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公开(公告)号：US20120078163A1
公开(公告)日：2012-03-29
申请号：US13322457
申请日：2010-05-27
申请人： Dan Gazit , Gadi Pelled , Zulma Gazit , Nadav Kimelman-Bleich
发明人： Dan Gazit , Gadi Pelled , Zulma Gazit , Nadav Kimelman-Bleich
CPC分类号： A61K38/1875 , A61L27/14 , A61L27/24 , A61L27/3834 , A61L27/52 , A61L27/54 , A61L27/56 , A61L2300/252 , A61L2300/258 , A61L2300/414 , A61L2300/43 , A61L2430/02 , A61L2430/10
摘要： A method of generating bone or connective tissue in a subject in need thereof, the method comprising: (a) implanting a scaffold in a damaged region of the subject, the scaffold comprising a tissue growth promoting agent; and (b) enhancing uptake of the tissue growth promoting agent into cells located on the scaffold, wherein the enhancing is effected by induced poration of the cells thereby generating bone or connective tissue in the subject. Kits for generating bone or connective tissue are also provided.
摘要翻译： 一种在有需要的受试者中产生骨或结缔组织的方法，所述方法包括：（a）在受试者的受损区域植入支架，所述支架包括组织生长促进剂; 和（b）增强组织生长促进剂对位于支架上的细胞的吸收，其中通过诱导细胞培养来实现增强，从而在受试者中产生骨或结缔组织。 还提供了用于产生骨或结缔组织的试剂盒。
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2.发明申请公开(公告)号：US20090214649A1
公开(公告)日：2009-08-27
申请号：US12320594
申请日：2009-01-29
申请人： Dan Gazit , Gadi Pelled , Zulma Gazit , Nadav Kimelman-Bleich
发明人： Dan Gazit , Gadi Pelled , Zulma Gazit , Nadav Kimelman-Bleich
CPC分类号： A61L27/3843 , A61L27/225 , A61L27/3604 , A61L27/3834 , A61L27/52 , A61L27/56
摘要： Provided are fibrin or silk matrices comprising an oxygen carrier, and matrices, which comprise an oxygen carrier and mesenchymal stem cells. Also provided are methods of generating and using same for ex vivo or in vivo tissue regeneration and/or repair such as for treating a non-union bone fracture and a condition requiring spinal fusion.
摘要翻译： 提供了包含氧载体的纤维蛋白或丝素基质和包含氧载体和间充质干细胞的基质。 还提供了用于离体或体内组织再生和/或修复的方法，例如用于治疗非并发骨折和需要脊柱融合的病症。
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3.发明申请Composite scaffolds and methods using same for generating complex tissue grafts 有权复合支架和使用它们的方法来产生复杂的组织移植物公开(公告)号：US20090035349A1
公开(公告)日：2009-02-05
申请号：US12285107
申请日：2008-09-29
申请人： Dan Gazit , Abraham Domb , Gadi Turgeman , Gadi Pelled , Tony Azzam
发明人： Dan Gazit , Abraham Domb , Gadi Turgeman , Gadi Pelled , Tony Azzam
CPC分类号： A61L27/3604 , A61L27/18 , A61L27/20 , A61L27/22 , A61L27/3625 , A61L27/38 , A61L27/3839 , A61L27/3886 , A61L27/3891 , A61L27/3895 , A61L27/40 , A61L27/48 , A61L27/507 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/426 , A61L2300/604 , A61L2430/36 , C12M25/14 , C12N5/0068 , C12N5/0662 , C12N2501/155 , C12N2502/28 , C12N2510/00 , C12N2533/40 , C12N2533/54 , C12N2533/70 , C12N2533/72 , C08L67/04 , C08L71/02
摘要： A composite scaffold for engineering a heterogeneous tissue is provided. The composite scaffold includes: (a) a first scaffold being capable of supporting formation of a first tissue type thereupon; and (b) a second scaffold being capable of supporting formation of a second tissue type thereupon; wherein the first scaffold and the second scaffold are arranged with respect to each other such that when the first scaffold supports the first tissue type and the second scaffold supports the second tissue type, a distance between any cell of the second tissue type and the first tissue type does not exceed 200 μm.
