公开(公告)号：US08598519B2

公开(公告)日：2013-12-03

申请号：US13164590

申请日：2011-06-20

Applicant: Craig M. Whitehouse ,  Thomas Dresch ,  Bruce Andrien

Inventor： Craig M. Whitehouse ,  Thomas Dresch ,  Bruce Andrien

IPC: B01D59/44

CPC classification number: B01D59/44 ,  H01J49/0481 ,  H01J49/063

Abstract: A method includes directing ions from an atmospheric pressure ion source to a first ion guide; directing ions in the first ion guide to a second ion guide, the second ion guide being a multipole ion guide extending along an axis; periodically directing ions along the axis; receiving at least some of the ions in a time-of-flight analyzer; accelerating the ions in the time-of-flight mass analyzer orthogonal to the axis; and detecting the accelerated ions.

Abstract translation: 一种方法包括将离子从大气压离子源引导到第一离子导向器; 将所述第一离子导向器中的离子引导到第二离子引导件，所述第二离子引导件是沿着轴线延伸的多极离子引导件; 沿着轴定期引导离子; 在飞行时间分析仪中接收至少一些离子; 加速与轴垂直的飞行时间质量分析仪中的离子; 并检测加速离子。

公开(公告)号：US07019285B2

公开(公告)日：2006-03-28

申请号：US09808468

申请日：2001-03-14

Applicant: Thomas Dresch ,  Erol E. Gulcicek ,  Craig M. Whitehouse

Inventor： Thomas Dresch ,  Erol E. Gulcicek ,  Craig M. Whitehouse

IPC: H01J49/40

CPC classification number: H01J49/401

Abstract: A method and an apparatus which combines at least one linear two dimensional ion guide or a two dimensional ion storage device in tandem with a time-of-flight mass analyzer to analyze ionic chemical species generated by an ion source. The method improves the duty cycle, and therefore, the overall instrument sensitivity with respect to the analyzed chemical species.

公开(公告)号：US6020586A

公开(公告)日：2000-02-01

申请号：US971521

申请日：1997-11-17

Applicant: Thomas Dresch ,  Erol E. Gulcicek ,  Craig Whitehouse

Inventor： Thomas Dresch ,  Erol E. Gulcicek ,  Craig Whitehouse

IPC: G01N27/62 ,  H01J49/04 ,  H01J49/06 ,  H01J49/40

CPC classification number: H01J49/401 ,  H01J49/004 ,  H01J49/063

Abstract: A method and an apparatus which combines at least one linear two dimensional ion guide or a two dimensional ion storage device in tandem with a time-of-flight mass analyzer to analyze ionic chemical species generated by an ion source. The method improves the duty cycle, and therefore, the overall instrument sensitivity with respect to the analyzed chemical species.

Abstract translation: 将至少一个线性二维离子导向器或二维离子存储装置与飞行时间质量分析器串联组合以分析由离子源产生的离子化学物质的方法和装置。 该方法提高了相对于分析的化学物质的占空比，因此提高了仪器的整体灵敏度。

公开(公告)号：US5869829A

公开(公告)日：1999-02-09

申请号：US887615

申请日：1997-07-03

Applicant: Thomas Dresch

Inventor： Thomas Dresch

IPC: B01D59/44 ,  H01J49/10 ,  H01J49/40 ,  H01J48/40

CPC classification number: H01J49/405 ,  H01J49/40 ,  H01J49/403

Abstract: A Time-of-Flight Mass Spectrometer (TOF-MS) is configured to improve resolution and sensitivity performance. The TOF-MS includes an arrangement of electrodes comprising an ion accelerator with two stages of homogeneous electric fields, an ion reflector with a single stage of a homogeneous electric field, accelerator and reflector being separated by a first drift space, and an ion detector which is separated from the reflector by a second drift space. Contrary to known TOF-MS of similar configuration, the set of electric potentials which must be applied to said electrodes is predetermined for a given geometry in such a way that a spatial distribution of ions initially at rest in the first gap of the said accelerator is compressed at the location of the detector in the longitudinal direction to a focus of first and second order in the initial axial coordinate. Therefore, mass resolution is enhanced over a TOF-MS that provides only for longitudinal focusing of first order, while the number of passages through grid electrodes along the flight path is reduced, and hence ion transmission and instrument sensitivity are improved.

