公开(公告)号：US20240076333A1

公开(公告)日：2024-03-07

申请号：US18499499

申请日：2023-11-01

Applicant: Amgen Inc.

Inventor： Edward John Belouski ,  Murielle Marie Ellison ,  Agnes Eva Hamburger ,  Randy Ira Hecht ,  Yue-Sheng Li ,  Mark Leo Michaels ,  Jeonghoon Sun ,  JIng Xu

IPC: C07K14/50 ,  A61K38/18

CPC classification number: C07K14/50 ,  A61K38/1825 ,  A61K2039/505

Abstract: The invention provides nucleic acid molecules encoding FGF21 mutant polypeptides, FGF21 mutant polypeptides, pharmaceutical compositions comprising FGF21 mutant polypeptides, and methods for treating metabolic disorders using such nucleic acids, polypeptides, or pharmaceutical compositions.