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公开(公告)号：US20240238402A1
公开(公告)日：2024-07-18
申请号：US18349294
申请日：2023-07-10
Applicant: CureVac Manufacturing GmbH
Inventor： Thorsten MUTZKE , Markus KREUZ , Stefanie SEWING , Fabian Johannes EBER , Wenke WAGNER , Michael SONNTAG , Michael WIGGENHORN , Katharina KOLLAND
IPC: A61K39/145 , A61K9/51 , A61K39/00 , A61K39/12 , A61K47/64
CPC classification number: A61K39/145 , A61K9/5169 , A61K9/5192 , A61K39/12 , A61K47/6455 , A61K47/646 , A61K2039/55555 , C12N2760/16134
Abstract: The present invention relates to a method for producing a liquid composition comprising a nanoparticle comprising at least one RNA and at least one cationic or polycationic compound, advantageously on a large scale suitable for pharmaceutical applications. The present invention further concerns the use of the inventive method in the manufacture of a medicament or a vaccine. Furthermore, the invention relates to compositions containing the RNA-comprising nanoparticle, and to pharmaceutical compositions comprising the same.
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2.发明授权公开(公告)号：US11834651B2
公开(公告)日：2023-12-05
申请号：US18198258
申请日：2023-05-16
Applicant: CureVac Manufacturing GmbH
Inventor： Andreas Funkner , Stefanie Dorner , Stefanie Sewing , Johannes Kamm , Norbert Broghammer , Thomas Ketterer , Thorsten Mutzke
CPC classification number: C12N15/1017 , B01D61/145 , B01D71/12 , C12P19/34 , G01N30/02 , G01N2030/027
Abstract: The present invention relates to method for producing and purifying RNA comprising the steps of providing DNA encoding the RNA; transcription of the DNA into RNA; and conditioning and/or purifying of the solution comprising transcribed RNA by one or more steps of tangential flow filtration (TFF).
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公开(公告)号：US11491112B2
公开(公告)日：2022-11-08
申请号：US17542445
申请日：2021-12-05
Applicant: CureVac Manufacturing GmbH
Inventor： Thomas Ketterer , Thorsten Mutzke , Michael Wiggenhorn , Frank Schaubhut , Florian Von Der Mülbe
IPC: C07H21/04 , A61K9/19 , A61K31/7105 , C12Q1/6806 , A61K47/64 , A61K47/54 , C12N15/10
Abstract: The present invention is directed to the field of RNA formulation, in particular to lyophilization of RNA. The invention provides a method for lyophilization of RNA. The present invention further concerns a lyophilized composition obtainable by the inventive method, a pharmaceutical composition, a vaccine and a kit or kit of parts. Moreover, the present invention provides a novel use of a lyoprotectant for lyophilizing RNA, the use of the inventive method in the manufacture of a medicament as well as the first and second medical use of the composition obtainable by the inventive method, the pharmaceutical composition, the vaccine or the kit or kit of parts according to the invention.
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4.发明授权公开(公告)号：US12221605B2
公开(公告)日：2025-02-11
申请号：US18491943
申请日：2023-10-23
Applicant: CureVac Manufacturing GmbH
Inventor： Andreas Funkner , Stefanie Dorner , Stefanie Sewing , Johannes Kamm , Norbert Broghammer , Thomas Ketterer , Thorsten Mutzke
Abstract: The present invention relates to method for producing and purifying RNA comprising the steps of providing DNA encoding the RNA; transcription of the DNA into RNA; and conditioning and/or purifying of the solution comprising transcribed RNA by one or more steps of tangential flow filtration (TFF).
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5.发明公开公开(公告)号：US20230287388A1
公开(公告)日：2023-09-14
申请号：US18198258
申请日：2023-05-16
Applicant: CureVac Manufacturing GmbH
Inventor： Andreas FUNKNER , Stefanie DORNER , Stefanie SEWING , Johannes KAMM , Norbert BROGHAMMER , Thomas KETTERER , Thorsten MUTZKE
CPC classification number: C12N15/1017 , C12P19/34 , B01D61/145 , B01D71/12 , G01N30/02 , G01N2030/027
Abstract: The present invention relates to method for producing and purifying RNA comprising the steps of providing DNA encoding the RNA; transcription of the DNA into RNA; and conditioning and/or purifying of the solution comprising transcribed RNA by one or more steps of tangential flow filtration (TFF).
