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公开(公告)号：US08512749B2
公开(公告)日：2013-08-20
申请号：US10795132
申请日：2004-03-05
CPC分类号： A61K9/0075 , A61K9/7023 , A61K47/34
摘要： Compositions and methods are provided for forming tissue-adherent hydrogels using substantially dry precursors. The dehydrated precursors are premixed prior to in situ therapy and utilize naturally-occurring body fluids as an aqueous environment that initiates transformation, which causes dissolution and nearly simultaneous crosslinking of the precursors, thus forming an insoluble hydrogel implant. The dehydrated precursor-based hydrogels may be used as sealants for fluid leaks from tissue, as adherent drug delivery depots, as means for augmenting and/or supporting tissue, and as means for serving a variety of other useful medical and surgical purposes.
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公开(公告)号：US08535705B2
公开(公告)日：2013-09-17
申请号：US11985588
申请日：2007-11-16
IPC分类号： A61F2/00
CPC分类号： A61K9/0024 , A61K31/74 , A61K47/34 , A61K47/46 , A61L27/18 , A61L27/50 , A61L27/52 , A61L27/58 , A61L31/06 , A61L31/145 , A61L31/148 , C08G63/08 , C08G63/912
摘要： Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable or not are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants.
摘要翻译： 公开了生物相容的交联聚合物及其制备和使用的方法，其中生物相容的交联聚合物由具有能够原位反应和交联的亲电子基团和亲核基团的水溶性前体形成。 制备生物相容的交联聚合物可生物降解或不生物降解的方法与控制降解速率的方法一样。 交联反应可以在器官或组织上或身体外的原位进行。 用于这种生物相容性交联聚合物及其前体的应用包括药物的受控递送，术后粘连的预防，医疗装置如血管移植物，伤口敷料和手术密封剂的涂覆。
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公开(公告)号：US20080260802A1
公开(公告)日：2008-10-23
申请号：US12156085
申请日：2008-05-29
CPC分类号： A61K47/42 , A61K9/0014 , A61K9/0019 , A61L27/52 , A61L27/58 , A61L31/145 , A61L31/148 , C07K14/75 , C08L89/00 , C08L2666/02
摘要： Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic functional groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable, or not, are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants. Visualization agents may be included with the crosslinked polymers. Embodiments that include hydrogels having isolated hydrolytically degradable esters are set forth. Embodiments including the use of low molecular weight amines to make degradable hydrogels are also set forth.
摘要翻译： 公开了生物相容的交联聚合物及其制备和使用的方法，其中生物相容的交联聚合物由具有能够原位反应和交联的亲电子和亲核官能团的水溶性前体形成。 制备生物相容的交联聚合物可生物降解的方法也可以提供，以及用于控制降解速率的方法。 交联反应可以在器官或组织上或身体外的原位进行。 用于这种生物相容性交联聚合物及其前体的应用包括药物的受控递送，术后粘连的预防，医疗装置如血管移植物，伤口敷料和手术密封剂的涂覆。 可交联剂可以与交联聚合物一起包含。 阐述包括具有分离的水解可降解酯的水凝胶的实施方案。 还阐述了包括使用低分子量胺来制备可降解水凝胶的实施方案。
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公开(公告)号：US07009034B2
公开(公告)日：2006-03-07
申请号：US10010715
申请日：2001-11-09
CPC分类号： A61K47/34 , A61K9/0014 , A61K9/0019 , A61K9/0024 , A61K31/74 , A61K47/42 , A61L24/106 , A61L27/18 , A61L27/50 , A61L31/06 , C07K14/75 , C08G63/08 , C08G63/912 , C08L89/00 , G06K7/10831 , G06K2207/1016 , C08L2666/02
摘要： Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic functional groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable or not are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants. Visualization agents may be included with the crosslinked polymers.
