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    Silicon-on-insulator microchannels for biological sensors
    65.
    发明授权
    Silicon-on-insulator microchannels for biological sensors 有权
    用于生物传感器的绝缘体上硅微通道

    公开(公告)号：US09524900B2

    公开(公告)日：2016-12-20

    申请号：US14186839

    申请日：2014-02-21

    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

    Inventor： Sameer Walavalkar ,  Mark D. Goldberg ,  Axel Scherer

    IPC: H01L21/00 ,  H01L21/762

    CPC classification number: H01L21/76283 ,  H01L21/762

    Abstract: Novel methods to fabricate biological sensors and electronics are disclosed. A silicon-on-insulator wafer can be employed by etching a pattern of holes in the silicon layer, then a pattern of cavities in the insulating layer, and then sealing the top of the cavities. Further, n or p doped regions and metallic regions can be defined in the processed wafer, thereby enabling integration of biological sensing and electronic capabilities in the same wafer.

    Abstract translation: 公开了制造生物传感器和电子学的新方法。 可以通过蚀刻硅层中的孔的图案，然后在绝缘层中蚀刻空腔的图案，然后密封空腔的顶部来采用绝缘体上硅晶片。 此外，可以在经处理的晶片中限定n或p个掺杂区域和金属区域，从而使生物感测和电子能力能够集成在相同的晶片中。

    Methods and systems for exchanging signals with medical or physiological instrumentation
    66.
    发明授权
    Methods and systems for exchanging signals with medical or physiological instrumentation 有权
    用医疗或生理仪器交换信号的方法和系统

    公开(公告)号：US09480426B2

    公开(公告)日：2016-11-01

    申请号：US14153819

    申请日：2014-01-13

    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

    Inventor： Aditya Rajagopal ,  Axel Scherer ,  Akram Sarwat Sadek

    IPC: A61B5/1455 ,  A61B5/1459 ,  A61B5/00

    CPC classification number: A61B5/1459 ,  A61B5/0031 ,  A61B5/14552 ,  A61B5/6867 ,  A61B2560/0219

    Abstract: A process is described for testing a biomedical property of an internal tissue of a patient. Optical energy emitted by an external source is transferred through a nail of the patient to an instrument device implanted beneath the nail. A portion of the transferred optical energy is converted to electrical power for driving components of the implanted instrument. Using the electrical power, a characteristic of the internal tissue associated with the measurement of the biomedical property is sensed and an optical signal based on the sensed characteristic is transmitted through the nail to an external data reader.

    Abstract translation: 描述了用于测试患者内部组织的生物医学性质的方法。 由外部源发出的光能通过患者的指甲转移到植入在指甲下方的器械装置。 转移的光能的一部分被转换成用于驱动植入的仪器的部件的电力。 使用电力，检测与生物医学性质的测量相关联的内部组织的特性，并且基于感测到的特性的光学信号通过指甲传输到外部数据读取器。

    Mid-Infrared Hyperspectral Spectroscopy Systems and Methods Therefor
    67.
    发明申请
    Mid-Infrared Hyperspectral Spectroscopy Systems and Methods Therefor 有权
    中红外高光谱光谱系统及其方法

    公开(公告)号：US20160266035A1

    公开(公告)日：2016-09-15

    申请号：US15065792

    申请日：2016-03-09

    Applicant: California Institute of Technology

    Inventor： Axel Scherer ,  Frank T. Hartley

    IPC: G01N21/3577 ,  G01J3/28 ,  G01J3/42

    CPC classification number: G01N21/35 ,  G01J3/0208 ,  G01J3/0256 ,  G01J3/18 ,  G01J3/36 ,  G01J3/42 ,  G01J2003/1213 ,  G01N21/3577

    Abstract: MIR spectroscopy systems comprising hierarchical spectral dispersion that enables fine spectral resolution and high sensitivity spectroscopy are disclosed. Hierarchical spectral dispersion is derived by employing at least two diffractive lens arrays, located on either side of a test sample, each receiving input radiation having an input spectral range and distributing the input radiation into a plurality of output signals, each having a fraction of the spectral range of the input radiation. As a result, the signal multiplication factor of the two arrays is multiplied in a manner that mitigates the propagation of wavelength harmonics through the system. In some embodiments, an emitter array comprising a plurality of spectrally selective emitters provides the input MIR radiation to a spectroscopy system. In some embodiments, spectrally selective detectors are used to detect narrow spectral components in the radiation after they have passed through the test sample.

