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18 条记录 (耗时 0.051 秒)

    Process for preparing polyvalent and physiologically degradable carbohydrate-containing polymers by enzymatic glycosylation reactions and the use thereof for preparing carbohydrate building blocks
    8.
    发明授权
    Process for preparing polyvalent and physiologically degradable carbohydrate-containing polymers by enzymatic glycosylation reactions and the use thereof for preparing carbohydrate building blocks 失效
    通过酶促糖基化反应制备含多价和生理可降解碳水化合物的聚合物的方法及其制备碳水化合物结构单元的用途

    公开(公告)号：US06406894B1

    公开(公告)日：2002-06-18

    申请号：US08989136

    申请日：1997-12-11

    申请人： Brigitte Hoersch ,  Michael Ahlers ,  Gerhard Kretzschmar ,  Eckart Bartnik ,  Dick Seiffge

    发明人： Brigitte Hoersch ,  Michael Ahlers ,  Gerhard Kretzschmar ,  Eckart Bartnik ,  Dick Seiffge

    IPC分类号： C12P1918

    CPC分类号： C07H15/203 ,  A61K47/595 ,  A61K47/61 ,  A61K47/64 ,  C07H3/06 ,  C07H15/04 ,  C12P19/18 ,  C12P19/26 ,  C12P19/44

    摘要： A process for preparing polyvalent, physiologically degradable carbohydrate-containing polymers by enzymatic glycosylation reactions is described. The carbohydrate-containing polymers thus prepared may be used for preparing carbohydrate building blocks. The polyvalent carbohydrate-containing polymers of the invention cause no intolerance reactions in vivo, either in their intact form or in the form of degradation products. The carbohydrate side chain of the carbohydrate-containing polymer is assembled by enzymatic glycosylation reactions in homogeneous aqueous buffer systems directly on a biodegradable polymer. The yields of the glycosylation reaction are significantly improved over known processes, and are often quantitative. This also provides a significant increase in the loading densities. A process for preparing free oligosaccharides by means of the carbohydrate-containing polymers of the invention is also described.

    摘要翻译： 描述了通过酶促糖基化反应制备含多价，生理可降解的含碳水化合物的聚合物的方法。 如此制备的含碳水化合物的聚合物可用于制备碳水化合物结构单元。 本发明的含多价碳水化合物的聚合物在体内不会以其完整形式或降解产物的形式引起不耐受反应。 含碳水化合物的聚合物的碳水化合物侧链通过酶促糖基化反应在直接在可生物降解的聚合物上的均相含水缓冲体系中组装。 糖基化反应的产率比已知方法显着改善，并且通常是定量的。 这也显着增加了装载密度。 还描述了通过本发明的含碳水化合物的聚合物制备游离寡糖的方法。