公开(公告)号：US5332839A

公开(公告)日：1994-07-26

申请号：US584466

申请日：1990-09-18

申请人： Herman P. Benecke ,  Richard A. Markle ,  Richard G. Sinclair

发明人： Herman P. Benecke ,  Richard A. Markle ,  Richard G. Sinclair

IPC分类号： B01J21/04 ,  B01J21/08 ,  C07B61/00 ,  C07D319/12

CPC分类号： C07D319/12 ,  B01J2219/1942

摘要： The present invention is directed to a method for making lactide from aqueous lactic acid. The invention method comprises converting feed aqueous lactic acid to its vapor phase. The feed vapors then are passed through a reactor maintained at elevated temperature and in which optionally is disposed an alumina catalyst. Withdrawn from the reactor is product lactide, water, and unreacted lactic acid which are subjected to separation for recovery of the lactide product. The separated unreacted lactic acid is eligible for readmission to the process for making additional lactide. This cyclic process embodiment of the present invention comprises the steps of passing make-up aqueous lactic acid feed into a vaporization zone along with unreacted aqueous lactic acid filtrate from another step of the process and therein forming aqueous lactic acid feed vapors. The thus-generated vapors that are passed through a vapor phase reaction zone held at elevated temperature for forming lactide therein. Lactide as a solid is separated from unreacted aqueous lactic acid filtrate; and the filtrate is passed into the vaporization zone in the initial step of the process.

摘要翻译： 本发明涉及从乳酸水溶液制备丙交酯的方法。 本发明的方法包括将进料水乳酸转化成其气相。 然后将进料蒸气通过保持在升高温度下的反应器，并且其中任选地设置氧化铝催化剂。 从反应器中抽出的是产品丙交酯，水和未反应的乳酸，它们进行分离以回收丙交酯产物。 分离的未反应的乳酸有资格重新进入制备额外的丙交酯的方法。 本发明的循环方法实施方案包括以下步骤：将乳酸含水原料与来自该方法的另一步骤的未反应的乳酸水溶液一起送入蒸发区，并形成含水乳酸进料蒸气。 由此产生的蒸气通过保持在升高的温度下的气相反应区以在其中形成丙交酯。 作为固体的丙交酯与未反应的乳酸水溶液分离; 并且在该过程的初始步骤中将滤液进入蒸发区。

公开(公告)号：US5310945A

公开(公告)日：1994-05-10

申请号：US996218

申请日：1992-12-23

申请人： Thomas C. Forschner

发明人： Thomas C. Forschner

IPC分类号： B01J23/06 ,  B01J23/72 ,  B01J23/80 ,  B01J27/10 ,  B01J27/25 ,  B01J31/02 ,  B01J31/04 ,  C07B61/00 ,  C07D319/12

CPC分类号： C07D319/12 ,  B01J23/80

摘要： A highly selective dehydrogenation catalyst for the preparation of para-dioxanones is produced by impregnating copper and zinc on a promoter impregnated support. This catalyst is effective for the dehydrogenation of dialkylene glycols to produce a high purity 2-para-dioxanones.

摘要翻译： 用于制备对二恶烷酮的高选择性脱氢催化剂是通过将铜和锌浸渍在助催化剂浸渍的载体上来制备的。 该催化剂对于二烷基二醇的脱氢而产生高纯度2-对二恶烷酮是有效的。

公开(公告)号：US5274127A

公开(公告)日：1993-12-28

申请号：US584126

申请日：1990-09-18

申请人： Richard G. Sinclair ,  Richard A. Markle ,  Russell K. Smith

发明人： Richard G. Sinclair ,  Richard A. Markle ,  Russell K. Smith

IPC分类号： C07D319/12 ,  C08J5/18 ,  C08L67/04 ,  C09D167/04 ,  C07D319/00

CPC分类号： C08J5/18 ,  C07D319/12 ,  C08L67/04 ,  C09D167/04 ,  B01J2219/1942 ,  C08J2367/04

摘要： The present invention is directed to a method for making L-lactide from aqueous L-lactic acid. Aqueous lactic acid feed for present purposes comprehends an aqueous mixture of one or more of L.sub.1 A, L.sub.2 A, and L.sub.3 A, optionally with LD being present. L-lactic acid is the preferred feed configuration for making L-lactide, and is to be understood even though the configuration symbol is not used throughout this application. Aqueous lactic acid feed is treated for removal of water therefrom until a degree of polymerization (DP) not substantially above about 2 is reached. The treatment then is ceased to produce a crude LD product. LD then is separated from the crude LD product. A preferred treatment involves heating the feed at elevated temperature to remove water. LD can be separated from the crude LD product by a variety of techniques to produce an LD-depleted product. This LD-depleted product, optionally augmented with additional aqueous lactic acid and/or water then can be readmitted to the process for making additional lactide. This cyclic or recycle process embodiment of the present invention enables very high lactide conversions to be realized.

