公开(公告)号：US20160268116A1

公开(公告)日：2016-09-15

申请号：US15036433

申请日：2014-11-14

Applicant: SMITHS DETECTION MONTREAL INC.

Inventor： Jan Hendrikse ,  Vladimir Romanov

IPC: H01J49/16 ,  H01J49/24 ,  H01J49/00

CPC classification number: H01J49/168 ,  G01N33/0057 ,  H01J49/0004 ,  H01J49/0022 ,  H01J49/0036 ,  H01J49/0404 ,  H01J49/145 ,  H01J49/24

Abstract: A concentric APCI surface ionization probe, supersonic sampling tube, and method for use of the concentric APCI surface ionization probe and supersonic sampling tube are described. In an embodiment, the concentric APCI surface ionization probe includes an outer tube, an inner capillary, and a voltage source coupled to the outer tube and the inner capillary. The inner capillary is housed within and concentric with the outer tube such that ionized gas (e.g., air) travels out of the outer tube, reacts with a sample, and the resulting analyte ions are sucked into the inner capillary. A supersonic sampling tube can include a tube coupled to a mass spectrometer and/or concentric APCI surface ionization probe, where the tube includes at least one de Laval nozzle.

Abstract translation: 描述了同心APCI表面电离探针，超音速采样管以及用于同心APCI表面电离探针和超音速采样管的方法。 在一个实施例中，同心APCI表面电离探针包括外管，内毛细管和耦合到外管和内毛细管的电压源。 内部毛细管被容纳在外管中并与外管同心，使得电离气体（例如空气）从外管行进，与样品反应，并将所得到的分析物离子吸入内毛细管。 超音速采样管可以包括耦合到质谱仪和/或同心APCI表面电离探针的管，其中管包括至少一个德拉瓦尔喷嘴。

公开(公告)号：US20160189948A1

公开(公告)日：2016-06-30

申请号：US14912413

申请日：2014-08-19

Applicant: UNIVERSITÄT INNSBRUCK

Inventor： Martin BREITENLECHNER ,  Armin HANSEL

IPC: H01J49/14 ,  H01J49/04

CPC classification number: H01J49/145 ,  H01J49/0422 ,  H01J49/063

Abstract: A device for analyzing a sample gas comprises an ion source for generating primary ions, a reaction chamber to which the primary ions produced in the ion source and the sample gas to be analyzed can be supplied in order to form product ions by chemical ionization of components in the sample gas, and an analyzer/detector unit for determining different types of ions. A reaction space in the reaction chamber, within which the primary ions supplied to the reaction chamber and the product ions produced are guided and which extends between a first end facing the ion source and a second end facing the analyzer/detector unit, is surrounded by at least two electrodes which are in the form of helices which wind round a common axis with identical pitches and are offset with respect to one another in the direction of the axis. An AC voltage is applied to each of the electrodes.

Abstract translation: 用于分析样品气体的装置包括用于产生一次离子的离子源，可以提供在离子源中产生的一次离子和待分析样品气体的反应室，以便通过化学电离组分形成产物离子 在样品气体中，以及用于确定不同类型离子的分析仪/检测器单元。 反应室中的反应空间被提供给反应室的初级离子和产生的产物离子被引导并且在面向离子源的第一端和面向分析器/检测器单元的第二端之间延伸的反应空间被 至少两个电极，其形式为螺旋形，其以相同的间距绕公共轴线旋转，并且在轴线方向上相对于彼此偏移。 AC电压被施加到每个电极。

公开(公告)号：US20160111269A1

公开(公告)日：2016-04-21

申请号：US14967699

申请日：2015-12-14

Applicant: Carl Zeiss Microscopy GmbH ,  Carl Zeiss SMT GmbH

Inventor： Gennady Fedosenko ,  Michel Aliman ,  Hin Yiu Anthony Chung ,  Albrecht Ranck ,  Leonid Gorkhover

IPC: H01J49/04 ,  H01J49/14 ,  H01J49/00

CPC classification number: H01J49/04 ,  H01J49/0027 ,  H01J49/105 ,  H01J49/14 ,  H01J49/145 ,  H01J49/147

Abstract: The disclosure relates to a mass spectrometer for mass spectrometric examination of gas mixtures, including: an ionization device and an ion trap for storage and mass spectrometric examination of the gas mixture. In one aspect of the disclosure, the ionization device is embodied for supplying ions and/or metastable particles of an ionization gas and/or for supplying electrons to the ion trap for ionizing the gas mixture to be examined and the mass spectrometer is embodied to determine the number of ions and/or metastable particles of the ionization gas present in the ion trap and/or the number of ions of a residual gas present in the ion trap prior to examining the gas mixture. The disclosure also relates to the use of such a mass spectrometer and a method for mass spectrometric examination of a gas mixture.