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5.发明授权Dehydrated hydrogel precursor-based, tissue adherent compositions and methods of use 有权脱水水凝胶前体，组织粘附组合物和使用方法公开(公告)号：US06703047B2
公开(公告)日：2004-03-09
申请号：US09776120
申请日：2001-02-02
IPC分类号： A61K914
CPC分类号： A61K9/0075 , A61K9/7023 , A61K47/34
摘要： Compositions and methods are provided for forming tissue-adherent hydrogels using substantially dry precursors. The dehydrated precursors are premixed prior to in situ therapy and utilize naturally-occurring body fluids as an aqueous environment that initiates transformation, which causes dissolution and nearly simultaneous crosslinking of the precursors, thus forming an insoluble hydrogel implant. The dehydrated precursor-based hydrogels may be used as sealants for fluid leaks from tissue, as adherent drug delivery depots, as means for augmenting and/or supporting tissue, and as means for serving a variety of other useful medical and surgical purposes.
摘要翻译： 提供了使用基本上干燥的前体形成组织粘附水凝胶的组合物和方法。 脱水前体在原位治疗之前被预混合，并且利用天然存在的体液作为引发转化的水性环境，其导致前体的溶解和几乎同时的交联，从而形成不溶性水凝胶注入物。 脱水的基于前体的水凝胶可以用作来自组织的流体泄漏的密封剂，作为粘附药物递送贮库，作为用于增强和/或支持组织的手段，以及用于服务于各种其它有用的医学和外科用途的手段。
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公开(公告)号：US08003705B2
公开(公告)日：2011-08-23
申请号：US12156085
申请日：2008-05-29
CPC分类号： A61K47/42 , A61K9/0014 , A61K9/0019 , A61L27/52 , A61L27/58 , A61L31/145 , A61L31/148 , C07K14/75 , C08L89/00 , C08L2666/02
摘要： Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic functional groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable, or not, are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants. Visualization agents may be included with the crosslinked polymers. Embodiments that include hydrogels having isolated hydrolytically degradable esters are set forth. Embodiments including the use of low molecular weight amines to make degradable hydrogels are also set forth.
摘要翻译： 公开了生物相容的交联聚合物及其制备和使用的方法，其中生物相容的交联聚合物由具有能够原位反应和交联的亲电子和亲核官能团的水溶性前体形成。 制备生物相容的交联聚合物可生物降解的方法也可以提供，以及用于控制降解速率的方法。 交联反应可以在器官或组织上或身体外的原位进行。 用于这种生物相容性交联聚合物及其前体的应用包括药物的受控递送，术后粘连的预防，医疗装置如血管移植物，伤口敷料和手术密封剂的涂覆。 可交联剂可以与交联聚合物一起包含。 阐述包括具有分离的水解可降解酯的水凝胶的实施方案。 还阐述了包括使用低分子量胺来制备可降解水凝胶的实施方案。
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公开(公告)号：US07592418B2
公开(公告)日：2009-09-22
申请号：US12069821
申请日：2008-02-13
CPC分类号： A61K47/34 , A61K9/0014 , A61K9/0019 , A61K9/0024 , A61K31/74 , A61K47/42 , A61L24/106 , A61L27/18 , A61L27/50 , A61L31/06 , C07K14/75 , C08G63/08 , C08G63/912 , C08L89/00 , G06K7/10831 , G06K2207/1016 , C08L2666/02
摘要： Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic functional groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable or not are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants. Visualization agents may be included with the crosslinked polymers.