摘要翻译： 本发明涉及从L-乳酸水溶液制备L-丙交酯的方法。 用于本发明目的的乳酸乳液饲料包括L1A，L2A和L3A中的一种或多种的任何含水混合物，任选地存在LD。 L-乳酸是用于制备L-丙交酯的优选进料构型，并且即使在本申请中不使用配置符号也将被理解。 处理水性乳酸进料以从中除去水，直到达到基本上不超过约2的聚合度（DP）。 然后处理停止生产粗制LD产品。 然后将LD与粗LD产物分离。 优选的处理包括在升高的温度下加热进料以除去水。 LD可以通过各种技术与粗LD产物分离以产生LD-贫化的产物。 然后，任选地用另外的乳酸和/或水增加的LD-贫化产物可以重新进入用于制备额外的丙交酯的方法。 本发明的这种循环或再循环方法实现了能够实现非常高的丙交酯转化。

公开(公告)号：US5223630A

公开(公告)日：1993-06-29

申请号：US709175

申请日：1991-06-03

申请人： Kang Lin

发明人： Kang Lin

IPC分类号： C07D319/12

CPC分类号： C07D319/12

摘要： A process for preparing suture-grade .beta.-glycolide by purifying crude glycolide which comprises contacting the crude glycolide with a primary solvent which will dissolve the crude glycolide and residual impurities without dissolving primary impurities; removing the primary impurities; recovering the glycolide and residual impurities by evaporating the primary solvent at a temperature below 42.degree. C.; removing residual impurities by washing the glycolide with a washing solvent in which the residual impurities are soluble; and isolating the .beta.-glycolide crystals which remain.

摘要翻译： 通过纯化粗乙醇酸制备缝合级β-乙交酯的方法，其包括使粗乙醇交酯与主溶剂接触，所述主溶剂将溶解粗乙醇交酯和残留杂质而不溶解初级杂质; 去除主要杂质; 通过在低于42℃的温度下蒸发主要溶剂来回收乙交酯和残余杂质; 通过用残留杂质可溶的洗涤溶剂洗涤乙交酯来除去残留杂质; 并分离剩余的β-乙交酯晶体。

公开(公告)号：US5131940A

公开(公告)日：1992-07-21

申请号：US794540

申请日：1991-11-19

申请人： Mark A. Dekeyser ,  Allen R. Blem

发明人： Mark A. Dekeyser ,  Allen R. Blem

IPC分类号： A01N43/32 ,  C07D319/12

CPC分类号： C07D319/12 ,  A01N43/32

摘要： A compound having the structural formula ##STR1## where R is at least one of hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, halogen, cyano, phenyl, phenoxy, benzyl or COOR.sup.1 ; and R.sup.1 is C.sub.1 -C.sub.4 alkyl is disclosed. A composition comprising a growth regulant effective amount of the compound and a carrier therefor is also set forth. In addition, a process for regulating plant growth comprising applying a plant growth regulant effective amount of the compound to the locus of the plant whose growth is to be regulated is taught.

