知搜-全球专利检索

  1. Login
  2. Sign Up

Search Results

82 records (took 0.061 seconds)

    DRUG-DELIVERY ENDOVASCULAR STENT AND METHOD OF FORMING THE SAME
    1.
    发明申请
    DRUG-DELIVERY ENDOVASCULAR STENT AND METHOD OF FORMING THE SAME 审中-公开
    药物递送内支架及其形成方法

    公开(公告)号：US20140200654A1

    公开(公告)日：2014-07-17

    申请号：US14217948

    申请日：2014-03-18

    Applicant: Biosensors International Group, Ltd.

    Inventor： John E. Shulze ,  Ronald E. Betts ,  Douglas R. Savage

    IPC: A61L31/16 ,  A61L31/02 ,  A61L31/10 ,  A61F2/915 ,  A61L31/06

    CPC classification number: A61L31/16 ,  A61F2/90 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/072 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2230/0054 ,  A61F2240/001 ,  A61F2250/0067 ,  A61K9/0024 ,  A61L31/022 ,  A61L31/06 ,  A61L31/10 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2420/08 ,  C08L29/04 ,  C08L67/04

    Abstract: An intravascular stent and method for inhibiting restenosis, following vascular injury, is disclosed. The stent has an expandable, linked-filament body and a drug-release coating formed on the stent-body filaments, for contacting the vessel injury site when the stent is placed in-situ in an expanded condition. The coating releases, for a period of at least 4 weeks, a restenosis-inhibiting amount of a monocyclic triene immunosuppressive compound having an alkyl group substituent at carbon position 40 in the compound. The stent, when used to treat a vascular injury, gives good protection against clinical restenosis, even when the extent of vascular injury involves vessel overstretching by more than 30% diameter. Also disclosed is a stent having a drug-release coating composed of (i) 10 and 60 weight percent poly-dl-lactide polymer substrate and (ii) 40-90 weight percent of an anti-restenosis compound, and a polymer undercoat having a thickness of between 1-5 microns.

    Abstract translation: 公开了血管内支架和用于抑制血管损伤后再狭窄的方法。 支架具有可扩张的连接长丝体和形成在支架体细丝上的药物释放涂层，用于当支架在扩张状态下原位放置时接触血管损伤部位。 该涂层释放至少4周的再狭窄抑制量的化合物中在碳位置40具有烷基取代基的单环三烯免疫抑制化合物。 当支架用于治疗血管损伤时，即使在血管损伤程度超过30％直径的血管破裂的情况下，也能对抗临床再狭窄提供良好的保护。 还公开了一种支架，其具有由（i）10重量％和60重量％的聚-DL-丙交酯聚合物底物和（ii）40-90重量％的抗再狭窄化合物组成的药物释放包衣，以及聚合物底涂层，其具有 厚度介于1-5微米之间。

    Multi-dimensional image reconstruction
    3.
    发明授权
    Multi-dimensional image reconstruction 有权
    多维图像重建

    公开(公告)号：US08676292B2

    公开(公告)日：2014-03-18

    申请号：US11656548

    申请日：2007-01-23

    Applicant: Benny Rousso ,  Michael Nagler

    Inventor： Benny Rousso ,  Michael Nagler

    IPC: A61B5/00

    CPC classification number: A61B6/481 ,  A61B6/4057 ,  A61B6/4258 ,  A61B6/486 ,  A61B6/5217 ,  A61B6/5241 ,  A61B90/39 ,  A61M5/007 ,  G01T1/161 ,  G01T1/166

    Abstract: Apparatus for radiation based imaging of a non-homogenous target area having distinguishable regions therein, comprises: an imaging unit configured to obtain radiation intensity data from a target region in the spatial dimensions and at least one other dimension, and an image four-dimension analysis unit analyzes the intensity data in the spatial dimension and said at least one other dimension in order to map the distinguishable regions. The system typically detects rates of change over time in signals from radiopharmaceuticals and uses the rates of change to identify the tissues. In a preferred embodiment, two or more radiopharmaceuticals are used, the results of one being used as a constraint on the other.

    Abstract translation: 用于其中具有可区分区域的非均匀目标区域的用于基于辐射的成像的装置包括：成像单元，被配置为从空间维度和至少一个其他维度中的目标区域获得辐射强度数据，以及图像四维分析 单元分析空间维度中的强度数据和所述至少一个其他维度，以便映射可区分的区域。 该系统通常检测来自放射性药物的信号随时间的变化率，并使用变化率来识别组织。 在优选实施方案中，使用两种或更多种放射性药物，一种用于另一种放射性药物的结果。

    Untwisting restraint implant delivery system
    7.
    发明授权
    Untwisting restraint implant delivery system 有权
    解除约束植入物输送系统

    公开(公告)号：US08579954B2

    公开(公告)日：2013-11-12

    申请号：US11342316

    申请日：2006-01-27

    Applicant: David Licata

    Inventor： David Licata

    IPC: A61F2/06

    CPC classification number: A61F2/95 ,  A61F2/88 ,  A61F2002/9505 ,  A61F2002/9511 ,  A61F2002/9522 ,  A61F2250/0071

    Abstract: Medical devices and methods for delivery or implantation of prostheses within hollow body organs and vessels or other luminal anatomy are disclosed. The subject technologies may be used in the treatment of atherosclerosis in stenting procedures or be used in variety of other procedures. The systems may employ a self expanding stent restrained by one or more members released by an electrolytically erodable latch. Such release means do not connect directly to the implant, though one or more portions may contact it.

