公开(公告)号：US20240024534A1

公开(公告)日：2024-01-25

申请号：US18377058

申请日：2023-10-05

申请人： Advanced Biologics, LLC

发明人： Amit Prakash Govil ,  Christian Gamboa

IPC分类号： A61L27/20 ,  A61F2/46 ,  A61L27/12 ,  A61L27/54 ,  A61L27/50 ,  A61L27/36 ,  A61K35/32 ,  C08L5/08 ,  A61L27/38 ,  A61K35/28

CPC分类号： A61L27/20 ,  A61F2/4644 ,  A61L27/12 ,  A61L27/54 ,  A61L27/50 ,  A61L27/365 ,  A61L27/3608 ,  A61K35/32 ,  C08L5/08 ,  A61L27/3821 ,  A61L27/3834 ,  A61K35/28 ,  A61L27/3687 ,  A61L2400/16 ,  A61L2300/60 ,  A61F2002/4646 ,  A61L2430/02 ,  A61L2300/62 ,  A61L2300/45 ,  A61L2300/412 ,  A61L2300/404 ,  A61L2300/232 ,  A61L2300/406

摘要： Disclosed are various bioactive and/or biocompatible materials and methods of making the same.

公开(公告)号：US11877921B2

公开(公告)日：2024-01-23

申请号：US16831169

申请日：2020-03-26

申请人： Markman Biologics Corporation

发明人： Barry Markman

IPC分类号： A61F2/02 ,  A61F2/00 ,  A61L27/54

CPC分类号： A61F2/0077 ,  A61F2/0063 ,  A61L27/54 ,  A61F2002/0068 ,  A61F2002/0081 ,  A61F2240/002 ,  A61F2240/005 ,  A61F2250/0026 ,  A61F2250/0048 ,  A61F2250/0051 ,  A61F2250/0067

摘要： In a method of creating a modified tissue graft, at least one exterior surface of a graft is modified by compressing, cutting and/or removing one or more portions thereof, such as to create designed surface features which cause the tissue graft to have characteristics for a specific anatomical area. The modified tissue graft may include a medicated graft, such as by associating medicants with the surface features, or by associating a second graft or layer with a modified base tissue graft layer, where medicants are associated with the second graft or layer. The tissue graft may be modified by pressing a specially configured template or die, such as having blades thereon, into the tissue graft, such as to create a pattern of partial depth cuts.

公开(公告)号：US20240017086A1

公开(公告)日：2024-01-18

申请号：US18033523

申请日：2021-10-28

申请人： SYMBIOX, INC.

发明人： Jose-Tomás EGAÑA-ERAZO ,  Christian Dani GUZMÁN

IPC分类号： A61N5/06 ,  A61L27/36 ,  A61L27/54 ,  A61L31/02

CPC分类号： A61N5/062 ,  A61N5/0601 ,  A61L27/3637 ,  A61L27/54 ,  A61L31/022 ,  A61L2300/10 ,  A61N2005/0652 ,  A61N2005/063 ,  A61N2005/0626 ,  A61N2005/0633

摘要： Illumination devices, and illumination systems comprising illumination devices are provided herein. The illumination device can comprise a metal or other substrate, a living hinge, and a set of lighting elements supported by a set of printed circuit boards and connected via a set of cables. The set of lighting elements can be arranged in a rhomboid or hexagonal configuration. The illumination devices can be, for example, wearable, formed as a container, used with a container, or used inside of a body to illuminate a photosynthetic implant or other object.