摘要翻译： 提供了一种用于工程异质组织的复合支架。 所述复合支架包括：（a）第一支架能够支撑其上形成第一组织类型; 和（b）第二支架能够支持其上形成第二组织类型; 其中所述第一支架和所述第二支架相对于彼此布置，使得当所述第一支架支撑所述第一组织类型并且所述第二支架支撑所述第二组织型时，所述第二组织类型的任何细胞与所述第一组织之间的距离 类型不超过200马姆。
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公开(公告)号：US06849255B2
公开(公告)日：2005-02-01
申请号：US10067980
申请日：2002-02-08
申请人： Dan Gazit , Yoram Zilberman , Gadi Turgeman , Gadi Pelled , Gerhard Gross , Stefan Czichos , Andrea Hoffmann
发明人： Dan Gazit , Yoram Zilberman , Gadi Turgeman , Gadi Pelled , Gerhard Gross , Stefan Czichos , Andrea Hoffmann
CPC分类号： C12N5/0655 , A61K35/12 , C12N2510/00
摘要： The invention relates to methods of enhancing repair of a cartilage and/or inducing formation of a cartilage by administering a cell which expresses a factor of the T-box family, which includes inter-alia the brachyury. In another embodiment, the invention relates to an engineered cell, which is transfected with a vector comprising a nucleic acid sequence encoding a factor of the T-box family, thereby expressing a factor of the T-box family. In another embodiment, the invention relates to compositions comprising a vector which comprises a nucleic acid sequence encoding a factor of the T-box family and in another embodiment the composition comprising cell which expresses a factor of the T-box family, which includes inter-alia the brachyury.
摘要翻译： 本发明涉及增强软骨修复和/或诱导软骨形成的方法，该方法是通过施用表达T盒家族的因子的细胞，其特别包括brachyury。 在另一个实施方案中，本发明涉及工程改造的细胞，其用包含编码T盒家族因子的核酸序列的载体转染，从而表达T盒家族的因子。 在另一个实施方案中，本发明涉及包含载体的组合物，所述载体包含编码T盒家族因子的核酸序列，在另一个实施方案中，包含表达T盒家族因子的细胞的组合物包括： 特别是brachyury。
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5.发明授权Composite scaffolds and methods using same for generating complex tissue grafts 有权复合支架和使用它们的方法产生复杂的组织移植物公开(公告)号：US08197553B2
公开(公告)日：2012-06-12
申请号：US12285107
申请日：2008-09-29
申请人： Dan Gazit , Abraham J. Domb , Gadi Turgeman , Gadi Pelled , Tony Azzam
发明人： Dan Gazit , Abraham J. Domb , Gadi Turgeman , Gadi Pelled , Tony Azzam
IPC分类号： A61F2/02
CPC分类号： A61L27/3604 , A61L27/18 , A61L27/20 , A61L27/22 , A61L27/3625 , A61L27/38 , A61L27/3839 , A61L27/3886 , A61L27/3891 , A61L27/3895 , A61L27/40 , A61L27/48 , A61L27/507 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/426 , A61L2300/604 , A61L2430/36 , C12M25/14 , C12N5/0068 , C12N5/0662 , C12N2501/155 , C12N2502/28 , C12N2510/00 , C12N2533/40 , C12N2533/54 , C12N2533/70 , C12N2533/72 , C08L67/04 , C08L71/02
摘要： A composite scaffold for engineering a heterogeneous tissue is provided. The composite scaffold includes: (a) a first scaffold being capable of supporting formation of a first tissue type thereupon; and (b) a second scaffold being capable of supporting formation of a second tissue type thereupon; wherein the first scaffold and the second scaffold are arranged with respect to each other such that when the first scaffold supports the first tissue type and the second scaffold supports the second tissue type, a distance between any cell of the second tissue type and the first tissue type does not exceed 200 μm.
摘要翻译： 提供了一种用于工程异质组织的复合支架。 所述复合支架包括：（a）第一支架能够支撑其上形成第一组织类型; 和（b）第二支架能够支持其上形成第二组织类型; 其中所述第一支架和所述第二支架相对于彼此布置，使得当所述第一支架支撑所述第一组织类型并且所述第二支架支撑所述第二组织型时，所述第二组织类型的任何细胞与所述第一组织之间的距离 类型不超过200μm。
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6.发明申请公开(公告)号：US20110217730A1
公开(公告)日：2011-09-08
申请号：US13108038
申请日：2011-05-16
申请人： Dan Gazit , Boris Rubinsky , Gadi Pelled , Zulma Gazit
发明人： Dan Gazit , Boris Rubinsky , Gadi Pelled , Zulma Gazit
CPC分类号： C12Q1/04 , G01N15/1031 , G01N27/745 , G01N2015/1006 , G01N2015/1081
摘要： A system for qualifying cells of a cell sample labeled with a magnetic or magnetizable moiety is provided. The system includes a cell sample holder for holding a cell of the cells and a first cell analyzer which includes a magnetic field source for applying a magnetic field to the cell and a sensor for qualifying and/or quantifying an effect of the magnetic field on the cell.
