公开(公告)号：US20080275653A1

公开(公告)日：2008-11-06

申请号：US12066996

申请日：2006-09-14

Applicant: Stephen Cypes ,  Sam H. Bergh ,  Damian Hajduk

Inventor： Stephen Cypes ,  Sam H. Bergh ,  Damian Hajduk

IPC: G01N31/00 ,  B01D17/12 ,  B01D3/06

CPC classification number: B01D3/065 ,  B01L3/5027 ,  G01N2001/4033

Abstract: Systems, methods and apparatus implementing techniques for separating and/or analyzing fluid mixtures. The techniques employ microfluidic separation devices that include an inlet port for receiving a fluid feed stream, a microscale fluid flow channel in fluid communication with the fluid inlet port, a phase equilibrium control region located along the fluid flow channel for controlling conditions including temperature and/or pressure to provide a thermal equilibrium, a capillary network in the temperature control region, a first outlet port in indirect fluid communication with the fluid flow channel through the capillary network, and a second outlet port in direct fluid communication with the fluid flow channel. A plurality of microfluidic separation devices can be coupled in fluidic communication to provide for separation of complex mixtures. The systems, methods and apparatus can be used to characterize fluid mixtures.

Abstract translation: 用于分离和/或分析流体混合物的系统，方法和设备实施技术。 该技术使用微流体分离装置，其包括用于接收流体进料流的入口端口，与流体入口端口流体连通的微流体流动通道，沿着流体流动通道定位的相位平衡控制区域，用于控制包括温度和/ 或压力以提供热平衡，温度控制区域中的毛细管网络，与通过毛细管网络的流体流动通道间接流体连通的第一出口端口和与流体流动通道直接流体连通的第二出口端口。 多个微流体分离装置可以流体连通地联接以提供复杂混合物的分离。 系统，方法和装置可用于表征流体混合物。

公开(公告)号：US20060133968A1

公开(公告)日：2006-06-22

申请号：US11272249

申请日：2005-11-10

Applicant: G. Dales ,  Johannes van Beek ,  Damian Hajduk ,  Ralph Nielsen ,  Paul Mansky ,  Leonid Matsiev ,  Eric McFarland

Inventor： G. Dales ,  Johannes van Beek ,  Damian Hajduk ,  Ralph Nielsen ,  Paul Mansky ,  Leonid Matsiev ,  Eric McFarland

IPC: B01J19/00

CPC classification number: B01L3/50851 ,  B01F13/0818 ,  B01F13/0827 ,  B01F15/00201 ,  B01F15/00207 ,  B01F15/00246 ,  B01J19/0006 ,  B01J19/0013 ,  B01J19/004 ,  B01J19/0046 ,  B01J2219/00029 ,  B01J2219/00162 ,  B01J2219/002 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00333 ,  B01J2219/00335 ,  B01J2219/00351 ,  B01J2219/00367 ,  B01J2219/00373 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00601 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00736 ,  B01J2219/00738 ,  B01J2219/00745 ,  B01L3/50853 ,  B01L7/54 ,  B01L2200/026 ,  B01L2300/049 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/14 ,  B01L2300/1805 ,  C40B40/14 ,  C40B40/18 ,  G01K13/00 ,  G01N11/16 ,  G01N35/1079 ,  Y10T436/11 ,  Y10T436/115831 ,  Y10T436/119163 ,  Y10T436/12 ,  Y10T436/25 ,  Y10T436/25875

Abstract: Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. Computer-based methods are disclosed for process monitoring and control, and for data display and analysis.

公开(公告)号：US06936471B2

公开(公告)日：2005-08-30

申请号：US09779149

申请日：2001-02-08

Applicant: Damian Hajduk ,  Eric Carlson ,  J. Christopher Freitag ,  Oleg Kolosov ,  James R. Engstrom ,  Adam Safir ,  Ravi Srinivasan ,  Leonid Matsiev

Inventor： Damian Hajduk ,  Eric Carlson ,  J. Christopher Freitag ,  Oleg Kolosov ,  James R. Engstrom ,  Adam Safir ,  Ravi Srinivasan ,  Leonid Matsiev

IPC: G01N11/00 ,  B01L3/00 ,  G01N1/28 ,  G01N3/02 ,  G01N3/08 ,  G01N3/20 ,  G01N3/32 ,  G01N5/00 ,  G01N19/00 ,  G01N29/02 ,  G01N29/22 ,  G01N37/00 ,  G01N31/00 ,  G01N3/00

CPC classification number: B01L3/5085 ,  B01J2219/00707 ,  B01J2219/00718 ,  G01N5/00 ,  G01N11/00 ,  G01N19/00 ,  G01N29/02 ,  G01N29/222 ,  G01N2203/0286 ,  G01N2291/02466 ,  G01N2291/0255 ,  G01N2291/02818 ,  G01N2291/106 ,  Y10T436/12

