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公开(公告)号：US08900828B2
公开(公告)日：2014-12-02
申请号：US11742028
申请日：2007-04-30
申请人： Joseph H. Smith , David H. Persing , Alan Wortman , Ronald Chang , David Swenson
发明人： Joseph H. Smith , David H. Persing , Alan Wortman , Ronald Chang , David Swenson
CPC分类号： C12Q1/686 , B01L3/502738 , B01L7/52 , B01L2300/0654 , B01L2300/0816 , B01L2300/0864 , B01L2400/0644 , C12Q1/6848 , C12Q1/6851 , C12Q1/689 , C12Q2565/629 , C12Q2547/101 , C12Q2537/149 , C12Q2537/143 , C12Q2565/101 , C12Q2527/107
摘要： The invention provides methods and apparatus for carrying out multiple amplification reactions in a single reaction chamber by successive cycles of loading reaction mixture, amplifying, and removing spent reaction mixture in a fluidly closed reaction system. In particular, the present invention allows amplification of a plurality of target polynucleotides from a single sample by carrying out under closed-loop control successive amplifications of different target polynucleotides from different portions of the sample.
摘要翻译： 本发明提供了在单个反应室中进行多次扩增反应的方法和装置，其通过连续循环的负载反应混合物，在流体封闭的反应体系中放大和除去废反应混合物。 特别地，本发明允许通过在闭环控制下从样品的不同部分连续扩增不同靶多核苷酸而从单个样品扩增多个靶多核苷酸。
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2.发明授权公开(公告)号：US08318697B2
公开(公告)日：2012-11-27
申请号：US13042312
申请日：2011-03-07
申请人： David H. Persing , Richard Thomas Crane , Gary T. Elliott , J. Terry Ulrich , Michael J. Lacy , David A. Johnson , Jory R. Baldridge , Rong Wang
发明人： David H. Persing , Richard Thomas Crane , Gary T. Elliott , J. Terry Ulrich , Michael J. Lacy , David A. Johnson , Jory R. Baldridge , Rong Wang
IPC分类号： A61K31/7008 , A61K31/7012
CPC分类号： C07H13/04 , A61K31/7008 , A61K31/7024 , C07H11/00 , C07H13/06 , C07H15/14
摘要： Methods and compositions for treating or ameliorating diseases and other conditions, such as infectious diseases, autoimmune diseases and allergies are provided. The methods employ mono- and disaccharide-based compounds for selectively stimulating immune responses in animals and plants.
摘要翻译： 提供了治疗或改善疾病和其他病症如感染性疾病，自身免疫疾病和过敏症的方法和组合物。 该方法使用基于单糖和二糖的化合物来选择性地刺激动物和植物中的免疫应答。
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公开(公告)号：US20080207548A1
公开(公告)日：2008-08-28
申请号：US11930088
申请日：2007-10-31
CPC分类号： C07K16/3015 , A61K35/12 , A61K38/00 , A61K39/00 , A61K2039/5154 , A61K2039/57 , C07K14/47 , C07K14/4748 , C07K2317/34 , C07K2319/00 , C12N9/00 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158 , G01N33/57415 , G01N2500/00
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
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公开(公告)号：US20080207486A1
公开(公告)日：2008-08-28
申请号：US11930089
申请日：2007-10-31
CPC分类号： C07K16/3015 , A61K35/12 , A61K38/00 , A61K39/00 , A61K2039/5154 , A61K2039/57 , C07K14/47 , C07K14/4748 , C07K2317/34 , C07K2319/00 , C12N9/00 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158 , G01N33/57415 , G01N2500/00
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
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5.发明申请公开(公告)号：US20080206234A1
公开(公告)日：2008-08-28
申请号：US11930083
申请日：2007-10-30
申请人： Gary R. Fanger , Shannon Kathleen Hirst , Davin C. Dillon , Teresa M. Foy , Raymond L. Houghton , David H. Persing , Michael D. Kalos
发明人： Gary R. Fanger , Shannon Kathleen Hirst , Davin C. Dillon , Teresa M. Foy , Raymond L. Houghton , David H. Persing , Michael D. Kalos
IPC分类号： A61K39/395 , C07H21/04 , C07K14/00 , C12N15/63 , A61P35/00 , C12N5/00 , C07K16/00 , C12Q1/68
CPC分类号： C07K14/4748 , A61K35/12 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/505 , A61K2039/5154 , A61K2039/5156 , A61K2039/53 , A61K2039/57 , C07K14/005 , C07K14/47 , C07K14/82 , C07K16/3015 , C07K2317/21 , C07K2319/00 , C12N2710/14143 , C12N2710/24143 , C12N2740/10022 , C12N2740/14022 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
摘要翻译： 公开了用于治疗和诊断癌症，特别是乳腺癌的组合物和方法。 示例性组合物包含一种或多种乳腺肿瘤多肽，其免疫原性部分，编码该多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达该多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是乳腺癌的诊断，预防和/或治疗。
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公开(公告)号：US20130102488A1
公开(公告)日：2013-04-25
申请号：US13658276
申请日：2012-10-23
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6886 , C12Q2600/118 , C12Q2600/16 , C12Q2600/178
摘要： Methods of detecting cervical dysplasia, such as cervical dysplasia likely to progress to carcinoma in a sample of human cervical cells, are provided. Methods of detecting changes in expression of one or more microRNAs or mRNAs associated with cervical dysplasia or cervical cancer are also provided. Compositions and kits are also provided.
