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    METHODS OF TREATING PSYCHOSIS AND SCHIZOPHRENIA BASED ON POLYMORPHISMS IN THE ERBB4 GENE
    1.
    发明申请
    METHODS OF TREATING PSYCHOSIS AND SCHIZOPHRENIA BASED ON POLYMORPHISMS IN THE ERBB4 GENE 审中-公开
    基于ERBB4基因多态性的心理治疗方法与研究方法

    公开(公告)号：US20100144781A1

    公开(公告)日：2010-06-10

    申请号：US12608386

    申请日：2009-10-29

    Applicant: Dong-Jing Fu ,  Qingqin S. Li ,  Dai Wang

    Inventor： Dong-Jing Fu ,  Qingqin S. Li ,  Dai Wang

    IPC: A61K31/4375 ,  C12Q1/68

    CPC classification number: A61K31/4375 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/16 ,  C12Q2600/172

    Abstract: The present application is directed to the use of genetic polymorphism in the ErbB4 gene to predict whether a patient is likely to respond to psychotic medication Paliperidone. The polymorphism in the ErbB4 gene is also used to predict whether a patient is likely to display placebo effect among patients in need of psychotic treatment. A method of treating patients with antipsychotic medication Paliperidone using the polymorphism in the ErbB4 gene and a kit of are also provided.

    Abstract translation: 本申请涉及在ErbB4基因中使用遗传多态性来预测患者是否可能对精神病药物帕利哌酮有反应。 ErbB4基因多态性也用于预测患者是否可能在需要精神病治疗的患者中显示安慰剂效应。 一种治疗患有抗精神病药物的方法也提供了使用ErbB4基因中的多态性的一种试剂盒。

    Methods and Kits for Multiplex Hybridization Assays
    2.
    发明申请
    Methods and Kits for Multiplex Hybridization Assays 审中-公开
    多重杂交试验方法和试剂盒

    公开(公告)号：US20080206779A1

    公开(公告)日：2008-08-28

    申请号：US12116064

    申请日：2008-05-06

    Applicant: Xin Miao ,  James Ireland ,  Paul Hardenbol ,  Thomas Matthew Daly ,  Dong-Jing Fu ,  Richard D. Hockett

    Inventor： Xin Miao ,  James Ireland ,  Paul Hardenbol ,  Thomas Matthew Daly ,  Dong-Jing Fu ,  Richard D. Hockett

    IPC: C12Q1/68

    CPC classification number: C12Q1/6827 ,  C12Q2521/501

    Abstract: The invention provides a method for genotyping interfering polymorphic loci in a target polynucleotide, such as a strand of genomic DNA, in a multiplex hybridization-based assay. The invention also provides nucleic acid standards for validating the performance of such hybridization-based assays. In one aspect, the method of the invention is carried out by providing for each interfering polymorphic locus one or more probes so that at least one probe is capable of forming a perfectly match duplex at the locus regardless of the characteristic sequence of an adjacent polymorphism.

    Abstract translation: 本发明提供了一种用于基于多重杂交的测定法在靶多核苷酸（例如基因组DNA链）中基因分型干扰多态性基因座的方法。 本发明还提供用于验证这种基于杂交的测定的性能的核酸标准。 在一个方面，本发明的方法是通过为每个干扰多态性位点提供一个或多个探针来进行的，使得至少一个探针能够在所述位点形成完全匹配的双链体，而与相邻多态性的特征序列无关。

    Method and kits for multiplex hybridization assays
    3.
    发明授权
    Method and kits for multiplex hybridization assays 有权
    多重杂交测定法和试剂盒

    公开(公告)号：US07368242B2

    公开(公告)日：2008-05-06

    申请号：US11152460

    申请日：2005-06-14

    Applicant: Xin Miao ,  James Ireland ,  Paul Hardenbol ,  Thomas Matthew Daly ,  Dong-Jing Fu ,  Richard D. Hockett

    Inventor： Xin Miao ,  James Ireland ,  Paul Hardenbol ,  Thomas Matthew Daly ,  Dong-Jing Fu ,  Richard D. Hockett

    IPC: C12Q1/68 ,  C07H21/02 ,  C07H21/04

    CPC classification number: C12Q1/6827 ,  C12Q2521/501

    Abstract: The invention provides a method for genotyping interfering polymorphic loci in a target polynucleotide, such as a strand of genomic DNA, in a multiplex hybridization-based assay. The invention also provides nucleic acid standards for validating the performance of such hybridization-based assays. In one aspect, the method of the invention is carried out by providing for each interfering polymorphic locus one or more probes so that at least one probe is capable of forming a perfectly match duplex at the locus regardless of the characteristic sequence of an adjacent polymorphism.

    Abstract translation: 本发明提供了一种用于基于多重杂交的测定法在靶多核苷酸（例如基因组DNA链）中基因分型干扰多态性基因座的方法。 本发明还提供用于验证这种基于杂交的测定的性能的核酸标准。 在一个方面，本发明的方法是通过为每个干扰多态性位点提供一个或多个探针来进行的，使得至少一个探针能够在所述位点形成完全匹配的双链体，而与相邻多态性的特征序列无关。

    Solid phase sequencing of double-stranded nucleic acids
    5.
    发明授权
    Solid phase sequencing of double-stranded nucleic acids 失效
    双链核酸的固相测序

    公开(公告)号：US06436635B1

    公开(公告)日：2002-08-20

    申请号：US08614151

    申请日：1996-03-12

    Applicant: Dong-Jing Fu ,  Charles R. Cantor ,  Hubert Köster ,  Cassandra L. Smith

