公开(公告)号：US6061925A

公开(公告)日：2000-05-16

申请号：US134816

申请日：1998-08-17

申请人： Takuya Amano ,  Akira Kondo ,  Ken Takizawa

发明人： Takuya Amano ,  Akira Kondo ,  Ken Takizawa

IPC分类号： F27B7/20 ,  F26B11/04 ,  F27B7/08 ,  F27B7/16 ,  F27B7/42 ,  F27D21/00 ,  F26B11/02

CPC分类号： F27B7/2016 ,  F26B11/0445 ,  F26B11/0481 ,  F27B7/08 ,  F27B7/42 ,  F27D21/0014 ,  F27B2007/165

摘要： An object of the invention is to provide a rotary type heat treatment device wherein, when a material to be sintered is continuously and stably sintered in a container, the material in the container is stably detected for a long period of time, and a temperature control method for the device. In order to perform temperature control with high accuracy, the inside of a container 6 is divided with screws 18 into temperatures control regions (1) through (6). Heat-resisting protective tubes 20, which are provided on the inner cylindrical wall of the container in such a manner that they are juxtaposed, and complementary thermocouples, are extended to the respective temperature control regions and are bent laterally. The temperature detecting sections 25 of the thermocouples that are led out of the protective pipes 20 are covered with heat-resisting material, and transmit electrical signals outside through a current collecting section consisting of a slip ring and brushes. The shift in temperature measuring position of the thermocouples is positively prevented. In addition, the thermocouples are prevented from being damaged; that is, they are prevented from being brought into contact with the inner cylindrical wall of the container. With the device, the sintering operation can be continuously and stably carried out for a long period of time.

摘要翻译： 本发明的目的是提供一种旋转式热处理装置，其中，当待烧结材料在容器中连续稳定地烧结时，长时间稳定地检测出容器中的材料，并进行温度控制 设备方法 为了以高精度进行温度控制，将容器6的内部用螺钉18分割成温度控制区域（1）〜（6）。 以与它们并列的方式设置在容器的内圆筒壁上的耐热保护管20和互补的热电偶被延伸到相应的温度控制区域并且被横向弯曲。 从保护管20引出的热电偶的温度检测部25被耐热材料覆盖，并且通过由滑环和刷子组成的集电部分将电信号传输到外部。 热电偶温度测量位置的变化被积极地防止。 此外，防止热电偶受损; 也就是说，防止与容器的内圆筒壁接触。 利用该装置，可以长时间连续稳定地进行烧结操作。

公开(公告)号：US5880258A

公开(公告)日：1999-03-09

申请号：US909735

申请日：1997-08-12

申请人： Ryo Muramatsu ,  Akiko Sukesada ,  Satoru Misawa ,  Eriko Nukui ,  Koichi Wada ,  Masaharu Nakano ,  Tadanori Morikawa ,  Kyoichi Kobashi

发明人： Ryo Muramatsu ,  Akiko Sukesada ,  Satoru Misawa ,  Eriko Nukui ,  Koichi Wada ,  Masaharu Nakano ,  Tadanori Morikawa ,  Kyoichi Kobashi

IPC分类号： A61K38/00 ,  C07K14/815 ,  C07K14/00

CPC分类号： C07K14/815 ,  A61K38/00

摘要： The present invention relates to hirudin variants having high anti-thrombin and anti-platelet activity, methods for producing them, and anti-coagulants having said variants as active ingredients.Hirudin variants shown in formula (I) having tyrosine residues or having their hydroxyl group sulfated.Methods for producing hirudin variants by sulfating hydroxyl group of said tyrosine residues, and anti-coagulants having hirudin variants shown in formula (I) as active ingredients.Phe-Glu-A-Ile-Pro-D-Tyr(R) Tyr(R) (I)�In the formula, A represents Glu or Pro, R represents Glu, Tyr (R), Glu-Asp or Glu-Tyr(R), and (R) represents the hydroxy group or its sulfated ester (--O--SO.sub.3 H) of tyrosine residue.!

