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公开(公告)号：US10345264B2
公开(公告)日：2019-07-09
申请号：US15569822
申请日：2016-04-28
发明人： Jan Hendrikse , Vladimir Romanov , Udo Verkerk , Alan Hopkinson
摘要： The present disclosure relates to an ion exchange process, as well as a process and system for detecting nitrates, which employ a class of dopants comprising at least two functional groups capable of simultaneous convergent hydrogen bonding with a nitrate ion. In an aspect, the present disclosure provides an ion exchange process for forming a negatively charged nitrate-dopant ion analyte for analysis by a spectrometry analysis instrument, comprising: providing a gas comprising a dopant in both neutral and ionized forms; contacting a nitrate-containing sample with the gas comprising the dopant and thereby desorbing a nitrate ion from the sample to form a negatively charged nitrate-dopant ion analyte and replacing the desorbed nitrate ion with a negatively charged ionized dopant molecule; wherein the dopant is an organic compound comprising two or more carbon atoms and two or more functional groups capable of simultaneous convergent hydrogen bonding with a nitrate ion; or the dopant is an organic compound comprising at least two carbon atoms and only a single functional group capable of hydrogen bonding with a nitrate ion, which group is a —COOH functional group, and where the carbon atom of the —COOH functional group is bonded directly to another carbonyl group; and with the proviso that the dopant is not lactic acid, a lactic acid salt or a compound that forms lactate ions upon ionization.
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公开(公告)号：US20170365455A1
公开(公告)日：2017-12-21
申请号：US15634151
申请日：2017-06-27
发明人： Jan Hendrikse , Vladimir Romanov
CPC分类号： H01J49/168 , G01N33/0057 , H01J49/0004 , H01J49/0022 , H01J49/0036 , H01J49/0404 , H01J49/145 , H01J49/24
摘要： A concentric APCI surface ionization probe, supersonic sampling tube, and method for use of the concentric APCI surface ionization probe and supersonic sampling tube are described. In an embodiment, the concentric APCI surface ionization probe includes an outer tube, an inner capillary, and a voltage source coupled to the outer tube and the inner capillary. The inner capillary is housed within and concentric with the outer tube such that ionized gas (e.g., air) travels out of the outer tube, reacts with a sample, and the resulting analyte ions are sucked into the inner capillary. A supersonic sampling tube can include a tube coupled to a mass spectrometer and/or concentric APCI surface ionization probe, where the tube includes at least one de Laval nozzle.
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公开(公告)号：US09728389B2
公开(公告)日：2017-08-08
申请号：US15036433
申请日：2014-11-14
发明人： Jan Hendrikse , Vladimir Romanov
CPC分类号： H01J49/168 , G01N33/0057 , H01J49/0004 , H01J49/0022 , H01J49/0036 , H01J49/0404 , H01J49/145 , H01J49/24
摘要： A concentric APCI surface ionization probe, supersonic sampling tube, and method for use of the concentric APCI surface ionization probe and supersonic sampling tube are described. In an embodiment, the concentric APCI surface ionization probe includes an outer tube, an inner capillary, and a voltage source coupled to the outer tube and the inner capillary. The inner capillary is housed within and concentric with the outer tube such that ionized gas (e.g., air) travels out of the outer tube, reacts with a sample, and the resulting analyte ions are sucked into the inner capillary. A supersonic sampling tube can include a tube coupled to a mass spectrometer and/or concentric APCI surface ionization probe, where the tube includes at least one de Laval nozzle.
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公开(公告)号：US20150371807A1
公开(公告)日：2015-12-24
申请号：US14764834
申请日：2014-01-30
发明人： Jan Hendrikse , Vladimir Romanov
CPC分类号： H01J27/26 , G01N27/64 , H01J49/142 , H01J49/16 , H01J49/26
摘要： A surface ionization source comprises a tube having a first end, a second end, and an interior bore extending through the tube from the first end to the second end. The first end of the tube is configured to receive a flow of gas and the second end of the tube is configured to direct the flow of gas onto a surface configured to hold an analyte. A radioactive source is at least substantially disposed in the interior bore of the tube. The radioactive source is configured to form ions in the flow of gas as the flow of gas passes through the interior bore. The flow of gas containing the ions is directed onto the analyte to at least partially ionize the analyte.
摘要翻译： 表面电离源包括具有第一端，第二端和从第一端到第二端延伸穿过管的内孔的管。 管的第一端被配置为接收气流，并且管的第二端被配置成将气流引导到构造成保持分析物的表面上。 放射源至少基本上设置在管的内孔中。 放射源被配置成随着气流通过内孔而在气流中形成离子。 含有离子的气体流被引导到被分析物上以至少部分地离子化分析物。
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公开(公告)号：US11959846B2
公开(公告)日：2024-04-16
申请号：US16806315
申请日：2020-03-02
发明人： Jan Hendrikse , Vladimir Romanov
CPC分类号： G01N1/44 , G01N1/02 , H01J49/142 , H01J49/16 , G01N2001/028
摘要： A method for providing in situ chemical transformation and ionization of a portion (e.g., inorganic oxidizer) of a sample via an analyte detection system is disclosed herein. The method includes introducing a gas into an ionization some of the analyte detection system via an inlet. The method further includes generating ions within the ionization source and directing the gas and generated ions through and out of the ionization source and to the sample. The sample is located proximal to the ionization source in an ambient environment. The ions chemically react with the sample and desorb and ionize an analytic from the sample, the analyte being generated from the inorganic oxidizer, the desorbed analyte having a lower melting point and/or better desorption kinetics than the inorganic oxidizer. The method further includes receiving the desorbed analyte via an analyzer of the analyte detection system.
