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公开(公告)号：US09664613B2
公开(公告)日：2017-05-30
申请号：US12944218
申请日：2010-11-11
Applicant: Jacob N. Wohlstadter , Eli Glezer , James Wilbur , George Sigal , Kent Johnson , Charles Clinton , Alan Kishbaugh , Bandele Jeffrey-Coker , Jeff D. Debad , Alan B. Fischer
Inventor： Jacob N. Wohlstadter , Eli Glezer , James Wilbur , George Sigal , Kent Johnson , Charles Clinton , Alan Kishbaugh , Bandele Jeffrey-Coker , Jeff D. Debad , Alan B. Fischer
CPC classification number: G01N21/253 , B01L3/5085 , B01L9/50 , B01L2300/021 , B01L2300/0645 , B01L2300/0829 , B01L2300/0851 , B01L2300/12 , G01N21/645 , G01N21/66 , G01N21/76 , G01N2035/042 , G01N2035/0425 , G01N2035/0494 , Y10T29/49155 , Y10T83/04
Abstract: Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
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2.发明授权公开(公告)号：US08790578B2
公开(公告)日：2014-07-29
申请号：US13439309
申请日：2012-04-04
Applicant: Jacob N. Wohlstadter , Eli Glezer , James Wilbur , George Sigal , Kent Johnson , Charles Clinton , Alan Kishbaugh , Bandele Jeffrey-Coker , Jeff D. Debad , Alan B. Fischer
Inventor： Jacob N. Wohlstadter , Eli Glezer , James Wilbur , George Sigal , Kent Johnson , Charles Clinton , Alan Kishbaugh , Bandele Jeffrey-Coker , Jeff D. Debad , Alan B. Fischer
IPC: G01N27/00
CPC classification number: G01N21/253 , B01L3/5085 , B01L9/50 , B01L2300/021 , B01L2300/0645 , B01L2300/0829 , B01L2300/0851 , B01L2300/12 , G01N21/645 , G01N21/66 , G01N21/76 , G01N2035/042 , G01N2035/0425 , G01N2035/0494 , Y10T29/49155 , Y10T83/04
Abstract: Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
Abstract translation: 使用具有集成电极的测定模块进行发光测试测量，所述测量模块具有适于接收测定模块的读取器设备，在测定模块的孔或测定区域中诱导发光，优选电极诱导的发光并测量诱导的发光。
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公开(公告)号：US20090075299A1
公开(公告)日：2009-03-19
申请号：US12209701
申请日：2008-09-12
Applicant: Anu Mathew , Martin Stengelin , Eli Glezer
Inventor： Anu Mathew , Martin Stengelin , Eli Glezer
IPC: G01N33/573 , G01N33/53
CPC classification number: G01N33/57442 , G01N33/57449 , G01N2333/475 , G01N2333/71 , G01N2333/91215 , G01N2333/96419 , G01N2800/60
Abstract: The present invention relates to methods of diagnosing cancerous conditions in a patient, as well as methods of monitoring the progression of a cancerous condition and/or methods of monitoring a treatment protocol of a therapeutic agent or a chemotherapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
Abstract translation: 本发明涉及诊断患者癌症状况的方法，以及监测癌症状态进展的方法和/或监测治疗剂或化疗方案治疗方案的方法。 本发明还涉及结合本文所述的诊断方法使用的测定方法。
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4.发明申请公开(公告)号：US20070202538A1
公开(公告)日：2007-08-30
申请号：US11642970
申请日：2006-12-21
Applicant: Eli Glezer , Bandele Jeffrey-Coker , Jeff Debad , Sudeep Kumar , George Sigal , Gisbert Spieles , Michael Tsionsky , Michael Warnock
Inventor： Eli Glezer , Bandele Jeffrey-Coker , Jeff Debad , Sudeep Kumar , George Sigal , Gisbert Spieles , Michael Tsionsky , Michael Warnock
CPC classification number: B01L3/5025 , B01L3/5085 , B01L2200/12 , B01L2200/16 , B01L2300/0636 , B01L2300/0645 , B01L2300/0829 , B01L2300/0851 , B01L2300/0858 , B01L2300/105 , G01N33/54366 , G01N33/54393 , Y10S436/809
Abstract: We describe assay modules (e.g., assay plates, cartridges, multi-well assay plates, reaction vessels, etc.), processes for their preparation, and method of their use for conducting assays. Reagents may be present in free form or supported on solid phases including the surfaces of compartments (e.g., chambers, channels, flow cells, wells, etc.) in the assay modules or the surface of colloids, beads, or other particulate supports. In particular, dry reagents can be incorporated into the compartments of these assay modules and reconstituted prior to their use in accordance with the assay methods. A desiccant material may be used to maintain and stabilize these reagents in a dry state.