摘要翻译： 本发明涉及具有高抗凝血酶和抗血小板活性的水蛭素变体，其制备方法和具有所述变体作为活性成分的抗凝血剂。 具有酪氨酸残基或其羟基硫酸化的式（I）所示的水蛭素变体。 通过硫酸化所述酪氨酸残基的羟基来生产水蛭变异体的方法和具有式（I）所示的水蛭素变体的抗凝血剂作为活性成分。Phe-Glu-A-Ile-Pro-D-Tyr（R）Tyr ）（I）[式中，A表示Glu或Pro，R表示Glu，Tyr（R），Glu-Asp或Glu-Tyr（R），（R）表示羟基或其硫酸酯 -SO3H）酪氨酸残基。

公开(公告)号：US5821247A

公开(公告)日：1998-10-13

申请号：US933208

申请日：1997-09-16

申请人： Yoshiaki Isobe ,  Yuso Goto ,  Masanori Tobe ,  Osamu Takahashi

发明人： Yoshiaki Isobe ,  Yuso Goto ,  Masanori Tobe ,  Osamu Takahashi

IPC分类号： C07D239/54 ,  C07D239/545 ,  C07D405/12 ,  A61K31/51

CPC分类号： C07D239/545 ,  C07D405/12

摘要： Disclosed is a hydroquinone derivative or a pharmaceutically acceptable salt thereof, the hydroquinone derivative being represented by formula (I): ##STR1## wherein R.sup.1 is a phenyl group which is unsubstituted or substituted with a substituent or substituents each independently selected from the group consisting of a halogen atom, a C1-4 alkyl group and a C1-4 alkoxy group; R.sup.2 is a hydrogen atom or a C1-4 alkyl group; each of R.sup.3 and R.sup.4 is independently a hydrogen atom or a C1-4 alkyl group; R.sup.5 is a hydrogen atom or a C1-4 alkyl group; each of R.sup.6, R.sup.7 and R.sup.8 is independently a hydrogen atom or a C1-4 alkyl group; P is a hydroxyl group; Q is a hydroxyl group, a C1-4 alkoxy group, a C1-18 acyloxy group or an oxo group; P may form together with Q an ether bond; R is a hydroxyl group, a C1-4 alkoxy group, a C1-18 acyloxy group or an oxo group, provided that when one of said Q and said R is an oxo group, the other is also an oxo group; X is a single bond, an --NR.sup.10 --group or a --CH.sub.2 --NR.sup.10 --group in which R.sup.10 is a hydrogen atom or a C1-4 alkyl group; Y is a methylene group or a carbonyl group; and dotted bonds in a six membered ring represent that said six membered ring has the maximum number of double bonds.

摘要翻译： 公开了氢醌衍生物或其药学上可接受的盐，所述对苯二酚衍生物由式（I）表示：未取代的或被各自独立地选自卤素原子，C 1-4烷基的取代基或取代基取代 和C 1-4烷氧基; R2是氢原子或C1-4烷基; R 3和R 4各自独立地为氢原子或C 1-4烷基; R5是氢原子或C1-4烷基; R6，R7和R8各自独立地为氢原子或C1-4烷基; P是羟基; Q是羟基，C 1-4烷氧基，C 1-18酰氧基或氧代基; P可与Q形成醚键; R是羟基，C 1-4烷氧基，C 1-18酰氧基或氧代基，条件是当所述Q和所述R中的一个是氧代基时，另一个也是氧代基; X是单键，-NR 10 - 基或-CH 2 -NR 10 - 基，其中R 10是氢原子或C 1-4烷基; Y是亚甲基或羰基; 六元环中的点状键表示所述六元环具有最大数量的双键。

公开(公告)号：US5716450A

公开(公告)日：1998-02-10

申请号：US557095

申请日：1995-12-06

申请人： Seiji Togawa ,  Hitoshi Okazaki

发明人： Seiji Togawa ,  Hitoshi Okazaki

IPC分类号： C30B23/02 ,  C30B25/02 ,  H01L21/20 ,  H01L33/16 ,  H01L33/32 ,  C30B23/00

CPC分类号： C30B23/02 ,  C30B25/02 ,  C30B29/403 ,  C30B29/406 ,  H01L21/0242 ,  H01L21/02433 ,  H01L21/0254 ,  H01L21/0262 ,  H01L33/007 ,  Y10S117/902

摘要： In a method of growing a gallium nitride related compound semiconductor crystal on a single crystal substrate, the {011} plane or the {101} plane of rare earth group 13 (3B) perovskite is used as the single crystal substrate. As a result, a gallium nitride group semiconductor crystal excellent in crystallinity can be grown epitaxially.