摘要翻译： 提供了用磁性或可磁化部分标记的细胞样品的细胞鉴定系统。 该系统包括用于保持单元的单元的单元样本保持器和包括用于向单元施加磁场的磁场源的第一单元分析器和用于限定和/或量化磁场对磁场的影响的传感器 细胞。
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公开(公告)号：US20100209400A1
公开(公告)日：2010-08-19
申请号：US12627034
申请日：2009-11-30
申请人： Dan Gazit , Gadi Pelled , Gadi Turgeman , Andrea Hoffmann , Gerhard Gross , Claas Wodarczyk , Kristin Verschueren
发明人： Dan Gazit , Gadi Pelled , Gadi Turgeman , Andrea Hoffmann , Gerhard Gross , Claas Wodarczyk , Kristin Verschueren
IPC分类号： A61K35/12 , A61K31/7105 , A61K31/711 , A61P19/08 , A61P19/10 , A61P19/02
CPC分类号： C12N9/1205 , A61K31/38
摘要： This invention is directed to methods, nucleic acids and compositions in TAK1-mediated regulation of SMAD activity. Promotion of TAK1 interaction with MH2 domains in SMADs negatively regulates SMAD biological activity. BMP-mediated SMAD activity is subject to TAK1 effects.
摘要翻译： 本发明涉及TAK1介导的SMAD活性调节中的方法，核酸和组合物。 促进与SMAD中MH2结构域的TAK1相互作用负调控SMAD生物活性。 BMP介导的SMAD活性受TAK1作用。
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公开(公告)号：US09381273B2
公开(公告)日：2016-07-05
申请号：US12320594
申请日：2009-01-29
申请人： Dan Gazit , Gadi Pelled , Zulma Gazit , Nadav Kimelman-Bleich
发明人： Dan Gazit , Gadi Pelled , Zulma Gazit , Nadav Kimelman-Bleich
CPC分类号： A61L27/3843 , A61L27/225 , A61L27/3604 , A61L27/3834 , A61L27/52 , A61L27/56
摘要： Provided are fibrin or silk matrices comprising an oxygen carrier, and matrices, which comprise an oxygen carrier and mesenchymal stem cells. Also provided are methods of generating and using same for ex vivo or in vivo tissue regeneration and/or repair such as for treating a non-union bone fracture and a condition requiring spinal fusion.
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公开(公告)号：US07951582B2
公开(公告)日：2011-05-31
申请号：US12086780
申请日：2006-11-06
申请人： Dan Gazit , Boris Rubinsky , Gadi Pelled , Zulma Gazit
发明人： Dan Gazit , Boris Rubinsky , Gadi Pelled , Zulma Gazit
CPC分类号： C12Q1/04 , G01N15/1031 , G01N27/745 , G01N2015/1006 , G01N2015/1081
摘要： A system for qualifying cells of a cell sample labeled with a magnetic or magnetizable moiety is provided. The system includes a cell sample holder for holding a cell of the cells and a first cell analyzer which includes a magnetic field source for applying a magnetic field to the cell and a sensor for qualifying and/or quantifying an effect of the magnetic field on the cell.
摘要翻译： 提供了用磁性或可磁化部分标记的细胞样品的细胞鉴定系统。 该系统包括用于保持单元的单元的单元样本保持器和包括用于向单元施加磁场的磁场源的第一单元分析器和用于限定和/或量化磁场对磁场的影响的传感器 细胞。
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公开(公告)号：US20120082704A1
公开(公告)日：2012-04-05
申请号：US13200961
申请日：2011-10-04
CPC分类号： A61K35/32 , A61K9/0026 , A61L27/3608 , A61L2430/02
摘要： An improved composition for inducing bone growth is provided that is a combination of at least DBM and an oxygen carrier. Injection/implantation of a composition of DBM and an oxygen carrier (e.g. a perfluorocarbon) results in enhancement of bone formation compared to DBM alone.
摘要翻译： 提供了用于诱导骨生长的改进组合物，其是至少DBM和氧载体的组合。 DBM和氧载体（例如全氟化碳）的组合物的注射/植入导致与单独的DBM相比增强骨形成。
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