Abstract translation: 本公开涉及用于气体混合物质谱检测的质谱仪，包括：用于气体混合物的存储和质谱检查的离子阱和离子阱。 在本公开的一个方面，电离装置被实施用于提供电离气体的离子和/或亚稳颗粒和/或用于向离子阱提供电子以电离待检查的气体混合物，并且体现质谱仪以确定 存在于离子阱中的离子和/或亚稳颗粒的数量和/或在检查气体混合物之前存在于离子阱中的残留气体的离子数。 本公开还涉及使用这种质谱仪和气体混合物的质谱检测方法。

公开(公告)号：US09299551B2

公开(公告)日：2016-03-29

申请号：US14751809

申请日：2015-06-26

Applicant: LECO Corporation

Inventor： Anatoly N. Verenchikov ,  Anatoly Zamyatin

IPC: H01J49/00 ,  H01J49/10 ,  H01J49/14 ,  H01J49/24 ,  H01J27/02

CPC classification number: H01J49/107 ,  H01J27/022 ,  H01J49/10 ,  H01J49/145 ,  H01J49/24

Abstract: An ion detection system including an ion source and at least one ion detector is disclosed. The ion source includes a source housing, a reactor, first and second ionizers and a sampling channel. The first ionizer is a glow discharge ionizer. The ion detector communicates with the sampling channel. A conditioner, which is sized to remove fast diffusing electrons, connects the first glow discharge ionizer to the reactor. A corresponding method of ionization is also disclosed. The method includes ionizing and conditioning an ionizer gas, receiving the ionizer gas and analyte molecule ions into a reactor, and delivering a flow from the reactor. The conditioning of the ionizer gas removes fast diffusing electrons from the gas flow.

Abstract translation: 公开了一种包括离子源和至少一个离子检测器的离子检测系统。 离子源包括源壳体，反应器，第一和第二离子发生器以及采样通道。 第一台电离器是辉光放电电离器。 离子检测器与采样通道通信。 尺寸适于去除快速扩散电子的调理器将第一辉光放电电离器连接到反应器。 还公开了相应的电离方法。 该方法包括电离和调节电离器气体，将离子发生器气体和分析物分子离子接收到反应器中，并从反应器输送流。 电离器气体的调节从气流中去除快速扩散的电子。

公开(公告)号：US09240311B2

公开(公告)日：2016-01-19

申请号：US13487037

申请日：2012-06-01

Applicant: Craig M. Whitehouse ,  Thomas Dresch

Inventor： Craig M. Whitehouse ,  Thomas Dresch

IPC: H01J49/00 ,  H01J49/14 ,  H01J49/04 ,  H01J49/24

CPC classification number: H01J49/145 ,  H01J49/0413 ,  H01J49/0431 ,  H01J49/0459 ,  H01J49/24

Abstract: A Direct Sample Analysis (DSA) ion source system operating at essentially atmospheric pressure is configured to facilitate the ionization, or desorption and ionization, of sample species from a wide variety of gaseous, liquid, and/or solid samples, for chemical analysis by mass spectrometry or other gas phase ion detectors. The DSA system includes one or more means of ionizing samples and includes a sealed enclosure which provides protection from high voltages and hazardous vapors, and in which the local background gas environment may be monitored and well-controlled. The DSA system is configured to accommodate single or multiple samples at any one time, and provide external control of individual sample positioning, sample conditioning, sample heating, positional sensing, and temperature measurement.