摘要翻译： PCT No.PCT / JP95 / 00654 Sec。 371 1995年12月6日第 102（e）日期1995年12月6日PCT 1995年4月5日提交PCT公布。 出版物WO95 / 27815 日期：1995年10月19日在单晶衬底上生长氮化镓相关化合物半导体晶体的方法中，使用稀土族13（3B）钙钛矿的{011}面或{101}面作为单晶衬底 。 结果，可以外延生长结晶性优异的氮化镓族半导体结晶。

公开(公告)号：US5585684A

公开(公告)日：1996-12-17

申请号：US567805

申请日：1995-12-06

申请人： Hidenori Abe

发明人： Hidenori Abe

IPC分类号： H03H9/00 ,  H03H9/02 ,  H03H9/145 ,  H03H9/64 ,  H01L41/08

CPC分类号： H03H9/02543 ,  H03H9/1455 ,  H03H9/6426

摘要： A surface acoustic wave device comprises, on a lithium tetraborate substrate 10, a central interdigital transducer 21, 31, and first and second interdigital transducers 22, 23, 32, 33 disposed adjacently on both sides of the central interdigital transducer 21, 31 in a propagation direction of surface acoustic waves, or comprises a first such row of transducers 20 and a second such row of transducers 30 connected in cascade to each other. A sum Nc+Ns of a number of the central interdigital transducer pairs Nc, and a total number of the first and second interdigital transducers pairs Ns is set at a suitable range. The surface acoustic wave device has flat group delay times, relatively wide specific band widths, small insertion losses and large attenuation outside the pass band.

摘要翻译： 表面声波装置在四硼酸锂基板10上包括中央叉指式换能器21,31以及相邻设置在中央叉指式换能器21,31的两侧上的第一和第二叉指式换能器22,23,32,33， 表面声波的传播方向，或者包括彼此级联连接的第一这样的换能器行20和第二排换能器30。 多个中央叉指式换能器对Nc的总和Nc + Ns以及第一和第二指数间换能器对Ns的总数被设定在合适的范围。 声表面波器件具有平坦的延迟时间，相对宽的特定带宽，小的插入损耗和通带外的大的衰减。

公开(公告)号：US5573929A

公开(公告)日：1996-11-12

申请号：US348972

申请日：1994-11-28

申请人： Satoru Misawa ,  Hitoshi Matsuda ,  Yoshifumi Inoue ,  Hideyuki Furuya

发明人： Satoru Misawa ,  Hitoshi Matsuda ,  Yoshifumi Inoue ,  Hideyuki Furuya

IPC分类号： A61K38/00 ,  C07K14/815 ,  C12N1/21 ,  C12N9/16 ,  C12N15/10 ,  C12N15/12 ,  C12N15/15 ,  C12N15/55 ,  C12N15/62 ,  C12N15/70 ,  C12P21/06 ,  C12N1/20 ,  C12N15/63

CPC分类号： C07K14/815 ,  C12N15/10 ,  C12N9/16 ,  A61K38/00 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/036 ,  C07K2319/33

摘要： Provided is a chimeric HV1/HV3 hirudin analog useful as an anti-coagulant, exhibiting higher anti-thrombin activity and less tendency to cause bleeding than hirudin HV1. Also provided are a method of producing hirudins and hirudin analogs, as well as other proteins, employing secretion vectors, and transformed microorganisms such as E. coli. Pharmaceutical compositions comprising various hirudins or the chimeric HV1/HV3 hirudin analog of the present invention and a pharmaceutically acceptable carrier are also disclosed.