    Abstract translation: 公开了用于在中空身体器官和血管或其他腔内解剖结构中输送或植入假体的医疗装置和方法。 主题技术可用于治疗支架术中的动脉粥样硬化，或用于各种其他手术。 该系统可以采用由电解腐蚀的闩锁释放的一个或多个构件约束的自扩张支架。 这种释放装置不直接连接到植入物，尽管一个或多个部分可以与其接触。

    DRUG-DELIVERY ENDOVASCULAR STENT AND METHOD FOR TREATING RESTENOSIS
    8.
    发明申请
    DRUG-DELIVERY ENDOVASCULAR STENT AND METHOD FOR TREATING RESTENOSIS 有权
    药物递送内支架和治疗抑郁症的方法

    公开(公告)号：US20120290076A1

    公开(公告)日：2012-11-15

    申请号：US13556893

    申请日：2012-07-24

    Applicant: Douglas R. SAVAGE ,  Ronald E. BETTS

    Inventor： Douglas R. SAVAGE ,  Ronald E. BETTS

    IPC: A61F2/82

    CPC classification number: A61L31/16 ,  A61F2/91 ,  A61L2300/416

    Abstract: A radially expandable, endovascular stent designed for placement at a site of vascular injury, for inhibiting restenosis at the site, a method of using, and a method of making the stent. The stent includes a radially expandable body formed of one or more metallic filaments and a liquid-infusible mechanical anchoring layer attached to or formed in outer surface of the filaments. A drug coating in the stent is composed of a substantially polymer-free composition of an anti-restenosis drug, and has a substratum infused in the anchoring layer and a substantially continuous surface stratum of drug that is brought into direct contact with the vessel walls at the vascular site. Thus, the rate of release of the anti-restenosis drug from the surface stratum into said vascular site is determined solely by the composition of said drug coating.

    Abstract translation: 设计用于放置在血管损伤部位，用于抑制现场再狭窄的径向可扩张的血管内支架，使用方法和制造支架的方法。 该支架包括由一个或多个金属细丝形成的径向可扩张体，以及附着于细丝的外表面或形成于细丝的外表面的液体不可渗透的机械锚定层。 支架中的药物涂层由基本上无聚合物的抗再狭窄药物组合物组成，并且具有输注在锚定层中的基质和药物的基本连续的表面层，其与血管壁直接接触 血管部位。 因此，抗再狭窄药物从表层到所述血管部位的释放速率仅由所述药物包衣的组成确定。

    Drug-delivery endovascular stent and method for treating restenosis
    9.
    发明授权
    Drug-delivery endovascular stent and method for treating restenosis 有权
    药物输送血管内支架和治疗再狭窄的方法

    公开(公告)号：US08252047B2

    公开(公告)日：2012-08-28

    申请号：US13023312

    申请日：2011-02-08

    Applicant: Douglas R. Savage ,  Ronald E. Betts

    Inventor： Douglas R. Savage ,  Ronald E. Betts

    IPC: A61F2/82

    CPC classification number: A61L31/16 ,  A61F2/91 ,  A61L2300/416

    Abstract: A radially expandable, endovascular stent designed for placement at a site of vascular injury, for inhibiting restenosis at the site, a method of using, and a method of making the stent. The stent includes a radially expandable body formed of one or more metallic filaments and a liquid-infusible mechanical anchoring layer attached to or formed in outer surface of the filaments. A drug coating in the stent is composed of a substantially polymer-free composition of an anti-restenosis drug, and has a substratum infused in the anchoring layer and a substantially continuous surface stratum of drug that is brought into direct contact with the vessel walls at the vascular site. Thus, the rate of release of the anti-restenosis drug from the surface stratum into said vascular site is determined solely by the composition of said drug coating.

    Abstract translation: 设计用于放置在血管损伤部位，用于抑制现场再狭窄的径向可扩张的血管内支架，使用方法和制造支架的方法。 该支架包括由一个或多个金属细丝形成的径向可扩张体，以及附着于细丝的外表面或形成于细丝的外表面的液体不可渗透的机械锚定层。 支架中的药物涂层由基本上无聚合物的抗再狭窄药物组合物组成，并且具有输注在锚定层中的基质和药物的基本连续的表面层，其与血管壁直接接触 血管部位。 因此，抗再狭窄药物从表层到所述血管部位的释放速率仅由所述药物包衣的组成确定。

    Guidewire-less stent delivery methods
    10.
    发明授权
    Guidewire-less stent delivery methods 有权
    无丝支架输送方法

    公开(公告)号：US08016869B2

    公开(公告)日：2011-09-13

    申请号：US10745778

    申请日：2003-12-24

    Applicant: Julian Nikolchev

    Inventor： Julian Nikolchev

    IPC: A61F2/06

    CPC classification number: A61B17/12022 ,  A61B17/12109 ,  A61B17/12136 ,  A61B17/1214 ,  A61B90/39 ,  A61B2017/00867 ,  A61B2017/1205 ,  A61B2017/12063 ,  A61F2/95 ,  A61F2002/9511

    Abstract: The invention provides an atraumatic, low profile device for the delivery of one or more implants into tubular organs or open regions of the body. The implant delivery device may simultaneously or independently release portions of the implant, e.g., the proximal and distal ends of the implant. This independent release feature allows better implant positioning at the target site. Upon deployment, the implants may be placed at the target site without a sheath.

    Abstract translation: 本发明提供了一种用于将一个或多个植入物递送到体内的管状器官或开放区域中的无创伤的低调装置。 植入物递送装置可以同时或独立地释放植入物的部分，例如植入物的近端和远端。 这种独立的释放特征允许在目标部位更好的植入物定位。 部署后，植入物可以放置在目标部位而不需要护套。

Patent Agency Ranking