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公开(公告)号：US12059450B2
公开(公告)日：2024-08-13
申请号：US17281808
申请日：2019-10-02
申请人： Korea University Research And Business Foundation , CHA UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人： Min-Jeong Shin , Hyeon Soo Kim , Inhyeok Jeong , Eun Hye Yoo , Ji Hyung Chung
CPC分类号： A61K38/1709 , A23L33/17 , A61P35/00
摘要： The present invention pertains to an anticancer composition containing IF1 (ATPase inhibitory factor 1). The IF1 (ATPase inhibitory factor 1) according to the present invention has the effect of releasing extracellular ATP, induces cytotoxicity in various cancer cells and exhibits anticancer efficacy, and is thus very useful as an active ingredient of a powerful anticancer agent.
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公开(公告)号：US20240252547A1
公开(公告)日：2024-08-01
申请号：US18564485
申请日：2022-05-26
发明人： Jihwan SONG
IPC分类号： A61K35/30 , A61P9/10 , C12N5/0797
CPC分类号： A61K35/30 , A61P9/10 , C12N5/0623 , C12N2500/32 , C12N2500/38 , C12N2500/98 , C12N2501/115 , C12N2506/45 , C12N2533/52
摘要： A pharmaceutical composition for preventing or treating a stroke, the pharmaceutical composition comprising, as an active ingredient, neural precursor cells differentiated from HLA homozygous human induced pluripotent stem cells (hiPSC-NPC), wherein, through the use of a homozygous type, immunorejection may be eliminated and stable therapeutic effects for stroke may be exhibited.
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3.发明公开公开(公告)号：US20230330151A1
公开(公告)日：2023-10-19
申请号：US18042635
申请日：2021-08-24
发明人： Jisook MOON , Chul KIM , Jae Hyun PARK , Ji-Min PARK , Young Sook SONG , Chul Woo LIM , Yuri CHOI
IPC分类号： A61K35/30 , C12N5/0793
CPC分类号： A61K35/30 , C12N5/0619 , C12N2500/40 , C12N2500/38 , C12N2500/74
摘要： Provided are a composition and a method for promoting differentiation of neural stem cells into dopaminergic neurons, the composition including fusaric acid, ascorbic acid, nicotinamide adenine dinucleotide, or a combination thereof. The composition and method according to an aspect may not only increase differentiation of neural stem cells isolated at an early stage of development into dopaminergic neurons, but also increase differentiation of subcultured neural stem cells into dopaminergic neurons, and thus, it is possible to secure more dopaminergic neurons, and increase therapeutic effects on Parkinson's disease.
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公开(公告)号：US20230272555A1
公开(公告)日：2023-08-31
申请号：US18315532
申请日：2023-05-11
发明人： Kwang-Hyun BAEK , So-Ra KIM , Seul-Ki KWON , Soo-Yeon KIM , Da-Hye LEE
摘要： Provided is a vector library for yeast two-hybrid screening of a deubiquitinating enzyme that binds to a target protein and a method for identifying a deubiquitinating enzyme binding to a target protein using the same. Further provided is a method for screening an agent having anti-cancer activity targeting the deubiquitinating enzyme USP1, USP7, USP12, or USP49 identified by the identifying method.
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公开(公告)号：US20230131962A1
公开(公告)日：2023-04-27
申请号：US17905132
申请日：2020-08-26
发明人： Kyung-Ah LEE , Kyeoung-Hwa KIM , Mi Kyoung KOONG
IPC分类号： C12Q1/6883
摘要： According to a composition and a kit for diagnosing ovarian reserve, and a method of providing information for diagnosing ovarian reserve by using the same, according to an aspect, the development of follicles may be predicted early. In addition, by predicting not only the number of oocytes but also the quality of oocytes, a comprehensive diagnosis of ovarian reserve may be made.