Abstract translation: 我们描述测定模块（例如，测定板，盒，多孔测定板，反应容器等），其制备方法及其用于进行测定的方法。 试剂可以以游离形式存在或在固相上负载，包括测定模块或胶体，珠粒或其它颗粒载体表面的隔室（例如，室，通道，流动池，孔等）的表面。 特别地，干试剂可以并入到这些测定模块的隔室中，并根据测定方法在使用之前重构。 干燥剂材料可用于在干燥状态下维持和稳定这些试剂。
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5.发明申请公开(公告)号：US20120190590A1
公开(公告)日：2012-07-26
申请号：US13439270
申请日：2012-04-04
Applicant: Jacob N. Wohlstadter , Eli Glezer , James Wilbur , George Sigal , Kent Johnson , Charles Clinton , Alan Kishbaugh , Bandele Jeffrey-Coker , Jeff D. Debad , Alan B. Fischer
Inventor： Jacob N. Wohlstadter , Eli Glezer , James Wilbur , George Sigal , Kent Johnson , Charles Clinton , Alan Kishbaugh , Bandele Jeffrey-Coker , Jeff D. Debad , Alan B. Fischer
IPC: C40B60/12
CPC classification number: G01N21/253 , B01L3/5085 , B01L9/50 , B01L2300/021 , B01L2300/0645 , B01L2300/0829 , B01L2300/0851 , B01L2300/12 , G01N21/645 , G01N21/66 , G01N21/76 , G01N2035/042 , G01N2035/0425 , G01N2035/0494 , Y10T29/49155 , Y10T83/04
Abstract: Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
Abstract translation: 使用具有集成电极的测定模块进行发光测试测量，所述测量模块具有适于接收测定模块的读取器设备，在测定模块的孔或测定区域中诱导发光，优选电极诱导的发光并测量诱导的发光。
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Patent Agency Ranking
公开(公告)号：US20060205012A1
公开(公告)日：2006-09-14
申请号：US11301274
申请日：2005-12-09
Applicant: Jeff Debad , Eli Glezer , Sudeep Kumar
Inventor： Jeff Debad , Eli Glezer , Sudeep Kumar
IPC: G01N33/53
CPC classification number: G01N33/6893 , G01N33/6863 , G01N2333/523 , G01N2333/525 , G01N2333/70578 , G01N2800/065 , G01N2800/52
Abstract: Disclosed are methods for conducting diagnostic tests for the detection of the inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. Also described are methods for monitoring a patient by administering tests of the present invention. Also described are methods for monitoring patient's treatment by administering tests of the present invention. Also described are methods for evaluating the effectiveness of a drug or a drug candidate by administering tests of the present invention to samples from patients, animal models, and cell cultures treated with a drug or a drug candidate. Also disclosed are methods for determining the usefulness of analytes, e.g. cytokines, for acting as diagnostic and monitoring markers for inflammatory bowel disease in the various methods of the invention.