Abstract translation: 以基本上大气压力运行的直接样品分析（DSA）离子源系统被配置为促进来自各种气态，液体和/或固体样品的样品物质的电离或解吸和电离，用于通过质量进行化学分析 光谱仪或其他气相离子检测器。 DSA系统包括一种或多种离子化样品的方法，并且包括密封的外壳，其提供对高电压和危险蒸汽的保护，并且其中可以监测和良好控制本地背景气体环境。 DSA系统配置为可以随时容纳单个或多个样品，并提供单独样品定位，样品调节，样品加热，位置检测和温度测量的外部控制。

公开(公告)号：US20150338384A1

公开(公告)日：2015-11-26

申请号：US14377259

申请日：2013-01-30

Applicant: Waters Technologies Corporation

Inventor： Douglas M. Stevens

IPC: G01N30/84 ,  H01J27/26

CPC classification number: G01N30/84 ,  G01N30/7206 ,  G01N2030/8447 ,  H01J27/26 ,  H01J49/0422 ,  H01J49/0468 ,  H01J49/145 ,  H01J49/165

Abstract: An apparatus for ionizing analyte molecules comprised in a flow of a first gas. The apparatus includes an inlet tube through which the first gas may be discharged into an ionization region. The apparatus also includes a nozzle electrode disposed around the inlet tube to define a substantially annular space between the exterior of the inlet tube and the interior of the nozzle electrode. The sheath tube includes an inlet for introducing a fluid into the substantially annular space and an outlet through which the fluid may be discharged into the ionization region. The apparatus is configured to ionize the analyte molecules optionally via electrospray or chemical ionization.

Abstract translation: 一种用于电离包含在第一气体流中的分析物分子的装置。 该装置包括入口管，第一气体可以通过该入口管排出到电离区域中。 该设备还包括设置在入口管周围的喷嘴电极，以在入口管的外部和喷嘴电极的内部之间限定基本上环形的空间。 护套管包括用于将流体引入大致环形空间的入口和流体可以通过该出口排入电离区域的出口。 该装置被配置为通过电喷雾或化学电离任选地离子化分析物分子。

公开(公告)号：US20150249000A1

公开(公告)日：2015-09-03

申请号：US14433177

申请日：2013-10-02

Applicant: IONICON ANALYTIK GESELLSCHAFT M.B.H

Inventor： Philipp Sulzer ,  Alfons Jordan ,  Tilmann Mark ,  Lukas Mark

IPC: H01J49/00 ,  H01J49/14

CPC classification number: H01J49/0072 ,  H01J49/0031 ,  H01J49/145

Abstract: Instrument for analysing compounds, comprising an ion source, an adjacent drift tube and a mass spectrometer including an ion detector for separation and detection of product ions, wherein instrumental parameters of the instrument can be altered by actuating elements for actuating variables of at least one of the group consisting of ion source, adjacent drift tube, mass spectrometer and ion detector, characterized by a controlling unit which is connectable to a storage device, wherein the storage device comprises a specification for certain compounds, the specification for each compound comprising a set of data comprising at least two different instrumental parameters and corresponding intensity signals for product ions detected with the ion detector, wherein the controlling unit alters the actuating elements in accordance with the specification for each compound, wherein a correspondence signal is displayed on a display unit if the detected intensity signal for the product ion corresponds with the stored intensity signals.

Abstract translation: 用于分析化合物的仪器，包括离子源，相邻漂移管和质谱仪，所述质谱仪包括用于分离和检测产物离子的离子检测器，其中所述仪器的仪器参数可以通过用于致动元件的致动元件来改变， 由离子源，相邻漂移管，质谱仪和离子检测器组成的组，其特征在于可连接到存储装置的控制单元，其中存储装置包括某些化合物的规格，每种化合物的说明书包括一组 数据包括用离子检测器检测到的产物离子的至少两个不同的仪器参数和相应的强度信号，其中控制单元根据每个化合物的说明书来改变致动元件，其中在显示单元上显示对应信号，如果 检测产品离子对应的强度信号 存储强度信号。

公开(公告)号：US09097732B2

公开(公告)日：2015-08-04

申请号：US14464336

申请日：2014-08-20

Applicant: Quest Diagnostics Investments Incorporated

Inventor： Scott M. Goldman ,  Julie A. Neidich

IPC: G01N30/72 ,  G01N33/92 ,  H01J49/26 ,  G01N33/26 ,  H01J49/00 ,  H01J49/14 ,  H01J49/16

CPC classification number: G01N33/92 ,  G01N30/7266 ,  G01N33/26 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/145 ,  H01J49/165 ,  H01J49/168 ,  Y10T436/104165 ,  Y10T436/24 ,  Y10T436/25 ,  Y10T436/25125 ,  Y10T436/25375 ,  Y10T436/255

Abstract: The invention relates to the detection of DHA and EPA. In a particular aspect, the invention relates to methods for detecting DHA and EPA by mass spectrometry and kits for carrying out such methods.

