公开(公告)号：US20240285781A1

公开(公告)日：2024-08-29

申请号：US18568539

申请日：2022-06-13

申请人： GenEdit, Inc.

发明人： Kunwoo Lee ,  Santanu Maity ,  Rammohan Devula-Pally ,  Brian Patrick Mead ,  Gopinath Tiruchinapally ,  Sara Marie Peyrot

IPC分类号： A61K47/59 ,  C08G69/10 ,  C08G69/48

CPC分类号： A61K47/595 ,  C08G69/10 ,  C08G69/48

摘要： Provided is a polymer comprising a hydrolysable polymer backbone, the polymer backbone comprising: (i) monomer units comprising a hydrophobic side chain; (ii) monomer units comprising a side chain comprising a polyamine group and a polyalkylene oxide group; and, optionally, (iii) monomer units comprising a side chain comprising a polyamine group without a polyalkylene oxide group, as well as a method of preparing said polymer, and a method of delivering a nucleic acid and/or polypeptide to a cell using the polymer.

公开(公告)号：US20240100191A1

公开(公告)日：2024-03-28

申请号：US18218325

申请日：2023-07-05

申请人： Wisconsin Alumni Research Foundation

发明人： Aseem Ansari ,  Graham Erwin ,  Matthew Grieshop

IPC分类号： A61K48/00 ,  A61K31/5517 ,  A61K47/54 ,  A61K47/59 ,  A61P43/00 ,  C07D495/14 ,  C12N15/00 ,  C12N15/11

CPC分类号： A61K48/0066 ,  A61K31/5517 ,  A61K47/545 ,  A61K47/595 ,  A61K48/0041 ,  A61P43/00 ,  C07D495/14 ,  C12N15/00 ,  C12N15/11 ,  A61K47/60 ,  C12N2310/113 ,  C12N2310/152 ,  C12N2310/343 ,  C12N2310/3513 ,  C12N2310/3519

摘要： The present technology relates to compositions and methods for modulating expression of genes which include a target oligonucleotide sequence, such as repeats of a particular oligonucleotide sequence containing 3 to 10 nucleotides. In particular aspects, the present technology relates to agents having a formula A-L-B, wherein -L- is a linker; A- is a Brd4 binding moiety; and -B is a nucleic acid binding moiety, such as a polyamide or complementary oligonucleotide, that specifically binds to the target oligonucleotide sequence.

公开(公告)号：US20240016798A1

公开(公告)日：2024-01-18

申请号：US18370069

申请日：2023-09-19

申请人： Serina Therapeutics, Inc.

发明人： Michael Bentley ,  Zhihao Fang ,  Rebecca Weimer ,  Tacey Viegas ,  Randall Moreadith

IPC分类号： A61K31/485 ,  A61K47/59 ,  A61K9/00 ,  A61K31/05 ,  A61K31/12 ,  A61K31/137 ,  A61K31/15 ,  A61K31/198 ,  A61K31/24 ,  A61K31/277 ,  A61K31/36 ,  A61K31/55 ,  A61K47/14 ,  A61K47/18 ,  A61K47/20 ,  A61K47/22

CPC分类号： A61K31/485 ,  A61K47/595 ,  A61K9/0019 ,  A61K31/05 ,  A61K31/12 ,  A61K31/137 ,  A61K31/15 ,  A61K31/198 ,  A61K31/24 ,  A61K31/277 ,  A61K31/36 ,  A61K31/55 ,  A61K47/14 ,  A61K47/18 ,  A61K47/20 ,  A61K47/22 ,  A61K47/59

摘要： Described are conjugates comprising a water-soluble polymer linked to a compound comprising a catechol moiety via a cleavable linkage, wherein the cleavable linkage is formed between the water-soluble polymer and a first phenolic hydroxyl group of the catechol moiety and a second phenolic hydroxyl group of the catechol moiety is linked to a blocking group wherein the rate of hydrolytic release of the compound comprising the catechol moiety is controlled, at least in part, through structure or design of the blocking group on the second phenolic hydroxyl group of the catechol moiety. Therefore, the rate of hydrolytic release of the compound comprising the catechol moiety can be tuned through structural design of the group on the second phenolic hydroxyl group of the catechol moiety. Compounds used in the synthesis of the described conjugates and methods of using the described conjugate and other compounds in the treatment of dopamine-responsive disorders are also described.

