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    Biocompatible polymers and hydrogels and methods of use
    61.
    发明授权
    Biocompatible polymers and hydrogels and methods of use 有权
    生物相容性聚合物和水凝胶及其使用方法

    公开(公告)号：US08535705B2

    公开(公告)日：2013-09-17

    申请号：US11985588

    申请日：2007-11-16

    申请人： Chandrashekhar P. Pathak ,  Amarpreet S. Sawhney ,  Peter G. Edelman

    发明人： Chandrashekhar P. Pathak ,  Amarpreet S. Sawhney ,  Peter G. Edelman

    IPC分类号： A61F2/00

    CPC分类号： A61K9/0024 ,  A61K31/74 ,  A61K47/34 ,  A61K47/46 ,  A61L27/18 ,  A61L27/50 ,  A61L27/52 ,  A61L27/58 ,  A61L31/06 ,  A61L31/145 ,  A61L31/148 ,  C08G63/08 ,  C08G63/912

    摘要： Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable or not are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants.

    摘要翻译： 公开了生物相容的交联聚合物及其制备和使用的方法，其中生物相容的交联聚合物由具有能够原位反应和交联的亲电子基团和亲核基团的水溶性前体形成。 制备生物相容的交联聚合物可生物降解或不生物降解的方法与控制降解速率的方法一样。 交联反应可以在器官或组织上或身体外的原位进行。 用于这种生物相容性交联聚合物及其前体的应用包括药物的受控递送，术后粘连的预防，医疗装置如血管移植物，伤口敷料和手术密封剂的涂覆。

    Surgical delivery system for medical sealant
    62.
    发明授权
    Surgical delivery system for medical sealant 有权
    医用密封胶手术输送系统

    公开(公告)号：US07862538B2

    公开(公告)日：2011-01-04

    申请号：US12012606

    申请日：2008-02-04

    申请人： Amarpreet S. Sawhney ,  William H. Ransone, II ,  Mukesh Singhal

    发明人： Amarpreet S. Sawhney ,  William H. Ransone, II ,  Mukesh Singhal

    IPC分类号： A61M37/00

    CPC分类号： A61B17/0057 ,  A61B2017/00495 ,  A61B2017/0065

    摘要： Described herein are systems for packaging dual or multiple-component adhesive systems that provide enhanced convenience and efficacy. In one aspect, the components of such a system may be divided into containers that allow for foolproof mixing schemes to avoid mixing the wrong components while also providing a sterile surface for mixing materials, with the sterile surface having optimal physical properties for mixing the materials, especially in small amounts. Certain embodiments include a surgical delivery system for a medical sealant including a packaging system with a detachable a sterile surface for mixing the sealant as needed for application.

    摘要翻译： 本文描述的是用于包装双组分或多组分粘合剂体系的系统，其提供增强的便利性和有效性。 在一个方面，这种系统的组件可以被分成容器，其允许防混合方案以避免混合错误的组分，同时还提供用于混合材料的无菌表面，无菌表面具有用于混合材料的最佳物理性质， 特别是少量。 某些实施方案包括用于医用密封剂的手术递送系统，其包括具有可拆卸无菌表面的包装系统，用于根据需要混合密封剂。

    Biocompatible hydrogels made with small molecule precursors
    64.
    发明申请
    Biocompatible hydrogels made with small molecule precursors 有权
    用小分子前体制备的生物相容性水凝胶

    公开(公告)号：US20080260802A1

    公开(公告)日：2008-10-23

    申请号：US12156085

    申请日：2008-05-29

    申请人： Amarpreet S. Sawhney ,  Steven Bennett ,  Peter G. Edelman

    发明人： Amarpreet S. Sawhney ,  Steven Bennett ,  Peter G. Edelman

    IPC分类号： A61L27/58 ,  A61L27/52

    CPC分类号： A61K47/42 ,  A61K9/0014 ,  A61K9/0019 ,  A61L27/52 ,  A61L27/58 ,  A61L31/145 ,  A61L31/148 ,  C07K14/75 ,  C08L89/00 ,  C08L2666/02

    摘要： Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic functional groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable, or not, are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants. Visualization agents may be included with the crosslinked polymers. Embodiments that include hydrogels having isolated hydrolytically degradable esters are set forth. Embodiments including the use of low molecular weight amines to make degradable hydrogels are also set forth.