公开(公告)号：US20240009349A1

公开(公告)日：2024-01-11

申请号：US18370878

申请日：2023-09-21

申请人： AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

发明人： Yun-Hoon CHOUNG ,  Jong Hoon CHUNG ,  Hoon SEONWOO ,  Kyoung-Je JANG ,  Beomyong SHIN

IPC分类号： A61L27/18 ,  A61L27/54 ,  C08G63/08 ,  D01D5/00

CPC分类号： A61L27/18 ,  A61L27/54 ,  C08G63/08 ,  D01D5/003 ,  A61F2/18

摘要： Disclosed is a method of treating a chronic tympanic perforation with a PCL patch tissue regeneration scaffold comprising preparing solution by adding polycaprolactone (PCL) and an acid to an organic solvent; preparing an electrospinning solution by adding a growth factor to the solution and stirring; collecting nanofibers arranged in a spindle shape on a collector by connecting the electrospinning solution prepared to a syringe pump and operating the electrospinning device; and administering the PCL patch tissue regeneration scaffold to a subject.

公开(公告)号：US20230383099A1

公开(公告)日：2023-11-30

申请号：US18147703

申请日：2022-12-29

申请人： Hangzhou Singclean Medical Products Co., Ltd

发明人： Jue Wang ,  Jie Zheng ,  Xingyu Liu ,  Meiqin Zhu ,  Qianqian Jia

IPC分类号： C08L5/08 ,  C08B37/08 ,  C08J3/075 ,  C12N5/00 ,  A61L27/52 ,  A61L27/54 ,  A61L27/20

CPC分类号： C08L5/08 ,  C08B37/003 ,  C08J3/075 ,  C12N5/0018 ,  A61L27/52 ,  A61L27/54 ,  A61L27/20 ,  C08J2305/08 ,  C12N2500/34 ,  A61L2430/34

摘要： Disclosed in the present disclosure are a hydroxybutyl chitin, a hydroxybutyl chitin hydrogel and a preparation method thereof. Chitin is subjected to pulverization, dissolution, modification with epoxybutane, and purification to obtain a final product, namely the hydroxybutyl chitin. The hydroxybutyl chitin prepared by the method has good solubility in purified water, and a hydrogel with a low solid content can be formed. The hydroxybutyl chitin hydrogel will have a wide application aspect in biomedicine, absorbable materials, and other fields.

公开(公告)号：US11826398B2

公开(公告)日：2023-11-28

申请号：US17326561

申请日：2021-05-21

申请人： University of Washington

发明人： Valerie Daggett ,  Alissa Bleem

IPC分类号： A61K38/02 ,  A61K38/16 ,  A61L27/34 ,  A61L29/08 ,  A61L31/10 ,  C07K16/00 ,  A61K9/70 ,  A61P31/04 ,  A61L27/22 ,  A61L27/54 ,  A61L31/16 ,  A61L29/16 ,  A61P41/00

CPC分类号： A61K38/16 ,  A61K9/70 ,  A61K38/02 ,  A61L27/22 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61P31/04 ,  A61P41/00 ,  A61L2202/24 ,  A61L2300/25 ,  A61L2300/252 ,  A61L2300/404 ,  A61L2300/606 ,  A61L2420/02 ,  C07K16/00

摘要： Disclosed herein are α-sheet peptides and their use for treating a bacterial infection and/or limiting bacterial biofilm formation.

公开(公告)号：US11819522B2

公开(公告)日：2023-11-21

申请号：US17568553

申请日：2022-01-04

申请人： MicroVascular Tissues, Inc.

发明人： Dale R. Peterson ,  Ralph-Heiko Mattern ,  Kevin L Ohashi ,  Lael J. Pickett ,  Glen Gong ,  Mohammad A. El-Kalay

IPC分类号： A61K35/28 ,  A61K35/44 ,  A61L27/36 ,  C12N5/077 ,  A61L27/38 ,  A61L27/54 ,  A61K35/12 ,  A61K35/545

CPC分类号： A61K35/44 ,  A61K35/12 ,  A61K35/545 ,  A61L27/3625 ,  A61L27/3687 ,  A61L27/3691 ,  A61L27/3834 ,  A61L27/3878 ,  A61L27/54 ,  C12N5/0653 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2400/06 ,  A61L2430/02 ,  A61L2430/06 ,  A61L2430/10 ,  A61L2430/32 ,  A61L2430/34 ,  A61L2430/38

摘要： The present invention provides novel compositions comprising multipotent cells or microvascular tissue, wherein the cells or tissue has been sterilized and/or treated to inactivated viruses, and related methods of using these compositions to treat or prevent tissue injury or disease in an allogeneic subject.