公开(公告)号：US11684569B2

公开(公告)日：2023-06-27

申请号：US17000059

申请日：2020-08-21

申请人： Wayne State University

发明人： Kannan Rangaramanujam ,  Raymond Iezzi ,  Bharath Raja Guru ,  Sujatha Kannan

IPC分类号： A61K9/00 ,  A61K9/16 ,  A61K9/50 ,  A61K9/51 ,  A61K31/58 ,  A61K31/65 ,  A61K47/59 ,  A61K47/69 ,  C08G73/02 ,  C08G83/00 ,  C08L79/02 ,  C08L101/00 ,  B82Y5/00 ,  A61P7/00 ,  A61P9/00 ,  A61P9/10 ,  A61P25/00 ,  A61P25/02 ,  A61P25/32 ,  A61P27/02 ,  A61P29/00 ,  A61P25/28 ,  A61P31/04 ,  A61K31/7088

CPC分类号： A61K9/0048 ,  A61K9/0051 ,  A61K9/1647 ,  A61K9/5031 ,  A61K9/5153 ,  A61K31/58 ,  A61K31/65 ,  A61K31/7088 ,  A61K47/595 ,  A61K47/6935 ,  C08G73/028 ,  C08G83/003 ,  C08L79/02 ,  C08L101/005 ,  B82Y5/00

摘要： Dendrimer-based compositions and methods are provided, that are useful for administering pharmaceutical compositions to target cells and tissues for treatment of ocular diseases including macular degeneration, diabetic retinopathy, and retinitis pigmentosa.

公开(公告)号：US20180243443A1

公开(公告)日：2018-08-30

申请号：US15553855

申请日：2016-03-03

申请人： UNIVERSITY OF MIAMI

发明人： Paolo Serafini ,  Jennifer Vella ,  Vicenzo Bronte ,  Pirouz Daftarian ,  Angel Kaifer ,  Serena Zilio

IPC分类号： A61K47/69 ,  C12N15/113 ,  A61K47/59 ,  A61K49/00 ,  A61K47/64 ,  A61K31/683 ,  A61K31/713 ,  A61P35/00

CPC分类号： A61K47/6935 ,  A61K31/683 ,  A61K31/713 ,  A61K47/595 ,  A61K47/642 ,  A61K49/0004 ,  A61P35/00 ,  C12N15/1135 ,  C12N2310/122 ,  C12N2310/141 ,  C12N2310/3513 ,  C12N2310/531

摘要： Described herein are nanoparticle-based compositions, kits and methods and platforms for delivering one or more nucleic acids to a myeloid cell.

公开(公告)号：US20180235897A1

公开(公告)日：2018-08-23

申请号：US15892140

申请日：2018-02-08

申请人： Wisconsin Alumni Research Foundation

发明人： Shaoqin GONG ,  Wei XU ,  Yuyuan WANG ,  Fabao LIU

IPC分类号： A61K9/51 ,  A61K38/00 ,  A61K38/10

CPC分类号： A61K9/5146 ,  A61K9/513 ,  A61K38/005 ,  A61K38/10 ,  A61K47/595 ,  A61K47/60 ,  C07K7/08 ,  C07K17/06

摘要： Provided herein are peptides comprising an amino acid sequence having at least about 85% sequence identity to RYRPRAPIIAVT (SEQ ID NO: 1). These cationic peptides inhibit PKM2 methylation and may be used in the treatment of breast cancer and other diseases or conditions in which PKM2 is overexpressed. Such PKM2 peptides may be delivered to cancer cells using pH sensitive unimolecular nanoparticles comprising anionic polymers.

公开(公告)号：US09907861B2

公开(公告)日：2018-03-06

申请号：US14373312

申请日：2013-01-18

申请人： University of Utah Research Foundation

发明人： Sung Wan Kim ,  Hye Yeong Nam ,  Kihoon Nam ,  David A. Bull

IPC分类号： A61K47/48 ,  A61K48/00 ,  C12N15/85 ,  A61K47/30 ,  A61K47/34 ,  C12N15/11 ,  A61K47/59

CPC分类号： A61K48/0041 ,  A61K47/34 ,  A61K47/595 ,  C12N15/111 ,  C12N15/85 ,  C12N2310/14 ,  C12N2320/32

摘要： The polymeric carrier for delivering nucleic acid material to a cell is provided herein. The polymeric carrier can include a dendrimer group having 2 to 8 termini, each of the termini having an arginine-grafted bioreducible polymer attached thereto. In one embodiment, only a portion of the termini can have an arginine-grafted bioreducible polymer attached thereto.

