gas-assisted cooling may be used to cause the ions to settle in the target ion trap.

Abstract translation: 本发明涉及一种捕获离子和离子捕获组件的方法。 特别地，本发明在质谱仪中对离子的质量分析之前，已经将其应用于离子阱中的气体辅助捕获。 本发明提供了一种捕集离子捕获组件的靶离子阱中的离子的方法，该离子捕获组件包括一系列体积，这些体积被布置成使得离子可以从一个体积向下一个体积穿过，包括靶离子阱，其中离子被允许 反复通过体积，使得它们也被进入和离开目标离子阱而不被捕获。 电位可用于从离子捕获组件的相应末端反射离子。 任选地，潜在的井和/或气体辅助冷却可用于使离子沉淀在目标离子阱中。

公开(公告)号：US20100193680A1

公开(公告)日：2010-08-05

申请号：US12762140

申请日：2010-04-16

Applicant: Alexander Alekseevich MAKAROV ,  Eduard V. Denisov ,  Gerhard Jung ,  Alexander Kholomeev ,  Oliver Lange

Inventor： Alexander Alekseevich MAKAROV ,  Eduard V. Denisov ,  Gerhard Jung ,  Alexander Kholomeev ,  Oliver Lange

IPC: H01J49/26

CPC classification number: H01J49/04

Abstract: This invention relates to a mass spectrometer including a reaction cell and to a method of using such a mass spectrometer. In particular, although not exclusively, this invention relates to a tandem mass spectrometer and to tandem mass spectrometry. The invention provides a method of mass spectrometry using a mass spectrometer having a longitudinal axis, comprising guiding ions to travel along the longitudinal axis of the mass spectrometer in a forwards direction to pass through an intermediate ion store and then to enter a reaction cell, to process the ions within the reaction cell, to eject the processed ions to travel back along the longitudinal axis to enter the intermediate ion store once more, and to eject one or more pulses of the processed ions in an off-axis direction to a mass analyser.

Abstract translation: 本发明涉及包括反应池的质谱仪和使用这种质谱仪的方法。 具体地说，尽管不是排他地，本发明涉及串联质谱仪和串联质谱法。 本发明提供了使用具有纵向轴线的质谱仪的质谱法，其包括引导离子沿着向前方向沿着质谱仪的纵向轴线行进以通过中间离子储存器然后进入反应池，至 处理反应池内的离子，以便使经处理的离子沿着纵轴排出回来，再次进入中间离子储存区，并将处理离子的一个或多个脉冲沿离轴方向排出到质量分析器 。

公开(公告)号：US20080315080A1

公开(公告)日：2008-12-25

申请号：US10587478

申请日：2006-06-05

Applicant: Alexander Makarov ,  Eduard V. Denisov ,  Gerhard Jung ,  Wilko Balschun ,  Stevan Roy Horning

Inventor： Alexander Makarov ,  Eduard V. Denisov ,  Gerhard Jung ,  Wilko Balschun ,  Stevan Roy Horning

IPC: B01D59/46

CPC classification number: H01J49/4245 ,  H01J49/0027 ,  H01J49/02 ,  H01J49/282 ,  H01J49/406 ,  H01J49/425

Abstract: An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U′(r,φ,z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U′(r, φ,z) is the result of a perturbation W to an ideal field U(r, φ,z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, φ,z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than about 2π radians over an ion detection period Tm.

Abstract translation: 公开了诸如轨道捕获器的静电捕获器，具有电极结构。 产生U'（r，phi，z）形式的静电捕获场，以捕获陷阱内的离子，使它们经历同步振荡。 捕获场U'（r，phi，z）是对于理想场U（r，phi，z）的扰动W的结果，其在例如轨道捕获的情况下例如是超对数的。 扰动W可以以各种方式引入，例如通过使陷波器的几何形状变形，使得其不再遵循理想场U（r，phi，z）的等电位，或者通过添加失真场（电或 磁性）。 扰动的幅度使得至少一些捕获的离子在离子检测周期Tm之后具有大于零但小于约2pi弧度的绝对相位扩展。

公开(公告)号：US5552599A

公开(公告)日：1996-09-03

申请号：US315569

申请日：1994-09-30

Applicant: Ulrich Giessmann ,  Gerhard Jung ,  Curt Brunnee

Inventor： Ulrich Giessmann ,  Gerhard Jung ,  Curt Brunnee

IPC: H01J49/02 ,  H01J49/10 ,  H01J49/32

CPC classification number: H01J49/32 ,  H01J49/105

Abstract: A mass spectrometer includes an inductive coupled plasma source whose flame is near ground potential, an interface, a flight tube, and an analyzer that includes magnetic and electric sectors, and an ion detector, which detector is operated at high voltage for ion acceleration. The magnetic sector includes a magnet and pole pieces that are insulated electrically relative to the flight tube. The pressure within the interface preferably does not exceed 10.sup.-3 mbar. By varying the magnetic field and the acceleration potential, identification of a specified mass over defined time intervals is carried out. The disclosed mass spectrometer provides improved coupling between the plasma ion source and a double-focussing analyzer, while advantageously providing a low voltage regime for the plasma source.

Abstract translation: 质谱仪包括其火焰接近地电位的感应耦合等离子体源，界面，飞行管和包括磁性和电气部分的分析仪，以及离子检测器，该检测器以高电压操作用于离子加速。 磁性部件包括相对于飞行管电绝缘的磁体和极片。 界面内的压力优选不超过10-3毫巴。 通过改变磁场和加速电位，执行在规定的时间间隔内确定指定的质量。 所公开的质谱仪提供等离子体离子源和双重聚焦分析仪之间的改进的耦合，同时有利地为等离子体源提供低电压状态。

公开(公告)号：US4766314A

公开(公告)日：1988-08-23

申请号：US857168

申请日：1986-04-29

Applicant: Gerhard Jung

Inventor： Gerhard Jung

IPC: H01J49/06 ,  H01J49/32

CPC classification number: H01J49/06 ,  H01J49/32

Abstract: A lens arrangement (30) for the focusing of a beam of electrically charged particles (24) in the beam path of imaging systems, more particularly in mass spectrometers (10), is indicated, the lens arrangement (30) being connected to an electrical voltage supply. The lens arrangement (30) is situated at the location or in the vicinity of the intermediate image (29) produced by the imaging system, and consists of a plurality of plates (32 to 35) disposed in succession, with aligned transmission apertures (38 to 41), the plates being connected to adjustable electrical voltages.

Abstract translation: 指示用于在成像系统的光束路径中更特别地在质谱仪（10）中聚焦带电粒子（24）的透镜装置（30），透镜装置（30）连接到电气 电压供应 透镜装置（30）位于由成像系统产生的中间图像（29）的位置或附近，并且由多个连续布置的板（32至35）组成，具有对准的传输孔（38 到41），板被连接到可调节的电压。