公开(公告)号：US09240311B2

公开(公告)日：2016-01-19

申请号：US13487037

申请日：2012-06-01

Applicant: Craig M. Whitehouse ,  Thomas Dresch

Inventor： Craig M. Whitehouse ,  Thomas Dresch

IPC: H01J49/00 ,  H01J49/14 ,  H01J49/04 ,  H01J49/24

CPC classification number: H01J49/145 ,  H01J49/0413 ,  H01J49/0431 ,  H01J49/0459 ,  H01J49/24

Abstract: A Direct Sample Analysis (DSA) ion source system operating at essentially atmospheric pressure is configured to facilitate the ionization, or desorption and ionization, of sample species from a wide variety of gaseous, liquid, and/or solid samples, for chemical analysis by mass spectrometry or other gas phase ion detectors. The DSA system includes one or more means of ionizing samples and includes a sealed enclosure which provides protection from high voltages and hazardous vapors, and in which the local background gas environment may be monitored and well-controlled. The DSA system is configured to accommodate single or multiple samples at any one time, and provide external control of individual sample positioning, sample conditioning, sample heating, positional sensing, and temperature measurement.

Abstract translation: 以基本上大气压力运行的直接样品分析（DSA）离子源系统被配置为促进来自各种气态，液体和/或固体样品的样品物质的电离或解吸和电离，用于通过质量进行化学分析 光谱仪或其他气相离子检测器。 DSA系统包括一种或多种离子化样品的方法，并且包括密封的外壳，其提供对高电压和危险蒸汽的保护，并且其中可以监测和良好控制本地背景气体环境。 DSA系统配置为可以随时容纳单个或多个样品，并提供单独样品定位，样品调节，样品加热，位置检测和温度测量的外部控制。

公开(公告)号：US20110309244A1

公开(公告)日：2011-12-22

申请号：US13164617

申请日：2011-06-20

Applicant: Craig M. Whitehouse ,  Thomas Dresch ,  Bruce Andrien

Inventor： Craig M. Whitehouse ,  Thomas Dresch ,  Bruce Andrien

IPC: H01J49/40

CPC classification number: B01D59/44 ,  H01J49/004 ,  H01J49/063 ,  H01J49/401

Abstract: A Time-Of-Flight mass analyzer includes a multipole ion guide located in the ion flight path between the ion source and the flight tube of the Time-Of-Flight mass analyzer. In one preferred embodiment, a Time-Of-Flight (TOF) mass analyzer is configured such that a multipole ion guide is positioned in the ion path between the ion source and the ion pulsing region of the TOF mass analyzer. The multipole ion guide electronics and the ion guide entrance and exit electrostatic lenses are configured to enable the trapping or passing through of ions delivered from an atmospheric pressure ion source. The ion guide electronics can be set to select the mass to charge (m/z) range of ions which can be successfully transmitted or trapped in the ion guide. More than one set of m/z values can be selected using techniques such as notch filtering with resonant frequency ion ejection of unwanted m/z values. All or a portion of the ions with stable ion guide trajectories in transmission or trapping mode can then undergo Collisional Induced Dissociation (CID) using one of at least three techniques. During the ion fragmentation step the multipole ion guide AC and DC electric potentials are set to transmit or trap all or a portion of the fragment ions produced by the CID process. All or a portion of the parent and fragment ion population are delivered from the multipole ion guide to the pulsing region of Time-OF-Flight mass analyzer for mass analysis. After the first ion fragmentation step, the multipole ion guide AC and DC electric potentials can again be set to select a narrow m/z range to clear the ion guide in trapping mode of all but a selected set of fragment ions. The m/z selection and ion fragmentation step can be repeated a number of times with mass analysis occurring at the end of all the MS/MSn steps or at various times during the MS/MSn stepwise process. A technique is also described where the normally stepwise MS/MSn analysis function can be merged into a single step, increasing the effective duty cycle. The multipole ion guide used for ion transmission, trapping and fragmentation can reside in one vacuum pumping stage or can extend continuously into more than one vacuum pumping stage.

