-
公开(公告)号:USD1023290S1
公开(公告)日:2024-04-16
申请号:US29900985
申请日:2023-08-28
Applicant: AMGEN INC.
Designer: Margaux Frances Boyaval , Sigrid Moeslinger , Masamichi Udagawa
Abstract: The file of this patent contains at least one drawing/photograph executed in color. Copies of this patent with color drawing(s)/photograph(s) will be provided by the Office upon request and payment of the necessary fee.
FIG. 1 is a perspective view showing a new design for an autoinjector with a removable cap, showing the removable cap disposed on the autoinjector;
FIG. 2 is a front view of the autoinjector of FIG. 1;
FIG. 3 is a rear view of the autoinjector with removable cap of FIG. 1;
FIG. 4 is a left-side view of the autoinjector with removable cap of FIG. 1;
FIG. 5 is a right-side view of the autoinjector with removable cap of FIG. 1;
FIG. 6 is a top view of the autoinjector with removable cap of FIG. 1;
FIG. 7 is a bottom view of the autoinjector with removable cap of FIG. 1; and,
FIG. 8 is a perspective view showing the autoinjector with removable cap of FIGS. 1-7 with the removable cap removed.-
公开(公告)号:US11959486B2
公开(公告)日:2024-04-16
申请号:US17400044
申请日:2021-08-11
Applicant: AMGEN INC.
Inventor: Derek Maclean , Qun Yin
IPC: A61K38/08 , A61K9/00 , A61K9/08 , A61K47/12 , A61P3/00 , A61P3/14 , A61P5/00 , A61P5/18 , A61P43/00 , F01D15/10 , F04D25/06
CPC classification number: F04D25/0606 , A61K9/0019 , A61K9/08 , A61K38/08 , A61K47/12 , F01D15/10
Abstract: A liquid formulation comprising a peptide agonist of the calcium sensing receptor and method of preparing and using the formulation are provided.
-
公开(公告)号:US11946085B2
公开(公告)日:2024-04-02
申请号:US18134291
申请日:2023-04-13
Applicant: Amgen Inc.
Inventor: Chung-Jr Huang , Xiaoming Yang
CPC classification number: C12P21/005 , C07K16/00 , C12N5/0018 , C07K2317/41 , C12N2500/34
Abstract: The present invention relates to methods of upregulating the high mannose glycoform content of a recombinant protein during a mammalian cell culture by manipulating the mannose to total hexose ratio in the cell culture media formulation.
-
公开(公告)号:US20240101570A1
公开(公告)日:2024-03-28
申请号:US18255575
申请日:2021-11-22
Applicant: AMGEN INC.
Inventor: Albert AMEGADZIE , Diane Jennifer BEYLKIN , Shon BOOKER , Matthew Paul BOURBEAU , John R. BUTLER , Sanne Ormholt Schroder GLAD , Todd J. KOHN , Brian Alan LANMAN , Kexue LI , Qingyian LIU , Patricia LOPEZ , Francesco MANONI , Primali Vasundera NAVARATNE , Liping H. PETTUS , Rene RAHIMOFF , Nuria A. TAMAYO , Mikkel VESTERGAARD , Hui-Ling WANG , Nicholas Anthony WEIRES
IPC: C07D491/048 , A61K35/00 , C07D401/12 , C07D401/14 , C07D471/04 , C07D471/14 , C07D487/04 , C07D491/147 , C07D495/04 , C07D498/04 , C07D519/00
CPC classification number: C07D491/048 , A61K35/00 , C07D401/12 , C07D401/14 , C07D471/04 , C07D471/14 , C07D487/04 , C07D491/147 , C07D495/04 , C07D498/04 , C07D519/00
Abstract: Described herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, such as cancer, metabolic and blood disorders. Compounds of Formula (I) have the following structure of Formula (I).
-
公开(公告)号:US20240100247A1
公开(公告)日:2024-03-28
申请号:US17767466
申请日:2020-10-01
Applicant: AMGEN INC.
Inventor: Tohid Pirbodaghi , Joshua Tamsky , Paul Daniel Faucher , Jeff Lind , Scott R. Gibson , Sheldon B. Moberg , Samin Akbari
CPC classification number: A61M5/14248 , A61M5/1454 , A61M5/16881 , A61M39/26 , A61M2005/14252
Abstract: A drug delivery device includes a housing, a container disposed in the housing, an activation mechanism, a needle insertion mechanism, and a fluid flow path. The container has an inner volume to contain a medicament which is urged out of the container by the activation mechanism. The needle insertion mechanism includes an actuation assembly adapted to insert a needle and a cannula to deliver the medicament from the container and a valve assembly. The fluid flow connection is coupled with the container and the needle insertion mechanism and is adapted to allow the medicament to flow from the container to the needle insertion mechanism. The valve assembly is repeatedly movable between at least a valve open position and a valve closed position to selectively allow and restrict the medicament to flow through the needle and/or the cannula.
-
公开(公告)号:US20240076333A1
公开(公告)日:2024-03-07
申请号:US18499499
申请日:2023-11-01
Applicant: Amgen Inc.
