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    Analgesic agent for newborn or fetal subjects
    1.
    发明授权
    Analgesic agent for newborn or fetal subjects 有权
    新生儿或胎儿受试者的止痛剂

    公开(公告)号：US07632872B2

    公开(公告)日：2009-12-15

    申请号：US10524316

    申请日：2003-08-05

    申请人： Nicholas Peter Franks ,  Mervyn Maze

    发明人： Nicholas Peter Franks ,  Mervyn Maze

    IPC分类号： A61K33/00

    CPC分类号： A61K33/00 ,  Y10S514/816 ,  Y10S514/937 ,  Y10S514/959

    摘要： In a first aspect, the present invention relates to the use of xenon in the preparation of a medicament for providing analgesia in a newborn subject and/or a fetal subject. In a second aspect, the invention relates to a method of providing analgesia in a newborn subject, the method comprising administering to the subject a therapeutically effective amount of xenon. In a third aspect, the invention relates to a method of providing analgesia in a fetal subject, the method comprising administering to the mother of the fetal subject a therapeutically effective amount of xenon for both the mother and fetal subject.

    摘要翻译： 在第一方面，本发明涉及氙在制备用于在新生儿受试者和/或胎儿受试者中提供止痛的药物中的用途。 在第二方面，本发明涉及在新生儿受试者中提供止痛的方法，所述方法包括向受试者施用治疗有效量的氙。 在第三方面，本发明涉及一种在胎儿受试者中提供镇痛的方法，所述方法包括向胎儿受试者的母亲施用治疗有效量的母体和胎儿受试者的氙。

    Eliciting analgesia by transcranial electrical stimulation
    3.
    发明授权
    Eliciting analgesia by transcranial electrical stimulation 有权
    通过经颅电刺激引起止痛

    公开(公告)号：US06567702B1

    公开(公告)日：2003-05-20

    申请号：US09687985

    申请日：2000-10-13

    申请人： Vladimir Nekhendzy ,  Mervyn Maze

    发明人： Vladimir Nekhendzy ,  Mervyn Maze

    IPC分类号： A61N134

    CPC分类号： A61N1/36021 ,  A61N1/36025

    摘要： A method of eliciting analgesia in a human subject by Transcranial Electrical Stimulation (TCES) is provided. Electrodes are secured to the skin of the subject's head and used to apply an electrical current to the electrodes. The current includes a direct current combined with rectangular current pulses (alternating current) delivered at a frequency of between 30 and 65 Hz. The frequency at which the pulses are delivered is periodically changed to a different value within the 30-65 Hz range. The total current supplied, a sum of the DC component and a Mean Absolute Deviation (MAD) of the current pulses, preferably has a value between 0.2 and 20 mA. The method is used during surgery and the post-operative procedure, and may also be used to treat a wide variety of neurological and other conditions.

    摘要翻译： 提供了通过经颅电刺激（TCES）引起人类受试者镇痛的方法。 电极被固定到受检者头部的皮肤上，并用于向电极施加电流。 该电流包括与以30Hz和65Hz之间的频率传送的矩形电流脉冲（交流电）组合的直流电流。 将脉冲输送的频率周期性地改变为30-65Hz范围内的不同值。 提供的总电流，DC分量和当前脉冲的平均绝对偏差（MAD）的总和优选地具有在0.2和20mA之间的值。 该方法在手术和术后手术中使用，也可用于治疗各种神经系统和其他病症。

    Analgesic agent for newborn or fetal subjects
    4.
    发明申请
    Analgesic agent for newborn or fetal subjects 有权

    公开(公告)号：US20060233885A1

    公开(公告)日：2006-10-19

    申请号：US10524316

    申请日：2003-08-05

    申请人： Nicholas Franks ,  Mervyn Maze

    发明人： Nicholas Franks ,  Mervyn Maze

    IPC分类号： A61K33/00

    CPC分类号： A61K33/00 ,  Y10S514/816 ,  Y10S514/937 ,  Y10S514/959

    摘要： In a first aspect, the present invention relates to the use of xenon in the preparation of a medicament for providing analgesia in a newborn subject and/or a fetal subject. In a second aspect, the invention relates to a method of providing analgesia in a newborn subject, the method comprising administering to the subject a therapeutically effective amount of xenon. In a third aspect, the invention relates to a method of providing analgesia in a fetal subject, the method comprising administering to the mother of the fetal subject a therapeutically effective amount of xenon for both the mother and fetal subject.

    USE OF XENON AS NEUROPROTECTANT IN A NEONATAL SUBJECT
    6.
    发明申请
    USE OF XENON AS NEUROPROTECTANT IN A NEONATAL SUBJECT 审中-公开
    使用XENON作为神经病学在一个新生主体

    公开(公告)号：US20090311340A1

    公开(公告)日：2009-12-17

    申请号：US11667065

    申请日：2005-08-19

    申请人： Nicholas Peter Franks ,  Mervyn Maze

    发明人： Nicholas Peter Franks ,  Mervyn Maze

    IPC分类号： A61K33/00 ,  A61P25/00

    CPC分类号： A61K33/00 ,  A61K31/08 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention relates to the use of xenon in the preparation of a medicament for preventing and/or alleviating one or more anesthetic-induced neurological deficits in a neonatal subject. The present invention further relates to combinations of xenon and sevoflurane, and use thereof as preconditioning agents for administration prior to hypoxic-ischaemic injury.

    摘要翻译： 本发明涉及氙在制备用于预防和/或减轻新生儿受试者中一种或多种麻醉诱导的神经功能缺陷的药物中的用途。 本发明还涉及氙和七氟烷的组合及其在缺氧缺血性损伤之前用于给药的预处理剂的用途。

    NMDA antagonist
    8.
    发明授权
    NMDA antagonist 有权
    NMDA拮抗剂

    公开(公告)号：US06274633B1

    公开(公告)日：2001-08-14

    申请号：US09378806

    申请日：1999-08-23

    申请人： Nicholas Peter Franks ,  Mervyn Maze

    发明人： Nicholas Peter Franks ,  Mervyn Maze

    IPC分类号： A61K3300

    CPC分类号： A61K33/00 ,  Y10S514/812 ,  Y10S514/816 ,  Y10S514/959

    摘要： The present invention relates to the use of xenon as an NMDA antagonist. In particular, the invention relates to a method of treatment comprising modulating the activity of an NMDA receptor in a mammal, the method comprising modulating the activity of the NMDA receptor by administering to the mammal a therapeutically effective amount of xenon. In a further aspect, the invention provides a process for the preparation of a pharmaceutical composition suitable for modulating the activity of an NMDA receptor.

    摘要翻译： 本发明涉及氙作为NMDA拮抗剂的用途。 特别地，本发明涉及包括调节哺乳动物NMDA受体活性的治疗方法，所述方法包括通过向哺乳动物施用治疗有效量的氙来调节NMDA受体的活性。 在另一方面，本发明提供了制备适于调节NMDA受体活性的药物组合物的方法。