Abstract: An apparatus and method for screening combinatorial libraries of materials by measuring the response of individual library members to mechanical perturbations is described. The apparatus generally includes a sample holder for containing the library members, an array of probes for mechanically perturbing individual library members, and an array of sensors for measuring the response of each of the library members to the mechanical perturbations. Library members undergoing screening make up a sample array, and individual library members constitute elements of the sample array that are confined to specific locations on the sample holder. During screening, the apparatus mechanically perturbs individual library members by displacing the sample array (sample holder) and the array of probes. Typically, all of the elements of the sample array are perturbed simultaneously, but the apparatus also can also perturb individual or groups of sample array elements sequentially. The flexible apparatus and method can screen libraries of materials based on many different bulk physical properties, including Young's modulus (flexure, uniaxial extension, biaxial compression, and shear); hardness (indentation), failure (stress and strain at failure, toughness), adhesion (tack, loop tack), and flow (viscosity, melt flow indexing, and rheology), among others.

Abstract translation: 描述了通过测量单个文库成员对机械扰动的响应来筛选材料组合文库的装置和方法。 该装置通常包括用于容纳库构件的样本保持器，用于机械扰乱各个库构件的探针阵列，以及用于测量每个库构件对机械扰动的响应的传感器阵列。 正在进行筛选的图书馆成员组成一个样本数组，单独的图书馆成员构成了样本数组的元素，它们限于样本持有者的特定位置。 在筛选期间，设备通过移位样品阵列（样品架）和探针阵列来机械地干扰各个库成员。 通常，样本阵列的所有元素都被同时扰动，但是该装置也可以顺序扰乱单个或组的样本阵列元素。 灵活的装置和方法可以基于许多不同的体积物理性质（包括杨氏模量（挠曲，单轴延伸，双轴压缩和剪切））筛选材料库; 硬度（压痕），破坏（破坏时的应力和应变，韧性），粘附性（粘性，环粘性）和流动性（粘度，熔体流动指数和流变学）等。

公开(公告)号：US06605473B1

公开(公告)日：2003-08-12

申请号：US09667119

申请日：2000-09-20

Applicant: Damian Hajduk ,  James Bennett ,  Rakesh Jain

Inventor： Damian Hajduk ,  James Bennett ,  Rakesh Jain

IPC: G01N2300

CPC classification number: G01N23/20 ,  B01J19/0046 ,  B01J2219/00315 ,  B01J2219/00511 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00659 ,  B01J2219/00704 ,  B01J2219/00707 ,  B01J2219/00745 ,  C40B40/18 ,  Y10T436/25

Abstract: A method for preparing a library is provided in which the library contains an array of elements and each element contains a different combination of materials. A related apparatus includes an x-ray beam directed at the library, a chamber which houses the library and a beamline for directing the x-ray beam onto the library in the chamber. The chamber may include a translation stage that holds the library and that is programmable to change the position of the library relative to the x-ray beam and a controller that controls the movement of the translation stage to expose an element to the x-ray beam in order to rapidly characterize the element in the library. During the characterization, the x-ray beam scatters off of the element and a detector detects the scattered x-ray beam in order to generate characterization data for the element.

Abstract translation: 提供了一种制备库的方法，其中库包含元素阵列，并且每个元素包含不同的材料组合。 相关装置包括指向图书馆的x射线束，容纳文库的腔室和用于将x射线束引导到腔室中的文库的束线。 所述腔室可以包括平移台，其保持所述库并且可编程以改变所述库相对于所述X射线束的位置;以及控制器，所述控制器控制所述平移台的运动以将元件暴露于所述X射线束 以便快速表征图书馆中的元素。 在表征期间，X射线束从元件散射，并且检测器检测散射的X射线束，以便产生该元件的表征数据。

公开(公告)号：US20070238807A1

公开(公告)日：2007-10-11

申请号：US11732238

申请日：2007-04-03

Applicant: Adam L. Safir ,  Damian Hajduk ,  Didier G. Benoit ,  Marcelo E. Piotti ,  Shaofeng Ran ,  Steven X. Zong

Inventor： Adam L. Safir ,  Damian Hajduk ,  Didier G. Benoit ,  Marcelo E. Piotti ,  Shaofeng Ran ,  Steven X. Zong

IPC: A61L24/00

CPC classification number: A61L26/0066 ,  A61K8/8135 ,  A61K8/8152 ,  A61K9/0014 ,  A61K9/7015 ,  A61L26/0014 ,  A61L2300/402 ,  A61L2300/404 ,  A61L2300/442 ,  A61L2300/602 ,  A61L2300/80 ,  A61Q17/00 ,  C09D4/06 ,  C08L33/10 ,  C08L33/08

Abstract: Water Resistant Film Forming Compositions Incorporating Hydrophilic Activities A film forming composition that includes a polymer having from about 80 mole percent to about 100 mole percent of a hydrophobic component, and from about 0 to about 20 mole percent of a charged component; a bioactive agent; and a solvent in which the polymer and the bioactive agent are homogeneously dispersed in the composition. The film forming composition can be used as a “liquid bandage” to form a water resistant film on a biological surface, where the polymer and the bioactive agent remain miscible.

