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1085 条记录 (耗时 0.055 秒)

    Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them
    62.
    发明授权
    Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them 有权
    吲哚和苯并呋喃稠合的亚奎宁衍生物及其制备方法

    公开(公告)号：US09150584B2

    公开(公告)日：2015-10-06

    申请号：US13749593

    申请日：2013-01-24

    申请人： DemeRx, Inc.

    发明人： Robert M. Moriarty

    IPC分类号： C07D491/22 ,  C07D471/22

    CPC分类号： C07D453/00 ,  C07D471/22 ,  C07D491/22

    摘要： Provided herein are indole and benzofuran fused isoquinuclidene derivatives. Also provided herein are processes, preferably enantioselective processes, for preparing such derivatives including processes for preparing (−) and (+) noribogaine or a salt thereof, in substantially enantiomerically pure forms.

    摘要翻译： 本文提供的是吲哚和苯并呋喃稠合的亚奎宁衍生物。 本文还提供用于制备此类衍生物的方法，优选对映选择性方法，包括以基本上对映体纯的形式制备（ - ）和（+）诺布恩或其盐的方法。

    Tetrandrine derivatives with substituted 5-carbon, preparation method and use thereof
    63.
    发明授权
    Tetrandrine derivatives with substituted 5-carbon, preparation method and use thereof 有权
    具有取代的5碳的替康德林衍生物，其制备方法和用途

    公开(公告)号：US09133207B2

    公开(公告)日：2015-09-15

    申请号：US14239759

    申请日：2012-08-20

    申请人： Rongzhen Xu ,  Frank Rong ,  Fuwen Xie ,  Hongxi Lai

    发明人： Rongzhen Xu ,  Frank Rong ,  Fuwen Xie ,  Hongxi Lai

    IPC分类号： C07D491/18 ,  C07D491/22 ,  C07D491/147

    CPC分类号： C07D491/22 ,  C07D491/147 ,  C07D491/18

    摘要： The present invention belongs to the field of natural medicine and pharmaceutical chemistry and specifically relates to novel 5-substituted tetrandrine derivatives of formula (I) and a pharmaceutically acceptable adduct, complex and salt thereof, to a process for the preparation of these compounds, pharmaceutical compositions containing such compounds and their use in preparing antineoplastic medicaments.

    摘要翻译： 本发明属于天然药物和药物化学领域，具体涉及式（I）的新型5-取代四甲基环戊二烯衍生物及其药学上可接受的加合物，其络合物和盐，用于制备这些化合物，药物 含有这些化合物的组合物及其在制备抗肿瘤药物中的用途。

    Morphinan derivative
    68.
    发明授权
    Morphinan derivative 有权
    吗啡衍生物

    公开(公告)号：US08952030B2

    公开(公告)日：2015-02-10

    申请号：US14343218

    申请日：2012-09-07

    申请人： Hiroshi Nagase ,  Hideaki Fujii ,  Eriko Nakata ,  Yoshikazu Watanabe ,  Toshihiro Takahashi

    发明人： Hiroshi Nagase ,  Hideaki Fujii ,  Eriko Nakata ,  Yoshikazu Watanabe ,  Toshihiro Takahashi

    IPC分类号： A61K31/485 ,  C07D491/18 ,  C07D487/08 ,  C07F7/18

    CPC分类号： C07D491/18 ,  C07D471/08 ,  C07D471/22 ,  C07D487/08 ,  C07D491/22 ,  C07F7/1804

    摘要： A morphinan derivative represented by the following general formula (I): (in the formula, R1 represents hydrogen, C1-6 alkyl, cycloalkylalkyl (the cycloalkyl moiety has 3 to 6 carbon atoms, and the alkylene moiety has 1 to 5 carbon atoms), aralkyl (the aryl moiety has 6 to 10 carbon atoms, and the alkylene moiety has 1 to 5 carbon atoms) and the like, R2 represents hydrogen, C1-6 alkyl, C3-6 cycloalkyl, C6-10 aryl, aralkyl (the aryl moiety has 6 to 10 carbon atoms, and the alkylene moiety has 1 to 5 carbon atoms) and the like, R3, R4 and R5 represent hydrogen, hydroxy, carbamoyl, C1-6 alkoxy, C6-10 aryloxy and the like, R6a, R6b, R7, R8, R9, and R10 represent hydrogen and the like, X represents O or CH2, and Y represents C═O, SO2, an atomic bond and the like), or an acid addition salt thereof is used as an analgesic.

    摘要翻译： 由以下通式（I）表示的吗啡喃衍生物：（式中，R 1表示氢，C 1-6烷基，环烷基烷基（环烷基部分具有3〜6个碳原子，亚烷基部分具有1〜5个碳原子） ，芳烷基（芳基部分具有6〜10个碳原子，亚烷基部分具有1〜5个碳原子）等，R 2表示氢，C 1-6烷基，C 3-6环烷基，C 6-10芳基，芳烷基（ 芳基部分具有6至10个碳原子，亚烷基部分具有1至5个碳原子）等，R 3，R 4和R 5表示氢，羟基，氨基甲酰基，C 1-6烷氧基，C 6-10芳氧基等，R 6a ，R6b，R7，R8，R9和R10表示氢等，X表示O或CH2，Y表示C = O，SO2，原子键等）或其酸加成盐作为 镇痛药