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486 条记录 (耗时 0.083 秒)

    Surface protein of Neisseria bacteria
    72.
    发明申请
    Surface protein of Neisseria bacteria 有权
    奈瑟菌细菌的表面蛋白

    公开(公告)号：US20050281835A1

    公开(公告)日：2005-12-22

    申请号：US10867662

    申请日：2004-06-16

    申请人： Chiou-Ying Yang

    发明人： Chiou-Ying Yang

    IPC分类号： A61K39/00 ,  A61K39/02 ,  A61K48/00 ,  C07H21/04 ,  C07K14/22

    CPC分类号： C07K14/22 ,  A61K39/00

    摘要： Present invention provides a monoclonal antibody binding to Neisseria bacteria and its target antigen Ag473, which include the sequences of its polynucleotide and its amino acid, wherein the Neisseria bacteria can be Neisseria meningitidis or Neisseria gonorrhoeae; and wherein Ag473 can be made into a vaccine or a diagnostic or therapeutic reagent.

    摘要翻译： 本发明提供了结合奈瑟氏球菌及其靶抗原Ag473的单克隆抗体，其包括其多核苷酸及其氨基酸的序列，其中奈瑟氏菌属细菌可以是脑膜炎奈瑟氏球菌或淋病奈瑟氏球菌; 并且其中Ag473可以制成疫苗或诊断或治疗试剂。

    Gene expression during meningococcus adhesion
    76.
    发明申请
    Gene expression during meningococcus adhesion 审中-公开
    脑膜炎球菌粘附中的基因表达

    公开(公告)号：US20050130917A1

    公开(公告)日：2005-06-16

    申请号：US10481456

    申请日：2002-06-19

    申请人： Guido Grandi

    发明人： Guido Grandi

    IPC分类号： C07K14/22 ,  C12N15/31 ,  C12Q1/68 ,  A61K48/00 ,  C07H21/04 ,  G01N33/554 ,  G01N33/569

    CPC分类号： C07K14/22

    摘要： The first step in human meningococcal infection involves adhesion to the epithelial cells of the nasopharynx tract. The invention provides various methods and compounds for preventing the attachment of Neisserial cells to epithelial cells and is based on the identification of 347 meningococcal genes which play a role in the adhesion process.

    摘要翻译： 人类脑膜炎球菌感染的第一步涉及粘附到鼻咽道的上皮细胞。 本发明提供了用于预防奈瑟氏球菌细胞附着于上皮细胞的各种方法和化合物，并且基于在粘附过程中发挥作用的347种脑膜炎球菌基因的鉴定。

    Neisseria mutants, lipooligosaccharides and immunogenic compositions
    78.
    发明申请
    Neisseria mutants, lipooligosaccharides and immunogenic compositions 有权
    奈瑟氏球菌突变体，脂寡糖和免疫原性组合物

    公开(公告)号：US20050106184A1

    公开(公告)日：2005-05-19

    申请号：US10508309

    申请日：2003-03-20

    申请人： Nicholas Franks ,  Mervyn Maze

    发明人： Nicholas Franks ,  Mervyn Maze

    IPC分类号： A61K39/095 ,  C07K14/22 ,  C12N15/52 ,  C07H21/04 ,  C08B37/00 ,  C12N1/21

    CPC分类号： C12N15/52 ,  A61K39/095 ,  A61K2039/522 ,  A61K2039/523 ,  A61K2039/53 ,  C07K14/22 ,  C07K2319/23

    摘要： Provided herein are mutant strains of Neisseria meningitidis which produce Kdo-free lipid A as well as the Kdo-free lipid A molecules and immunogenic compositions containing such Kdo-free lipid A molecules from a Neisseria strain containing a genetically stable mutation which inactivates a gene selected from the group consisting of genes encoding arabinose-5-phosphate isomerase, CMP-Kdo synthetase and CMP-Kdo transferase. N. meningitidis NMB206 is a specifically exemplified strain which harbors a stable insertion mutation in the gene (ApsF) encoding A5P isomerase; strain NMB-249 is a specifically exemplified strain with a stable insertion mutation in the gene (kdtA) encoding CMP-Kdo synthetase, and strain NMB259 is specifically exemplified strain with a stable insertion mutation in the gene (kdsB) encoding CMP-Kdo transferase. Also provided by the present invention are methods for the production of Lipid A flee of 3-keto-3-deoxyoctanoic acid using these genetically stable N. meningitidis mutants. Also describes is pYT250, a plasmid functional in neisseriae and in enterics such as Escherichia coli.

    摘要翻译： 本文提供脑膜炎奈瑟球菌的突变菌株，其产生不含Kdo的脂质A以及不含Kdo的脂质A分子和含有来自包含基因稳定突变的不含Kdo的脂质A分子的免疫脂质A分子，所述遗传稳定突变使所选择的基因失活 来自编码阿拉伯糖-5-磷酸异构酶，CMP-Kdo合成酶和CMP-Kdo转移酶的基因组。 脑膜炎奈瑟球菌NMB206是在编码A5P异构酶的基因（ApsF）中具有稳定插入突变的特异性例证菌株; 菌株NMB-249是编码CMP-Kdo合成酶的基因（kdtA）中具有稳定插入突变的特异性例证菌株，并且菌株NMB259具体示例是在编码CMP-Kdo转移酶的基因（kdsB）中具有稳定插入突变的菌株。 本发明还提供了使用这些遗传稳定的脑膜炎奈瑟球菌突变体生产3-酮-3-脱氧辛酸脂质A的方法。 还描述了pYT250，一种在奈瑟氏菌中和在诸如大肠杆菌等肠道中功能的质粒。