    Inventor： Dong-Jing Fu ,  Charles R. Cantor ,  Hubert Köster ,  Cassandra L. Smith

    IPC: C12Q168

    CPC classification number: C12Q1/6874 ,  B01J19/0046 ,  B01J2219/00527 ,  B01J2219/00529 ,  B01J2219/0059 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00722 ,  C12Q1/6816 ,  C12Q1/6837 ,  C12Q1/6872 ,  C40B40/06 ,  C12Q2565/537 ,  C12Q2525/161 ,  C12Q2565/501 ,  C12Q2565/627

    Abstract: This invention relates to methods for detecting and sequencing of target double-stranded nucleic acid sequences, to nucleic acid probes and arrays of probes useful in these methods, and to kits and systems which contain these probes. Useful methods involve hybridizing the nucleic acids or nucleic acids which represent complementary or homologous sequences of the target to an array of nucleic acid probes. These probe comprise a single-stranded portion, an optional double-stranded portion and a variable sequence within the single-stranded portion. The molecular weights of the hybridized nucleic acids of the set can be determined by mass spectroscopy, and the sequence of the target determined from the molecular weights of the fragments. Nucleic acids whose sequences can be determined include nucleic acids in biological samples such as patient biopsies and environmental samples. Probes may be fixed to a solid support such as a hybridization chip to facilitate automated determination of molecular weights and identification of the target sequence.

    Abstract translation: 本发明涉及用于检测和测序靶双链核酸序列，用于这些方法的核酸探针和探针阵列的方法，以及含有这些探针的试剂盒和系统。 有用的方法包括将代表靶的互补或同源序列的核酸或核酸与核酸探针阵列进行杂交。 这些探针包含在单链部分内的单链部分，任选的双链部分和可变序列。 该组的杂交核酸的分子量可以通过质谱法测定，并且靶标的序列由片段的分子量确定。 可以确定其序列的核酸包括生物样品中的核酸，例如患者活组织检查和环境样品。 探针可以固定在固体支持物例如杂交芯片上以促进分子量的自动测定和靶序列的鉴定。

    Method and kits for multiplex hybridization assays
    7.
    发明申请
    Method and kits for multiplex hybridization assays 有权
    多重杂交测定法和试剂盒

    公开(公告)号：US20060281098A1

    公开(公告)日：2006-12-14

    申请号：US11152460

    申请日：2005-06-14

    Applicant: Xin Miao ,  James Ireland ,  Paul Hardenbol ,  Thomas Daly ,  Dong-Jing Fu ,  Richard Hockett

    Inventor： Xin Miao ,  James Ireland ,  Paul Hardenbol ,  Thomas Daly ,  Dong-Jing Fu ,  Richard Hockett

    IPC: C12Q1/68

    CPC classification number: C12Q1/6827 ,  C12Q2521/501

    Abstract: The invention provides a method for genotyping interfering polymorphic loci in a target polynucleotide, such as a strand of genomic DNA, in a multiplex hybridization-based assay. The invention also provides nucleic acid standards for validating the performance of such hybridization-based assays. In one aspect, the method of the invention is carried out by providing for each interfering polymorphic locus one or more probes so that at least one probe is capable of forming a perfectly match duplex at the locus regardless of the characteristic sequence of an adjacent polymorphism.

    Abstract translation: 本发明提供了一种用于基于多重杂交的测定法在靶多核苷酸（例如基因组DNA链）中基因分型干扰多态性基因座的方法。 本发明还提供用于验证这种基于杂交的测定的性能的核酸标准。 在一个方面，本发明的方法是通过为每个干扰多态性位点提供一个或多个探针来进行的，使得至少一个探针能够在所述位点形成完全匹配的双链体，而与相邻多态性的特征序列无关。

    Solid phase sequencing of double-stranded nucleic acids
    8.
    发明申请
    Solid phase sequencing of double-stranded nucleic acids 审中-公开
    双链核酸的固相测序

    公开(公告)号：US20060063193A1

    公开(公告)日：2006-03-23

    申请号：US11259426

    申请日：2005-10-25

    Applicant: Dong-Jing Fu ,  Charles Canton ,  Hubert Koster ,  Cassandra Smith

    Inventor： Dong-Jing Fu ,  Charles Canton ,  Hubert Koster ,  Cassandra Smith

    IPC: C12Q1/68

    CPC classification number: C12Q1/6872 ,  C12Q2565/501

    Abstract: Methods for detecting target nucleic acid molecules in a sample are provided. The methods involve hybridizing the nucleic acids or nucleic acids which represent complementary or homologous sequences of the target to an array of nucleic acid probes. These probes include a double-stranded portion, a single-stranded portion and a variable sequence within the single-stranded portion, where the single-stranded region of the probes includes a sequence complementary or homologous to a sequence of the target nucleic acid to be detected. The molecular weights of the hybridized nucleic acids of the set are determined by mass spectroscopy, and from the molecular weights of the hybridized probes, the presence of the target nucleic acid is detected by the presence of its sequence in the sample.

    Abstract translation: 提供了检测样品中靶核酸分子的方法。 所述方法包括将表示所述靶的互补序列或同源序列的核酸或核酸与核酸探针阵列进行杂交。 这些探针包括单链部分中的双链部分，单链部分和可变序列，其中探针的单链区域包含与待靶核酸序列互补或同源的序列 检测到。 通过质谱法测定该组杂交核酸的分子量，并且通过杂交探针的分子量，通过样品中其序列的存在来检测靶核酸的存在。

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