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    USE OF A NEUROFILAMENT PEPTIDE FOR THE TREATMENT OF GLIOMA
    81.
    发明申请
    USE OF A NEUROFILAMENT PEPTIDE FOR THE TREATMENT OF GLIOMA 有权
    使用神经纤维肽治疗谷氨酸

    公开(公告)号：US20130004429A1

    公开(公告)日：2013-01-03

    申请号：US13514884

    申请日：2010-12-14

    Applicant: Joël Eyer ,  Alan Peterson ,  Julien Balzeau ,  Raphaël Berges

    Inventor： Joël Eyer ,  Alan Peterson ,  Julien Balzeau ,  Raphaël Berges

    IPC: A61K49/00 ,  G01N33/574 ,  G01N21/64 ,  A61K38/16 ,  A61P35/00

    CPC classification number: A61K38/16 ,  A61K49/0039 ,  A61K49/0056

    Abstract: The present invention provides a new drug to treat malignant glioma, which is the most prevalent type of primary tumor of the central nervous system (CNS). The present invention indeed shows that the isolated NFL-TBS40-63 peptide is highly specific for glioma cells, in which it triggers apoptosis. It is therefore presented here for use in a method for treating malignant glioma. The present invention further relates to the use of the NFL-TBS40-63 peptide for detecting specifically glioma cells either in vivo, or in vitro, or for addressing chemical compounds to said tumor cells.

    Abstract translation: 本发明提供了一种治疗恶性胶质瘤的新药，它是中枢神经系统（CNS）中最普遍的原发性肿瘤。 本发明确实表明，分离的NFL-TBS40-63肽对于神经胶质瘤细胞是高度特异性的，其中它触发凋亡。 因此，这里用于治疗恶性胶质瘤的方法。 本发明还涉及NFL-TBS40-63肽在体内或体外特异性检测神经胶质瘤细胞或用于将化学化合物用于所述肿瘤细胞的用途。

    Matriptase, a serine protease and its applications
    85.
    发明授权
    Matriptase, a serine protease and its applications 有权
    Matriptase，丝氨酸蛋白酶及其应用

    公开(公告)号：US07960163B2

    公开(公告)日：2011-06-14

    申请号：US12040467

    申请日：2008-02-29

    Applicant: Robert B. Dickson ,  Chen-Yong Lin ,  Michael Johnson ,  Shaomeng Wang ,  Istvan Enyedy

    Inventor： Robert B. Dickson ,  Chen-Yong Lin ,  Michael Johnson ,  Shaomeng Wang ,  Istvan Enyedy

    IPC: C12N9/00 ,  C12N9/50 ,  C12N1/20 ,  C12N15/00 ,  C07H21/04

    CPC classification number: A61K49/0039 ,  A61K38/00 ,  A61K49/0056 ,  A61K49/0058 ,  A61K51/10 ,  C12Q1/37 ,  G01N33/573 ,  G01N2333/96433 ,  G01N2500/20

    Abstract: The invention is directed to a method of detecting a malignancy or a pre-malignant lesion in breast or other tissue, or a pathologic condition, by detecting the presence of single-chain or two-chain forms of matriptase in the tissue. The invention is further directed to a method of treating malignancies, which have the phenotype of matriptase production by administering a tumor formation inhibiting effective amount of concentrate of Bowman-Birk inhibitor (BBIC), or other matriptase inhibitor. The invention also is directed to nucleic acids encoding a matriptase protein or fragments thereof, and their use for structure elucidation and modeling to identify other inhibitors of matriptase, as well as to methods of identifying matriptase modulating agents, including activators and inhibitors.

    Abstract translation: 本发明涉及通过检测组织中单链或双链形式的matriptase的存在来检测乳腺或其他组织或病理状况中的恶性肿瘤或恶性前病变的方法。 本发明进一步涉及通过施用抑制有效量的Bowman-Birk抑制剂（BBIC）浓缩物或其它片剂酶抑制剂的肿瘤形成来治疗恶性肿瘤的方法，所述恶性肿瘤具有基质酶产生的表型。 本发明还涉及编码matriptase蛋白质或其片段的核酸，以及其用于结构阐明和建模以鉴定其它抑制剂的用途，以及鉴定片段酶调节剂（包括活化剂和抑制剂）的方法。

    Matriptase, a serine protease and its applications
    86.
    发明授权
    Matriptase, a serine protease and its applications 有权
    Matriptase，丝氨酸蛋白酶及其应用

    公开(公告)号：US07355015B1

    公开(公告)日：2008-04-08

    申请号：US09936333

    申请日：2000-03-10

    Applicant: Robert B. Dickson ,  Chen-Yong Lin ,  Michael Johnson ,  Shaomeng Wang ,  Istvan Enyedy