Abstract translation: 本发明涉及DHA和EPA的检测。 在一个特定方面，本发明涉及通过质谱法检测DHA和EPA的方法以及用于进行这些方法的试剂盒。

公开(公告)号：US09070542B2

公开(公告)日：2015-06-30

申请号：US13858417

申请日：2013-04-08

Applicant: Implant Sciences Corporation

Inventor： Dmitriy V. Ivashin ,  Said Boumsellek

IPC: H01J49/10 ,  G01N27/64 ,  G01N27/62 ,  H01J49/14

CPC classification number: H01J49/105 ,  G01N27/624 ,  G01N27/64 ,  H01J49/145

Abstract: Selective ionization at atmospheric or near atmospheric pressure of a sample diluted in air is provided in multiple steps. Initially, components of air and/or other gas are ionized to generate reactive ions. The reactive ions are then filtered using a high frequency filter to yield selected reactive ions. Thereafter, the selected reactive ions are reacted with sample molecules of a sample being analyzed in a charge transfer process. Depending on the properties of the sample molecules, the filter may select some reactive ions to enter the sample zone and block others entirely thus controlling ion chemistry and charge transfer yields in the sample zone. The described system is directed to controlling ions at the ion source level, using a high frequency filter technique, in connection with subsequent analysis. The method generates the ions of choice for subsequent analysis in such platforms as ion mobility and differential mobility spectrometers.

Abstract translation: 在空气中稀释的样品的大气压或接近大气压下的选择性电离分几步提供。 最初，将空气和/或其它气体的组分电离以产生活性离子。 然后使用高频滤波器过滤反应离子以产生选定的反应离子。 此后，所选择的反应离子与电荷转移过程中正在分析的样品的样品分子反应。 取决于样品分子的性质，过滤器可以选择一些反应性离子进入样品区域并完全阻断其他离子，从而控制样品区域中的离子化学和电荷转移产率。 所描述的系统涉及使用高频滤波器技术结合后续分析来控制离子源水平的离子。 该方法产生离子，用于离子迁移率和差分迁移率光谱仪等平台中的后续分析。

公开(公告)号：US20150097114A1

公开(公告)日：2015-04-09

申请号：US14401300

申请日：2013-05-16

Applicant: Micromass UK Limited

Inventor： Martin Raymond Green ,  Jeffery Mark Brown

IPC: H01J49/42 ,  H01J49/10 ,  H01J49/24 ,  H01J49/00

CPC classification number: H01J49/422 ,  H01J49/0059 ,  H01J49/062 ,  H01J49/10 ,  H01J49/145 ,  H01J49/162 ,  H01J49/24

Abstract: A mass spectrometer is disclosed comprising an RF ion guide or ion trap and a device arranged and adapted to supply a reagent gas within the RF ion guide or ion trap. The mass spectrometer further comprises a photo-ionisation device and a control system arranged and adapted: (i) to cause first ions to fragment or dissociate within the RF ion guide or ion trap to form second ions and neutral molecules; and (ii) to cause the photo-ionisation device to photo-ionise and/or photo-excite the reagent gas to form reagent ions, excited species or radical species. The reagent ions, excited species or radical species interact with at least some of the neutral molecules located within the RF ion guide or ion trap to form analyte ions.

Abstract translation: 公开了一种质谱仪，其包括RF离子导向器或离子阱，以及布置并适于在RF离子导向器或离子阱内提供反应气体的装置。 质谱仪还包括光电离装置和控制系统，其布置和适应：（i）使第一离子在RF离子导向器或离子阱内分裂或解离以形成第二离子和中性分子; 和（ii）使光电离装置光电离和/或光激发反应气体以形成试剂离子，激发的物质或自由基物质。 试剂离子，激发的物质或自由基物质与位于RF离子导向器或离子阱内的至少一些中性分子相互作用以形成分析物离子。