摘要翻译： 提供了一种嵌合型HV1 / HV3水蛭素类似物，可用作抗凝血剂，与水蛭素HV1相比表现出更高的抗凝血酶活性和较少的引起出血的倾向。 还提供了生产水蛭素和水蛭素类似物的方法，以及使用分泌载体和转化的微生物如大肠杆菌的其它蛋白质的方法。 还公开了包含本发明的各种水蛭素或嵌合HV1 / HV3水蛭素类似物的药物组合物和药学上可接受的载体。

公开(公告)号：US5560854A

公开(公告)日：1996-10-01

申请号：US470019

申请日：1995-06-06

申请人： Takashi Kaimai ,  Hiroki Tawaki ,  Sumio Yokoo

发明人： Takashi Kaimai ,  Hiroki Tawaki ,  Sumio Yokoo

IPC分类号： C10M169/04 ,  C09K5/04 ,  C10M171/00 ,  C10N30/06 ,  C10N40/30 ,  C10M105/08 ,  C10M133/38

CPC分类号： C09K5/041 ,  C09K5/045 ,  C10M169/04 ,  C10M171/008 ,  C09K2205/132 ,  C09K2205/24 ,  C10M2207/281 ,  C10M2207/282 ,  C10M2207/2825 ,  C10M2207/283 ,  C10M2207/2835 ,  C10M2207/2855 ,  C10M2207/286 ,  C10M2209/1033 ,  C10M2209/1045 ,  C10M2209/105 ,  C10M2209/1055 ,  C10M2209/1065 ,  C10M2209/107 ,  C10M2209/1075 ,  C10M2209/1085 ,  C10M2209/1095 ,  C10M2215/22 ,  C10M2215/221 ,  C10M2215/223 ,  C10M2215/225 ,  C10M2215/226 ,  C10M2215/30 ,  C10N2240/00 ,  C10N2240/22 ,  C10N2240/30 ,  C10N2240/50 ,  C10N2240/52 ,  C10N2240/54 ,  C10N2240/56 ,  C10N2240/58 ,  C10N2240/60 ,  C10N2240/66

摘要： A working fluid composition for a compression type refrigerator, comprising:(A) a refrigerant composed of ammonia or at least one hydrofluorocarbon having the number of carbon being not more than 2 and containing no chlorine; and(B) a lubricant for the refrigerator, said lubricant comprising 100 parts by weight of a synthetic oil and 0.5 to 10.0 parts by weight of at least one benzotriazole derivative expressed by the following formula (I). ##STR1## in which R.sup.1 is hydrogen or an alkyl group having the number of carbons being 1-10, and R.sup.2 and R.sup.3 independently indicate an alkyl group having the number of carbons being 4-18.

摘要翻译： 一种用于压缩式冷冻机的工作流体组合物，包括：（A）由氨或至少一种碳数不超过2的不含氯的氢氟烃组成的制冷剂; 和（B）用于冰箱的润滑剂，所述润滑剂包含100重量份的合成油和0.5至10.0重量份的由下式（I）表示的至少一种苯并三唑衍生物。 （I）其中R1是氢或碳数为1-10的烷基，R2和R3独立地表示碳原子数为4-18的烷基。

公开(公告)号：US5536704A

公开(公告)日：1996-07-16

申请号：US240067

申请日：1994-05-09

申请人： Yasuji Yamada ,  Minoru Tagami ,  Masaru Nakamura ,  Hideki Sakai ,  Koichi Uehara ,  Yuh Shiohara ,  Shoji Tanaka

发明人： Yasuji Yamada ,  Minoru Tagami ,  Masaru Nakamura ,  Hideki Sakai ,  Koichi Uehara ,  Yuh Shiohara ,  Shoji Tanaka

IPC分类号： C01G1/00 ,  C30B15/00 ,  C30B29/22 ,  H01L39/02 ,  H01L39/24 ,  C30B19/02

CPC分类号： C30B29/225 ,  C30B15/00 ,  H01L39/2461 ,  Y10S505/729

摘要： A composite material comprising a bulky substrate of a Y-series 123 metal oxide crystal, and at least one layer provided on a surface of the substrate and formed of a crystal of a Y-series 123 metal oxide. The substrate may be produced by immersing a seed material in a liquid phase which comprises components constituting the metal oxide. The liquid phase contains a solid phase located at a position different from the position at which the seed material contacts the liquid phase. The solid phase provides the liquid phase with solutes which constitute the Y-series 123 metal oxide so that the solutes are transported to the position at which the seed material and the liquid phase contact, thereby permitting the Y-series 123 metal oxide to grow on the seed material as primary crystals and to obtain the bulky substrate. The layer of a Y-series 123 metal oxide may be formed on the substrate by a sputtering method, a vacuum deposition method, a laser abrasion method, a CVD method or a liquid phase epitaxy method.

