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公开(公告)号：US11434514B2
公开(公告)日：2022-09-06
申请号：US17533004
申请日：2021-11-22
Applicant: Amgen Inc.
Inventor： Chung-Jr Huang , Xiaoming Yang
Abstract: The present invention relates to methods of upregulating the high mannose glycoform content of a recombinant protein during a mammalian cell culture by manipulating the mannose to total hexose ratio in the cell culture media formulation.
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公开(公告)号：US10894972B2
公开(公告)日：2021-01-19
申请号：US16537490
申请日：2019-08-09
Applicant: AMGEN INC.
Inventor： Chung-Jr Huang , Xiaoming Yang
Abstract: The present invention relates to methods of upregulating the high mannose glycoform content of a recombinant protein during a mammalian cell culture by manipulating the mannose to total hexose ratio in the cell culture media formulation.
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Patent Agency Ranking
公开(公告)号：US10421987B2
公开(公告)日：2019-09-24
申请号：US16039123
申请日：2018-07-18
Applicant: AMGEN INC.
Inventor： Chung-Jr Huang , Xiaoming Yang
Abstract: The present invention relates to methods of upregulating the high mannose glycoform content of a recombinant protein during a mammalian cell culture by manipulating the mannose to total hexose ratio in the cell culture media formulation.
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公开(公告)号：US10184143B2
公开(公告)日：2019-01-22
申请号：US15285392
申请日：2016-10-04
Applicant: AMGEN INC.
Inventor： Chung-Jr Huang , Xiaoming Yang
Abstract: The present invention relates to methods of upregulating the high mannose glycoform content of a recombinant protein during a mammalian cell culture by manipulating the mannose to total hexose ratio in the cell culture media formulation.
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公开(公告)号：US11946085B2
公开(公告)日：2024-04-02
申请号：US18134291
申请日：2023-04-13
Applicant: Amgen Inc.
Inventor： Chung-Jr Huang , Xiaoming Yang
CPC classification number: C12P21/005 , C07K16/00 , C12N5/0018 , C07K2317/41 , C12N2500/34
Abstract: The present invention relates to methods of upregulating the high mannose glycoform content of a recombinant protein during a mammalian cell culture by manipulating the mannose to total hexose ratio in the cell culture media formulation.
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公开(公告)号：US11597959B2
公开(公告)日：2023-03-07
申请号：US17121419
申请日：2020-12-14
Applicant: Amgen Inc.
Inventor： Chung-Jr Huang , Xiaoming Yang
Abstract: The present invention relates to methods of upregulating the high mannose glycoform content of a recombinant protein during a mammalian cell culture by manipulating the mannose to total hexose ratio in the cell culture media formulation.
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公开(公告)号：US09481901B2
公开(公告)日：2016-11-01
申请号：US14289943
申请日：2014-05-29
Applicant: Amgen Inc.
Inventor： Chung-Jr Huang , Xiaoming Yang
CPC classification number: C12P21/005 , C07K16/00 , C07K2317/41 , C12N5/0018 , C12N2500/34
Abstract: The present invention relates to methods of upregulating the high mannose glycoform content of a recombinant protein during a mammalian cell culture by manipulating the mannose to total hexose ratio in the cell culture media formulation.
Abstract translation: 本发明涉及在哺乳动物细胞培养过程中通过在细胞培养基制剂中操纵甘露糖至总己糖比来上调重组蛋白的高甘露糖糖型含量的方法。
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