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公开(公告)号：US20120078163A1
公开(公告)日：2012-03-29
申请号：US13322457
申请日：2010-05-27
申请人： Dan Gazit , Gadi Pelled , Zulma Gazit , Nadav Kimelman-Bleich
发明人： Dan Gazit , Gadi Pelled , Zulma Gazit , Nadav Kimelman-Bleich
CPC分类号： A61K38/1875 , A61L27/14 , A61L27/24 , A61L27/3834 , A61L27/52 , A61L27/54 , A61L27/56 , A61L2300/252 , A61L2300/258 , A61L2300/414 , A61L2300/43 , A61L2430/02 , A61L2430/10
摘要： A method of generating bone or connective tissue in a subject in need thereof, the method comprising: (a) implanting a scaffold in a damaged region of the subject, the scaffold comprising a tissue growth promoting agent; and (b) enhancing uptake of the tissue growth promoting agent into cells located on the scaffold, wherein the enhancing is effected by induced poration of the cells thereby generating bone or connective tissue in the subject. Kits for generating bone or connective tissue are also provided.
摘要翻译： 一种在有需要的受试者中产生骨或结缔组织的方法，所述方法包括：（a）在受试者的受损区域植入支架，所述支架包括组织生长促进剂; 和（b）增强组织生长促进剂对位于支架上的细胞的吸收，其中通过诱导细胞培养来实现增强，从而在受试者中产生骨或结缔组织。 还提供了用于产生骨或结缔组织的试剂盒。
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2.发明申请公开(公告)号：US20090214649A1
公开(公告)日：2009-08-27
申请号：US12320594
申请日：2009-01-29
申请人： Dan Gazit , Gadi Pelled , Zulma Gazit , Nadav Kimelman-Bleich
发明人： Dan Gazit , Gadi Pelled , Zulma Gazit , Nadav Kimelman-Bleich
CPC分类号： A61L27/3843 , A61L27/225 , A61L27/3604 , A61L27/3834 , A61L27/52 , A61L27/56
摘要： Provided are fibrin or silk matrices comprising an oxygen carrier, and matrices, which comprise an oxygen carrier and mesenchymal stem cells. Also provided are methods of generating and using same for ex vivo or in vivo tissue regeneration and/or repair such as for treating a non-union bone fracture and a condition requiring spinal fusion.
摘要翻译： 提供了包含氧载体的纤维蛋白或丝素基质和包含氧载体和间充质干细胞的基质。 还提供了用于离体或体内组织再生和/或修复的方法，例如用于治疗非并发骨折和需要脊柱融合的病症。
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公开(公告)号：US09381273B2
公开(公告)日：2016-07-05
申请号：US12320594
申请日：2009-01-29
申请人： Dan Gazit , Gadi Pelled , Zulma Gazit , Nadav Kimelman-Bleich
发明人： Dan Gazit , Gadi Pelled , Zulma Gazit , Nadav Kimelman-Bleich
CPC分类号： A61L27/3843 , A61L27/225 , A61L27/3604 , A61L27/3834 , A61L27/52 , A61L27/56
摘要： Provided are fibrin or silk matrices comprising an oxygen carrier, and matrices, which comprise an oxygen carrier and mesenchymal stem cells. Also provided are methods of generating and using same for ex vivo or in vivo tissue regeneration and/or repair such as for treating a non-union bone fracture and a condition requiring spinal fusion.
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