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公开(公告)号：US20220194998A1
公开(公告)日：2022-06-23
申请号：US17310517
申请日：2020-02-06
Inventor： Kwang-Hyun BAEK , Ji-Hye CHOI
IPC: C07K14/47
Abstract: The present invention provides an Oct-3/4 protein variant wherein lysine at position 156; lysine at position 286; or lysines at positions 156 and 286 in the Oct-3/4 protein is (are) substituted with arginine. The Oct-3/4 protein variant according to the present invention can inhibit a protein degradation mechanism through ubiquitination, and shows a higher half-life, compared to the wild-type Oct-3/4, thereby exhibiting high stability.
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Patent Agency Ranking
公开(公告)号：US20220090198A1
公开(公告)日：2022-03-24
申请号：US17310163
申请日：2020-01-22
Inventor： Kwang-Hyun BAEK , Jun-Hyeok PARK
IPC: C12Q1/6883 , C12Q1/686
Abstract: Provided is an analytical method for providing information necessary for a diagnosis of urolithiasis, including measuring an expression level of a gene encoding a YOD1, USP6, USP19, PSMD14, or USP26 protein in a biological sample from a subject to be diagnosed; and a kit for a diagnosis of urolithiasis which is used in the analytical method.
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公开(公告)号：US20230272555A1
公开(公告)日：2023-08-31
申请号：US18315532
申请日：2023-05-11
Inventor： Kwang-Hyun BAEK , So-Ra KIM , Seul-Ki KWON , Soo-Yeon KIM , Da-Hye LEE
CPC classification number: C40B30/06 , C12N9/48 , C12N15/1055 , C12N15/81 , C12Q1/37 , C40B40/02 , C40B40/08
Abstract: Provided is a vector library for yeast two-hybrid screening of a deubiquitinating enzyme that binds to a target protein and a method for identifying a deubiquitinating enzyme binding to a target protein using the same. Further provided is a method for screening an agent having anti-cancer activity targeting the deubiquitinating enzyme USP1, USP7, USP12, or USP49 identified by the identifying method.
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公开(公告)号：US20210032619A1
公开(公告)日：2021-02-04
申请号：US16636523
申请日：2018-08-06
Inventor： Kwang-Hyun BAEK , So-Ra KIM , Seul-Ki KWON , Soo-Yeon KIM , Da-Hye LEE
Abstract: The present invention provides a vector library for yeast two-hybrid screening of a deubiquitinating enzyme that binds to a target protein and a method for identifying a deubiquitinating enzyme binding to a target protein using the same. Also, the present invention provides a method for screening an agent having anti-cancer activity targeting the deubiquitinating enzyme USP1, USP7, USP12, or USP49 identified by said identifying method.
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公开(公告)号：US20210324475A1
公开(公告)日：2021-10-21
申请号：US17285370
申请日：2019-09-17
Inventor： Kwang-Hyun BAEK , Soo-Ji KANG
IPC: C12Q1/6883 , G01N33/68
Abstract: Provided is an analytical method for providing information necessary for a diagnosis of alcohol use disorder, including measuring (i) an expression level of a gene encoding a JNK or p-JNK protein in a subject's sample, (ii) an expression level of a gene encoding a JNK or p-JNK protein and an expression level of a gene encoding the Elk-1 protein in a subject's sample, or (iii) expression levels of genes encoding JNK, p-JNK, and Elk-1 proteins in a subject's sample, respectively; and a kit for a diagnosis of alcohol use disorder which is used in the analytical method.
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公开(公告)号：US20230213531A1
公开(公告)日：2023-07-06
申请号：US17905364
申请日：2021-02-26
Inventor： Kwang-Hyun BAEK , Chang-Zhu PEI
IPC: G01N33/68 , C12Q1/6837 , C12Q1/6883
CPC classification number: G01N33/689 , C12Q1/6837 , C12Q1/6883 , C12Q2600/158 , G01N2800/368
Abstract: Provided are an analytical method for providing information necessary for diagnosing recurrent pregnancy loss, comprising measuring an expression level of HtrA4 protein or an expression level of a gene encoding the same in a subject’s sample, and a kit for diagnosing recurrent pregnancy loss, comprising a molecule capable of measuring an expression level of HtrA4 protein or an expression level of a gene encoding the same
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