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    Agonists of Guanylate Cyclase Useful For the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders
    71.
    发明申请
    Agonists of Guanylate Cyclase Useful For the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders 有权
    鸟苷酸环化酶的激动剂有助于治疗胃肠道疾病，炎症，癌症和其他疾病

    公开(公告)号：US20130096071A1

    公开(公告)日：2013-04-18

    申请号：US13716874

    申请日：2012-12-17

    Applicant: SYNERGY PHARMACEUTICALS INC.

    Inventor： Kunwar Shailubhai ,  Gary S. Jacob

    IPC: C07K7/64

    CPC classification number: C07K7/64 ,  A61K38/04 ,  A61K45/06 ,  C07K7/08 ,  A61K2300/00

    Abstract: The invention provides novel guanylate cyclase-C agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e.g., a gastrointestinal cancer). The peptides can be administered either alone or in combination with an inhibitor of cGMP-dependent phosphodiesterase. The gastrointestinal disorder may be classified as either irritable bowel syndrome, constipation, or excessive acidity etc. The gastrointestinal disease may be classified as either inflammatory bowel disease or other GI condition including Crohn's disease and ulcerative colitis, and cancer.

    Abstract translation: 本发明提供新的鸟苷酸环化酶-C激动剂肽及其在治疗包括胃肠道疾病，炎症或癌症（例如胃肠癌））的人类疾病中的用途。 肽可以单独施用或与cGMP依赖性磷酸二酯酶抑制剂组合施用。 胃肠道疾病可以分为肠易激综合征，便秘或过度酸度等。胃肠道疾病可分为炎症性肠病或其他胃肠道疾病，包括克罗恩病和溃疡性结肠炎，以及癌症。

    COMPOSITION FOR IMPROVING BRAIN FUNCTION AND METHOD FOR IMPROVING BRAIN FUNCTION
    74.
    发明申请
    COMPOSITION FOR IMPROVING BRAIN FUNCTION AND METHOD FOR IMPROVING BRAIN FUNCTION 有权
    用于改善脑功能的组合物和用于改善脑功能的方法

    公开(公告)号：US20120277160A1

    公开(公告)日：2012-11-01

    申请号：US13532394

    申请日：2012-06-25

    Applicant: Kazuhito OHSAWA ,  Naoto UCHIDA ,  Kohji OHKI ,  Hiroaki GOTO

    Inventor： Kazuhito OHSAWA ,  Naoto UCHIDA ,  Kohji OHKI ,  Hiroaki GOTO

    IPC: A61K38/16 ,  C07K7/06 ,  A61P25/00 ,  C07K14/00

    CPC classification number: A61K38/04 ,  C07K7/08

    Abstract: Provided are a composition for improving the brain function, which can be orally taken at a low dose, and a method therefor. The composition for improving the brain function contains, as the active ingredient, X-Pro-Pro-Leu-Thr-Gln-Thr-Pro-Val-Val-Val-Pro-Pro-Phe-Leu-Gln-Pro-Glu-Y (wherein X is nil or represents Ile or Asn-Ile; and Y is nil or represents Val-Met), X-Val-Val-Val-Pro-Pro-Phe-Leu-Gln-Pro-Glu-Y (wherein X is abscent or represents Thr-Gln-Thr-Pro, Pro-Leu-Thr-Gln-Thr-Pro, Leu-Thr-Gln-Thr-Pro or Pro; and Y is abscent or represents Val-Met), or a salt of the same. The method for improving the brain function comprises administering said peptide or a salt of the same.

    Abstract translation: 提供了可以以低剂量口服摄取的用于改善脑功能的组合物及其方法。 用于改善脑功能的组合物含有作为活性成分的X-Pro-Pro-Leu-Thr-Gln-Thr-Pro-Val-Val-Val-Pro-Pro-Phe-Leu-Gln-Pro-Glu- Y（其中X为零或表示Ile或Asn-Ile; Y为无或表示Val-Met），X-Val-Val-Val-Pro-Pro-Phe-Leu-Gln-Pro-Glu-Y X缺失或表示Thr-Gln-Thr-Pro，Pro-Leu-Thr-Gln-Thr-Pro，Leu-Thr-Gln-Thr-Pro或Pro; Y为缺失或代表Val-Met） 盐相同。 改善脑功能的方法包括施用所述肽或其相同的盐。

