公开(公告)号：US20090263377A1

公开(公告)日：2009-10-22

申请号：US12420972

申请日：2009-04-09

申请人： Charles Lin

发明人： Charles Lin

IPC分类号： A61K39/395 ,  C12Q1/02 ,  C12Q1/68 ,  A61K38/16 ,  A61K31/7088 ,  A61P35/00

CPC分类号： A61K31/7088 ,  C12Q1/6886 ,  C12Q2600/106 ,  G01N33/57415 ,  G01N33/6893 ,  G01N2333/54 ,  G01N2800/26

摘要： Methods for the diagnosis and treatment of IL-32β over-expressing cancers are provided. Also provided are methods for the treatment of wounds, hair loss and the promoting and/or restoration of hair growth utilized IL-32β antagonists. Finally, a sepsis model utilizing IL-32β is provided, as are methods for treating sepsis and inflammation using IL-32β antagonists.

摘要翻译： 提供了诊断和治疗IL-32beta过表达癌症的方法。 还提供了用于治疗伤口，脱发以及利用IL-32beta拮抗剂促进和/或恢复毛发生长的方法。 最后，提供了利用IL-32beta的败血症模型，以及使用IL-32beta拮抗剂治疗败血症和炎症的方法。

公开(公告)号：US20090057482A1

公开(公告)日：2009-03-05

申请号：US11846570

申请日：2007-08-29

申请人： Charles Lin

发明人： Charles Lin

IPC分类号： B64D35/04

CPC分类号： B64C27/10 ,  B64C27/14

摘要： A transmission device includes: a transmission shaft having first and second shaft sections and a gear mounting portion; a first tube sleeved rotatably on the first shaft section, and including a tube body and an annular portion; a second tube sleeved on the second shaft section; a plurality of first planetary bevel gears mounted rotatably on the gear mounting portion; a plurality of second planetary bevel gears mounted rotatably on the annular portion; a transmission gear disposed rotatably on the tube body and meshing with the first and second planetary bevel gears; a first output bevel gear disposed rotatably on the second tube and meshing with the first planetary bevel gears; and a second output bevel gear disposed rotatably on the tube body of the first tube and meshing with the second planetary bevel gears.

摘要翻译： 传动装置包括：具有第一和第二轴部的传动轴和齿轮安装部; 第一管，其可旋转地套在所述第一轴部上，并且包括管体和环形部分; 套在第二轴部分上的第二管; 多个第一行星齿轮，其可旋转地安装在所述齿轮安装部上; 多个第二行星齿轮，其可旋转地安装在所述环形部分上; 传动齿轮可旋转地设置在管体上并与第一和第二行星锥齿轮啮合; 第一输出锥齿轮，可旋转地设置在第二管上并与第一行星齿轮啮合; 以及第二输出锥齿轮，其可旋转地设置在第一管的管体上并与第二行星锥齿轮啮合。

公开(公告)号：US20090057481A1

公开(公告)日：2009-03-05

申请号：US11846564

申请日：2007-08-29

申请人： Charles Lin

发明人： Charles Lin

IPC分类号： B65D35/04

CPC分类号： A63H27/12

摘要： A dual-power transmission device includes: a first output shaft secured rotatably in a housing and having a first rotor coupling portion extending outwardly of the housing; a second output shaft disposed to surround the first rotor coupling portion, secured rotatably in the housing, and having a second rotor coupling portion extending outwardly of the housing; first and second bevel gears mounted respectively on the first and second output shafts; first, second and third thrust bearings for positioning the first and second bevel gears in the housing; and first and second input units respectively coupled to first and second power sources and each meshing with the first and second bevel gears.

摘要翻译： 双功率传动装置包括：第一输出轴，其可旋转地固定在壳体中，并具有从壳体向外延伸的第一转子联接部分; 第二输出轴，设置成围绕第一转子联接部分，可旋转地固定在壳体中，并且具有从壳体向外延伸的第二转子联接部分; 分别安装在第一和第二输出轴上的第一和第二锥齿轮; 用于将第一和第二锥齿轮定位在壳体中的第一，第二和第三推力轴承; 以及分别耦合到第一和第二电源并且与第一和第二锥齿轮啮合的第一和第二输入单元。

公开(公告)号：US07429313B2

公开(公告)日：2008-09-30

申请号：US10834684

申请日：2004-04-29

申请人： Charles Lin ,  Jay Dahlgren ,  Scott Morris ,  Richard Thompson

发明人： Charles Lin ,  Jay Dahlgren ,  Scott Morris ,  Richard Thompson

IPC分类号： B01J19/08

CPC分类号： C09H3/00

摘要： Methods of forming electrostatically charged gelatin are provided. Gelatin is extracted by an acid extraction method (12) thereby producing a gelatin dispersion (14), the pH of which is adjusted to the isoelectric point of the gelatin. The pH of the gelatin dispersion (14) is then further adjusted (22) so as to cause the gelatin to assume an electrostatic charge.

