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1.发明申请公开(公告)号：US20110217730A1
公开(公告)日：2011-09-08
申请号：US13108038
申请日：2011-05-16
申请人： Dan Gazit , Boris Rubinsky , Gadi Pelled , Zulma Gazit
发明人： Dan Gazit , Boris Rubinsky , Gadi Pelled , Zulma Gazit
CPC分类号： C12Q1/04 , G01N15/1031 , G01N27/745 , G01N2015/1006 , G01N2015/1081
摘要： A system for qualifying cells of a cell sample labeled with a magnetic or magnetizable moiety is provided. The system includes a cell sample holder for holding a cell of the cells and a first cell analyzer which includes a magnetic field source for applying a magnetic field to the cell and a sensor for qualifying and/or quantifying an effect of the magnetic field on the cell.
摘要翻译： 提供了用磁性或可磁化部分标记的细胞样品的细胞鉴定系统。 该系统包括用于保持单元的单元的单元样本保持器和包括用于向单元施加磁场的磁场源的第一单元分析器和用于限定和/或量化磁场对磁场的影响的传感器 细胞。
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2.发明授权Methods of implanting mesenchymal stem cells for tissue repair and formation 有权植入间充质干细胞用于组织修复和形成的方法公开(公告)号：US08142773B2
公开(公告)日：2012-03-27
申请号：US12007954
申请日：2008-01-17
申请人： Hadi Aslan , Dan Gazit , Zulma Gazit
发明人： Hadi Aslan , Dan Gazit , Zulma Gazit
IPC分类号： A61K48/00
CPC分类号： C07K16/2842 , A61K35/28 , A61K2035/124 , C07K16/2884 , C07K16/289 , C07K16/2896 , C12N5/0663
摘要： The invention relates to methods of isolating and implanting mesenchymal stem cells for tissue repair or formation, without prior culture expansion of the mesenchymal stem cells. In particular, the invention relates to methods of isolating mesenchymal stem cells from bone marrow, for repairing or inducing formation of bone, without prior culture expansion of the mesenchymal stem cells. The invention further relates to an isolated, non-culturally expanded human adult mesenchymal stem cell population.
摘要翻译： 本发明涉及分离和植入间充质干细胞用于组织修复或形成的方法，而不需要间充质干细胞的先前培养扩增。 特别地，本发明涉及从骨髓中分离间充质干细胞，用于修复或诱导骨形成，而不需要间充质干细胞的先前培养扩增的方法。 本发明还涉及分离的非文化扩展的人成人间充质干细胞群体。
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公开(公告)号：US09381273B2
公开(公告)日：2016-07-05
申请号：US12320594
申请日：2009-01-29
申请人： Dan Gazit , Gadi Pelled , Zulma Gazit , Nadav Kimelman-Bleich
发明人： Dan Gazit , Gadi Pelled , Zulma Gazit , Nadav Kimelman-Bleich
CPC分类号： A61L27/3843 , A61L27/225 , A61L27/3604 , A61L27/3834 , A61L27/52 , A61L27/56
摘要： Provided are fibrin or silk matrices comprising an oxygen carrier, and matrices, which comprise an oxygen carrier and mesenchymal stem cells. Also provided are methods of generating and using same for ex vivo or in vivo tissue regeneration and/or repair such as for treating a non-union bone fracture and a condition requiring spinal fusion.
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公开(公告)号：US07951582B2
公开(公告)日：2011-05-31
申请号：US12086780
申请日：2006-11-06
申请人： Dan Gazit , Boris Rubinsky , Gadi Pelled , Zulma Gazit
发明人： Dan Gazit , Boris Rubinsky , Gadi Pelled , Zulma Gazit
CPC分类号： C12Q1/04 , G01N15/1031 , G01N27/745 , G01N2015/1006 , G01N2015/1081
摘要： A system for qualifying cells of a cell sample labeled with a magnetic or magnetizable moiety is provided. The system includes a cell sample holder for holding a cell of the cells and a first cell analyzer which includes a magnetic field source for applying a magnetic field to the cell and a sensor for qualifying and/or quantifying an effect of the magnetic field on the cell.