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Patent Agency Ranking
6.发明授权公开(公告)号：US11667910B2
公开(公告)日：2023-06-06
申请号：US17591978
申请日：2022-02-03
Applicant: CureVac Manufacturing GmbH
Inventor： Andreas Funkner , Stefanie Dorner , Stefanie Sewing , Johannes Kamm , Norbert Broghammer , Thomas Ketterer , Thorsten Mutzke
CPC classification number: C12N15/1017 , B01D61/145 , B01D71/12 , C12P19/34 , G01N30/02 , G01N2030/027
Abstract: The present invention relates to method for producing and purifying RNA comprising the steps of providing DNA encoding the RNA; transcription of the DNA into RNA; and conditioning and/or purifying of the solution comprising transcribed RNA by one or more steps of tangential flow filtration (TFF).
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公开(公告)号：US20230313268A1
公开(公告)日：2023-10-05
申请号：US18050940
申请日：2022-10-28
Applicant: CureVac Manufacturing GmbH
Inventor： Aniela WOCHNER
IPC: C12Q1/6806 , B01D15/16 , B01D15/32 , C07H21/02 , G01N30/88
CPC classification number: C12Q1/6806 , B01D15/163 , B01D15/325 , C07H21/02 , G01N30/88 , G01N2030/8827
Abstract: The present invention relates to the field of RNA analysis. In particular, the invention concerns the use of a catalytic nucleic acid molecule for the analysis of an RNA molecule. The invention concerns methods for analyzing the 5′ terminal structures of an RNA molecule having a cleavage site for a catalytic nucleic acid molecule. In particular, the invention concerns a method for determining the presence of a cap structure in an RNA molecule having a cleavage site for a catalytic nucleic acid molecule, a method for determining the capping degree of a population of RNA molecules having a cleavage site for a catalytic nucleic acid molecule, a method for determining the orientation of the cap structure in a capped RNA molecule having a cleavage site for a catalytic nucleic acid molecule and a method for determining relative amounts of correctly capped RNA molecules and reverse-capped RNA molecules in a population of RNA molecules, wherein the population comprises correctly capped and/or reverse-capped RNA molecules that have a cleavage site for a catalytic nucleic acid molecule. Moreover, the present invention provides uses of a catalytic nucleic acid molecule.
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8.发明授权公开(公告)号：US11760992B2
公开(公告)日：2023-09-19
申请号：US17820242
申请日：2022-08-16
Applicant: CureVac Manufacturing GmbH
Inventor： Andreas Funkner , Stefanie Dorner , Stefanie Sewing , Johannes Kamm , Norbert Broghammer , Thomas Ketterer , Thorsten Mutzke
CPC classification number: C12N15/1017 , B01D61/145 , B01D71/12 , C12P19/34 , G01N30/02 , G01N2030/027
Abstract: The present invention relates to method for producing and purifying RNA comprising the steps of providing DNA encoding the RNA; transcription of the DNA into RNA; and conditioning and/or purifying of the solution comprising transcribed RNA by one or more steps of tangential flow filtration (TFF).
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公开(公告)号：US20230167456A2
公开(公告)日：2023-06-01
申请号：US15750745
申请日：2016-08-04
Applicant: CureVac Manufacturing GmbH
Inventor： Jim WILLIAMS
IPC: C12N15/67
CPC classification number: C12N15/67 , C12N2830/50 , C12N2820/55 , C12N2820/60 , C12N2800/101 , C12N2800/202 , C12N2800/204
Abstract: The present invention relates to a covalently closed circular recombinant DNA molecule comprising an origin of replication and an insert comprising a homopolymeric region, wherein the homopolymeric region is located at a distance of least 500 bp from the origin of replication in the direction of replication and/or wherein the insert comprising a homopolymeric region is oriented so that the direction of transcription of the insert is the same as the direction of replication of the origin of replication. The invention further relates to the use of the covalently closed circular recombinant DNA molecule for increasing the yield and/or shortening the fermentation time during fermentation.
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公开(公告)号：US11661634B2
公开(公告)日：2023-05-30
申请号：US17814214
申请日：2022-07-21
Applicant: CureVac Manufacturing GmbH
Inventor： Florian Von Der Mülbe , Ladislaus Reidel , Thomas Ketterer , Lilia Gontcharova , Susanne Bauer , Steve Pascolo , Jochen Probst , Andreas Schmid
CPC classification number: C12Q1/689 , C12N15/1003 , C12P19/34 , C12Q2600/158
Abstract: The present invention relates to a method for producing RNA. In particular, the present invention relates to a method for producing RNA, which is scalable and provides RNA at a high purity. The present invention provides a method for producing RNA under GMP and/or cGMP-compliant conditions. The invention further provides specific processes for use as a quality control in the manufacturing of a template DNA and/or in a method for producing RNA, in particular by in vitro transcription.
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