Abstract translation: 引入亲水活性的耐水膜成型组合物成膜组合物包括具有约80摩尔％至约100摩尔％疏水组分和约0至约20摩尔％带电组分的聚合物; 生物活性剂; 和其中聚合物和生物活性剂均匀分散在组合物中的溶剂。 成膜组合物可以用作“液体绷带”，以在生物表面上形成防水膜，其中聚合物和生物活性剂保持混溶。

公开(公告)号：US07047794B2

公开(公告)日：2006-05-23

申请号：US11090755

申请日：2005-03-25

Applicant: Damian Hajduk ,  Eric Carlson ,  Ravi Srinivasan

Inventor： Damian Hajduk ,  Eric Carlson ,  Ravi Srinivasan

IPC: G01N11/10

CPC classification number: G01N3/24 ,  G01N11/16 ,  G01N2203/0051 ,  G01N2203/0286 ,  G01N2203/0623

Abstract: The present invention relates to a miniature rheometer, a parallel rheometer, and improved force sensor elements which may advantageously be used in combination with the miniature rheometer and the parallel rheometer. The miniature rheometer is adapted to determine rheological characteristics of materials which are provided in the form of small quantity samples. The miniature rheometer comprises an actuating element, a sensing element and a feedback circuit to provide rebalance of the shear force applied by the sample to the sensing element, which insures an exceptional stiffness in determining the shear strain so as to allow measurements of high accuracy. The parallel rheometer of the present invention allows simultaneous measurements of a plurality of samples so as to allow of a plurality of samples within a short time period. The force sensor element according to the present invention allows simultaneous measurement of a shear force and a normal force applied to the sensor element. Moreover, a rheometer is provided which comprises a force sensor based on stress-optic material.

Abstract translation: 本发明涉及微型流变仪，平行流变仪和改进的力传感器元件，其可有利地与微型流变仪和平行流变仪组合使用。 微型流变仪适用于确定以少量样品形式提供的材料的流变特性。 微型流变仪包括致动元件，感测元件和反馈电路，以提供由样品施加到感测元件的剪切力的重新平衡，这确保了确定剪切应变的特殊刚度，以便允许高精度的测量。 本发明的并行流变仪允许多个样本的同时测量，以便在短时间内允许多个样本。 根据本发明的力传感器元件允许同时测量施加到传感器元件的剪切力和法向力。 此外，提供了一种流变仪，其包括基于应力光学材料的力传感器。

公开(公告)号：US20060100126A1

公开(公告)日：2006-05-11

申请号：US10542421

申请日：2003-12-29

Applicant: Andrew Avery ,  Dominique Charmot ,  Jean Frechet ,  Damian Hajduk ,  Ezat Khoshdel ,  Mingjun Liu

Inventor： Andrew Avery ,  Dominique Charmot ,  Jean Frechet ,  Damian Hajduk ,  Ezat Khoshdel ,  Mingjun Liu

IPC: C11D3/37 ,  C11D3/02

CPC classification number: C11D3/3742 ,  A61K8/894 ,  A61K8/91 ,  A61K2800/54 ,  A61Q5/00 ,  A61Q5/12 ,  A61Q19/00 ,  C11D3/373

Abstract: A composition for personal, home, or laundry treatment comprising a polymer made up of one or more crosslinked rake or comb silicone copolymer segments. A process for making copolymers for use in such compositions involves hydrosilylation in the presence of a catalyst.

Abstract translation: 一种用于个人，家庭或衣物处理的组合物，其包含由一种或多种交联的耙式或梳状硅氧烷共聚物片段组成的聚合物。 制备用于这种组合物的共聚物的方法包括在催化剂存在下的氢化硅烷化。

公开(公告)号：US06732574B2

公开(公告)日：2004-05-11

申请号：US10104203

申请日：2002-03-22

Applicant: Damian Hajduk ,  Paul Mansky

Inventor： Damian Hajduk ,  Paul Mansky

IPC: G01N1106

CPC classification number: G01N11/06

Abstract: An apparatus and method for measuring viscosity or related properties of fluid samples in parallel is disclosed. The apparatus includes a plurality of tubes and reservoirs in fluid communication with the tubes. The tubes provide flow paths for the fluid samples, which are initially contained within the reservoirs. The apparatus also includes a mechanism for filling the reservoirs with the fluid samples, and a device for determining volumetric flow rates of fluid samples flowing from the reservoirs through the plurality of tubes simultaneously. The disclosed apparatus is capable of measuring viscosity or related properties of at least five fluid samples simultaneously. Useful reservoirs and tubes include syringes.