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公开(公告)号：US20080311124A1
公开(公告)日：2008-12-18
申请号：US11930077
申请日：2007-10-30
申请人： Gary R. Fanger , Shannon Kathleen Hirst , Davin C. Dillon , Teresa M. Foy , Raymond L. Houghton , David H. Persing , Michael D. Kalos
发明人： Gary R. Fanger , Shannon Kathleen Hirst , Davin C. Dillon , Teresa M. Foy , Raymond L. Houghton , David H. Persing , Michael D. Kalos
IPC分类号： A61K39/395 , C07H21/04 , C07K2/00 , C12N15/63 , C12N5/00 , C07K16/00 , A61K35/12 , C12Q1/68 , A61P35/04 , A61K39/00 , G01N33/574 , C07K14/00 , C12N5/02 , A61K38/00 , A61K31/7088
CPC分类号： C07K14/4748 , A61K35/12 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/505 , A61K2039/5154 , A61K2039/5156 , A61K2039/53 , A61K2039/57 , C07K14/005 , C07K14/47 , C07K14/82 , C07K16/3015 , C07K2317/21 , C07K2319/00 , C12N2710/14143 , C12N2710/24143 , C12N2740/10022 , C12N2740/14022 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
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公开(公告)号：US06958361B2
公开(公告)日：2005-10-25
申请号：US10076622
申请日：2002-02-13
CPC分类号： C07K14/47 , A61K35/12 , A61K38/00 , A61K39/00 , A61K2039/5154 , A61K2039/57 , C07K14/4748 , C07K2319/00 , C12N9/00 , C12Q1/6886 , C12Q2600/158 , Y10S514/885
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
摘要翻译： 公开了用于治疗和诊断癌症，特别是乳腺癌的组合物和方法。 示例性组合物包含一种或多种乳腺肿瘤多肽，其免疫原性部分，编码该多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达该多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是乳腺癌的诊断，预防和/或治疗。
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公开(公告)号：US06258320B1
公开(公告)日：2001-07-10
申请号：US09058089
申请日：1998-04-09
申请人： David H. Persing , Susan H. Persing
发明人： David H. Persing , Susan H. Persing
IPC分类号： B01L1100
CPC分类号： A01N1/00
摘要： A method for long-term maintenance of intact nucleic acid is provided. The method comprises introducing a nucleic acid containing receptacle into a cavity of a storage device. The nucleic acid containing receptacle comprises an amount of isolated vertebrate nucleic acid in a cavity of the receptacle, wherein either the receptacle or storage device is formed of a natural material. The nucleic acid is retained in the cavity by a fastener. A sealant is introduced into the aperture of the cavity of the device to form a nucleic acid storage device.
摘要翻译： 提供了用于完整核酸的长期维持的方法。 该方法包括将含有核酸的容器引入存储装置的空腔中。 含有核酸的容器在容器的空腔中包含一定量的分离的脊椎动物核酸，其中容器或储存装置由天然材料形成。 核酸通过紧固件保留在空腔中。 将密封剂引入装置的腔的孔中以形成核酸储存装置。
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公开(公告)号：US6045804A
公开(公告)日：2000-04-04
申请号：US612231
申请日：1996-03-07
申请人： David H. Persing
发明人： David H. Persing
IPC分类号： G01N33/569 , A01N63/00 , A61K39/00 , A61K39/02 , C12Q1/00
CPC分类号： G01N33/56911 , G01N2333/20
摘要： The present invention provides a method for detecting B. burgdorferi infection utilizing an antigen preparation lacking a detectable level of outer surface protein A (OspA). The antigen preparation is made from an isolate of B. burgdorferi that lacks the plasmid encoding outer surface protein A (OspA). The method of the invention discriminates B. burgdorferi infection from OspA vaccination.
摘要翻译： 本发明提供一种利用缺乏可检测水平的外表面蛋白A（OspA）的抗原制剂检测布氏疏螺旋体感染的方法。 抗原制备物由缺少编码外表面蛋白A（OspA）的质粒的布氏疏螺旋体的分离物制成。 本发明的方法鉴别了来自OspA疫苗接种的布氏疏螺旋体感染。
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