    METHODS AND COMPOSITIONS FOR INHIBITION OF BCL6 REPRESSION
    79.
    发明申请
    METHODS AND COMPOSITIONS FOR INHIBITION OF BCL6 REPRESSION 有权
    用于抑制BCL6代谢的方法和组合物

    公开(公告)号：US20110152200A1

    公开(公告)日：2011-06-23

    申请号：US12737122

    申请日：2009-06-10

    Applicant: Ari M. Melnick ,  Leandro Cerchietti

    Inventor： Ari M. Melnick ,  Leandro Cerchietti

    IPC: A61K38/08 ,  C12N5/02 ,  C12N15/63 ,  A61P35/00 ,  C07K2/00 ,  C07K7/06 ,  C07H21/04

    CPC classification number: C07K7/06 ,  A61K38/00 ,  A61K38/04 ,  A61K38/08 ,  A61K47/645 ,  C07K7/00 ,  C07K2319/00 ,  C07K2319/10

    Abstract: The invention is directed to a compound that binds to a BCL6 lateral groove and prevents binding of a corepressor to the lateral groove. The present invention is further directed to methods for blocking corepressor binding to a BCL6 lateral groove, methods for inhibiting BCL6 repression in a mammalian cell, and methods for treating a mammal with cancer, wherein the cancer requires BCL6 repression. The present invention is further directed to polypeptides comprising a portion of the corepressor binding site for BCL6 and related polynucleotides and vectors.

    Abstract translation: 本发明涉及一种结合BCL6横向沟槽并防止夹压抑制剂与横向沟槽结合的化合物。 本发明进一步涉及用于阻断与BCL6侧槽的结合键的方法，用于抑制哺乳动物细胞中BCL6抑制的方法，以及用于治疗患有癌症的哺乳动物的方法，其中所述癌症需要BCL6抑制。 本发明进一步涉及包含BCL6的一部分共抑制子结合位点和相关多核苷酸和载体的多肽。

    Method of Reduction of Wrinkles on Skin, Darkening of Hair and Acceleration of Wound Healing by Applying Peptides Related to Basic Fibroblast Growth Factor (bFGF)
    80.
    发明申请
    Method of Reduction of Wrinkles on Skin, Darkening of Hair and Acceleration of Wound Healing by Applying Peptides Related to Basic Fibroblast Growth Factor (bFGF) 有权
    通过应用与碱性成纤维细胞生长因子（bFGF）相关的肽来减少皮肤皱纹，毛发变黑和伤口愈合加速的方法

    公开(公告)号：US20100323962A1

    公开(公告)日：2010-12-23

    申请号：US12764530

    申请日：2010-04-21

    Applicant: Abburi Ramaiah

    Inventor： Abburi Ramaiah

    IPC: A61K38/18 ,  A61K8/64 ,  A61P17/02 ,  A61Q5/00 ,  A61Q19/08

    CPC classification number: A61K38/1825 ,  A61K8/64 ,  A61K38/04 ,  A61Q5/065 ,  A61Q19/08 ,  C07K14/503

    Abstract: The present invention is directed to synergistic therapies for the treatment of vitiligo. Particularly, the invention is directed to a composition for the reduction of wrinkles on skin, the acceleration of wound healing, and the darkening of hair including a peptide and an acceptable carrier. The peptide may be selected from the group consisting of the peptide of SEQ. ID 1, the peptide of SEQ. ID 2, the peptide of SEQ. ID 3, the peptide of SEQ. ID 4, the peptide of SEQ. ID 5, the peptide of SEQ. ID 6, the peptide of SEQ. ID 7, and the peptide of SEQ. ID 8.

    Abstract translation: 本发明涉及用于治疗白癜风的协同疗法。 特别地，本发明涉及用于减少皮肤皱纹，加速伤口愈合以及包含肽和可接受载体的头发变黑的组合物。 肽可以选自SEQ ID NO：1的肽。 ID 1，SEQ。 ID 2，SEQ。 ID 3，SEQ。 ID 4，SEQ。 ID 5，SEQ。 ID 6，SEQ。 SEQ ID NO：7，以及SEQ。 ID 8。

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