公开(公告)号：US20180050373A1

公开(公告)日：2018-02-22

申请号：US15678165

申请日：2017-08-16

申请人： REMEDIATION PRODUCTS, INC.

发明人： SCOTT NOLAND

IPC分类号： B09C1/10 ,  A61K31/715 ,  A61K47/18 ,  A61K47/26 ,  A61K47/59 ,  C02F3/10

CPC分类号： B09C1/10 ,  A61K31/715 ,  A61K47/183 ,  A61K47/26 ,  A61K47/595 ,  B09C1/00 ,  B09C1/002 ,  B09C2101/00 ,  C02F1/281 ,  C02F1/283 ,  C02F1/288 ,  C02F3/108 ,  C02F2003/001 ,  C02F2101/003 ,  C02F2103/06 ,  C12N1/00

摘要： A composition useful for removing energetic compounds from contaminated environments. The composition includes a supported reactant including an adsorbent with high affinity for energetic compounds. Further, the composition includes a first bioremediation material comprising at least one organism capable of degrading an energetic compound and a polymeric substance fueling the first bioremediation material during the degrading of the energetic compound. Additionally, the composition includes a second bioremediation material breaking the polymeric substance into smaller molecules over a degradation time period to provide the fueling of the first bioremediation material in a time-release manner.

公开(公告)号：US09868951B2

公开(公告)日：2018-01-16

申请号：US14955539

申请日：2015-12-01

申请人： The Wistar Institute of Anatomy and Biology

发明人： Hui Hu ,  Jose R. Conejo-Garcia ,  Tom-Li Stephen

IPC分类号： A61K35/17 ,  A61K48/00 ,  C12N15/113 ,  A61K39/00 ,  A61K31/713 ,  A61K38/20 ,  A61K39/395 ,  A61K45/06 ,  A61N5/10 ,  A61K47/59

CPC分类号： C12N15/113 ,  A61K31/713 ,  A61K35/17 ,  A61K38/2046 ,  A61K39/0011 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/595 ,  A61K48/005 ,  A61K2039/5156 ,  A61K2039/5158 ,  A61N5/10 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2330/50 ,  C12N2740/16043

摘要： Compositions, e.g., therapeutic agents, and methods are provided for modulating gene and protein expression of Forkhead Box protein 1 (Foxp1). The therapeutic agents include short nucleic acid molecules that modulate gene and protein expression of Forkhead Box protein 1 (Foxp1) expression, viral vectors containing such molecules, T cells transduced with these viruses for adoptive therapies, and any small molecules that bind to and inactivate Foxp1. These compounds and methods have applications in cancer therapy either alone or in combination with other therapies that stimulate the endogenous immune system in the environment of the cancer, e.g., tumor.

公开(公告)号：US09855223B2

公开(公告)日：2018-01-02

申请号：US14913272

申请日：2014-08-21

申请人： Concordia University

发明人： Abhay Singh Chauhan ,  Eric Andrew Newenhouse ,  Armin Henry Gerhardt

IPC分类号： A61K31/05 ,  A61K9/00 ,  A61K9/10 ,  A61K47/48 ,  A61K9/06 ,  A61K45/06 ,  A61K9/51

CPC分类号： A61K31/05 ,  A61K9/0014 ,  A61K9/0053 ,  A61K9/06 ,  A61K9/10 ,  A61K9/5146 ,  A61K45/06 ,  A61K47/595

摘要： Compositions and pharmaceutical compositions including a dendrimer-resveratrol complex and methods for making and using the compositions are described herein. Methods of treating cancer, cardiovascular disease, cardiac failure, diabetes, Alzheimer's disease, Parkinson's disease and other brain diseases, fatty liver disease, obesity, cataracts, osteoporosis, muscle wasting, sleep disorders, acoustic trauma, inflammatory disease, psoriasis, arthritis, colitis, aging, viral disease, reproductive disease, and skin conditions or disorders including administering a therapeutically effective amount of the compositions to a subject in need are also provided. The compositions may be topically applied to skin or mucous membranes.