摘要翻译： 提供了用磁性或可磁化部分标记的细胞样品的细胞鉴定系统。 该系统包括用于保持单元的单元的单元样本保持器和包括用于向单元施加磁场的磁场源的第一单元分析器和用于限定和/或量化磁场对磁场的影响的传感器 细胞。
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5.发明申请Methods of implanting mesenchymal stem cells for tissue repair and formation 有权植入间充质干细胞用于组织修复和形成的方法公开(公告)号：US20080112936A1
公开(公告)日：2008-05-15
申请号：US12007954
申请日：2008-01-17
申请人： Hadi Aslan , Dan Gazit , Zulma Gazit
发明人： Hadi Aslan , Dan Gazit , Zulma Gazit
CPC分类号： C07K16/2842 , A61K35/28 , A61K2035/124 , C07K16/2884 , C07K16/289 , C07K16/2896 , C12N5/0663
摘要： The invention relates to methods of isolating and implanting mesenchymal stem cells for tissue repair or formation, without prior culture expansion of the mesenchymal stem cells. In particular, the invention relates to methods of isolating mesenchymal stem cells from bone marrow, for repairing or inducing formation of bone, without prior culture expansion of the mesenchymal stem cells. The invention further relates to an isolated, non-culurally expanded human adult mesenchymal stem cell population.
摘要翻译： 本发明涉及分离和植入间充质干细胞用于组织修复或形成的方法，而不需要间充质干细胞的先前培养扩增。 特别地，本发明涉及从骨髓中分离间充质干细胞，用于修复或诱导骨形成，而不需要间充质干细胞的先前培养扩增的方法。 本发明还涉及一种分离的非成人扩增的人成年间充质干细胞群体。
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公开(公告)号：US20120082704A1
公开(公告)日：2012-04-05
申请号：US13200961
申请日：2011-10-04
CPC分类号： A61K35/32 , A61K9/0026 , A61L27/3608 , A61L2430/02
摘要： An improved composition for inducing bone growth is provided that is a combination of at least DBM and an oxygen carrier. Injection/implantation of a composition of DBM and an oxygen carrier (e.g. a perfluorocarbon) results in enhancement of bone formation compared to DBM alone.
摘要翻译： 提供了用于诱导骨生长的改进组合物，其是至少DBM和氧载体的组合。 DBM和氧载体（例如全氟化碳）的组合物的注射/植入导致与单独的DBM相比增强骨形成。
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公开(公告)号：US20090029407A1
公开(公告)日：2009-01-29
申请号：US12086780
申请日：2006-11-06
申请人： Dan Gazit , Boris Rubinsky , Gadi Pelled , Zulma Gazit
发明人： Dan Gazit , Boris Rubinsky , Gadi Pelled , Zulma Gazit
CPC分类号： C12Q1/04 , G01N15/1031 , G01N27/745 , G01N2015/1006 , G01N2015/1081
摘要： A system for qualifying cells of a cell sample labeled with a magnetic or magnetizable moiety is provided. The system includes a cell sample holder for holding a cell of the cells and a first cell analyzer which includes a magnetic field source for applying a magnetic field to the cell and a sensor for qualifying and/or quantifying an effect of the magnetic field on the cell.