    Inventor： Robert B. Dickson ,  Chen-Yong Lin ,  Michael Johnson ,  Shaomeng Wang ,  Istvan Enyedy

    IPC: C07K16/00 ,  C07K16/40 ,  A61K38/43

    CPC classification number: A61K49/0039 ,  A61K38/00 ,  A61K49/0056 ,  A61K49/0058 ,  A61K51/10 ,  C12Q1/37 ,  G01N33/573 ,  G01N2333/96433 ,  G01N2500/20

    Abstract: The invention is directed to a method of detecting a malignancy or a pre-malignant lesion in breast or other tissue, or a pathologic condition, by detecting the presence of single-chain or two-chain forms of matriptase in the tissue. The invention is further directed to a method of treating malignancies, which have the phenotype of matriptase production by administering a tumor formation inhibiting effective amount of concentrate of Bowman-Birk inhibitor (BBIC), or other matriptase inhibitor. The invention also is directed to nucleic acids encoding a matriptase protein or fragments thereof, and their use for structure elucidation and modeling to identify other inhibitors of matriptase, as well as to methods of identifying matriptase modulating agents, including activators and inhibitors.

    Abstract translation: 本发明涉及通过检测组织中单链或双链形式的matriptase的存在来检测乳腺或其他组织或病理状况中的恶性肿瘤或恶性前病变的方法。 本发明进一步涉及通过施用抑制有效量的Bowman-Birk抑制剂（BBIC）浓缩物或其它片剂酶抑制剂的肿瘤形成来治疗恶性肿瘤的方法，所述恶性肿瘤具有基质酶产生的表型。 本发明还涉及编码matriptase蛋白质或其片段的核酸，以及其用于结构阐明和建模以鉴定其它抑制剂的用途，以及鉴定片段酶调节剂（包括活化剂和抑制剂）的方法。

    Method for detecting chitin-containing organisms
    90.
    发明授权
    Method for detecting chitin-containing organisms 有权
    检测含几丁质的生物体的方法

    公开(公告)号：US06875421B2

    公开(公告)日：2005-04-05

    申请号：US10200984

    申请日：2002-07-22

    Applicant: Edward R. Burns ,  Murray Wittner ,  Fagie Faskowitz

    Inventor： Edward R. Burns ,  Murray Wittner ,  Fagie Faskowitz

    IPC: A61K49/00 ,  C12Q1/04 ,  G01N33/52 ,  A61B10/00 ,  A61B5/00 ,  A61B8/00

    CPC classification number: A61K49/0021 ,  A61K49/0039 ,  C12Q1/04 ,  G01N33/52

    Abstract: The present invention provides a method for detecting chitin-containing organisms on an area of a person or animal by contacting the particular area with a dye that is capable of binding or conjugating to chitin and emitting fluorescence upon exposure to light. If a chitin-containing organism is present in the treated area, the chitin of the organism will bind or conjugate the dye and, upon exposure to light, the chitin-containing organisms may be visualized and removed. Also provided by the present invention are solutions and suspensions that contain a dye capable of binding or conjugating to a chitin-containing organism and emitting fluorescence upon exposure to light. The solutions and suspensions provided herein may be in the form of a shampoo, cream, lotion or detergent for the detection of chitin-containing organisms present in body hair, on the skin, clothing or the fur of animals. The solutions and suspensions may also be in a form suitable for spraying on clothes, as well as on the hair, skin and fur. Further provided by the present invention are kits comprising a solution or suspension that contains a dye capable of binding or conjugating to a chitin-containing organism and a source of light that emits a wavelength capable of exciting fluorescence from the chitin-bound or chitin-conjugated dye.

    Abstract translation: 本发明提供了一种用于通过使特定区域与能够结合或缀合于甲壳素并在暴露于光时发射荧光的染料接触来检测人或动物区域上的含几丁质的生物体的方法。 如果在处理区域中存在含几丁质的生物体，则生物体的几丁质将结合或缀合染料，并且在暴露于光下时，可以可视化和去除含几丁质的生物体。 本发明还提供了包含能够结合或缀合到含几丁质的生物体并在暴露于光时发射荧光的染料的溶液和悬浮液。 本文提供的溶液和悬浮液可以是洗发剂，霜剂，洗剂或洗涤剂的形式，用于检测身体毛发，皮肤，衣物或动物毛皮中存在的含甲壳虫的生物体。 溶液和悬浮液也可以是适于喷洒在衣服上以及在头发，皮肤和毛皮上的形式。 本发明进一步提供的是包含溶液或悬浮液的试剂盒，该溶液或悬浮液含有能够结合或缀合到含几丁质的生物体的染料和发出可从几丁质结合或几丁质结合的荧光的波长的光源 染料。

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