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公开(公告)号：US20200271557A1
公开(公告)日：2020-08-27
申请号：US16806315
申请日：2020-03-02
发明人： Jan Hendrikse , Vladimir Romanov
摘要： A method for providing in situ chemical transformation and ionization of a portion (e.g., inorganic oxidizer) of a sample via an analyte detection system is disclosed herein. The method includes introducing a gas into an ionization some of the analyte detection system via an inlet. The method further includes generating ions within the ionization source and directing the gas and generated ions through and out of the ionization source and to the sample. The sample is located proximal to the ionization source in an ambient environment. The ions chemically react with the sample and desorb and ionize an analytic from the sample, the analyte being generated from the inorganic oxidizer, the desorbed analyte having a lower melting point and/or better desorption kinetics than the inorganic oxidizer. The method further includes receiving the desorbed analyte via an analyzer of the analyte detection system.
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公开(公告)号：US10578526B2
公开(公告)日：2020-03-03
申请号：US14907196
申请日：2014-07-24
发明人： Jan Hendrikse , Vladimir Romanov
摘要： A method for providing in situ chemical transformation and ionization of a portion (e.g., inorganic oxidizer) of a sample via an analyte detection system is disclosed herein. The method includes introducing a gas into an ionization source of the analyte detection system via an inlet. The method further includes generating ions within the ionization source and directing the gas and generated ions through and out of the ionization source and to the sample. The sample is located proximal to the ionization source in an ambient environment. The ions chemically react with the sample and desorb and ionize an analyte from the sample, the analyte being generated from the inorganic oxidizer, the desorbed analyte having a lower melting point and/or better desorption kinetics than the inorganic oxidizer. The method further includes receiving the desorbed analyte via an analyzer of the analyte detection system.
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公开(公告)号：US09972482B2
公开(公告)日：2018-05-15
申请号：US15634151
申请日：2017-06-27
发明人： Jan Hendrikse , Vladimir Romanov
CPC分类号： H01J49/168 , G01N33/0057 , H01J49/0004 , H01J49/0022 , H01J49/0036 , H01J49/0404 , H01J49/145 , H01J49/24
摘要： A concentric APCI surface ionization probe, supersonic sampling tube, and method for use of the concentric APCI surface ionization probe and supersonic sampling tube are described. In an embodiment, the concentric APCI surface ionization probe includes an outer tube, an inner capillary, and a voltage source coupled to the outer tube and the inner capillary. The inner capillary is housed within and concentric with the outer tube such that ionized gas (e.g., air) travels out of the outer tube, reacts with a sample, and the resulting analyte ions are sucked into the inner capillary. A supersonic sampling tube can include a tube coupled to a mass spectrometer and/or concentric APCI surface ionization probe, where the tube includes at least one de Laval nozzle.
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9.发明申请CONCENTRIC APCI SURFACE IONIZATION ION SOURCE, ION GUIDE, AND METHOD OF USE 审中-公开浓缩APCI表面离子离子源，离子指导和使用方法公开(公告)号：US20160268116A1
公开(公告)日：2016-09-15
申请号：US15036433
申请日：2014-11-14
发明人： Jan Hendrikse , Vladimir Romanov
CPC分类号： H01J49/168 , G01N33/0057 , H01J49/0004 , H01J49/0022 , H01J49/0036 , H01J49/0404 , H01J49/145 , H01J49/24
摘要： A concentric APCI surface ionization probe, supersonic sampling tube, and method for use of the concentric APCI surface ionization probe and supersonic sampling tube are described. In an embodiment, the concentric APCI surface ionization probe includes an outer tube, an inner capillary, and a voltage source coupled to the outer tube and the inner capillary. The inner capillary is housed within and concentric with the outer tube such that ionized gas (e.g., air) travels out of the outer tube, reacts with a sample, and the resulting analyte ions are sucked into the inner capillary. A supersonic sampling tube can include a tube coupled to a mass spectrometer and/or concentric APCI surface ionization probe, where the tube includes at least one de Laval nozzle.
摘要翻译： 描述了同心APCI表面电离探针，超音速采样管以及用于同心APCI表面电离探针和超音速采样管的方法。 在一个实施例中，同心APCI表面电离探针包括外管，内毛细管和耦合到外管和内毛细管的电压源。 内部毛细管被容纳在外管中并与外管同心，使得电离气体（例如空气）从外管行进，与样品反应，并将所得到的分析物离子吸入内毛细管。 超音速采样管可以包括耦合到质谱仪和/或同心APCI表面电离探针的管，其中管包括至少一个德拉瓦尔喷嘴。
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