公开(公告)号：US20230364300A1

公开(公告)日：2023-11-16

申请号：US18357299

申请日：2023-07-24

申请人： LifeCell Corporation

发明人： Yi Chen ,  Sean Collins ,  Li Ting Huang ,  Eric Stec ,  Hui Xu

IPC分类号： A61L27/34 ,  A61L27/24 ,  A61L27/56 ,  A61F2/00 ,  A61L27/16 ,  A61L27/36 ,  A61L27/54

CPC分类号： A61L27/34 ,  A61L27/24 ,  A61L27/56 ,  A61F2/0063 ,  A61L27/16 ,  A61L27/362 ,  A61L27/3687 ,  A61L27/54 ,  A61F2210/0004 ,  A61L2300/254

摘要： The present application relates to use of transglutaminases to treat various products, including medical devices such as tissue grafts, tissue matrices or other tissue-derived materials, and synthetics. The transglutaminases can be applied to the medical devices to provide advantages such as adhesion resistance or abrasion resistance.

公开(公告)号：US20230355843A1

公开(公告)日：2023-11-09

申请号：US18225051

申请日：2023-07-21

申请人： SUPRA B B.V. ,  ACADEMISCH MEDISCH CENTRUM

发明人： Anton Willem BOSMAN ,  Theodoor Henri SMIT ,  Gino Matheus Melanie Johannes KERKHOFFS ,  Tobias STORNEBRINK

IPC分类号： A61L27/52 ,  A61L27/54 ,  A61L27/18

CPC分类号： A61L27/52 ,  A61L27/54 ,  A61L27/18 ,  A61L2430/06 ,  A61L2400/06 ,  A61L2430/38

摘要： The invention relates to a kit of parts, consisting of compositions (C1) and (C2) in separate containers, for use in the treatment or prevention of osteoarthritis in a vertebrate, wherein: (a) composition (C1) is a liquid hydrogel formulation comprising a polymer gellant with chemically cross-linkable groups; (b) composition (C2) is an aqueous auxiliary formulation comprising either one or more dissolved cross-linkers Z having two or more reactive groups that can chemically cross-link the polymer gellant by forming covalent bonds; or comprising one or more dissolved compounds Y, selected from the group consisting of oxidant, oxidase, peroxidase and combinations thereof, that initiate or mediate chemical cross-linking of the polymer gellant; wherein said treatment comprises combining compositions (C1) and (C2) to form a liquid hydrogel composition (C3) and administering said liquid hydrogel composition (C3) to the synovial fluid or to the cavity of a synovial joint of the vertebrate, to form a cross-linked hydrogel (C4) in the synovial joint of the vertebrate; or wherein said treatment comprises in a first step administering one of the compositions (C1) or (C2) to the synovial fluid or to the cavity of a synovial joint of the vertebrate and in a second step administering the other of the compositions (C1) or (C2), to form a liquid hydrogel composition (C3) in the synovial joint of the vertebrate that reacts to a cross-linked hydrogel (C4).

公开(公告)号：US20230355842A1

公开(公告)日：2023-11-09

申请号：US18157653

申请日：2023-01-20

申请人： TELA Bio, Inc.

发明人： E. Skott GREENHALGH

IPC分类号： A61L27/52 ,  A61L27/24 ,  A61L27/54 ,  A61L27/58

CPC分类号： A61L27/52 ,  A61L27/24 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/626 ,  A61L2430/34

摘要： The apparatuses and methods described herein relates generally to the field of active agent (drug) release from surgical grafts useful for soft tissue reconstruction, regeneration, or repair. More particularly, described herein are surgical grafts for soft tissue repair that include an active agent that is released over time while advantageously matching the biomechanical properties of tissue during healing and recovery.