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公开(公告)号：US20220401077A1
公开(公告)日：2022-12-22
申请号：US17771939
申请日：2020-09-18
申请人： KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION , CHA UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人： Bo Kyoung SEO , Mi-Ryung HAN , Ah Young PARK
IPC分类号： A61B8/08
摘要： The present invention relates to: a method for providing information for choosing a breast cancer treatment method by using a breast cancer ultrasonic image and gene information; a system for choosing a breast cancer treatment method by using a breast cancer ultrasonic image; and a method for providing information required for predicting the prognosis of a breast cancer patient.
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公开(公告)号：US11351194B2
公开(公告)日：2022-06-07
申请号：US15518184
申请日：2014-10-10
发明人： Jisook Moon , Hyun-Seob Lee , Yeon-Ho Shin
摘要： The present invention provides a method for proliferating neural progenitor cells and a composition for treating neurological diseases, the composition including a proliferated neural progenitor cell. When a fetal neural progenitor cell is cultured under a hypoxia condition and/or in a medium containing tocoperol, tocoperol acetate, or a mixture thereof, the improved cell proliferation rates of the fetal neural progenitor cell are confirmed. In addition, considering an effect of the neural progenitor cell on preventing differentiation thereof into neurons at the time of proliferation, the present disclosure may contribute to mass production of neural stem cells, and accordingly, the proliferated neural progenitor cell is expected to be utilized in the treatment of a neurological disease.
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公开(公告)号：US20220023393A1
公开(公告)日：2022-01-27
申请号：US17276212
申请日：2019-09-11
申请人： KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION , CHA UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人： Min-Jeong SHIN , Hyeon Soo KIM , Ji Hyung CHUNG
摘要： The present invention relates to a composition for preventing or treating obesity or sarcopenia, containing ATPase inhibitory factor 1 (IF1) and, more specifically, to a pharmaceutical composition and a food for preventing or treating obesity or sarcopenia, containing, as an active ingredient, IF1 having an effect of suppressed appetite or effects increased muscle mass and muscle production. According to the present invention, ATPase inhibitory factor 1 (IF1) exhibits, in an obesity-induced mouse model, effects of inhibited weight gain and decreased dietary intake without side effects, and exhibits, in obesity-induced or aged mouse, effects of increased muscle mass, increased muscle protein and muscle production, and thus is very useful as an agent for preventing, alleviating or treating metabolic diseases such as obesity, an agent for suppressing appetite and an agent for preventing, alleviating or treating muscle loss-related diseases such as sarcopenia.
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公开(公告)号：US11214558B2
公开(公告)日：2022-01-04
申请号：US16967797
申请日：2019-02-08
发明人： David Tae Aug Kim , A-Ram Kim , Young-Ger Suh , Jaehoon Sim
IPC分类号： C07D307/33
摘要： The present disclosure relates to a novel method for synthesizing DHPV, and more particularly, to a novel method for synthesizing DHPV (5-(3′,4′-dihydroxyphenyl)-γ-valerolactone)) which is a major metabolite of cacao. This method has the advantage of not only facilitating a large-scale synthesis by a new synthesis method that can overcome existing defects, but also making it easy to select antioxidants and isomers exhibiting anti-aging bioactivities. Therefore, it is effective in enabling mass production of DHPV having high value as a functional material for cosmetics and pharmaceuticals in a simple and economical manner.
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公开(公告)号：US20210032619A1
公开(公告)日：2021-02-04
申请号：US16636523
申请日：2018-08-06
发明人： Kwang-Hyun BAEK , So-Ra KIM , Seul-Ki KWON , Soo-Yeon KIM , Da-Hye LEE
摘要： The present invention provides a vector library for yeast two-hybrid screening of a deubiquitinating enzyme that binds to a target protein and a method for identifying a deubiquitinating enzyme binding to a target protein using the same. Also, the present invention provides a method for screening an agent having anti-cancer activity targeting the deubiquitinating enzyme USP1, USP7, USP12, or USP49 identified by said identifying method.
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