    摘要翻译： 公开了生物相容的交联聚合物及其制备和使用的方法，其中生物相容的交联聚合物由具有能够原位反应和交联的亲电子和亲核官能团的水溶性前体形成。 制备生物相容的交联聚合物可生物降解的方法也可以提供，以及用于控制降解速率的方法。 交联反应可以在器官或组织上或身体外的原位进行。 用于这种生物相容性交联聚合物及其前体的应用包括药物的受控递送，术后粘连的预防，医疗装置如血管移植物，伤口敷料和手术密封剂的涂覆。 可交联剂可以与交联聚合物一起包含。 阐述包括具有分离的水解可降解酯的水凝胶的实施方案。 还阐述了包括使用低分子量胺来制备可降解水凝胶的实施方案。

    Dehydrated hydrogel precursor-based, tissue adherent compositions and methods of use
    68.
    发明授权
    Dehydrated hydrogel precursor-based, tissue adherent compositions and methods of use 有权
    脱水水凝胶前体，组织粘附组合物和使用方法

    公开(公告)号：US06703047B2

    公开(公告)日：2004-03-09

    申请号：US09776120

    申请日：2001-02-02

    申请人： Amarpreet S. Sawhney ,  Peter G. Edelman

    发明人： Amarpreet S. Sawhney ,  Peter G. Edelman

    IPC分类号： A61K914

    CPC分类号： A61K9/0075 ,  A61K9/7023 ,  A61K47/34

    摘要： Compositions and methods are provided for forming tissue-adherent hydrogels using substantially dry precursors. The dehydrated precursors are premixed prior to in situ therapy and utilize naturally-occurring body fluids as an aqueous environment that initiates transformation, which causes dissolution and nearly simultaneous crosslinking of the precursors, thus forming an insoluble hydrogel implant. The dehydrated precursor-based hydrogels may be used as sealants for fluid leaks from tissue, as adherent drug delivery depots, as means for augmenting and/or supporting tissue, and as means for serving a variety of other useful medical and surgical purposes.

    摘要翻译： 提供了使用基本上干燥的前体形成组织粘附水凝胶的组合物和方法。 脱水前体在原位治疗之前被预混合，并且利用天然存在的体液作为引发转化的水性环境，其导致前体的溶解和几乎同时的交联，从而形成不溶性水凝胶注入物。 脱水的基于前体的水凝胶可以用作来自组织的流体泄漏的密封剂，作为粘附药物递送贮库，作为用于增强和/或支持组织的手段，以及用于服务于各种其它有用的医学和外科用途的手段。

    Methods and apparatus for in situ formation of hydrogels
    69.
    发明授权
    Methods and apparatus for in situ formation of hydrogels 有权
    水凝胶原位形成方法和装置

    公开(公告)号：US06673093B1

    公开(公告)日：2004-01-06

    申请号：US09513491

    申请日：2000-04-21

    申请人： Amarpreet S. Sawhney

    发明人： Amarpreet S. Sawhney

    IPC分类号： A61B1704

    CPC分类号： A61M35/00 ,  A61B17/00491 ,  A61B2017/00495 ,  A61M25/0071

    摘要： Methods and apparatus of forming in situ tissue adherent barriers are provided using a sprayer capable of applying two or more viscous crosslinkable components to tissue. The sprayer comprises separate spray nozzles for each of two or more crosslinkable solutions, with each nozzle surrounded by an annular gas flow outlet. Crosslinkable solutions are stored in separate compartments and communicated under pressure to the spray nozzles. In the presence of gas flow through the annular gas flow outlets, the crosslinkable solutions are atomized and mixed in the gas flow to form a spray. Multi-component hydrogel systems suitable for use with the inventive methods and apparatus are also described.

    摘要翻译： 使用能够向组织施加两种或更多种粘性可交联组分的喷雾器来提供形成原位组织粘附屏障的方法和装置。 喷雾器包括用于两个或更多个可交联溶液中的每一个的单独的喷嘴，每个喷嘴由环形气流出口包围。 可交联溶液储存在独立的隔间中，并在压力下与喷嘴相通。 在存在通过环形气流出口的气流的情况下，将可交联溶液雾化并在气流中混合形成喷雾。 还描述了适用于本发明方法和装置的多组分水凝胶体系。