摘要翻译： 其中R是氢，C 1 -C 4烷基，C 1 -C 4烷氧基，卤素，氰基，苯基，苯氧基，苄基或COOR 1中的至少一个的结构式的化合物。 并且R 1是C 1 -C 4烷基。 还提出了包含生长调节剂有效量的化合物及其载体的组合物。 此外，教导了一种用于调节植物生长的方法，包括将植物生长调节剂有效量的化合物施用于其生长被调节的植物的场所。

公开(公告)号：US5117008A

公开(公告)日：1992-05-26

申请号：US602346

申请日：1990-10-23

申请人： Kamlesh K. Bhatia ,  Neville E. Drysdale ,  John R. Kosak

发明人： Kamlesh K. Bhatia ,  Neville E. Drysdale ,  John R. Kosak

IPC分类号： C07D319/06 ,  C07D319/12

CPC分类号： C07D319/12

摘要： An improved process for the recovery of lactide or other dimeric cyclic ester from a gas stream containing the cyclic ester and such hydroxylic impurities as water and open-chain hydroxycarboxylic acids by scrubbing the gas stream with a nonpolar water-immiscible solvent at a temperature at which the cyclic ester is removed from the solvent and any water present in the gas stream is vaporized from the solvent. The cyclic ester is recovered from the solvent in a high state of optical purity.

摘要翻译： 一种改进的方法，其用于从含有环酯的气流和这些羟基杂质如水和开链羟基羧酸中回收丙交酯或其它二聚环酯，通过在非极性水不混溶溶剂中洗涤气流， 从溶剂中除去环状酯，并且从溶剂中蒸发存在于气流中的任何水。 环状酯以高纯度的光学纯度从溶剂中回收。

公开(公告)号：US5089632A

公开(公告)日：1992-02-18

申请号：US648003

申请日：1991-01-30

申请人： Donald C. Paul

发明人： Donald C. Paul

IPC分类号： C07D319/12

CPC分类号： C07D319/12

摘要： Process for preparing high purity solvent-free cyclic esters from alpha hydroxycarboxylic acids via an intermediate oligomer wherein a fluorocarbon or a mixture of fluorocarbons is employed to strip the ester from the oligomer as well as a refrigerant to quench lactide from a gaseous reaction stream comprising, besides cyclic ester, unconverted alpha-hydroxycarboxylic acid and water.

摘要翻译： 用于通过中间体低聚制备高纯度无溶剂环状酯的方法，其中使用碳氟化合物或碳氟化合物的混合物来从低聚物中除去酯，以及制冷剂以从气态反应流中淬灭丙交酯， 除了酯，未转化的α-羟基羧酸和水。

公开(公告)号：US5072002A

公开(公告)日：1991-12-10

申请号：US381485

申请日：1989-07-18

申请人： Derrick L. J. Clive ,  Andrew G. H. Wee ,  Kammaralli S. K. Murthy

发明人： Derrick L. J. Clive ,  Andrew G. H. Wee ,  Kammaralli S. K. Murthy

IPC分类号： C07D309/30 ,  C07D319/12 ,  C07F7/18

CPC分类号： C07D309/30 ,  C07D319/12 ,  C07F7/1856

摘要： Processes of synthesizing compounds of the formula: ##STR1## wherein R.sub.1 is H, lower alkyl (1 to 6 C), lower dialkyl (1 to 6 C), lower cycloalkyl (3 to 7 C), or lower dicycloalkyl (3 to 7 C);R.sub.2 is H, lower alkyl (1 to 6 C), or lower cycloalkyl (3 to 7 C);R.sub.5 C(O) is an acyl group with R.sub.5 being alkyl (1 to 18 C), cycloalkyl, bicycloalkyl, tricycloalkyl, alkenyl (1 to 18 C), alkadienyl (1 to 18 C), aryloxy-, alkoxy-, substituted alkyl, wherein the substituents are acetoxy-, acyl-, alkoxy-, alkoxycarbonyl-, alkylamido-, alkylsulfonyl-, alkylsulfoxido-, alkylthio-, alkylthiocarbonyl-, amino-, aroyl-, aryl-, aryloxy-, arylthio-, azido-, carboxy-, dialkylamido-, dialkylamino-, dihalogeno-, hydroxy-, monohalogeno-, trihalogeno-, or arylalkylthio-.Compounds of the above formula are capable of appreciably lowering blood levels of cholesterol in human beings. Some of the above compounds are known fungal metabolites; however, the process of this invention provides a total synthetic approach to making any of the above compounds.