Abstract translation: 公开了用于进行诸如克罗恩病和溃疡性结肠炎的炎症性肠病的检测的诊断测试的方法。 还描述了通过管理本发明的测试来监测患者的方法。 还描述了通过管理本发明的测试来监测患者治疗的方法。 还描述了通过将本发明的试验施用于用药物或候选药物治疗的患者，动物模型和细胞培养物的样品来评价药物或药物候选物的有效性的方法。 还公开了用于确定分析物的有用性的方法，例如， 用作本发明各种方法中用于炎性肠病的诊断和监测标志物的细胞因子。
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公开(公告)号：US20060019319A1
公开(公告)日：2006-01-26
申请号：US11145528
申请日：2005-06-03
Applicant: Mark Billadeau , Jeff Debad , Eli Glezer , Jonathan Leland , Charles Wijayawardhana
Inventor： Mark Billadeau , Jeff Debad , Eli Glezer , Jonathan Leland , Charles Wijayawardhana
IPC: G01N33/567
CPC classification number: G01N33/543 , G01N33/523 , G01N33/54366 , Y10T436/106664 , Y10T436/117497 , Y10T436/25125 , Y10T436/25375
Abstract: Disclosed are methods for conducting assays of samples, such as whole blood, that may contain cells or other particulate matter. Also disclosed are systems, devices, equipment, kits and reagents for use in such methods. One advantage of certain disclosed methods and systems is the ability to rapidly measure the concentration of an analyte of interest in blood plasma from a whole blood sample without blood separation and hematocrit correction.
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公开(公告)号：US20050136497A1
公开(公告)日：2005-06-23
申请号：US11055472
申请日：2005-02-09
Applicant: Michael Tsionsky , Eli Glezer , Selen Altunata , George Sigal , Jonathan Leland , Mark Billadeau , Svetlana Leytner , Mark Martin , Larry Helms
Inventor： Michael Tsionsky , Eli Glezer , Selen Altunata , George Sigal , Jonathan Leland , Mark Billadeau , Svetlana Leytner , Mark Martin , Larry Helms
IPC: G01N33/53 , C12Q1/42 , C12Q1/48 , G01N21/76 , G01N33/531 , G01N33/543 , G01N33/58 , G01N33/68 , G01N33/537
CPC classification number: G01N33/573 , C12Q1/485 , G01N21/76 , G01N33/5306 , G01N33/54386 , G01N33/58 , G01N33/582 , G01N2333/91205 , G01N2458/30 , G01N2458/40 , Y10S435/967 , Y10S435/968 , Y10T436/10 , Y10T436/108331
Abstract: Compositions, reagents, kits, systems, system components, and methods for performing assays. More particularly, the invention relates to the use of novel combinations of reagents to provide improved assay performance.
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9.发明申请公开(公告)号：US20110269642A1
公开(公告)日：2011-11-03
申请号：US13159991
申请日：2011-06-14
Applicant: Eli Glezer , Kent Johnson , Bandele Jeffrey-Coker , Alan Kishbaugh , Charles Clinton
Inventor： Eli Glezer , Kent Johnson , Bandele Jeffrey-Coker , Alan Kishbaugh , Charles Clinton
CPC classification number: G01N21/76 , B01L3/5085 , B01L3/50855 , B01L2300/021 , B01L2300/0645 , B01L2300/0829 , B01L2300/0851 , G01N21/253 , G01N21/66 , G01N33/54366 , G01N35/028
Abstract: Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
Abstract translation: 使用具有集成电极的测定模块进行发光测试测量，所述测量模块具有适于接收测定模块的读取器设备，在测定模块的孔或测定区域中诱导发光，优选电极诱导的发光并测量诱导的发光。
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10.发明授权公开(公告)号：US07981362B2
公开(公告)日：2011-07-19
申请号：US10980198
申请日：2004-11-03
Applicant: Eli Glezer , Kent Johnson , Bandele Jeffrey-Coker , Alan Kishbaugh , Charles Clinton
Inventor： Eli Glezer , Kent Johnson , Bandele Jeffrey-Coker , Alan Kishbaugh , Charles Clinton
IPC: B01L3/00
CPC classification number: G01N21/76 , B01L3/5085 , B01L3/50855 , B01L2300/021 , B01L2300/0645 , B01L2300/0829 , B01L2300/0851 , G01N21/253 , G01N21/66 , G01N33/54366 , G01N35/028
Abstract: Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
Abstract translation: 使用具有集成电极的测定模块进行发光测试测量，所述测量模块具有适于接收测定模块的读取器设备，在测定模块的孔或测定区域中诱导发光，优选电极诱导的发光并测量诱导的发光。
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