摘要翻译： 一种复合材料，其特征在于，包括Y系123金属氧化物晶体的体积大的基板，以及设置在所述基板的表面上的由Y系123金属氧化物晶体形成的至少一层。 基材可以通过将种子材料浸入包含构成金属氧化物的组分的液相中来制备。 液相含有位于与种子材料接触液相的位置不同的位置的固相。 固相为构成Y系123金属氧化物的溶质提供液相，使得溶质被输送到种子材料和液相接触的位置，从而允许Y系列123金属氧化物生长 种子材料作为主要晶体并获得体积大的底物。 可以通过溅射法，真空沉积法，激光磨蚀法，CVD法或液相外延法在基板上形成Y系123金属氧化物层。

公开(公告)号：US5471938A

公开(公告)日：1995-12-05

申请号：US405980

申请日：1995-03-17

申请人： Masayuki Uchida ,  Kenji Kohiro ,  Osamu Oda

发明人： Masayuki Uchida ,  Kenji Kohiro ,  Osamu Oda

IPC分类号： C30B11/06 ,  C30B11/00 ,  C30B27/00 ,  H01L21/208 ,  C30B11/08

CPC分类号： C30B29/40 ,  C30B11/00 ,  Y10T117/1092

摘要： A process for growing a multielement compound single crystal, includes the steps of placing a crucible holding a raw multielement compound of a predetermined set of composition ratios Y in a vertical crystal growing furnace having a heater, melting the raw multielement compound held in the crucible with the heater to produce a melt of the raw multielement compound in the crucible, controlling the output of the heater to grow a multielement compound single crystal of a predetermined set of composition ratios X from the melt so that the melt is solidified successively upwards from part of the melt in contact with the bottom of the crucible, and feeding to the melt as a solute at least one element of the raw multielement compound from above the level of the melt in the crucible so as to maintain the predetermined set of composition ratios X of the solute during growth of the multielement compound single crystal. The process can keep constant the composition of the grown multielement compound single crystal. The process is applicable to the growth of multielement compound semiconductor single crystals and multielement compound oxide single crystals.

公开(公告)号：US5441628A

公开(公告)日：1995-08-15

申请号：US202173

申请日：1994-02-25

申请人： Hiroshi Tasaki ,  Eiji Nishimura

发明人： Hiroshi Tasaki ,  Eiji Nishimura

IPC分类号： B05D1/18 ,  C25D21/18

CPC分类号： C25D3/66 ,  C23C30/00 ,  C25D3/565

摘要： A Zn-Ni alloy having a high Ni content is used for supplying Ni.sup.2+ and Zn.sup.2+ ions into an acidic plating bath and for supplying Ni and Zn into a hot dip galvanizing bath. This alloy is characterized by being produced by using a flux consisting of a fused-salt former, which forms a salt having a melting temperature of 700.degree. C. or less, and Na.sub.2 B.sub.4 O.sub.7 and occasionaly additionally Na.sub.2 CO.sub.3. By using the inventive alloy, the bath can be quickly prepared, and Zn and Ni can be supplied to the bath without leaving the undissolved residue.

摘要翻译： 使用具有高Ni含量的Zn-Ni合金将Ni2 +和Zn2 +离子供应到酸性电镀浴中，并将Ni和Zn供应到热浸镀锌浴中。 该合金的特征在于使用由熔融盐形成剂形成的助熔剂，其形成熔融温度为700℃以下的盐和Na 2 B 4 O 7，另外还含有Na 2 CO 3。 通过使用本发明的合金，可以快速制备浴，并且可以将Zn和Ni供应到浴中而不留下未溶解的残余物。