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1.发明申请公开(公告)号：US20190338294A1
公开(公告)日：2019-11-07
申请号：US16467890
申请日：2017-12-07
发明人： Jef D. Boeke , Shigehito Ikushima
摘要： The invention features compositions and methods for identifying orthogonal transcriptional switches derived from Tet repressor homologs for Saccharomyces cerevishiae regulated by 2,4-diacetylphloroglucinol (DAPG) and other ligands.
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2.发明公开公开(公告)号：US20240358600A1
公开(公告)日：2024-10-31
申请号：US18556244
申请日：2022-04-19
CPC分类号： A61J15/0069 , A61J15/0023 , A61J15/0042 , A61J15/0061 , A61M2025/0047 , A61M25/0097 , A61M2025/0681 , A61M25/10
摘要： A sleeved gastrojejunostomy (GJ) tube, according to the present invention, includes an inner cannula or feeding cannula that is housed in a sleeve. This arrangement allows the inner cannula to be replaced easily at the bedside by non-specialists. Traditional methods to insert the sleeved GJ tube are utilized, but in the event of feeding cannula damage or clogs, the inner cannula can be easily removed and a new one can be placed, without the need for fluoroscopy or anesthesia. The use of sleeved GJ tubes will expedite patient care, reduce complications, and decrease healthcare costs. The present invention aims to solve the common issue of a clogged GJ Tube. Clogged GJ tubes lead to emergency room visits, hospital admission, and interventional procedures. The present invention would enable exchanges of a clogged feeding cannula by providers or parents without radiation, sedation, or room time.
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公开(公告)号：US20240356113A1
公开(公告)日：2024-10-24
申请号：US18642938
申请日：2024-04-23
IPC分类号： H01M50/105 , H01M4/04 , H01M4/66 , H01M10/04 , H01M50/403 , H01M50/411
CPC分类号： H01M50/105 , H01M4/0404 , H01M4/661 , H01M10/0481 , H01M50/403 , H01M50/411
摘要： Disclosed herein are systems and methods of making flexible fiber batteries. The fiber batteries are amenable for deployment in textiles, for example, wearable fabrics. The fiber battery can be used to provide power to wearable electronic devices. The fiber battery disclosed herein can be a sub-millimeter (mm) diameter active battery stack having a coating that provides a fiber having a diameter of up to 1 mm that can be woven, stitched, knitted, or otherwise incorporated into a fabric.
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公开(公告)号：US20240345093A1
公开(公告)日：2024-10-17
申请号：US18506393
申请日：2023-11-10
IPC分类号： G01N33/574
CPC分类号： G01N33/57449 , G01N2333/99
摘要： This document provides methods and materials for identifying biomarkers (e.g., peptide biomarkers) that can be used to identify a mammal as having a disease (e.g., cancer). This document also provides methods and materials for identifying and/or treating cancer. For example, this document provides methods and materials for using one or more peptide fragments derived from a peptidyl-prolyl cis-trans isomerase A (PPIA) polypeptide to identify a mammal as having cancer (e.g., ovarian cancer).
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5.发明公开公开(公告)号：US20240336660A1
公开(公告)日：2024-10-10
申请号：US18577642
申请日：2022-07-08
发明人： Stephen J. Gould , Chenxu Guo , Shang-Jui Tsai , Linda Marban
IPC分类号： C07K14/005 , A61K9/50 , A61K39/00
CPC分类号： C07K14/005 , A61K9/5068 , A61K39/00 , C07K2319/02 , C07K2319/03 , C12N2770/20022 , C12N2770/20034
摘要： Coronavirus egress is mediated by lysosomal exocytosis. It is demonstrated herein that the D614G mutation enhances Spike trafficking to lysosomes and the lysosomal accumulation of newly synthesized virus particles, augments Spike-mediated disruption of endomembrane homeostasis, and causes a 3-fold reduction in cell surface Spike expression. Moreover, it is shown that the D614G mutation is an intragenic suppressor of the 12 nucleotide-long furin cleavage site (FCS) insertion, restoring Spike trafficking to lysosomes and TMPRSS2-independent infectivity, both of which had been impaired by the prior FCS insertion mutation. This data identifies enhanced lysosomal sorting as the earliest known manifestation of the D614G mutation, have implications for virus evolution, immunity, and vaccine design, and support a lysosomal model of coronavirus biogenesis and entry.
