公开(公告)号：US09266897B2

公开(公告)日：2016-02-23

申请号：US14354019

申请日：2012-10-24

申请人： Institute of Materia Medica, Chinese Academy of Medical Sciences

发明人： Hailin Qin ,  Wenjie Wang ,  Zhihui Zhang ,  Lianqiu Wu ,  Anjun Deng ,  Jinqian Yu ,  Zhihong Li

IPC分类号： A61K31/4741 ,  C07D491/22 ,  C07D455/03 ,  C07D491/04 ,  C07D491/147

CPC分类号： C07D491/22 ,  C07D455/03 ,  C07D491/04 ,  C07D491/147

摘要： Disclosed are derivatives of protoberberine biological alkaloids or physiologically acceptable salts thereof produced by means of a derivative reaction of a source material of biological alkaline quaternary ammonium salts of protoberberine alkaloids, a preparation method for same and pharmaceutical uses thereof. The derivatives of protoberberine biological alkaloids or the physiologically acceptable salts thereof show activity inhibiting ulcerative colitis and can be used in the preparation of drugs for same.

摘要翻译： 公开了通过原花青素生物碱的生物碱性季铵盐的源材料的衍生反应，其制备方法及其药学用途而产生的原柏生物生物碱或其生理学上可接受的盐的衍生物。 原花青素生物碱的衍生物或其生理上可接受的盐显示出抑制溃疡性结肠炎的活性，可用于制备相同的药物。

公开(公告)号：US11725006B2

公开(公告)日：2023-08-15

申请号：US17046927

申请日：2019-10-17

申请人： INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES

发明人： Hailin Qin ,  Lianqiu Wu ,  Xiang Li ,  Haijing Zhang ,  Li Song ,  Huachen Song ,  Anjun Deng ,  Xiaonan Tang ,  Zhihui Zhang ,  Xiang Li ,  Zhihong Li

IPC分类号： C07D455/03 ,  A61P31/04 ,  A61P29/00 ,  A61P1/04 ,  A61P31/10 ,  A61P35/00 ,  C07D493/14 ,  C07D493/22

CPC分类号： C07D455/03 ,  A61P1/04 ,  A61P29/00 ,  A61P31/04 ,  A61P31/10 ,  A61P35/00 ,  C07D493/14 ,  C07D493/22

摘要： An 8-dihalomethyl berberine-type quaternary ammonium salt compound represented by general formula (I) or (II) and an application thereof in preparing a drug. The compound shows hydrophilicity and has antimicrobial, anti-inflammatory, anti-ulcerative colitis, and antitumor activities, while having no or low toxicity.

公开(公告)号：US20150031717A1

公开(公告)日：2015-01-29

申请号：US14354019

申请日：2012-10-24

申请人： Institute of Materia Medica, Chinese Academy of Medical Sciences

发明人： Hailin Qin ,  Wenjie Wang ,  Zhihui Zhang ,  Lianqiu Wu ,  Anjun Deng ,  Jinqian Yu ,  Zhihong Li

IPC分类号： C07D491/22 ,  C07D491/147

CPC分类号： C07D491/22 ,  C07D455/03 ,  C07D491/04 ,  C07D491/147

摘要： Disclosed are derivatives of protoberberine biological alkaloids or physiologically acceptable salts thereof produced by means of a derivative reaction of a source material of biological alkaline quaternary ammonium salts of protoberberine alkaloids, a preparation method for same and pharmaceutical uses thereof. The derivatives of protoberberine biological alkaloids or the physiologically acceptable salts thereof show activity inhibiting ulcerative colitis and can be used in the preparation of drugs for same.

摘要翻译： 公开了通过原花青素生物碱的生物碱性季铵盐的源材料的衍生反应，其制备方法及其药学用途而产生的原柏生物生物碱或其生理学上可接受的盐的衍生物。 原花青素生物碱的衍生物或其生理上可接受的盐显示出抑制溃疡性结肠炎的活性，可用于制备相同的药物。