摘要翻译： 合成下式的化合物的方法：其中R 1为H，低级烷基（1-6），低级二烷基（1至6 C），低级环烷基（3至7 C）或低级二环烷基（3至7 C）; R2是H，低级烷基（1-6C）或低级环烷基（3至7C）; R5C（O）是R5是烷基（1至18C），环烷基，双环烷基，三环烷基，烯基（1至18C），链二烯基（1至18 C），芳氧基 - ，烷氧基 - 取代的烷基， 其中取代基是乙酰氧基 - ，酰基 - ，烷氧基 - ，烷氧基羰基 - ，烷基酰氨基 - ，烷基磺酰基 - ，烷基亚磺酰基 - ，烷硫基 - ，烷硫基羰基 - ，氨基 - ，芳酰基 - ，芳基 - ，芳氧基 - ，芳硫基 - ，叠氮基 - - ，二烷基氨基 - ，二烷基氨基 - ，二卤代 - ，羟基 - ，单卤代 - ，三卤代 - 或芳基烷硫基。 上述式的化合物能够明显降低人类胆固醇的血液水平。 一些上述化合物是已知的真菌代谢物; 然而，本发明的方法提供了制备任何上述化合物的总合成方法。

公开(公告)号：US5008406A

公开(公告)日：1991-04-16

申请号：US340754

申请日：1989-04-20

申请人： Guy Vanlerberghe ,  Alexandre Zysman ,  Henri Sebag

发明人： Guy Vanlerberghe ,  Alexandre Zysman ,  Henri Sebag

IPC分类号： A61K8/14 ,  A61K9/127 ,  A61K47/48 ,  A61Q19/00 ,  B01F17/32 ,  B01J13/02 ,  C07B41/00 ,  C07B43/00 ,  C07C43/04 ,  C07C43/11 ,  C07C43/13 ,  C07C43/178 ,  C07C43/305 ,  C07C217/08 ,  C07C323/12 ,  C07D319/06 ,  C07D319/12 ,  C07D321/08 ,  C07K16/00

CPC分类号： A61Q19/00 ,  A61K47/48238 ,  A61K47/48815 ,  A61K8/14 ,  A61K9/1272 ,  C07C217/08 ,  C07C323/00 ,  C07C323/12 ,  C07C43/11 ,  C07C43/135 ,  C07C43/178 ,  C07D319/12 ,  C07D321/08 ,  A61K2800/57 ,  Y10S424/812 ,  Y10S530/81 ,  Y10T428/2984

摘要： The invention relates to compounds of formula: ##STR1## in which m, n, p and q are equal to 0 or 1, p being different from q and the sum m+n+p+q being equal to 2, A denotes a nonionic chain arrangement chosen from the groups:--C.sub.2 H.sub.4 O--.sub.rand/or--C.sub.3 H.sub.5 (OH)O--.sub.s,in which r denotes a number which can assume all integral values between 0 and 5 or a statistical average value between 0 and 20,s denotes a number which can assume all integral values between 0 and 5 or a statistical average value between 0 and 10,u is equal to 0 or 1, with the restriction that when u=0, s and r are also zero,R denotes(i) a linear or branched hydrocarbon radical which has 1 to 32 carbon atoms and can contain one or more oxygen atoms in the chain or bear one or more OH groups or(ii) a (C.sub.8 -C.sub.18 alkyl)phenyl radical.These compounds can be used for preparing stable chemical compounds, for conveying active substances or for forming vesicles.

公开(公告)号：US4983745A

公开(公告)日：1991-01-08

申请号：US335089

申请日：1989-04-03

申请人： Manfred Muller ,  Joachim Hess ,  Wilhem-Gustav Schnell ,  Dieter Bendix ,  Gunther Entenmann

发明人： Manfred Muller ,  Joachim Hess ,  Wilhem-Gustav Schnell ,  Dieter Bendix ,  Gunther Entenmann

IPC分类号： A61K47/34 ,  A61L15/64 ,  A61L17/00 ,  A61L17/12 ,  A61L27/18 ,  A61L31/06 ,  C07D319/12 ,  C08G63/08 ,  C08G63/64

CPC分类号： C08G63/64 ,  A61K47/34 ,  A61L15/64 ,  A61L17/12 ,  A61L27/18 ,  A61L31/06 ,  C07D319/12 ,  C08G63/08

摘要： The invention relates to a meso-lactide having a melting point of 52.8.degree. C., processes for its preparation, and its use in the preparation of resorbable polymers and copolymers.

摘要翻译： 本发明涉及熔点为52.8℃的内消旋丙交酯，其制备方法及其在制备可再吸收的聚合物和共聚物中的应用。