摘要翻译： 提供了形成静电荷的明胶的方法。 通过酸提取方法（12）提取明胶，从而制备明胶分散体（14），将其调节至明胶的等电点。 然后进一步调整明胶分散体（14）的pH值（22），以使明胶呈现静电电荷。

公开(公告)号：US20060259022A1

公开(公告)日：2006-11-16

申请号：US11428018

申请日：2006-07-26

申请人： Charles Lin

发明人： Charles Lin

IPC分类号： A61B18/18

CPC分类号： A61B18/20 ,  A61B2017/00057 ,  A61B2018/00636 ,  A61B2018/00642 ,  A61F9/008 ,  A61F9/00821 ,  A61F2009/00844 ,  A61F2009/00855 ,  A61F2009/00863 ,  A61F2009/00897

摘要： A method of scanning a laser beam across a set of cells includes during a first interval, scanning a laser beam across a set of cells; and during a second interval, deflecting the laser beam away from the set of cells. The first interval is selected to cause microcavitation in at least a portion of the cells from the set of cells.

摘要翻译： 扫描激光束跨越一组单元的方法包括在第一间隔期间扫描激光束穿过一组单元; 并且在第二间隔期间，使激光束偏离该组电池。 选择第一间隔以在来自该组细胞的至少一部分细胞中引起微腔化。

公开(公告)号：US20060141607A1

公开(公告)日：2006-06-29

申请号：US10525559

申请日：2003-08-27

申请人： John Wikswo ,  Franz Baudenbacher ,  Alex Prokop ,  Eugene Leboeuf ,  Chang Chung ,  David Cliffel ,  Frederick Haselton ,  William Hofmeister ,  Charles Lin ,  Lisa McCawley ,  Randall Reiserer ,  Mark Stremler

发明人： John Wikswo ,  Franz Baudenbacher ,  Alex Prokop ,  Eugene Leboeuf ,  Chang Chung ,  David Cliffel ,  Frederick Haselton ,  William Hofmeister ,  Charles Lin ,  Lisa McCawley ,  Randall Reiserer ,  Mark Stremler

IPC分类号： C12M1/34

CPC分类号： B01L3/502761 ,  B01L3/502746 ,  B01L2200/0668 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0877 ,  B01L2300/10 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/0487 ,  C12M23/16 ,  C12M29/10

摘要： A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor includes a first substrate having a first surface, an opposite second surface and edges. The bioreactor further includes a second substrate having a first surface and an opposite second surface, defining a cavity with a bottom surface, where the bottom surface is located therebetween the first surface and the second surface. The first surface of the first substrate is received by the second surface of the second substrate to cover the cavity so as to form a channel for receiving cells and a liquid medium. In forming the bioreactor, the channel is sized to allow the growth of a layer of cells on a biocompatible coating layer and a flow of liquid in the channel. The flow of liquid is controlled so as to provide a known shear force to the layer of cells. The flow of liquid can be further controlled so as to provide an environment that simulates a vascular space in the channel.

公开(公告)号：US20060134003A1

公开(公告)日：2006-06-22

申请号：US11016545

申请日：2004-12-17

申请人： Irene Georgakoudi ,  Charles Lin

发明人： Irene Georgakoudi ,  Charles Lin

IPC分类号： A61B10/00

CPC分类号： A61B5/1455 ,  A61B2503/40 ,  G01N15/1459 ,  G01N2015/0073 ,  G01N2015/008 ,  G01N2015/0084 ,  G01N2015/1486 ,  G01N2015/1488

摘要： The present invention provides methods and systems for performing in-vivo flow cytometry to obtain desired information regarding one or more cell types of interest flowing through a subject's circulatory system. In one embodiment of the invention, a portion of the subject's circulating blood is illuminated with radiation having multiple wavelength components, and the backscattered radiation generated in response to the excitation radiation is detected at a plurality of scattering angles and analyzed to derive the desired information.