Inventor: Edward John Belouski , Murielle Marie Ellison , Agnes Eva Hamburger , Randy Ira Hecht , Yue-Sheng Li , Mark Leo Michaels , Jeonghoon Sun , JIng Xu
CPC classification number: C07K14/50 , A61K38/1825 , A61K2039/505
Abstract: The invention provides nucleic acid molecules encoding FGF21 mutant polypeptides, FGF21 mutant polypeptides, pharmaceutical compositions comprising FGF21 mutant polypeptides, and methods for treating metabolic disorders using such nucleic acids, polypeptides, or pharmaceutical compositions.
-
公开(公告)号:US20240075406A1
公开(公告)日:2024-03-07
申请号:US18268683
申请日:2022-02-17
Applicant: AMGEN INC.
Inventor: Jeremy S. Conner , Glenn M. Hunter , Kenneth Shoemaker , Neil Soice , Bret Wylie , John B. Flynn , Nakorn Kaeonil , Thuy N. Nguyen , Siddharth Sigh
CPC classification number: B01D15/1885 , C07K1/16
Abstract: Parallel chromatography systems and continuous manufacturing methods are described herein that utilize two or more chromatography column skids having columns operating in parallel with automation controls governing which column to load at a given time.
-
78.
公开(公告)号:US11918650B2
公开(公告)日:2024-03-05
申请号:US15972489
申请日:2018-05-07
Applicant: AMGEN INC.
Inventor: Jeff Abel , Lingwen Cui , Devrishi Goswami , Joon Huh , Bharadwaj Jagannathan , Sekhar Kanapuram , Arnold McAuley , Michael Schneider , Ananthakrishnan G. Sethuraman , Michael Treuheit , Jun Zhang
IPC: A61K39/395 , A61K9/00 , A61K9/08 , A61K9/19 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/24 , A61K47/26 , C07K16/28 , C07K16/46 , A61J1/05 , A61J1/10 , A61K39/00
CPC classification number: A61K39/39591 , A61K9/0019 , A61K9/08 , A61K9/19 , A61K39/3955 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/183 , A61K47/24 , A61K47/26 , C07K16/2803 , C07K16/2809 , C07K16/2863 , C07K16/468 , A61J1/05 , A61J1/10 , A61K2039/54 , A61K2039/545 , A61K2039/627 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/569
Abstract: The present invention provides an improved pharmaceutical composition for storage and administration comprising (a) a bispecific antibody construct comprising a first domain binding to a target cell surface antigen and a second domain binding to a second antigen, wherein the bispecific antibody construct is present at a concentration in the range from about 0.5 μg/ml to 20 mg/ml, (b) a preservative at a concentration effective to inhibit the growth of microbes, and (c) a diluent wherein bispecific antibody construct is stable and recoverable.
-
公开(公告)号:US11904143B2
公开(公告)日:2024-02-20
申请号:US16609466
申请日:2018-06-04
Applicant: AMGEN INC.
Inventor: Adam B. McCullough , Ronald Forster , Joseph Michael Iglesias , Matias Melander , Rasmus Øhlenschlaeger , Christian Plambech , Lars Stenholt , Bjarke Lykke Ludvig Svendsen
CPC classification number: A61M5/3145 , A61M5/20 , A61M5/31583 , A61M2005/3143
Abstract: An injector includes a housing having a syringe assembly and an actuating mechanism at least partially disposed within the housing. The syringe assembly includes a syringe barrel that stores a medicament to be injected into a user, a needle assembly, and a filter member disposed adjacent to the needle assembly. The actuating mechanism is operatively coupled to the syringe assembly and includes a torque spring that exerts a torque to urge the medicament through the filter member to be injected into the user. The actuating mechanism further includes a damper mechanism that exerts an opposing force to dampen the motion exerted by the torque spring.
-
公开(公告)号:US20240043939A1
公开(公告)日:2024-02-08
申请号:US18380117
申请日:2023-10-13
Applicant: Daiichi Sankyo Co., Ltd. , U3 Pharma GmbH , Amgen, Inc.
Inventor: Matthias SCHNEIDER , Sabine BLUM , Renee Jeanne MENDELL-HARARY , Daniel J. FREEMAN , Robert Allen BECKMAN , Xiaoping JIN
IPC: C12Q1/6886 , C07K16/32 , C07K16/28 , A61K39/395 , A61K45/06
CPC classification number: C12Q1/6886 , C07K16/32 , C07K16/2863 , A61K39/39558 , A61K45/06 , A61K2039/505
Abstract: The present invention is directed to methods of identifying and treating a human subject harboring a tumor or other disease comprising assessing HRG gene expression at an mRNA level in the human subject and administering a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at an mRNA level is assessed as high. The present invention is also directed to methods of identifying a human subject harboring a tumor or other disease comprising assessing HRG gene expression at an mRNA level in the human subject and withholding a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at an mRNA level is assessed as low.
-
-
-
-
-
-
-
-
-