公开(公告)号：US20120290076A1

公开(公告)日：2012-11-15

申请号：US13556893

申请日：2012-07-24

Applicant: Douglas R. SAVAGE ,  Ronald E. BETTS

Inventor： Douglas R. SAVAGE ,  Ronald E. BETTS

IPC: A61F2/82

CPC classification number: A61L31/16 ,  A61F2/91 ,  A61L2300/416

Abstract: A radially expandable, endovascular stent designed for placement at a site of vascular injury, for inhibiting restenosis at the site, a method of using, and a method of making the stent. The stent includes a radially expandable body formed of one or more metallic filaments and a liquid-infusible mechanical anchoring layer attached to or formed in outer surface of the filaments. A drug coating in the stent is composed of a substantially polymer-free composition of an anti-restenosis drug, and has a substratum infused in the anchoring layer and a substantially continuous surface stratum of drug that is brought into direct contact with the vessel walls at the vascular site. Thus, the rate of release of the anti-restenosis drug from the surface stratum into said vascular site is determined solely by the composition of said drug coating.

Abstract translation: 设计用于放置在血管损伤部位，用于抑制现场再狭窄的径向可扩张的血管内支架，使用方法和制造支架的方法。 该支架包括由一个或多个金属细丝形成的径向可扩张体，以及附着于细丝的外表面或形成于细丝的外表面的液体不可渗透的机械锚定层。 支架中的药物涂层由基本上无聚合物的抗再狭窄药物组合物组成，并且具有输注在锚定层中的基质和药物的基本连续的表面层，其与血管壁直接接触 血管部位。 因此，抗再狭窄药物从表层到所述血管部位的释放速率仅由所述药物包衣的组成确定。

公开(公告)号：US20130035754A1

公开(公告)日：2013-02-07

申请号：US13647977

申请日：2012-10-09

Applicant: John E. SHULZE ,  Ronald E. BETTS ,  Douglas R. SAVAGE

Inventor： John E. SHULZE ,  Ronald E. BETTS ,  Douglas R. SAVAGE

IPC: A61F2/06

CPC classification number: A61L31/16 ,  A61F2/90 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/072 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2230/0054 ,  A61F2240/001 ,  A61F2250/0067 ,  A61K9/0024 ,  A61L31/022 ,  A61L31/06 ,  A61L31/10 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2420/08 ,  C08L29/04 ,  C08L67/04

Abstract: An intravascular stent and method for inhibiting restenosis, following vascular injury, is disclosed. The stent has an expandable, linked-filament body and a drug-release coating formed on the stent-body filaments, for contacting the vessel injury site when the stent is placed in-situ in an expanded condition. The coating releases, for a period of at least 4 weeks, a restenosis-inhibiting amount of a monocyclic triene immunosuppressive compound having an alkyl group substituent at carbon position 40 in the compound. The stent, when used to treat a vascular injury, gives good protection against clinical restenosis, even when the extent of vascular injury involves vessel overstretching by more than 30% diameter. Also disclosed is a stent having a drug-release coating composed of (i) 10 and 60 weight percent poly-dl-Iactide polymer substrate and (ii) 40-90 weight percent of an anti-restenosis compound, and a polymer undercoat having a thickness of between 1-5 microns.

Abstract translation: 公开了血管内支架和用于抑制血管损伤后再狭窄的方法。 支架具有可扩张的连接长丝体和形成在支架体细丝上的药物释放涂层，用于当支架在扩张状态下原位放置时接触血管损伤部位。 该涂层释放至少4周的再狭窄抑制量的化合物中在碳位置40具有烷基取代基的单环三烯免疫抑制化合物。 当支架用于治疗血管损伤时，即使在血管损伤程度超过30％直径的血管破裂的情况下，也能对抗临床再狭窄提供良好的保护。 还公开了一种支架，其具有由（i）10重量％和60重量％的聚-DL-酰胺聚合物基材和（ii）40-90重量％的抗再狭窄化合物组成的药物释放包衣，以及聚合物底涂层，其具有 厚度介于1-5微米之间。