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    Ultrasound imaging and treatment
    76.
    发明授权
    Ultrasound imaging and treatment 失效
    超声成像和治疗

    公开(公告)号：US07078015B2

    公开(公告)日：2006-07-18

    申请号：US10983406

    申请日：2004-11-08

    Applicant: Evan C. Unger

    Inventor： Evan C. Unger

    IPC: A61B8/00

    CPC classification number: A61K9/1278 ,  A61B2017/00716 ,  A61B2017/22088 ,  A61K9/127 ,  A61K9/1277 ,  A61K41/0028 ,  A61K41/0052 ,  A61K47/6911 ,  A61K47/6925 ,  A61K49/1815 ,  A61K49/22 ,  A61K49/223 ,  A61K49/227 ,  A61M5/3145 ,  A61M2202/0476 ,  A61N7/02 ,  A61N2007/025

    Abstract: Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly usefull for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.Gas, gaseous precursors and perfluorocarbons are presented as novel potentiators for ultrasonic hyper-thermia. The gas, gaseous precursors and perfluorocarbons which may be administered into the vasculature, interstitially or into any body cavity are designed to accumulate in cancerous and diseased tissues. When therapeutic ultrasonic energy is applied to the diseased region heating is increased because of the greater effectiveness of sound energy absorption caused by these agents.

    Abstract translation: 描述了制备温度活化气态前体填充脂质体的方法和装置。 通过这些方法制备的气态前体填充脂质体在超声成像应用和治疗药物递送系统中特别有用。 气体，气体前体和全氟化碳被提出作为超声超热的新型增效剂。 可以施用到脉管系统，间质或任何体腔内的气体，气体前体和全氟化碳被设计成积累在癌和组织中。 当将治疗性超声能量应用于患病区域时，由于这些药剂引起的声能吸收的效力更高，因此加热是增加的。

    Ultrasonic imaging system utilizing a long-persistence contrast agent
    78.
    发明授权
    Ultrasonic imaging system utilizing a long-persistence contrast agent 失效
    超声波成像系统利用长持续造影剂

    公开(公告)号：US06939531B2

    公开(公告)日：2005-09-06

    申请号：US10644634

    申请日：2003-08-19

    Applicant: Ernest G. Schutt ,  Charles David Anderson ,  David P. Evitts

    Inventor： Ernest G. Schutt ,  Charles David Anderson ,  David P. Evitts

    IPC: A61K49/00 ,  A61B8/00 ,  A61K49/22 ,  B01J13/02 ,  F21V8/00 ,  A61K9/14

    CPC classification number: A61K49/227 ,  A61K49/223 ,  G02B6/0006

    Abstract: A microbubble preparation formed of a plurality of microbubbles comprising a first gas and second gas surrounded by a membrane such as a surfactant, wherein the first gas and the second gas are present in a molar ration of from about 1:100 to abut 1000:1, and wherein the first gas has a vapor pressure of at least about (760−X) mm Hg at 37° C., where x is the vapor pressure of the second gas at 37° C., and wherein the vapor pressure of each of the first and second gases is greater than about 75 mm Hg at 37° C.; also disclosed are methods for preparing microbubble compositions, including compositions that rapidly shrink from a first average diameter to a second average diameter less than about 75% of the first average diameter and are stabilized at the second average diameter; methods and kits for preparing microbubbles; and methods for using such microbubbles as contrast agents.

    Abstract translation: 由多个微泡形成的微泡制品，其包含第一气体和被诸如表面活性剂的膜包围的第二气体，其中第一气体和第二气体以约1:100至约1000:1的摩尔比率存在 ，并且其中所述第一气体在37℃下具有至少约（760-X）mm Hg的蒸汽压，其中x是所述第二气体在37℃的蒸汽压，并且其中每个 的第一和第二气体在37℃下大于约75mm Hg。 还公开了制备微泡组合物的方法，包括从第一平均直径快速收缩至小于第一平均直径的约75％的第二平均直径的组合物，并且稳定在第二平均直径; 制备微泡的方法和试剂盒; 以及使用这种微泡作为造影剂的方法。

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