    Abstract translation: 公开了包括能够进行精细光谱分辨率和高灵敏度光谱的分级光谱色散的MIR光谱系统。 通过采用位于测试样本两侧的至少两个衍射透镜阵列来导出分层光谱色散，每个衍射透镜阵列接收具有输入光谱范围的输入辐射并将输入辐射分配成多个输出信号，每个输出信号具有 输入辐射的光谱范围。 结果，两个阵列的信号乘法因子以减轻波长谐波通过系统的传播的方式相乘。 在一些实施例中，包括多个光谱选择性发射器的发射器阵列将输入MIR辐射提供给光谱系统。 在一些实施例中，光谱选择性检测器用于在它们通过测试样品之后检测辐射中的窄光谱分量。

    Optical resonator diagnostic device and methods of use
    68.
    发明授权
    Optical resonator diagnostic device and methods of use 有权
    光谐振器诊断装置及其使用方法

    公开(公告)号：US09435803B2

    公开(公告)日：2016-09-06

    申请号：US13684020

    申请日：2012-11-21

    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

    Inventor： Axel Scherer ,  Samuel Njoroge ,  Jingqing Huang

    IPC: G01N33/543 ,  G01N33/566 ,  A61B5/1459 ,  A61B5/1491

    CPC classification number: G01N33/566 ,  A61B5/1459 ,  A61B5/1491 ,  A61B2562/0233 ,  A61B2562/043 ,  G01N21/41 ,  G01N33/54373 ,  G01N33/552 ,  G01N2201/068 ,  G01N2201/08

    Abstract: An implantable diagnostic device in accordance with the present disclosure provides various benefits such as a compact size thereby allowing implanting of the device inside animate objects; low cost due to incorporation of inexpensive detection circuitry and the use of conventional IC fabrication techniques; re-usability by heating thereby allowing multiple diagnostic tests to be performed without discarding the device; and a configuration that allows performing of simultaneous and/or sequential diagnostic tests for detecting one or more similar or dissimilar target molecules concurrently or at different times.

    Abstract translation: 根据本公开的可植入诊断装置提供各种益处，例如紧凑的尺寸，从而允许将装置植入动画物体内; 由于结合廉价的检测电路和使用传统的IC制造技术而导致的低成本; 通过加热可重复使用，从而允许执行多个诊断测试而不丢弃设备; 以及允许同时或不同时间执行同时和/或顺序诊断测试以检测一个或多个相似或不同的靶分子的配置。

    APPARATUS AND METHODS FOR CONDUCTING ASSAYS AND HIGH THROUGHPUT SCREENING
    70.
    发明申请
    APPARATUS AND METHODS FOR CONDUCTING ASSAYS AND HIGH THROUGHPUT SCREENING 审中-公开
    用于导电测试和高通量筛选的装置和方法

    公开(公告)号：US20160123958A1

    公开(公告)日：2016-05-05

    申请号：US14928631

    申请日：2015-10-30

    Applicant: California Institute of Technology

    Inventor： Stephen R. Quake ,  Marc A. Unger ,  Hou-Pu Chou ,  Todd A. Thorsen ,  Axel Scherer

    IPC: G01N33/50 ,  B01L3/00

    Abstract: The present invention provides microfluidic devices and methods for using the same. In particular, microfluidic devices of the present invention are useful in conducting a variety of assays and high throughput screening. Microfluidic devices of the present invention include elastomeric components and comprise a main flow channel; a plurality of branch flow channels; a plurality of control channels; and a plurality of valves. Preferably, each of the valves comprises one of the control channels and an elastomeric segment that is deflectable into or retractable from the main or branch flow channel upon which the valve operates in response to an actuation force applied to the control channel.

    Abstract translation: 本发明提供微流体装置及其使用方法。 特别地，本发明的微流体装置可用于进行各种测定和高通量筛选。 本发明的微流体装置包括弹性体部件并且包括主流动通道; 多个分支流动通道; 多个控制信道; 和多个阀。 优选地，每个阀包括控制通道中的一个和可响应于施加到控制通道的致动力而从阀或液流通道偏转进入或从其中缩回的弹性体段。

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