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公开(公告)号：US12109070B2
公开(公告)日：2024-10-08
申请号：US17763069
申请日：2020-09-28
发明人： Muyinatu Bell , Alycen Wiacek
CPC分类号： A61B8/5207 , A61B5/0095 , A61B8/06 , A61B8/485 , G01S7/52026 , G01S7/52046 , G01S15/8915
摘要： A computer-implemented method for training and using a neural network to predict a coherence function includes: training a neural network by mapping a plurality of different sets of training input samples to respective coherence function truths to generate a trained neural network; receiving an operational input sample; inputting the operational input sample into the trained neural network; obtaining, from the trained neural network, a coherence function mapped to the operational input sample in response to the inputting the operational input sample into the trained neural network; and executing a computer-based instruction based on obtaining the coherence function. The coherence function may be used to differentiate solid masses from fluid-filled masses.
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公开(公告)号：US12104828B2
公开(公告)日：2024-10-01
申请号：US16496830
申请日：2018-03-23
CPC分类号： F24T10/20 , E21B7/04 , E21B7/18 , E21B43/305 , E21B43/17 , E21B43/26 , F24T2010/53 , Y02E10/10
摘要： A radiator (RAD) enhanced geothermal system (EGS) may comprise a radiator vane heat exchanger (RVHE). The RVHE may be configured to be located in a plane defined by an injector well and a production well that is defined by a principal stress direction (S1) of a plurality of principal stress directions and a maximum horizontal stress component (SHmax). The RVHE may include one or more stacked laterals oriented along SHmax. Each stacked lateral, of the one or more stacked laterals, may include one or more vertical branches oriented along S1. The RVHE may be configured to extract energy from a non-hydrothermal source of energy.
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公开(公告)号：US12104214B2
公开(公告)日：2024-10-01
申请号：US16934137
申请日：2020-07-21
发明人： Martin G. Pomper , Mark Castanares , Il Minn , Shawn Lupold
IPC分类号： C12N15/63 , A61K49/00 , A61K51/04 , C07K14/005 , C12N9/48 , C12N15/85 , C12N15/86 , C12Q1/6897 , G01N33/574
CPC分类号： C12Q1/6897 , A61K49/0021 , A61K51/0406 , A61K51/0455 , C07K14/005 , C12N9/485 , C12N15/85 , C12N15/86 , C12Y304/17021 , G01N33/57434 , G01N33/57492 , G01N33/57496 , C12N2710/10043 , C12N2710/10044 , C12N2710/10071 , C12N2710/16143 , C12N2710/16222 , C12N2830/60 , G01N2333/705 , G01N2458/00
摘要： Methods, reporter gene constructs, and kits for using prostate-specific membrane antigen (PSMA) as an imaging reporter to image a variety of cells and tissues are provided.
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公开(公告)号：US12098172B2
公开(公告)日：2024-09-24
申请号：US16635861
申请日：2018-07-31
IPC分类号： C07K14/435 , C07K14/705 , C12N15/86 , G01N33/50
CPC分类号： C07K14/435 , C07K14/70596 , C12N15/86 , G01N33/5011 , G01N33/5023 , C12N2750/14143
摘要： The present disclosure relates to compositions and methods for treating cancers. In particular, the present disclosure provides materials and methods for identifying mis-splicing-associated surface antigens (MASAs) generated by altered spliceosome proteins, as well as materials and methods for targeting cancerous tumors expressing MASAs.
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公开(公告)号：US20240312867A1
公开(公告)日：2024-09-19
申请号：US18423361
申请日：2024-01-26
CPC分类号： H01L23/38 , H10N10/01 , H10N10/13 , H10N10/17 , H10N10/81 , H10N10/852 , H01L33/645
摘要： Example superlattice structures and methods for thermoelectric devices are provided. An example structure may include a plurality of superlattice periods. Each superlattice period may include a first material layer disposed adjacent to a second material layer. For each superlattice period, the first material layer may be formed of a first material and the second material layer may be formed of a second material. The plurality of superlattice periods may include a first superlattice period and a second superlattice period. A thickness of a first material layer of the first superlattice period may be different than a thickness of a first material layer of the second superlattice period.
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