公开(公告)号：US20110303840A1

公开(公告)日：2011-12-15

申请号：US13164590

申请日：2011-06-20

Applicant: Craig M. Whitehouse ,  Thomas Dresch ,  Bruce Andrien

Inventor： Craig M. Whitehouse ,  Thomas Dresch ,  Bruce Andrien

IPC: H01J49/40

CPC classification number: B01D59/44 ,  H01J49/0481 ,  H01J49/063

Abstract: A method includes directing ions from an atmospheric pressure ion source to a first ion guide; directing ions in the first ion guide to a second ion guide, the second ion guide being a multipole ion guide extending along an axis; periodically directing ions along the axis; receiving at least some of the ions in a time-of-flight analyzer; accelerating the ions in the time-of-flight mass analyzer orthogonal to the axis; and detecting the accelerated ions.

Abstract translation: 一种方法包括将离子从大气压离子源引导到第一离子导向器; 将所述第一离子导向器中的离子引导到第二离子引导件，所述第二离子引导件是沿着轴线延伸的多极离子引导件; 沿着轴定期引导离子; 在飞行时间分析仪中接收至少一些离子; 加速与轴垂直的飞行时间质量分析仪中的离子; 并检测加速离子。

公开(公告)号：US08610056B2

公开(公告)日：2013-12-17

申请号：US13164617

申请日：2011-06-20

Applicant: Craig M. Whitehouse ,  Thomas Dresch ,  Bruce Andrien, Jr.

Inventor： Craig M. Whitehouse ,  Thomas Dresch ,  Bruce Andrien, Jr.

IPC: B01D59/44

CPC classification number: B01D59/44 ,  H01J49/004 ,  H01J49/063 ,  H01J49/401

Abstract: An apparatus includes an atmospheric pressure ion source; a first vacuum stage and a second vacuum stage separated from the first vacuum stage by a vacuum partition; a first ion guide positioned within a first vacuum stage and arranged to receive ions from the atmospheric pressure ion source; a second ion guide positioned within a second vacuum stage downstream of the first vacuum stage from the atmospheric pressure ion source, the second ion guide being a multipole ion guide arranged to receive ions from the first ion guide; and a time-of-flight mass analyzer that includes an orthogonal pulsing region arranged to receive ions from the second ion guide.

Abstract translation: 一种装置包括大气压离子源; 通过真空隔板与第一真空级分离的第一真空级和第二真空级; 位于第一真空级内并被布置成接收来自大气压离子源的离子的​​第一离子引导件; 位于第一真空级下游的第二真空级的第二离子导向器，其位于大气压离子源的下游，所述第二离子导向器是布置成接收来自第一离子导向器的离子的多极离子导向器; 以及飞行时间质量分析器，其包括布置成接收来自第二离子导向器的离子的正交脉冲区域。

公开(公告)号：US5847385A

公开(公告)日：1998-12-08

申请号：US880060

申请日：1997-06-20

Applicant: Thomas Dresch

Inventor： Thomas Dresch

IPC: H01J49/06 ,  H01J49/40 ,  H01J49/00

CPC classification number: H01J49/067 ,  H01J49/025 ,  H01J49/061 ,  H01J49/40

Abstract: Electrostatic deflectors are used in a time of flight mass spectrometer to steer ions into a detector positioned at a convenient location at the end of a drift region and where the detector assembly is tilted in relation with the steered ion beam in a manner which improves mass spectral resolution.

Abstract translation: 静电偏转器用于飞行时间质谱仪，以将离子转移到位于漂移区域末端的方便位置处的检测器中，并且检测器组件相对于转向离子束以改善质谱的方式倾斜 解析度。

公开(公告)号：US5689111A

公开(公告)日：1997-11-18

申请号：US689459

申请日：1996-08-09

Applicant: Thomas Dresch ,  Erol E. Gulcicek ,  Craig Whitehouse

Inventor： Thomas Dresch ,  Erol E. Gulcicek ,  Craig Whitehouse

IPC: G01N27/62 ,  H01J49/04 ,  H01J49/06 ,  H01J49/40

CPC classification number: H01J49/401 ,  H01J49/004 ,  H01J49/063

Abstract: A method and an apparatus which combines a linear two dimensional ion guide or a two dimensional ion storage device in tandem with a time-of-flight mass analyzer to analyze ionic chemical species generated by an ion source. The method improves the duty cycle, and therefore, the overall instrument sensitivity with respect to the analyzed chemical species.

Abstract translation: 一种将线性二维离子导向器或二维离子存储装置与飞行时间质量分析仪串联组合以分析由离子源产生的离子化学物质的方法和装置。 该方法提高了相对于分析的化学物质的占空比，因此提高了仪器的整体灵敏度。