摘要翻译： 提供了用磁性或可磁化部分标记的细胞样品的细胞鉴定系统。 该系统包括用于保持单元的单元的单元样本保持器和包括用于向单元施加磁场的磁场源的第一单元分析器和用于限定和/或量化磁场对磁场的影响的传感器 细胞。
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8.发明申请Methods of implating mesenchymal stem cells for tissue repair and formation 审中-公开诱导间充质干细胞用于组织修复和形成的方法公开(公告)号：US20050249731A1
公开(公告)日：2005-11-10
申请号：US10520271
申请日：2003-07-15
申请人： Hadi Aslan , Dan Gazit , Zulma Gazit
发明人： Hadi Aslan , Dan Gazit , Zulma Gazit
IPC分类号： C12N15/09 , A61K35/12 , A61K35/28 , A61K35/32 , A61K35/34 , A61K39/395 , A61K45/00 , A61P19/08 , A61P43/00 , C07K16/28 , C12N5/02 , C12N5/0775 , C12N5/10 , C12N5/08
CPC分类号： C07K16/2842 , A61K35/28 , A61K2035/124 , C07K16/2884 , C07K16/289 , C07K16/2896 , C12N5/0663
摘要： The invention relates to methods of isolating and implanting mesenchymal stem cells for tissue repair or formation, without prior culture expansion of the mesenchymal stem cells. In particular, the invention relates to methods of isolating mesenchymal stem cells from bone marrow, for repairing or inducing formation of bone, without prior culture expansion of the mesenchymal stem cells. The invention further relates to an isolated, non-culurally expanded human adult mesenchymal stem cell population.
摘要翻译： 本发明涉及分离和植入间充质干细胞用于组织修复或形成的方法，而不需要间充质干细胞的先前培养扩增。 特别地，本发明涉及从骨髓中分离间充质干细胞，用于修复或诱导骨形成，而不需要间充质干细胞的先前培养扩增的方法。 本发明还涉及一种分离的非成人扩增的人成年间充质干细胞群体。
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公开(公告)号：US20120078163A1
公开(公告)日：2012-03-29
申请号：US13322457
申请日：2010-05-27
申请人： Dan Gazit , Gadi Pelled , Zulma Gazit , Nadav Kimelman-Bleich
发明人： Dan Gazit , Gadi Pelled , Zulma Gazit , Nadav Kimelman-Bleich
CPC分类号： A61K38/1875 , A61L27/14 , A61L27/24 , A61L27/3834 , A61L27/52 , A61L27/54 , A61L27/56 , A61L2300/252 , A61L2300/258 , A61L2300/414 , A61L2300/43 , A61L2430/02 , A61L2430/10
摘要： A method of generating bone or connective tissue in a subject in need thereof, the method comprising: (a) implanting a scaffold in a damaged region of the subject, the scaffold comprising a tissue growth promoting agent; and (b) enhancing uptake of the tissue growth promoting agent into cells located on the scaffold, wherein the enhancing is effected by induced poration of the cells thereby generating bone or connective tissue in the subject. Kits for generating bone or connective tissue are also provided.
摘要翻译： 一种在有需要的受试者中产生骨或结缔组织的方法，所述方法包括：（a）在受试者的受损区域植入支架，所述支架包括组织生长促进剂; 和（b）增强组织生长促进剂对位于支架上的细胞的吸收，其中通过诱导细胞培养来实现增强，从而在受试者中产生骨或结缔组织。 还提供了用于产生骨或结缔组织的试剂盒。
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10.发明申请公开(公告)号：US20090214649A1
公开(公告)日：2009-08-27
申请号：US12320594
申请日：2009-01-29
申请人： Dan Gazit , Gadi Pelled , Zulma Gazit , Nadav Kimelman-Bleich
发明人： Dan Gazit , Gadi Pelled , Zulma Gazit , Nadav Kimelman-Bleich
CPC分类号： A61L27/3843 , A61L27/225 , A61L27/3604 , A61L27/3834 , A61L27/52 , A61L27/56
摘要： Provided are fibrin or silk matrices comprising an oxygen carrier, and matrices, which comprise an oxygen carrier and mesenchymal stem cells. Also provided are methods of generating and using same for ex vivo or in vivo tissue regeneration and/or repair such as for treating a non-union bone fracture and a condition requiring spinal fusion.
摘要翻译： 提供了包含氧载体的纤维蛋白或丝素基质和包含氧载体和间充质干细胞的基质。 还提供了用于离体或体内组织再生和/或修复的方法，例如用于治疗非并发骨折和需要脊柱融合的病症。
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