Abstract translation: 公开了一种并行测量流体样品的粘度或相关性质的装置和方法。 该装置包括与管流体连通的多个管和储存器。 管提供流体样品的流动路径，其最初包含在储存器内。 该装置还包括用于用流体样本填充储存器的机构，以及用于确定从贮存器同时流过多个管的流体样品的体积流量的装置。 所公开的装置能够同时测量至少五个流体样品的粘度或相关性质。 有用的储存器和管子包括注射器。

公开(公告)号：US06679130B2

公开(公告)日：2004-01-20

申请号：US09779148

申请日：2001-02-08

Applicant: Damian Hajduk ,  Eric Carlson ,  J. Christopher Freitag ,  Oleg Kosolov

Inventor： Damian Hajduk ,  Eric Carlson ,  J. Christopher Freitag ,  Oleg Kosolov

IPC: G01N300

CPC classification number: B01L3/5085 ,  B01J2219/00707 ,  B01J2219/00718 ,  G01N5/00 ,  G01N11/00 ,  G01N19/00 ,  G01N29/02 ,  G01N29/222 ,  G01N2203/0286 ,  G01N2291/02466 ,  G01N2291/0255 ,  G01N2291/02818 ,  G01N2291/106 ,  Y10T436/12

Abstract: An apparatus and method for screening combinatorial libraries of materials by measuring the response of individual library members to mechanical perturbations is described. The apparatus generally includes a sample holder for containing the library members, an array of probes for mechanically perturbing individual library members, and an array of sensors for measuring the response of each of the library members to the mechanical perturbations. Library members undergoing screening make up a sample array, and individual library members constitute elements of the sample array that are confined to specific locations on the sample holder. During screening, the apparatus mechanically perturbs individual library members by displacing the sample array (sample holder) and the array of probes. Typically, all of the elements of the sample array are perturbed simultaneously, but the apparatus also can also perturb individual or groups of sample array elements sequentially. The flexible apparatus and method can screen libraries of materials based on many different bulk physical properties, including Young's modulus (flexure, uniaxial extension, biaxial compression, and shear); hardness (indentation), failure (stress and strain at failure, toughness), adhesion (tack, loop tack), and flow (viscosity, melt flow indexing, and rheology), among others.

Abstract translation: 描述了通过测量单个文库成员对机械扰动的响应来筛选材料组合文库的装置和方法。 该装置通常包括用于容纳库构件的样本保持器，用于机械扰乱各个库构件的探针阵列，以及用于测量每个库构件对机械扰动的响应的传感器阵列。 正在进行筛选的图书馆成员组成一个样本数组，单独的图书馆成员构成了样本数组的元素，它们限于样本持有者的特定位置。 在筛选期间，设备通过移位样品阵列（样品架）和探针阵列来机械地干扰各个库成员。 通常，样本阵列的所有元素都被同时扰动，但是该装置也可以顺序扰乱单个或组的样本阵列元素。 灵活的装置和方法可以基于许多不同的体积物理性质（包括杨氏模量（挠曲，单轴延伸，双轴压缩和剪切））筛选材料库; 硬度（压痕），破坏（破坏时的应力和应变，韧性），粘附性（粘性，环粘性）和流动性（粘度，熔体流动指数和流变学）等。

公开(公告)号：US06655194B2

公开(公告)日：2003-12-02

申请号：US10262303

申请日：2002-10-01

Applicant: Damian Hajduk ,  Eric Carlson ,  Ravi Srinivasan

Inventor： Damian Hajduk ,  Eric Carlson ,  Ravi Srinivasan

IPC: G01N1110

CPC classification number: G01N3/24 ,  G01N11/16 ,  G01N2203/0051 ,  G01N2203/0286 ,  G01N2203/0623

Abstract: The present invention relates to a miniature rheometer, a parallel rheometer, and improved force sensor elements which may advantageously be used in combination with the miniature rheometer and the parallel rheometer. The miniature rheometer is adapted to determine rheological characteristics of materials which are provided in the form of small quantity samples. The miniature rheometer comprises an actuating element, a sensing element and a feedback circuit to provide rebalance of the shear force applied by the sample to the sensing element, which insures an exceptional stiffness in determining the shear strain so as to allow measurements of high accuracy. The parallel rheometer of the present invention allows simultaneous measurements of a plurality of samples so as to allow of a plurality of samples within a short time period. The force sensor element according to the present invention allows simultaneous measurement of a shear force and a normal force applied to the sensor element. Moreover, a rheometer is provided which comprises a force sensor based on stress-optic material.