摘要翻译： 公开了生物相容的交联聚合物及其制备和使用的方法，其中生物相容的交联聚合物由具有能够原位反应和交联的亲电子和亲核官能团的水溶性前体形成。 制备生物相容的交联聚合物可生物降解或不生物降解的方法与控制降解速率的方法一样。 交联反应可以在器官或组织上或身体外的原位进行。 用于这种生物相容性交联聚合物及其前体的应用包括药物的受控递送，术后粘连的预防，医疗装置如血管移植物，伤口敷料和手术密封剂的涂覆。 可交联剂可以与交联聚合物一起包含。
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公开(公告)号：US06610033B1
公开(公告)日：2003-08-26
申请号：US09687588
申请日：2000-10-13
IPC分类号： A61M500
CPC分类号： B05C17/00593 , A61B17/00491 , A61B2017/00482 , A61B2017/00495 , A61J1/201 , A61J1/2013 , A61J1/2055 , A61J1/2058 , A61J1/2096 , A61M5/1782 , A61M5/19 , A61M5/2448 , A61M2005/3139 , B05C17/00516
摘要： The present invention provides apparatus and methods for making and using a medicinal polymer formed from two components. The apparatus includes a double syringe holder housing first and second syringes that is adapted to be coupled with a predetermined orientation to a double vial holder housing first and second vials. The double syringe holder and double vial holder have mating key features that prevent the first syringe from being coupled to the second vial and the second syringe from being coupled to the first vial. The apparatus also includes a delivery device having first and second inlet ports and a key feature that prevents the first syringe from being coupled to the second inlet port and the second syringe from being coupled to the first inlet port.
摘要翻译： 本发明提供用于制造和使用由两种组分形成的医用聚合物的装置和方法。 该装置包括双重注射器支架，该双重注射器支架容纳第一和第二注射器，该第一和第二注射器适于以预定取向与第二和第二小瓶的双小瓶支架相结合。 双注射器支架和双小瓶支架具有配合的关键特征，其防止第一注射器与第二小瓶耦合，并且第二注射器与第一小瓶联接。 该装置还包括具有第一和第二入口端口的输送装置和防止第一注射器联接到第二入口端口并且第二注射器被联接到第一入口的关键特征。
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公开(公告)号：US06566406B1
公开(公告)日：2003-05-20
申请号：US09454900
申请日：1999-12-03
IPC分类号： A61K4730
CPC分类号： A61K9/0024 , A61K31/74 , A61K47/34 , A61K47/46 , A61L27/18 , A61L27/50 , A61L27/52 , A61L27/58 , A61L31/06 , A61L31/145 , A61L31/148 , C08G63/08 , C08G63/912
摘要： Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable or not are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants.
摘要翻译： 公开了生物相容的交联聚合物及其制备和使用的方法，其中生物相容的交联聚合物由具有能够原位反应和交联的亲电子基团和亲核基团的水溶性前体形成。 制备生物相容的交联聚合物可生物降解或不生物降解的方法与控制降解速率的方法一样。 交联反应可以在器官或组织上或身体外的原位进行。 用于这种生物相容性交联聚合物及其前体的应用包括药物的受控递送，术后粘连的预防，医疗装置如血管移植物，伤口敷料和手术密封剂的涂覆。
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公开(公告)号：US07332566B2
公开(公告)日：2008-02-19
申请号：US11293892
申请日：2005-12-02
CPC分类号： A61K47/34 , A61K9/0014 , A61K9/0019 , A61K9/0024 , A61K31/74 , A61K47/42 , A61L24/106 , A61L27/18 , A61L27/50 , A61L31/06 , C07K14/75 , C08G63/08 , C08G63/912 , C08L89/00 , G06K7/10831 , G06K2207/1016 , C08L2666/02
摘要： Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic functional groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable or not are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants. Visualization agents may be included with the crosslinked polymers.
摘要翻译： 公开了生物相容的交联聚合物及其制备和使用的方法，其中生物相容的交联聚合物由具有能够原位反应和交联的亲电子和亲核官能团的水溶性前体形成。 制备生物相容的交联聚合物可生物降解或不生物降解的方法与控制降解速率的方法一样。 交联反应可以在器官或组织上或身体外的原位进行。 用于这种生物相容性交联聚合物及其前体的应用包括药物的受控递送，术后粘连的预防，医疗装置如血管移植物，伤口敷料和手术密封剂的涂覆。 可交联剂可以与交联聚合物一起包含。
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