摘要翻译： 本发明提供用于进行体内流式细胞术以获得关于流过对象的循环系统的一种或多种感兴趣细胞类型的期望信息的方法和系统。 在本发明的一个实施例中，用具有多个波长分量的辐射照射受试者的循环血液的一部分，并且以多个散射角度检测响应于激发辐射而产生的反向散射辐射并分析以导出所需信息。

公开(公告)号：US20060134002A1

公开(公告)日：2006-06-22

申请号：US11015334

申请日：2004-12-17

申请人： Charles Lin

发明人： Charles Lin

IPC分类号： A61K49/00 ,  G01N33/567 ,  G01N33/53

CPC分类号： A61K49/0032 ,  A61K49/0056 ,  A61K49/0097 ,  G01N33/56966 ,  G01N33/57496 ,  G01N33/582 ,  G01N2510/00 ,  G01N2800/52 ,  Y10T436/101666 ,  Y10T436/13

摘要： The present invention provides methods and systems for performing in vivo flow cytometry. In one embodiments, selected circulating cells of interest of a subject are labeled with fluorescent probe molecules. The labeled cells are irradiated in vivo so as to excite the fluorescent probes, and the radiation emitted by the excited probes is detected, preferably confocally. The detected radiation is then analyzed to derive desired information, such as relative cell count, of the cells of interest.

公开(公告)号：US06899904B2

公开(公告)日：2005-05-31

申请号：US10607465

申请日：2003-06-26

申请人： Charles Lin ,  Jay Dahlgren ,  Scott Morris

发明人： Charles Lin ,  Jay Dahlgren ,  Scott Morris

IPC分类号： A23K1/16 ,  A23K1/165 ,  A23K1/18 ,  A23K1/00

CPC分类号： A23K20/147 ,  A23K20/10 ,  A23K20/168 ,  A23K20/189 ,  A23K40/25 ,  A23K50/40 ,  Y10S426/805 ,  Y10S426/807

摘要： Animal feed compositions comprising amounts of protein, carbohydrate, fat and a functional ingredient for preventing hairball formation are provided. The functional ingredient comprises an electrostatically charge ingredient, preferably selected from the group consisting of electrostatically charged proteins, amino acids, conjugated proteins, dipeptides, multipeptides, protein colloids, enzymes, protein hydrolysates, natural and artificial food additives, flavorings, seasonings, and mixtures thereof.

摘要翻译： 提供包含蛋白质，碳水化合物，脂肪和用于防止毛球形成的功能成分的动物饲料组合物。 功能成分包括静电电荷成分，优选选自静电荷蛋白，氨基酸，缀合蛋白，二肽，多肽，蛋白质胶体，酶，蛋白质水解产物，天然和人造食品添加剂，调味剂，调味料和混合物 其中。

公开(公告)号：US5918152A

公开(公告)日：1999-06-29

申请号：US933368

申请日：1997-09-19

申请人： Liu Erzhuang ,  Charles Lin ,  Yih-Shung Lin

发明人： Liu Erzhuang ,  Charles Lin ,  Yih-Shung Lin

IPC分类号： H01L21/3105 ,  H01L21/314 ,  H01L21/316 ,  H01L21/4763 ,  H01L21/31 ,  H01L21/469

CPC分类号： H01L21/316 ,  H01L21/31051

摘要： A method is described for filling narrow gaps in a surface that is being overcoated. This has been achieved by heating the overcoating layer to a sufficient extent so that it flows relatively easily. This, in combination with externally applied pressure, causes the overcoating layer to effectively fill any narrow gaps in the surface being coated. Temperature and pressure are applied for a time that is sufficient to allow small quantities of gas that may have become trapped in the gaps to bubble to the surface. In an alternative embodiment, the surface to be coated is subjected to negative pressure prior to application of the coating. This eliminates the possibility of trapping gas in the gaps so a waiting time is no longer necessary.

摘要翻译： 描述了用于填充正在被覆盖的表面中的窄间隙的方法。 这已经通过将外涂层加热到足够的程度来实现，使得它相对容易地流动。 这与外部施加的压力结合使得外涂层有效地填充被涂覆的表面中的任何窄缝隙。 施加温度和压力足够长的时间，以允许可能已经被捕获在间隙中的少量气体向表面起泡。 在替代实施例中，待涂覆的表面在施加涂层之前经受负压。 这消除了在间隙中捕获气体的可能性，因此不再需要等待时间。